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2024-04-19 22:02:35, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001199492 3602 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens programmed cell death 4 (neoplastic transformation
inhibitor) (PDCD4), transcript variant 3, mRNA.
ACCESSION NM_001199492
VERSION NM_001199492.1 GI:313760536
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3602)
AUTHORS Kolpa,H.J., Peal,D.S., Lynch,S.N., Giokas,A.C., Ghatak,S.,
Misra,S., Norris,R.A., Macrae,C.A., Markwald,R.R., Ellinor,P.,
Bischoff,J. and Milan,D.J.
TITLE miR-21 represses Pdcd4 during cardiac valvulogenesis
JOURNAL Development 140 (10), 2172-2180 (2013)
PUBMED 23578931
REMARK GeneRIF: miR-21 plays a necessary role in cardiac valvulogenesis,
in large part due to an obligatory downregulation of PDCD4
REFERENCE 2 (bases 1 to 3602)
AUTHORS Wang,Q., Zhu,J., Zhang,Y., Sun,Z., Guo,X., Wang,X., Lee,E.,
Bakthavatchalu,V., Yang,Q. and Yang,H.S.
TITLE Down-regulation of programmed cell death 4 leads to epithelial to
mesenchymal transition and promotes metastasis in mice
JOURNAL Eur. J. Cancer 49 (7), 1761-1770 (2013)
PUBMED 23312883
REMARK GeneRIF: Data indicate that programmed cell death 4 (Pdcd4)
knockdown altered the adhesion capacity of colon carcinoma GEO
cells.
REFERENCE 3 (bases 1 to 3602)
AUTHORS Paik,W.H., Kim,H.R., Park,J.K., Song,B.J., Lee,S.H. and Hwang,J.H.
TITLE Chemosensitivity induced by down-regulation of microRNA-21 in
gemcitabine-resistant pancreatic cancer cells by indole-3-carbinol
JOURNAL Anticancer Res. 33 (4), 1473-1481 (2013)
PUBMED 23564788
REMARK GeneRIF: Loss of PDCD4 indicates chemoresistance in pancreatic
cancer.
REFERENCE 4 (bases 1 to 3602)
AUTHORS Li,C.R., Su,J.J., Wang,W.Y., Lee,M.T., Wang,T.Y., Jiang,K.Y.,
Li,C.F., Hsu,J.M., Chen,C.K., Chen,M., Jiang,S.S., Weaver,V.M. and
Tsai,K.K.
TITLE Molecular profiling of prostatic acinar morphogenesis identifies
PDCD4 and KLF6 as tissue architecture-specific prognostic markers
in prostate cancer
JOURNAL Am. J. Pathol. 182 (2), 363-374 (2013)
PUBMED 23219426
REMARK GeneRIF: Programmed cell death protein 4 (PDCD4) and Kruppel-like
factor 6 (KLF6) were identified as critical regulators and
surrogate markers of prostatic tissue architectures.
REFERENCE 5 (bases 1 to 3602)
AUTHORS Ludwig,K., Fassan,M., Mescoli,C., Pizzi,M., Balistreri,M.,
Albertoni,L., Pucciarelli,S., Scarpa,M., Sturniolo,G.C.,
Angriman,I. and Rugge,M.
TITLE PDCD4/miR-21 dysregulation in inflammatory bowel disease-associated
carcinogenesis
JOURNAL Virchows Arch. 462 (1), 57-63 (2013)
PUBMED 23224068
REMARK GeneRIF: PDCD4 nuclear down-regulation (which parallels miR-21
up-regulation) is involved in the molecular pathway of inflammatory
bowel disease-associated carcinogenesis.
REFERENCE 6 (bases 1 to 3602)
AUTHORS Chen,Y., Knosel,T., Kristiansen,G., Pietas,A., Garber,M.E.,
Matsuhashi,S., Ozaki,I. and Petersen,I.
TITLE Loss of PDCD4 expression in human lung cancer correlates with
tumour progression and prognosis
JOURNAL J. Pathol. 200 (5), 640-646 (2003)
PUBMED 12898601
REFERENCE 7 (bases 1 to 3602)
AUTHORS Kang,M.J., Ahn,H.S., Lee,J.Y., Matsuhashi,S. and Park,W.Y.
TITLE Up-regulation of PDCD4 in senescent human diploid fibroblasts
JOURNAL Biochem. Biophys. Res. Commun. 293 (1), 617-621 (2002)
PUBMED 12054647
REMARK GeneRIF: up-regulated in senescent diploid fibroblasts
REFERENCE 8 (bases 1 to 3602)
AUTHORS Yoshinaga,H., Matsuhashi,S., Fujiyama,C. and Masaki,Z.
TITLE Novel human PDCD4 (H731) gene expressed in proliferative cells is
expressed in the small duct epithelial cells of the breast as
revealed by an anti-H731 antibody
JOURNAL Pathol. Int. 49 (12), 1067-1077 (1999)
PUBMED 10632927
REFERENCE 9 (bases 1 to 3602)
AUTHORS Soejima,H., Miyoshi,O., Yoshinaga,H., Masaki,Z., Ozaki,I.,
Kajiwara,S., Niikawa,N., Matsuhashi,S. and Mukai,T.
TITLE Assignment of the programmed cell death 4 gene (PDCD4) to human
chromosome band 10q24 by in situ hybridization
JOURNAL Cytogenet. Cell Genet. 87 (1-2), 113-114 (1999)
PUBMED 10640828
REFERENCE 10 (bases 1 to 3602)
AUTHORS Azzoni,L., Zatsepina,O., Abebe,B., Bennett,I.M., Kanakaraj,P. and
Perussia,B.
TITLE Differential transcriptional regulation of CD161 and a novel gene,
197/15a, by IL-2, IL-15, and IL-12 in NK and T cells
JOURNAL J. Immunol. 161 (7), 3493-3500 (1998)
PUBMED 9759869
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB241608.1, AL136368.24,
AK296753.1, AL158163.11 and BX647834.1.
Summary: This gene is a tumor suppressor and encodes a protein that
binds to the eukaryotic translation initiation factor 4A1 and
inhibits its function by preventing RNA binding. Alternative
splicing results in multiple transcript variants. [provided by
RefSeq, Dec 2010].
Transcript Variant: This variant (3) uses an alternate in-frame
splice site in the 5' coding region, compared to variant 1. The
resulting protein (isoform 3) is shorter, compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK296753.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-59 DB241608.1 1-59
60-60 AL136368.24 125230-125230
61-133 DB241608.1 61-133
134-349 AK296753.1 1-216
350-350 AL136368.24 134671-134671
351-1743 AK296753.1 218-1610
1744-1836 AL158163.11 15706-15798
1837-3322 BX647834.1 1719-3204
3323-3323 AL158163.11 17285-17285
3324-3602 BX647834.1 3206-3484
FEATURES Location/Qualifiers
source 1..3602
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q24"
gene 1..3602
/gene="PDCD4"
/gene_synonym="H731"
/note="programmed cell death 4 (neoplastic transformation
inhibitor)"
/db_xref="GeneID:27250"
/db_xref="HGNC:8763"
/db_xref="MIM:608610"
exon 1..224
/gene="PDCD4"
/gene_synonym="H731"
/inference="alignment:Splign:1.39.8"
exon 225..329
/gene="PDCD4"
/gene_synonym="H731"
/inference="alignment:Splign:1.39.8"
misc_feature 278..280
/gene="PDCD4"
/gene_synonym="H731"
/note="upstream in-frame stop codon"
CDS 287..1654
/gene="PDCD4"
/gene_synonym="H731"
/note="isoform 3 is encoded by transcript variant 3;
nuclear antigen H731; programmed cell death protein 4;
protein 197/15a; neoplastic transformation inhibitor
protein"
/codon_start=1
/product="programmed cell death protein 4 isoform 3"
/protein_id="NP_001186421.1"
/db_xref="GI:313760537"
/db_xref="GeneID:27250"
/db_xref="HGNC:8763"
/db_xref="MIM:608610"
/translation="
MDVENEQILNVNPAENAGTEEIKNEINGNWISASSINEARINAKAKRRLRKNSSRDSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFVSEGDGGRLKPESY
"
misc_feature 734..1069
/gene="PDCD4"
/gene_synonym="H731"
/note="Domain in DAP-5, eIF4G, MA-3 and other proteins;
Region: MA3; smart00544"
/db_xref="CDD:128817"
misc_feature 1223..1564
/gene="PDCD4"
/gene_synonym="H731"
/note="Domain in DAP-5, eIF4G, MA-3 and other proteins;
Region: MA3; smart00544"
/db_xref="CDD:128817"
exon 330..590
/gene="PDCD4"
/gene_synonym="H731"
/inference="alignment:Splign:1.39.8"
STS 440..596
/gene="PDCD4"
/gene_synonym="H731"
/standard_name="RH93337"
/db_xref="UniSTS:83971"
exon 591..685
/gene="PDCD4"
/gene_synonym="H731"
/inference="alignment:Splign:1.39.8"
exon 686..799
/gene="PDCD4"
/gene_synonym="H731"
/inference="alignment:Splign:1.39.8"
exon 800..1021
/gene="PDCD4"
/gene_synonym="H731"
/inference="alignment:Splign:1.39.8"
exon 1022..1119
/gene="PDCD4"
/gene_synonym="H731"
/inference="alignment:Splign:1.39.8"
STS 1040..1177
/gene="PDCD4"
/gene_synonym="H731"
/standard_name="MARC_26204-26205:1030736270:1"
/db_xref="UniSTS:268985"
exon 1120..1234
/gene="PDCD4"
/gene_synonym="H731"
/inference="alignment:Splign:1.39.8"
exon 1235..1342
/gene="PDCD4"
/gene_synonym="H731"
/inference="alignment:Splign:1.39.8"
exon 1343..1453
/gene="PDCD4"
/gene_synonym="H731"
/inference="alignment:Splign:1.39.8"
exon 1454..1593
/gene="PDCD4"
/gene_synonym="H731"
/inference="alignment:Splign:1.39.8"
exon 1594..3572
/gene="PDCD4"
/gene_synonym="H731"
/inference="alignment:Splign:1.39.8"
STS 2028..2243
/gene="PDCD4"
/gene_synonym="H731"
/standard_name="SHGC-35716"
/db_xref="UniSTS:82555"
polyA_signal 2285..2290
/gene="PDCD4"
/gene_synonym="H731"
polyA_site 2302
/gene="PDCD4"
/gene_synonym="H731"
polyA_site 2305
/gene="PDCD4"
/gene_synonym="H731"
polyA_site 2316
/gene="PDCD4"
/gene_synonym="H731"
polyA_signal 2690..2695
/gene="PDCD4"
/gene_synonym="H731"
polyA_site 2713
/gene="PDCD4"
/gene_synonym="H731"
variation complement(3317)
/gene="PDCD4"
/gene_synonym="H731"
/replace="c"
/replace="g"
/db_xref="dbSNP:11548763"
STS 3395..3519
/gene="PDCD4"
/gene_synonym="H731"
/standard_name="RH44657"
/db_xref="UniSTS:40387"
polyA_signal 3548..3553
/gene="PDCD4"
/gene_synonym="H731"
polyA_site 3572
/gene="PDCD4"
/gene_synonym="H731"
ORIGIN
cttttcctcctcagctccggctccgccgccacgattggccagccgaccacccggcctcggccaataagcgccgccctctcgcccccgtgttactgggtagaagaaaacaaaaacaaacagagcgagaagggccagagactctccgaggcggcggcagagacagaagagcggggtcggggccggctgaccaggaacctgggcgagcagcggcgggggcccgagggattctgaaggaagatttccattaggtaatttgtttaatcagtgcaagcgaaattaagggaaaatggatgtagaaaatgagcagatactgaatgtaaaccctgcagaaaatgctgggactgaggaaataaagaatgaaataaatggaaattggatttcagcatcctccattaacgaagctagaattaatgccaaggcaaaaaggcgactaaggaaaaactcatcccgggactctggcagaggcgattcggtcagcgacagtgggagtgacgcccttagaagtggattaactgtgccaaccagtccaaagggaaggttgctggataggcgatccagatctgggaaaggaaggggactaccaaagaaaggtggtgcaggaggcaaaggtgtctggggtacacctggacaggtgtatgatgtggaggaggtggatgtgaaagatcctaactatgatgatgaccaggagaactgtgtttatgaaactgtagttttgcctttggatgaaagggcatttgagaagactttaacaccaatcatacaggaatattttgagcatggagatactaatgaagttgcggaaatgttaagagatttaaatcttggtgaaatgaaaagtggagtaccagtgttggcagtatccttagcattggaggggaaggctagtcatagagagatgacatctaagcttctttctgacctttgtgggacagtaatgagcacaactgatgtggaaaaatcatttgataaattgttgaaagatctacctgaattagcactggatactcctagagcaccacagttggtgggccagtttattgctagagctgttggagatggaattttatgtaatacctatattgatagttacaaaggaactgtagattgtgtgcaggctagagctgctctggataaggctaccgtgcttctgagtatgtctaaaggtggaaagcgtaaagatagtgtgtggggctctggaggtgggcagcaatctgtcaatcaccttgttaaagagattgatatgctgctgaaagaatatttactctctggagacatatctgaagctgaacattgccttaaggaactggaagtacctcattttcaccatgagcttgtatatgaagctattataatggttttagagtcaactggagaaagtacatttaagatgattttggatttattaaagtccctttggaagtcttctaccattactgtagaccaaatgaaaagaggttatgagagaatttacaatgaaattccggacattaatctggatgtcccacattcatactctgtgctggagcggtttgtagaagaatgttttcaggctggaataatttccaaacaactcagagatctttgtccttcaaggggcagaaagcgttttgtaagcgaaggagatggaggtcgtcttaaaccagagagctactgaatataagaactcttgcagtcttagatgttataaaaatatatatctgaattgtaagagttgttagcacaagttttttttttttttttttttaagcacttgttttgggtacaaggcatttctgacattttataaacctacatttaaggggaatttttaaaggaaatgttttttcttttttttttgtttttcgagggggcaaggagggacagaaaagtaacctcttcttaagtggaatattctaataagctaccttttgtaagtgccatgtttattatctaatcattccaagttttgcattgatgtctgactgccactcctttctttcaaggacagtgttttttgtagtaaaatcactggtttatacaaagctttatttagggggtaaagttaagctgctaaaaccccatgttggctgctgctgttgagatactgtgctttgggagtaaaaaaagaaagttatttctttgtcttaaagaatttttaaaaaattagtcatgagacttattcatctttccagggaacatactgattggtcttaaaagactagacagttaagtaaaaggtggctggaacatctatttttctacaaaactggaaaaatgaacctggttctagaagaatgtacaccaaaataaaacatgtgaagcagtattgattctttattgggagtacatttttttaggtctcttaaactttaatttcacacagtaaattttgaatctcataaggaagcatatttgaacctagtcaatttaatcttagtgttcccttgaaaactttttttccctacaaaattttaagtgaaaaatacaatagtaaattaagattacactggggaaaaaaatgcaggtatcactttactccattgttatctgacctagagcttaattaagttttagaaatatgtaataccttccatcattccatcatccttaaattctgttaccaaataatggctaatgttacaaaaagttatactccagagacccaaagcttgacatttacctaatgtatgagaaaatattaccaattaacaataaagaatgatcatatttttaacctcttttacatagcctaataactcagcaaggcctcaacgtctgtgctaatttaaactgccaaatattgactgcagcaaacaagaattatattcagaatttatgagggtactgttaggagtatactgcttacaggtttagatatagtctgttagaattaaaaccaagtttagtgttcatatttacctcatgggctttatcaagcccatattacctcagcttatatatagttaccatttttaggtttttaattgtttgacacttggatgataaatgcagtcattttattctcaagtgcttaaaattaatgtaattaaaagcttagctgactacagaataggtgagggtttcttaaaaatgagatttaagggctgggcacggtggctcatgcctgtaatcccagcactttgggaggccgaggtgggcggatcacttgaggttgggagttcatgaccagcttgaccaacatgaagaaaccctgtctctattaaaaatacaaaagtagccaggcatggtggcgcatgcgtgtaatcccagctacttgggaggctgaggcaggagaattgcttgaacctgggaggcagaggttgcagtgagtcgagatggtgccattgctctcgtttgggcaacaagagtgaaactcttgtctcaaaaaaaaaaaaaaatgaggtttaagacagttttgtcattactggtgggatctggtcacacaagatagcattaaacgtgacatggcacataaaattggttaaaaaattttgttttttaattacgtaatgtaaaagcccaacaaacactttatgcaagattggaatgtatcttcaaattcagatttaataaacatgtaaagatcctctgtaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:27250 -> Molecular function: GO:0003723 [RNA binding] evidence: IEA
GeneID:27250 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:27250 -> Biological process: GO:0006915 [apoptotic process] evidence: NAS
GeneID:27250 -> Biological process: GO:0007569 [cell aging] evidence: IDA
GeneID:27250 -> Biological process: GO:0016070 [RNA metabolic process] evidence: IEA
GeneID:27250 -> Biological process: GO:0043508 [negative regulation of JUN kinase activity] evidence: ISS
GeneID:27250 -> Biological process: GO:0045786 [negative regulation of cell cycle] evidence: NAS
GeneID:27250 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:27250 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: ISS
GeneID:27250 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:27250 -> Cellular component: GO:0005634 [nucleus] evidence: IMP
GeneID:27250 -> Cellular component: GO:0005634 [nucleus] evidence: ISS
GeneID:27250 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:27250 -> Cellular component: GO:0005737 [cytoplasm] evidence: IMP
GeneID:27250 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
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@meso_cacase at
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