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2024-04-19 23:22:38, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001199427 7405 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens TNF receptor-associated factor 3 (TRAF3), transcript
variant 4, mRNA.
ACCESSION NM_001199427
VERSION NM_001199427.1 GI:313661482
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7405)
AUTHORS Cai,X., Du,J., Liu,Y., Xia,W., Liu,J., Zou,M., Wang,Y., Wang,M.,
Su,H. and Xu,D.
TITLE Identification and characterization of receptor-interacting protein
2 as a TNFR-associated factor 3 binding partner
JOURNAL Gene 517 (2), 205-211 (2013)
PUBMED 23333941
REMARK GeneRIF: In an attempt to explore TRAF3 binding partners that may
be involved in TRAF3-regulated signaling, a yeast two-hybrid screen
of a human spleen cDNA library was undertaken. RIP2 was identified
as a TRAF3 binding partner.
REFERENCE 2 (bases 1 to 7405)
AUTHORS Wolf,K. and Fields,K.A.
TITLE Chlamydia pneumoniae impairs the innate immune response in infected
epithelial cells by targeting TRAF3
JOURNAL J. Immunol. 190 (4), 1695-1701 (2013)
PUBMED 23303668
REMARK GeneRIF: Levels of TRAF3 degradation correlate with number of cells
infected with Chlamydia pneumoniae, because more TRAF3 is detected
at a lower multiplicity of C. pneumoniae infection.
REFERENCE 3 (bases 1 to 7405)
AUTHORS Shen,J., Qiao,Y.Q., Ran,Z.H. and Wang,T.R.
TITLE Up-regulation and pre-activation of TRAF3 and TRAF5 in inflammatory
bowel disease
JOURNAL Int J Med Sci 10 (2), 156-163 (2013)
PUBMED 23329887
REMARK GeneRIF: TRAF3 and TRAF5 are overexpressed in inflammatory bowel
disease. Although the endoscopic appearance can be normal, TRAF3
and TRAF5 pre-activation can be detected in non-inflamed colonic
segments
REFERENCE 4 (bases 1 to 7405)
AUTHORS Belgnaoui,S.M., Paz,S., Samuel,S., Goulet,M.L., Sun,Q., Kikkert,M.,
Iwai,K., Dikic,I., Hiscott,J. and Lin,R.
TITLE Linear ubiquitination of NEMO negatively regulates the interferon
antiviral response through disruption of the MAVS-TRAF3 complex
JOURNAL Cell Host Microbe 12 (2), 211-222 (2012)
PUBMED 22901541
REMARK GeneRIF: Ubiquitination of NEMO negatively regulates the interferon
antiviral response through disruption of the MAVS-TRAF3 complex.
REFERENCE 5 (bases 1 to 7405)
AUTHORS van Zuylen,W.J., Doyon,P., Clement,J.F., Khan,K.A.,
D'Ambrosio,L.M., Do,F., St-Amant-Verret,M., Wissanji,T., Emery,G.,
Gingras,A.C., Meloche,S. and Servant,M.J.
TITLE Proteomic profiling of the TRAF3 interactome network reveals a new
role for the ER-to-Golgi transport compartments in innate immunity
JOURNAL PLoS Pathog. 8 (7), E1002747 (2012)
PUBMED 22792062
REMARK GeneRIF: model proposed where dsDNA and dsRNA sensing induces the
formation of membrane-bound compartments originating from the
Golgi, which mediate the dynamic association of TRAF3 with MAVS
leading to an optimal induction of innate immune responses
REFERENCE 6 (bases 1 to 7405)
AUTHORS Hsu,H., Shu,H.B., Pan,M.G. and Goeddel,D.V.
TITLE TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF
receptor 1 signal transduction pathways
JOURNAL Cell 84 (2), 299-308 (1996)
PUBMED 8565075
REFERENCE 7 (bases 1 to 7405)
AUTHORS Cheng,G., Cleary,A.M., Ye,Z.S., Hong,D.I., Lederman,S. and
Baltimore,D.
TITLE Involvement of CRAF1, a relative of TRAF, in CD40 signaling
JOURNAL Science 267 (5203), 1494-1498 (1995)
PUBMED 7533327
REFERENCE 8 (bases 1 to 7405)
AUTHORS Mosialos,G., Birkenbach,M., Yalamanchili,R., VanArsdale,T., Ware,C.
and Kieff,E.
TITLE The Epstein-Barr virus transforming protein LMP1 engages signaling
proteins for the tumor necrosis factor receptor family
JOURNAL Cell 80 (3), 389-399 (1995)
PUBMED 7859281
REFERENCE 9 (bases 1 to 7405)
AUTHORS Sato,T., Irie,S. and Reed,J.C.
TITLE A novel member of the TRAF family of putative signal transducing
proteins binds to the cytosolic domain of CD40
JOURNAL FEBS Lett. 358 (2), 113-118 (1995)
PUBMED 7530216
REFERENCE 10 (bases 1 to 7405)
AUTHORS Hu,H.M., O'Rourke,K., Boguski,M.S. and Dixit,V.M.
TITLE A novel RING finger protein interacts with the cytoplasmic domain
of CD40
JOURNAL J. Biol. Chem. 269 (48), 30069-30072 (1994)
PUBMED 7527023
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from U21092.1, AL132801.5,
AK303172.1, AL117209.7 and BQ000015.1.
Summary: The protein encoded by this gene is a member of the TNF
receptor associated factor (TRAF) protein family. TRAF proteins
associate with, and mediate the signal transduction from, members
of the TNF receptor (TNFR) superfamily. This protein participates
in the signal transduction of CD40, a TNFR family member important
for the activation of the immune response. This protein is found to
be a critical component of the lymphotoxin-beta receptor (LTbetaR)
signaling complex, which induces NF-kappaB activation and cell
death initiated by LTbeta ligation. Epstein-Barr virus encoded
latent infection membrane protein-1 (LMP1) can interact with this
and several other members of the TRAF family, which may be
essential for the oncogenic effects of LMP1. Several alternatively
spliced transcript variants encoding three distinct isoforms have
been reported. [provided by RefSeq, Dec 2010].
Transcript Variant: This variant (4) differs in the 5' UTR and
lacks an in-frame coding segment compared to variant 1. The
resulting isoform (2) lacks an internal region as compared to
isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK303172.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-81 U21092.1 4-84
82-106 AL132801.5 21810-21834 c
107-288 U21092.1 110-291
289-687 AK303172.1 166-564
688-688 AL117209.7 92643-92643
689-1909 AK303172.1 566-1786
1910-7383 AL117209.7 122236-127709
7384-7405 BQ000015.1 1-22 c
FEATURES Location/Qualifiers
source 1..7405
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q32.32"
gene 1..7405
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/note="TNF receptor-associated factor 3"
/db_xref="GeneID:7187"
/db_xref="HGNC:12033"
/db_xref="MIM:601896"
exon 1..197
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 131
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1051750"
STS 190..1693
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/db_xref="UniSTS:482312"
STS 191..1754
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/db_xref="UniSTS:486323"
exon 198..459
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 207
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370752725"
variation 209
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:190521973"
CDS 215..1672
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/note="isoform 3 is encoded by transcript variant 4; CD40
binding protein; CD40 receptor associated factor 1; CD40
associated protein 1; LMP1-associated protein 1"
/codon_start=1
/product="TNF receptor-associated factor 3 isoform 3"
/protein_id="NP_001186356.1"
/db_xref="GI:313661483"
/db_xref="CCDS:CCDS55946.1"
/db_xref="GeneID:7187"
/db_xref="HGNC:12033"
/db_xref="MIM:601896"
/translation="
MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVDTSDLPDP
"
misc_feature 368..499
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/note="RING-finger (Really Interesting New Gene) domain, a
specialized type of Zn-finger of 40 to 60 residues that
binds two atoms of zinc; defined by the 'cross-brace'
motif C-X2-C-X(9-39)-C-X(1-3)-
H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved
in...; Region: RING; cd00162"
/db_xref="CDD:29102"
misc_feature order(371..373,380..382,416..418,422..424,431..433,
440..442,476..478,485..487)
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/note="cross-brace motif; other site"
/db_xref="CDD:29102"
misc_feature 620..784
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/note="TRAF-type zinc finger; Region: zf-TRAF; pfam02176"
/db_xref="CDD:190233"
misc_feature 1097..1654
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/note="Tumor Necrosis Factor Receptor (TNFR)-Associated
Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF
molecules serve as adapter proteins that link TNFRs and
downstream kinase cascades resulting in the activation of
transcription factors and the...; Region: MATH_TRAF3;
cd03777"
/db_xref="CDD:58108"
misc_feature order(1160..1162,1169..1171,1193..1195,1199..1201,
1220..1222,1226..1228,1310..1315,1406..1408,1415..1417,
1466..1468)
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/note="trimer interface [polypeptide binding]; other site"
/db_xref="CDD:58108"
misc_feature order(1334..1336,1340..1342,1352..1354,1358..1360,
1385..1387,1499..1501,1508..1510,1523..1525,1553..1564)
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/note="TNFR binding site; other site"
/db_xref="CDD:58108"
variation 223
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:377427517"
variation 248
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139127242"
variation 250
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199639339"
variation 261..262
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace=""
/replace="c"
/db_xref="dbSNP:376342002"
variation 267
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:145456077"
variation 288
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370955205"
variation 289
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1051749"
variation 290
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:375545964"
variation 330
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147686384"
variation 352
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:201415483"
variation 399
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:183443558"
variation 403
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142350527"
exon 460..511
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 460
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:146435455"
variation 481
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:147871145"
variation 484
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:149018928"
exon 512..616
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 555
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:12896018"
variation 561
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372370114"
variation 566
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143813189"
variation 591
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="t"
/db_xref="dbSNP:377142394"
variation 600
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1131877"
exon 617..784
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 663
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141920055"
variation 697
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374166578"
variation 721
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:145367471"
variation 776
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:137916856"
exon 785..925
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 803..804
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace=""
/replace="a"
/db_xref="dbSNP:35228820"
variation 919
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:182757817"
exon 926..1100
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 927
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148461790"
variation 934
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:1131876"
variation 952
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372134660"
variation 988
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145200267"
variation 1025
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369697250"
variation 1057
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201374351"
variation 1064
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147610812"
variation 1075
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1051743"
variation 1077
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144719184"
exon 1101..7388
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/inference="alignment:Splign:1.39.8"
variation 1150
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376141594"
variation 1159
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:151258452"
variation 1165
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370697221"
variation 1189
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:140423891"
variation 1192
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150483724"
variation 1204
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:111762207"
variation 1219
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201486992"
variation 1234
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377168511"
variation 1261
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:145391228"
variation 1279
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:3742448"
STS 1309..2199
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/standard_name="TRAF3_v555"
/db_xref="UniSTS:277842"
variation 1318
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1051742"
variation 1348
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141356642"
variation 1372
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200974693"
variation 1381
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150561735"
variation 1450
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199868254"
variation 1453
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:145126372"
variation 1474
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138943371"
variation 1479
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:186844617"
variation 1492
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:202084269"
variation 1507
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374255469"
variation 1543
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:142501447"
variation 1592
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:372089179"
variation 1599
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144637377"
variation 1609
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370725073"
variation 1654
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148195281"
variation 1663
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377148855"
variation 1689
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369453811"
STS 1710..1841
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/standard_name="RH69049"
/db_xref="UniSTS:33196"
variation 1728
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373244439"
variation 1777
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:191258518"
variation 1790
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377143104"
variation 1802
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139584485"
STS 1826..2063
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/standard_name="G15867"
/db_xref="UniSTS:12048"
variation 2022..2023
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace=""
/replace="ac"
/db_xref="dbSNP:371921986"
variation 2023..2024
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace=""
/replace="ac"
/db_xref="dbSNP:142806500"
variation 2023
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:201568881"
variation 2126
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:184183944"
variation 2555
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:188857207"
variation 2582..2583
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace=""
/replace="a"
/db_xref="dbSNP:57120368"
variation 2616
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142745057"
variation 2628
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:192894065"
variation 2649
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:147370186"
variation 2653
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:185305434"
variation 2696
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139583976"
variation 2739
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144980713"
variation 2741
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:80216614"
variation 2784
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:190155467"
variation 2902
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374592471"
variation 2953
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:75249707"
variation 2970..2971
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace=""
/replace="atct"
/db_xref="dbSNP:375424663"
variation 2985
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:72704737"
variation 3184
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373295670"
variation 3189
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372051148"
variation 3246
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:112261683"
variation 3284
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376429109"
variation 3291..3292
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace=""
/replace="ca"
/db_xref="dbSNP:201700309"
variation 3425
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:182212093"
variation 3458
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148584503"
variation 3526
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367719643"
variation 3596
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142988351"
variation 3609..3610
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace=""
/replace="a"
/db_xref="dbSNP:34474027"
variation 3625
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:151084914"
variation 3628
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:186127559"
variation 3677
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:141331668"
variation 3711
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:117897999"
variation 3718
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:117475076"
variation 3777
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:188198787"
variation 3871
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:114392221"
variation 3934
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376100146"
variation 3951
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:145120246"
variation 3993
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:117653635"
variation 3994
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:117106738"
variation 4020
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:7152158"
variation 4114
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace=""
/replace="c"
/db_xref="dbSNP:34578787"
variation 4172
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:116178840"
variation 4222
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374825187"
variation 4228
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:180688846"
variation 4261
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11160707"
variation 4435
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11552465"
variation 4612
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:185075993"
variation 4638
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146802843"
variation 4651
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:191356380"
variation 4688
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372945156"
variation 4713
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:183222973"
variation 4745
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:45517731"
variation 4818
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376995306"
variation 4881
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:45585743"
variation 4945
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:78630751"
variation 4978
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201281332"
variation 4997
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:186841343"
variation 5025
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:80197834"
variation 5057
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:191683954"
variation 5065
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:183394545"
variation 5091
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:74082969"
variation 5140
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:187691773"
variation 5145
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="t"
/db_xref="dbSNP:4906271"
variation 5254
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375292813"
variation 5367
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35360806"
variation 5469
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368940960"
variation 5582
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:4906272"
variation 5636
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375381789"
variation 5680
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138179996"
variation 5703
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:117406867"
variation 5708
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:149530934"
variation 5740
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143203754"
variation 5745
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:191019034"
variation 5790
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369985542"
variation 5809
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11620870"
variation 5833
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:182443319"
variation 5846
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:186731083"
variation 5876
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:192760623"
variation 5937
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:117597898"
variation 5945
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138947290"
variation 5958
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142791534"
variation 6031
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147406100"
variation 6035
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:4906273"
variation 6075
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="t"
/db_xref="dbSNP:373563762"
variation 6111
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138001318"
variation 6129
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376776135"
variation 6152
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370848396"
variation 6183
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:45478597"
variation 6189
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:188439936"
variation 6325
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374197709"
variation 6338
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:193031191"
variation 6341
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369332741"
variation 6379
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:4900558"
variation 6419
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377603736"
variation 6450
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:184726526"
variation 6583
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370260743"
variation 6617
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143573604"
variation 6618
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374968722"
variation 6683
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377708288"
variation 6807
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150503115"
variation 6872
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:10133111"
variation 6876
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1046299"
variation 6900
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:45528941"
variation 6905
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="g"
/replace="t"
/db_xref="dbSNP:11552464"
variation 7013
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:79926472"
variation 7022
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368377660"
variation 7028
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:117858701"
STS 7250..7358
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/standard_name="WI-13969"
/db_xref="UniSTS:60858"
variation 7271
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:115804335"
variation 7293
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
/replace="a"
/replace="t"
/db_xref="dbSNP:78211216"
polyA_signal 7365..7370
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
polyA_site 7388
/gene="TRAF3"
/gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1"
ORIGIN
gggagcgcggcgcggccgccgcgtgcgcgagccggggttgcagcccagccgggactttccagccggcggcagccgcggcggccgccggctcttccccgccccccgccatggggcagcccggggagcagaacgctgcggaccgcggcggaggacgcgcccggcgcccctgagccggccgagcggcgacggaccgcgagaactcctctttcctaaaatggagtcgagtaaaaagatggactctcctggcgcgctgcagactaacccgccgctaaagctgcacactgaccgcagtgctgggacgccagtttttgtccctgaacaaggaggttacaaggaaaagtttgtgaagaccgtggaggacaagtacaagtgtgagaagtgccacctggtgctgtgcagcccgaagcagaccgagtgtgggcaccgcttctgcgagagctgcatggcggccctgctgagctcttcaagtccaaaatgtacagcgtgtcaagagagcatcgttaaagataaggtgtttaaggataattgctgcaagagagaaattctggctcttcagatctattgtcggaatgaaagcagaggttgtgcagagcagttaatgctgggacatctgctggtgcatttaaaaaatgattgccattttgaagaacttccatgtgtgcgtcctgactgcaaagaaaaggtcttgaggaaagacctgcgagaccacgtggagaaggcgtgtaaataccgggaagccacatgcagccactgcaagagtcaggttccgatgatcgcgctgcaggtttccttgttgcagaatgaaagtgtagaaaaaaacaagagcatacaaagtttgcacaatcagatatgtagctttgaaattgaaattgagagacaaaaggaaatgcttcgaaataatgaatccaaaatccttcatttacagcgagtgatagacagccaagcagagaaactgaaggagcttgacaaggagatccggcccttccggcagaactgggaggaagcagacagcatgaagagcagcgtggagtccctccagaaccgcgtgaccgagctggagagcgtggacaagagcgcggggcaagtggctcggaacacaggcctgctggagtcccagctgagccggcatgaccagatgctgagtgtgcacgacatccgcctagccgacatggacctgcgcttccaggtcctggagaccgccagctacaatggagtgctcatctggaagattcgcgactacaagcggcggaagcaggaggccgtcatggggaagaccctgtccctttacagccagcctttctacactggttactttggctataagatgtgtgccagggtctacctgaacggggacgggatggggaaggggacgcacttgtcgctgttttttgtcatcatgcgtggagaatatgatgccctgcttccttggccgtttaagcagaaagtgacactcatgctgatggatcaggggtcctctcgacgtcatttgggagatgcattcaagcccgaccccaacagcagcagcttcaagaagcccactggagagatgaatatcgcctctggctgcccagtctttgtggcccaaactgttctagaaaatgggacatatattaaagatgatacaatttttattaaagtcatagtggatacttcggatctgcccgatccctgataagtagctggggaggtggatttagcagaaggcaactcctctgggggatttgaaccggtctgtcttcactgaggtcctcgcgctcagaaaaggaccttgtgagacggaggaagcggcagaaggcggacgcgtgccggcgggaggagccacgcgtgagcacacctgacacgttttataatagactagccacacttcactctgaagaattatttatccttcaacaagataaatattgctgtcagagaaggttttcattttcatttttaaagatctagttaattaaggtggaaaacatatatgctaaacaaaagaaacatgatttttcttccttaaacttgaacaccaaaaaaacacacacacacacacacgtggggatagctggacatgtcagcatgttaagtaaaaggagaatttatgaaatagtaatgcaattctgatatcttctttctaaaattcaagagtgcaattttgtttcaaatacagtatattgtctatttttaaggcctcatctggtctctgttttaataatttgtttgtcagaagaccctgaagtatatacctaggtcttttttttgaaagtctctaaattcagaatcattttttaatttaaagttctacaaataattgttactgcaaacattttattttaaaacgttgatagactgatatttcttggaagaaaatataaaatatcaaacactggttatcacttgtgataggaaagagaatattcaacctgttgttatttctcgttagaaatgtaaaccttcaaatatctgtcgtagttaatgacacgacttcacaattctgaacggagcctcgctcatggatgctgtgcatcattttcagatttataattgttttcaccctaaaatagggcatccgttgaactttggagttctaaacaaaatcctgtaggtgtttggattctgccccatgtgttcggacgagctctctgttgctgacagcaccggccttcggtctccatgtcaggggtgggcgggtgactgctgagggaggcccgcaggtgtgtttctccatcccgtcatcttgctgcatgccgtcaacggtctccgaaagcaacgttgtgcgtagagctggtggcatacggcccacgtgccttagatgggacatgctgcttctccaccctgggtttgcattgagcatcattctagaaagtgctagtttaaccagacttttctctccaccactagatctttgtctctacaagggccctcagacacctctgcacctgctgaggggaagccaggctccaccgtcggcttctggagcctccgctgcttaattaccacagattccaaatctctaggccccacgagtgagccgcctggtccaagtacggcctggtcccaccctgagggaggcaggtgtggaacagaagccgagcctctccgtgtccccaccggggccgtgggcacccccacagcccgaagcagaaccctctgagcattccagagaccgctgctcgggggcctgcccaggctgaccaacgggcgctcctgaccaccaccctggcgggaagggtggccacggggcccgtcgtcccagcctgtgcctgcccagatggcattttctcaactcactgtttactgtctctcagtgtccaactgtgattagaagcctggagcctgccccctgcaccccttttgctatgcaccacgcttcatggtgctcttaccactgatgggtgctacacgcgacgggtgcttcttaggcaaaaccaatgtgtgcgaactgtcacacctgtgccactcgcccacaagccgcgcccacaattggccagctgggccgtgcacgtcagactgcctgcctcggctctccccgtggccgcgcggggacagcttggtgggtgcccggtggcccacctgtctctggtgctgccatctgtcctgggtgtgccttcgccccagtgcctgctggaagtgccctccgtcgcacccctgtgccctgagctcccgtgaggggcccgccgcgccctttcgcggtcgaagcgttccgttgttcttatctgcctttcctttccccgctctcctgggattactttgggggaatgagtatccttggttctgccctgtgagggagtcgtgtgtccctgctcataaaggaaggacttcctgcagaagctgcggaaaactactgttccctcgaaggtgtcccccacctgaggcctgtcccctacctgccctcaggtagttttcctgaggccaggggttaacaacagggacatccctgcaacttccccttcacaaaatgtataatattagatgaaggatatgcaacatcttggtctagtaagaaccgtttcctcccctctgggttgaagtcctggtgtggcccccagaagcagcagtgcgtgtcactgggacgtctccagtagcccttcccaggcagacgctcctggcgggacgccatggggcccacctgagggtcccacagacgtaacctgagtgacaggagtccttgaggatgggatggcctatgtcacacactttgtccttgaacctgagtgatgggggtccttgaggatgggatggcctgtgtcacgcgctttgtctttgtgtttggttgtatcggggtctctgttctgagtgtgtcttcctctcatgtactcaacacagtgggcagcagcctgggacggcgtcccctctcccggcggcgggcaagccttgcgctgctccaccctcggcctgggcaccctcacttggcgctggccacctgggccagcctggggccatggtctctctgcagctgaggcccagtggccccttgggcagtgatcggccctccccgcatcacagggccctggcagcaagcgggaaatgggggcgcacactgtgtgcttgggggtgctgcttgtttaccacacatgaccagactcccagcaggacagagctgctcagtactttacagaaaccaactgagtcgtttgtgcatgaattaagccggtctgcttccccgtcaccttcgtaacaaaacaacgtcccctctcccctcgcctcgagcagtttcttcaggacaccgtggctcgggctgctccctgctgccaggcacgctggttggctggcctgggcccggctcacgtgaagggcactggctcttgtgaccacactgagccacgtgcaagccgcagccgggcctggaagcctgaccctctggttctagggcttgtcccgcggagcctgcagagctagacgttggggtgtgtccgtgatgatatgggggccaggctgggagtagggcctttctagcagggttgggtggctcagtgagggtgtggaagtgggggacccacggggcctggctttgggactagacatgccagccccagctgggctggagggagcctgagtgagccccgacatacgctgggcctttcagctcgccgtgctctggtgacacacaggcggccaggttgggatttgtgtcaattctaggagccatcaagcatgaatgtggttctgtctcctgagcgcaagcctcgccggacccctgggcgaaggcctggacttgcagatgtgtgttccctgtgcgggtggacagagggggcccttatgacccacattgcagccccattccaccaccccttcctccccagagcagtctctgccgagggacagcacctgtgtcccttcgatgccacaacagccagttgaacaggggagccctttgctcaggcagcttctcctgcctctccctcctttctccttccctgccccatccccgtgcccttcttggcctgtggcgctggggagccatggtgtggcatactggggctcctgctccttgggccacttcctcagcccgggccccacaggcccaccacctgccagggctcccactgcactggctgtggcaggaggcttccccatgaccccgtgtggcccagctcggtgaggatgcagttctaggcacagcccctgggacagccagctgcctcccagaccacgtcagcctgctccagggtcctcagtcaccctgggccaggggccacgtgtcccatggatgtcgaccatgccaacgtcacattccagcaccccttttgcttgatggcgtctggtggtagtcagcatggtggacccacatcctacagccagaggtgatgttggacaaaggaaggggagtctggatgggtccttaaacgaccattctgtccgcagcggggtcattccttgtcagcccaagggagggccggggagtacactgatcccaacagctgggctgacacctcctttctcccctgcacggggaggattggcctgaggaccgtcaccctgtgcacagccccagtagggtggcagtgccactgtctccttgggccgttgcaggattgggcgggtgcagactccccttgcgggccccttgctcaatccccggccctcccagactcctccctctactgggggtaatttgtgtgtcagaagggctctggcagagctgtaaaatactgttttttaaaaattttagtccagatctttacttattagactgcagaaggagagctagggagagtgggggaagcccccttgcttttgtatctgtgaggtgaatgagggtctgtcacccaaatctacttctcagcccatgaccatagttctgttttccgtttgcaaatctcagtagctctgttttctccaaagtagaatgtgcgcaccggggtcctagccaggcgaggtcagtgtcggcaggctacctggtcattattgctgcctcgtccaggctgatgctgatggtcacaggcacggtggcatcagggagccgggccagcaggcggcgtgaggcggggccagcagctcactgcaagggcattttccacctgatcctggtgtgccccacatgcggtggcagggcagacgtgtgaagcctcggccgtctcggggctggcaggtgtgcgggtgaggaggccccggtggccaagcagagcctgcgtttcatttctcctgctgcactgtgtctagtctgtcttgtgaactctcaccgtgaaaagaggctagaagtccaggatcgctgtaccgctcctgtaattaggtgatgactggatttgacaacttagtcccctcagacaagtaagataccctccaacagcaaattcaatgacttaattggaaaacacacaagctggcatgatgtccggtgatttctgtaagaaatgcctgtaggagaaggtctgtgaagtgtggagggcagtgtcgacgctgcacagcatctgcagattcgcagcctcttctctgccggtgcctctgttcggttctgttacccaaaaacaaagaccaaagaaggccaatctctcatttgaccctgtctttttaatctgcctgttttaaaagttgcgtctgtagtagccgcttgctgtgaagacacatcttgacagtccaagtgattttgtgaccagtgatttgggtcctgttttccgctcttctaagaaaaaacaaaaagaccgtgagttattgcccagcaataatcatgttgttactgtgagttagcaacatgcctgacttcctgatagcattactgttttctagttttgtttattgtatattatgtgtggttttatttggtatttatttgtgttttgaggtcttgcaatgtttttgtgtttctgatgctaataactaaagtttgtaagactgtagaatgcaaaactcggagatgctaaactgtcttattagaggaaaataaatctgattatggagtctcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7187 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: TAS
GeneID:7187 -> Molecular function: GO:0004871 [signal transducer activity] evidence: TAS
GeneID:7187 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7187 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:7187 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IEA
GeneID:7187 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI
GeneID:7187 -> Molecular function: GO:0031996 [thioesterase binding] evidence: IPI
GeneID:7187 -> Biological process: GO:0001817 [regulation of cytokine production] evidence: ISS
GeneID:7187 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: ISS
GeneID:7187 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
GeneID:7187 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
GeneID:7187 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:7187 -> Biological process: GO:0006917 [induction of apoptosis] evidence: TAS
GeneID:7187 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:7187 -> Biological process: GO:0008063 [Toll signaling pathway] evidence: IEA
GeneID:7187 -> Biological process: GO:0030162 [regulation of proteolysis] evidence: IMP
GeneID:7187 -> Biological process: GO:0032088 [negative regulation of NF-kappaB transcription factor activity] evidence: IMP
GeneID:7187 -> Biological process: GO:0032480 [negative regulation of type I interferon production] evidence: TAS
GeneID:7187 -> Biological process: GO:0032648 [regulation of interferon-beta production] evidence: ISS
GeneID:7187 -> Biological process: GO:0033209 [tumor necrosis factor-mediated signaling pathway] evidence: IMP
GeneID:7187 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
GeneID:7187 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
GeneID:7187 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:7187 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:7187 -> Biological process: GO:0050688 [regulation of defense response to virus] evidence: ISS
GeneID:7187 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
GeneID:7187 -> Cellular component: GO:0005768 [endosome] evidence: IEA
GeneID:7187 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:7187 -> Cellular component: GO:0009898 [internal side of plasma membrane] evidence: ISS
GeneID:7187 -> Cellular component: GO:0035631 [CD40 receptor complex] evidence: ISS
by
@meso_cacase at
DBCLS
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