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2024-04-26 19:10:05, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001199779 4391 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens proteasome (prosome, macropain) subunit, beta type, 2
(PSMB2), transcript variant 2, mRNA.
ACCESSION NM_001199779
VERSION NM_001199779.1 GI:315139005
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4391)
AUTHORS Collavoli,A., Comelli,L., Cervelli,T. and Galli,A.
TITLE The over-expression of the beta2 catalytic subunit of the
proteasome decreases homologous recombination and impairs DNA
double-strand break repair in human cells
JOURNAL J. Biomed. Biotechnol. 2011, 757960 (2011)
PUBMED 21660142
REMARK GeneRIF: Results showed that the overexpression of beta2 subunit
decreased homologous recombination in human cells without altering
the cell proteasome activity and the Rad51p level.
REFERENCE 2 (bases 1 to 4391)
AUTHORS Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
Kim,N.S.
TITLE Transcriptome analysis of human gastric cancer
JOURNAL Mamm. Genome 16 (12), 942-954 (2005)
PUBMED 16341674
REFERENCE 3 (bases 1 to 4391)
AUTHORS Listovsky,T., Oren,Y.S., Yudkovsky,Y., Mahbubani,H.M., Weiss,A.M.,
Lebendiker,M. and Brandeis,M.
TITLE Mammalian Cdh1/Fzr mediates its own degradation
JOURNAL EMBO J. 23 (7), 1619-1626 (2004)
PUBMED 15029244
REFERENCE 4 (bases 1 to 4391)
AUTHORS Conticello,S.G., Harris,R.S. and Neuberger,M.S.
TITLE The Vif protein of HIV triggers degradation of the human
antiretroviral DNA deaminase APOBEC3G
JOURNAL Curr. Biol. 13 (22), 2009-2013 (2003)
PUBMED 14614829
REFERENCE 5 (bases 1 to 4391)
AUTHORS Yu,X., Yu,Y., Liu,B., Luo,K., Kong,W., Mao,P. and Yu,X.F.
TITLE Induction of APOBEC3G ubiquitination and degradation by an HIV-1
Vif-Cul5-SCF complex
JOURNAL Science 302 (5647), 1056-1060 (2003)
PUBMED 14564014
REFERENCE 6 (bases 1 to 4391)
AUTHORS Coux,O., Tanaka,K. and Goldberg,A.L.
TITLE Structure and functions of the 20S and 26S proteasomes
JOURNAL Annu. Rev. Biochem. 65, 801-847 (1996)
PUBMED 8811196
REMARK Review article
REFERENCE 7 (bases 1 to 4391)
AUTHORS Kristensen,P., Johnsen,A.H., Uerkvitz,W., Tanaka,K. and Hendil,K.B.
TITLE Human proteasome subunits from 2-dimensional gels identified by
partial sequencing
JOURNAL Biochem. Biophys. Res. Commun. 205 (3), 1785-1789 (1994)
PUBMED 7811265
REMARK Erratum:[Biochem Biophys Res Commun. 1995 Feb 27;207(3):1059. PMID:
7864893]
REFERENCE 8 (bases 1 to 4391)
AUTHORS Nothwang,H.G., Tamura,T., Tanaka,K. and Ichihara,A.
TITLE Sequence analyses and inter-species comparisons of three novel
human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine
potential proteolytic active-site residues
JOURNAL Biochim. Biophys. Acta 1219 (2), 361-368 (1994)
PUBMED 7918633
REFERENCE 9 (bases 1 to 4391)
AUTHORS Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
Vandekerckhove,J.
TITLE Microsequences of 145 proteins recorded in the two-dimensional gel
protein database of normal human epidermal keratinocytes
JOURNAL Electrophoresis 13 (12), 960-969 (1992)
PUBMED 1286667
REFERENCE 10 (bases 1 to 4391)
AUTHORS Dawson,S.J. and White,L.A.
TITLE Treatment of Haemophilus aphrophilus endocarditis with
ciprofloxacin
JOURNAL J. Infect. 24 (3), 317-320 (1992)
PUBMED 1602151
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BM849239.1, AK296956.1,
AL157951.5 and BM664618.1.
Summary: The proteasome is a multicatalytic proteinase complex with
a highly ordered ring-shaped 20S core structure. The core structure
is composed of 4 rings of 28 non-identical subunits; 2 rings are
composed of 7 alpha subunits and 2 rings are composed of 7 beta
subunits. Proteasomes are distributed throughout eukaryotic cells
at a high concentration and cleave peptides in an
ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
essential function of a modified proteasome, the immunoproteasome,
is the processing of class I MHC peptides. This gene encodes a
member of the proteasome B-type family, also known as the T1B
family, that is a 20S core beta subunit. Multiple alternatively
spliced transcript variants encoding distinct isoforms have been
found for this gene. [provided by RefSeq, Dec 2010].
Transcript Variant: This variant (2) lacks an in-frame segment in
the 5' region, as compared to variant 1. The resulting isoform (2)
lacks an internal segment in the N-terminus, as compared to isoform
1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BM849239.1, AK296956.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-25 BM849239.1 1-25
26-1236 AK296956.1 1-1211
1237-4022 AL157951.5 6460-9245
4023-4391 BM664618.1 1-369 c
FEATURES Location/Qualifiers
source 1..4391
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p34.2"
gene 1..4391
/gene="PSMB2"
/gene_synonym="HC7-I"
/note="proteasome (prosome, macropain) subunit, beta type,
2"
/db_xref="GeneID:5690"
/db_xref="HGNC:9539"
/db_xref="MIM:602175"
exon 1..135
/gene="PSMB2"
/gene_synonym="HC7-I"
/inference="alignment:Splign:1.39.8"
variation 11
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace=""
/replace="t"
/db_xref="dbSNP:60039597"
STS 76..683
/gene="PSMB2"
/gene_synonym="HC7-I"
/db_xref="UniSTS:486264"
variation 100
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="a"
/replace="g"
/db_xref="dbSNP:11550442"
CDS 120..650
/gene="PSMB2"
/gene_synonym="HC7-I"
/EC_number="3.4.25.1"
/note="isoform 2 is encoded by transcript variant 2;
macropain subunit C7-I; multicatalytic endopeptidase
complex subunit C7-1; proteasome component C7-I;
proteasome subunit, beta type, 2; proteasome subunit beta
type-2; proteasome beta 2 subunit; multicatalytic
endopeptidase complex subunit C7-I"
/codon_start=1
/product="proteasome subunit beta type-2 isoform 2"
/protein_id="NP_001186708.1"
/db_xref="GI:315139006"
/db_xref="GeneID:5690"
/db_xref="HGNC:9539"
/db_xref="MIM:602175"
/translation="
MEYLIDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
"
misc_feature <135..638
/gene="PSMB2"
/gene_synonym="HC7-I"
/note="20S proteasome, alpha and beta subunits
[Posttranslational modification, protein turnover,
chaperones]; Region: PRE1; COG0638"
/db_xref="CDD:223711"
misc_feature 135..620
/gene="PSMB2"
/gene_synonym="HC7-I"
/note="proteasome beta type-2 subunit. The 20S proteasome,
multisubunit proteolytic complex, is the central enzyme of
nonlysosomal protein degradation in both the cytosol and
nucleus. It is composed of 28 subunits arranged as four
homoheptameric rings that...; Region:
proteasome_beta_type_2; cd03758"
/db_xref="CDD:239727"
exon 136..258
/gene="PSMB2"
/gene_synonym="HC7-I"
/inference="alignment:Splign:1.39.8"
variation 158
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="g"
/replace="t"
/db_xref="dbSNP:11550446"
variation 177
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="c"
/replace="t"
/db_xref="dbSNP:59158931"
variation 189
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="g"
/replace="t"
/db_xref="dbSNP:1804238"
variation 227
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="a"
/replace="g"
/db_xref="dbSNP:11550443"
variation 235
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="c"
/replace="t"
/db_xref="dbSNP:11550447"
exon 259..329
/gene="PSMB2"
/gene_synonym="HC7-I"
/inference="alignment:Splign:1.39.8"
exon 330..492
/gene="PSMB2"
/gene_synonym="HC7-I"
/inference="alignment:Splign:1.39.8"
exon 493..542
/gene="PSMB2"
/gene_synonym="HC7-I"
/inference="alignment:Splign:1.39.8"
variation 519
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="c"
/replace="t"
/db_xref="dbSNP:1804236"
exon 543..4376
/gene="PSMB2"
/gene_synonym="HC7-I"
/inference="alignment:Splign:1.39.8"
variation 604
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="g"
/replace="t"
/db_xref="dbSNP:1804237"
STS 649..750
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="SHGC-35307"
/db_xref="UniSTS:2779"
variation 655
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="a"
/replace="g"
/db_xref="dbSNP:12386"
variation 685
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="c"
/replace="t"
/db_xref="dbSNP:60768546"
variation 727
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="a"
/replace="g"
/db_xref="dbSNP:61192957"
variation 802
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="c"
/replace="t"
/db_xref="dbSNP:61038979"
STS 1144..1246
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="D11S3114"
/db_xref="UniSTS:152207"
STS 1228..2747
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 1228..1316
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 1247..2827
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="AB049870"
/db_xref="UniSTS:480103"
STS 1247..2788
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="D10S275"
/db_xref="UniSTS:147992"
STS 1673..1803
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="D15S1390"
/db_xref="UniSTS:474340"
variation 1734
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="a"
/replace="g"
/db_xref="dbSNP:1132065"
variation 1758
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="a"
/replace="g"
/db_xref="dbSNP:1132067"
variation 1769
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="a"
/replace="g"
/db_xref="dbSNP:1132068"
STS 2611..2786
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="D1S1425"
/db_xref="UniSTS:149621"
STS 2613..2783
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="G35510"
/db_xref="UniSTS:44150"
STS 3519..3662
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="SHGC-74572"
/db_xref="UniSTS:30275"
STS 4224..4328
/gene="PSMB2"
/gene_synonym="HC7-I"
/standard_name="SHGC-74576"
/db_xref="UniSTS:54319"
variation 4235
/gene="PSMB2"
/gene_synonym="HC7-I"
/replace="c"
/replace="t"
/db_xref="dbSNP:1062255"
polyA_site 4376
/gene="PSMB2"
/gene_synonym="HC7-I"
ORIGIN
gaagtcgtgctgcaggcgtcgcgccaatcttcgctctgaggtgctgtctcaccggtgagacctggaagcgggcgagtctcgtgctgtgtcggacctgcagcccctggccttccgccaccatggagtacctcatcgatcatgacaagatgtttaagatgagtgaaaagatattactcctgtgtgttggagaggctggagacactgtacagtttgcagaatatattcagaaaaacgtgcaactttataagatgcgaaatggatatgaattgtctcccacggcagcagctaacttcacacgccgaaacctggctgactgtcttcggagtcggaccccatatcatgtgaacctcctcctggctggctatgatgagcatgaagggccagcgctgtattacatggactacctggcagccttggccaaggccccttttgcagcccacggctatggtgccttcctgactctcagtatcctcgaccgatactacacaccgactatctcacgtgagagggcagtggaactccttaggaaatgtctggaggagctccagaaacgcttcatcctgaatctgccaaccttcagtgttcgaatcattgacaaaaatggcatccatgacctggataacatttccttccccaaacagggctcctaacatcatgtcctccctcccacttgccagggaacttttttttgatgggctcctttatttttttctactcttttcaggcgcactcttgataaatggttaattcagaataaaggtgactatggatataattgagccctctggtccaggtctcagtttacctaatattacctcagaaaggatatggagggaagatgatctttttgccaggtctgacttttcttcctgctccgccctccattaacgctcagtaccctttagcagctgacggccccacgttctactccatgcttggcttcctttccaactagctctttcatatattttacttgctagtatctccattctctctaaagtagtggttctttttgcccttaaacttaaatttttaaattaattaacctgaattaataatacatgcacttaatgtaacatgcaaacagtacaaaaacatgtagtgaaaaatatttcttccagagctgggtgtggtggctcatacctgtaatcccagcactttgggaggccgaggcgggcggatcacgaggtcaagagagcgagaccatcctgaccaacatggtaaaaccccgtctctactaaaaatacaaaaattagctgggcgtggtggcacgcacccctagtcccagctactggggaggctgagacaggagaatcggtcgaacccgggaggcagaggttgcagtgagcctagatcgcgccactgtactccagcctggcaacagagtgagactccgtctcaaaaaaagaaggaaaaatgtttcttccatccctataatccagtcatctgcttcctgcttcccttcctggaggaaacttcagctactaatttcttatgttttttaagagatattctgttactgtgtaaagtatacatacatacagacacatgccccctttaaattttttagatttatttatttatttagagacagggtctcactctagcccaggctggagtgctgtggcgtaatcttggctcactgcaacctccgcctcccgggcccaagtgatcctcccatctcagcctcctgagtagctaggattacaggcgcacaccaccaatgcccagctagtttttgtgtttttcatagagacagggtctcaccatgtcattcaggttggtcttgaactcctgggctcaagcagtctgcctgccttggcttcccagtgctgggattacaggcgtgagccaccgtgcccggctaaaaagtatttttaagttctgcatattgcttatttcacttaacactatattagagattgttttatatcaatacatatagatatgcttattcttgttgacagttgcataattttccattaaattgatgtatcatgggcagttaaccagttactcgttttactcttagcataactttagggaacaatgtggatgttttgtggttaaagctattaaaacagtggttcttgaccagatgtgtgtttcagaatgttcatctcacatttccagttgctactgatgctgctggtctaggaaccacatatcaaaaccatttggtctccgactaagataaaccctactttatccaattctgtgctcctcttaatatcatatacagataggtttttgttttgtctgtgattaaatgtatcatctaagatactacctactgatcataacgttcatattaaagtattgggttaacattagatttgggtgtcttatacactatttaatacgccaatgataaatgccttacaccataagaagaaagctaatcattgagtaaatgggagaaaagagatgattcacgtcactacagttgattcaacctccaacaccaccatgaatatgcataggtttgagcttttagctagattcctgagtgtaaggcatctattttaaaagtgccacaggttggccgggtgcggtggctcatgcctgtaatcccagcactttggccgcccgccgaggcgggcggatcacctgaggtcaggagttcaagaccagcctggccaacatggtgaaaccccatctctactaaaaaaatatataacaattagccaggcgtggtggcacacgcctgtaaacccaactacttgggaggctgaggcaggagaattgcttgagcccgggagagggaggttgcagtgagccgagatcatgccactgcactccagcctggctgacagagcaagactctgtctcaaaaaaaaaaaaaaaaaaaaaaaaaaagcgccacagatgattctgacgccctacccagtggagtgctgctactaaagcacagactatcctgctacatgattttcccatctgtacaatgactgaaatagcacctattctatgtggtagatatgagaattccatgaagtaatataggtaaacatttagttcagggcttggcatgtggtaagtgctcagtaagtgtataatgattggtaaacttgttattctgcattcaggcctcaccagggatgacatacggttctctgcctttgaatgtaagtgtccccagggcaatctcaggcaagcctgcaaacccatcctgactctcagtgtttttttgccaatctggatctctttcctgagctccaaatcaactcattcctagatagctcaccctccagatttagggacatcgaactcagtatgtctaaagctgagccttaccatctgcccctctccaaaccgcctctatgacattctgtcttagagaattagagctacctggtttcccaagtgcccaagtcagaaacccaggcatcatttatttttaataaatgttttattttggaataaatttggttttacagaaaagttgcaaagataatatggtgtccttataccccttattcagtttctgtaatgttaacatcttctatataccacagtatgtttgtcaaaactgagaaaccaacattggttggtgtattagtattactaagctccaggctttattcagattttaccagtttttccactaattttcttctgttctaggatataatccaagatacaacattgcatttagctgggcatcatttttatgccattctttatctcctgtctctacatggccaccaagttctggcatttctacatcctaaatcttttaattttattataattttttattgttgtttttcagagacagggtcttgctccatcacctaggctggagtacagtggcacgatcgtagcttactgcagtaagttcacttgaactcctgggctcaagtgaacctcttaccccagcctcccaactagctgggactagaggggtgcaccactgcacccagctaattttgtcaaaattttttgtagagacagggtctcgccatgttgcctaggctggtctcgaactcttggcctcaagtgatcctcccaccttggtctgccaaagcactgggattacagatgtgagccactgcacccagcctaatctttataaatctccatccccattactctggttcaccccctatcgtttcttagactatttaacagcctcctaacttcactctacttttaatctcttccctctccaggtctttctccatattttaaaaaactagtttcaccatccattcctctctgcccttaaaactttctggtggttttccatggcttaagagaataaagcccaattctttgatttgacatgctaggcattccataatcctctccgaacctaactccccacttcctttccctcctttacacctcataaagcctgtgttccaactaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5690 -> Molecular function: GO:0004298 [threonine-type endopeptidase activity] evidence: IEA
GeneID:5690 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
GeneID:5690 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
GeneID:5690 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:5690 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
GeneID:5690 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
GeneID:5690 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
GeneID:5690 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:5690 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
GeneID:5690 -> Biological process: GO:0010243 [response to organonitrogen compound] evidence: IEA
GeneID:5690 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:5690 -> Biological process: GO:0014070 [response to organic cyclic compound] evidence: IEA
GeneID:5690 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:5690 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:5690 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:5690 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:5690 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
GeneID:5690 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
GeneID:5690 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
GeneID:5690 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:5690 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:5690 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:5690 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5690 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5690 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
GeneID:5690 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS
GeneID:5690 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:5690 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5690 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:5690 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5690 -> Cellular component: GO:0005839 [proteasome core complex] evidence: ISS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001186708 -> EC 3.4.25.1
by
@meso_cacase at
DBCLS
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