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2024-03-28 20:49:14, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001199163            1507 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 5
            (PSMC5), transcript variant 2, mRNA.
ACCESSION   NM_001199163
VERSION     NM_001199163.1  GI:312596880
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1507)
  AUTHORS   Inostroza-Nieves,Y., Venkatraman,P. and Zavala-Ruiz,Z.
  TITLE     Role of Sug1, a 19S proteasome ATPase, in the transcription of MHC
            I and the atypical MHC II molecules, HLA-DM and HLA-DO
  JOURNAL   Immunol. Lett. 147 (1-2), 67-74 (2012)
   PUBMED   22771340
  REMARK    GeneRIF: Sug1 plays a critical role in transcription of MHC class
            I, and the MHC class II-like molecules, HLA-DM and HLA-DO.
REFERENCE   2  (bases 1 to 1507)
  AUTHORS   Wang,X.H., Zhang,L., Mitch,W.E., LeDoux,J.M., Hu,J. and Du,J.
  TITLE     Caspase-3 cleaves specific 19 S proteasome subunits in skeletal
            muscle stimulating proteasome activity
  JOURNAL   J. Biol. Chem. 285 (28), 21249-21257 (2010)
   PUBMED   20424172
  REMARK    GeneRIF: Caspase-3 cleaves specific 19 S proteasome subunits in
            skeletal muscle stimulating proteasome activity
REFERENCE   3  (bases 1 to 1507)
  AUTHORS   Koues,O.I., Dudley,R.K., Mehta,N.T. and Greer,S.F.
  TITLE     The 19S proteasome positively regulates histone methylation at
            cytokine inducible genes
  JOURNAL   Biochim. Biophys. Acta 1789 (11-12), 691-701 (2009)
   PUBMED   19660582
  REMARK    GeneRIF: Findings show that Sug1 is crucial for regulating histone
            H3K4me3 and H3R17me2 at the cytokine inducible MHC-II and CIITA
            promoters.
REFERENCE   4  (bases 1 to 1507)
  AUTHORS   Kaneko,T., Hamazaki,J., Iemura,S., Sasaki,K., Furuyama,K.,
            Natsume,T., Tanaka,K. and Murata,S.
  TITLE     Assembly pathway of the Mammalian proteasome base subcomplex is
            mediated by multiple specific chaperones
  JOURNAL   Cell 137 (5), 914-925 (2009)
   PUBMED   19490896
REFERENCE   5  (bases 1 to 1507)
  AUTHORS   Ferry,C., Gianni,M., Lalevee,S., Bruck,N., Plassat,J.L., Raska,I.
            Jr., Garattini,E. and Rochette-Egly,C.
  TITLE     SUG-1 plays proteolytic and non-proteolytic roles in the control of
            retinoic acid target genes via its interaction with SRC-3
  JOURNAL   J. Biol. Chem. 284 (12), 8127-8135 (2009)
   PUBMED   19144644
  REMARK    GeneRIF: SUG-1 has a unique role in linking the transcription and
            degradation processes via its ability to interact with SRC-3.
REFERENCE   6  (bases 1 to 1507)
  AUTHORS   Akiyama,K., Yokota,K., Kagawa,S., Shimbara,N., DeMartino,G.N.,
            Slaughter,C.A., Noda,C. and Tanaka,K.
  TITLE     cDNA cloning of a new putative ATPase subunit p45 of the human 26S
            proteasome, a homolog of yeast transcriptional factor Sug1p
  JOURNAL   FEBS Lett. 363 (1-2), 151-156 (1995)
   PUBMED   7729537
REFERENCE   7  (bases 1 to 1507)
  AUTHORS   Lee,J.W., Ryan,F., Swaffield,J.C., Johnston,S.A. and Moore,D.D.
  TITLE     Interaction of thyroid-hormone receptor with a conserved
            transcriptional mediator
  JOURNAL   Nature 374 (6517), 91-94 (1995)
   PUBMED   7870181
REFERENCE   8  (bases 1 to 1507)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol. Endocrinol. 9 (2), 243-254 (1995)
   PUBMED   7776974
REFERENCE   9  (bases 1 to 1507)
  AUTHORS   Dubiel,W., Ferrell,K., Pratt,G. and Rechsteiner,M.
  TITLE     Subunit 4 of the 26 S protease is a member of a novel eukaryotic
            ATPase family
  JOURNAL   J. Biol. Chem. 267 (32), 22699-22702 (1992)
   PUBMED   1429620
REFERENCE   10 (bases 1 to 1507)
  AUTHORS   Nelbock,P., Dillon,P.J., Perkins,A. and Rosen,C.A.
  TITLE     A cDNA for a protein that interacts with the human immunodeficiency
            virus Tat transactivator
  JOURNAL   Science 248 (4963), 1650-1653 (1990)
   PUBMED   2194290
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA056321.1, BC001932.1 and
            AI193169.1.
            
            Summary: The 26S proteasome is a multicatalytic proteinase complex
            with a highly ordered structure composed of 2 complexes, a 20S core
            and a 19S regulator. The 20S core is composed of 4 rings of 28
            non-identical subunits; 2 rings are composed of 7 alpha subunits
            and 2 rings are composed of 7 beta subunits. The 19S regulator is
            composed of a base, which contains 6 ATPase subunits and 2
            non-ATPase subunits, and a lid, which contains up to 10 non-ATPase
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes one of
            the ATPase subunits, a member of the triple-A family of ATPases
            which have a chaperone-like activity. In addition to participation
            in proteasome functions, this subunit may participate in
            transcriptional regulation since it has been shown to interact with
            the thyroid hormone receptor and retinoid X receptor-alpha. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2) is
            shorter at the N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-480               DA056321.1         1-480
            481-1487            BC001932.1         297-1303
            1488-1507           AI193169.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1507
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.3"
     gene            1..1507
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /note="proteasome (prosome, macropain) 26S subunit,
                     ATPase, 5"
                     /db_xref="GeneID:5705"
                     /db_xref="HGNC:9552"
                     /db_xref="MIM:601681"
     exon            1..240
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:1.39.8"
     variation       95
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182284542"
     variation       208
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186941288"
     variation       209
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139627174"
     misc_feature    226..228
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /note="upstream in-frame stop codon"
     CDS             241..1437
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     thyroid receptor interactor 1; proteasome subunit p45;
                     MSUG1 protein; Tat-binding protein homolog 10; proteasome
                     26S ATPase subunit 5; 26S protease regulatory subunit 8;
                     proteasome 26S subunit ATPase 5; thyroid hormone
                     receptor-interacting protein 1; 26S proteasome AAA-ATPase
                     subunit RPT6"
                     /codon_start=1
                     /product="26S protease regulatory subunit 8 isoform 2"
                     /protein_id="NP_001186092.1"
                     /db_xref="GI:312596881"
                     /db_xref="CCDS:CCDS56043.1"
                     /db_xref="GeneID:5705"
                     /db_xref="HGNC:9552"
                     /db_xref="MIM:601681"
                     /translation="
MELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
"
     misc_feature    241..1428
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /note="ATP-dependent 26S proteasome regulatory subunit
                     [Posttranslational modification, protein turnover,
                     chaperones]; Region: RPT1; COG1222"
                     /db_xref="CDD:224143"
     misc_feature    670..1173
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /note="The AAA+ (ATPases Associated with a wide variety of
                     cellular Activities) superfamily represents an ancient
                     group of ATPases belonging to the ASCE (for additional
                     strand, catalytic E) division of the P-loop NTPase fold.
                     The ASCE division also includes ABC; Region: AAA; cd00009"
                     /db_xref="CDD:99707"
     misc_feature    784..807
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /note="Walker A motif; other site"
                     /db_xref="CDD:99707"
     misc_feature    order(787..810,961..963,1102..1104)
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:99707"
     misc_feature    949..966
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /note="Walker B motif; other site"
                     /db_xref="CDD:99707"
     misc_feature    1144..1146
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /note="arginine finger; other site"
                     /db_xref="CDD:99707"
     exon            241..312
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:1.39.8"
     variation       252
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367952890"
     variation       259
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:138422324"
     variation       279
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200470216"
     variation       288
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372693739"
     variation       299
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200165127"
     exon            313..382
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:1.39.8"
     exon            383..480
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:1.39.8"
     variation       426
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:372235083"
     variation       441
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374448804"
     variation       444
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368371685"
     variation       468
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201733814"
     exon            481..537
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:1.39.8"
     exon            538..768
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:1.39.8"
     variation       555
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141233223"
     variation       609
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:368691895"
     variation       618
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374525393"
     variation       629
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1802130"
     variation       632
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201173463"
     variation       645
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199705459"
     variation       649
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146976250"
     variation       653
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200364182"
     variation       691
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202169906"
     variation       720
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201585705"
     variation       732
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370586480"
     exon            769..895
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:1.39.8"
     variation       792
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138131935"
     STS             819..1355
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /standard_name="PMC113761P5"
                     /db_xref="UniSTS:270256"
     variation       837
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138950745"
     variation       853
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143717913"
     variation       871
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:968719"
     exon            896..1086
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:1.39.8"
     variation       897
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201676701"
     variation       941
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148086513"
     variation       962
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1802131"
     variation       988
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11543211"
     variation       995
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:80345213"
     variation       1012
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1050708"
     variation       1036
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150616906"
     variation       1056
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13030"
     exon            1087..1185
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:1.39.8"
     variation       1116
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1050740"
     variation       1124
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374419165"
     variation       1125
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368192353"
     variation       1182
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371740165"
     exon            1186..1296
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:1.39.8"
     variation       1248
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377085708"
     exon            1297..1383
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:1.39.8"
     variation       1308
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1131321"
     STS             1333..1462
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /standard_name="SGC30177"
                     /db_xref="UniSTS:12005"
     exon            1384..1495
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /inference="alignment:Splign:1.39.8"
     variation       1400
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146352219"
     variation       1441
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376370493"
     variation       1454
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370922627"
     polyA_signal    1465..1470
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
     variation       1466
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373633732"
     polyA_site      1484
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
     variation       1490
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:115733234"
     polyA_site      1495
                     /gene="PSMC5"
                     /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10;
                     TRIP1"
ORIGIN      
ggtgagtcagggcaaggctgggagaggaagacgcggtagaagcggagtgagtgagggaagcgatgggcgcgggaatggccggcccacgggtcgcaggagacgggacgccagtcctttggctccgttccgctggctccttcgtcagtactgacacctcgggcttgtagagcacttcacgcagtgcaaagcgccccccgtctatatcatatcgcctctcggtcctcctaaaagtcgtatgagatggagctggaggaggggaaggcaggcagcggactccgccaatattatctgtccaagattgaagaactccagctgattgtgaatgataagagccaaaacctccggaggctgcaggcacagaggaacgaactaaatgctaaagttcgcctattgcgggaggagctacagctgctgcaggagcagggctcctatgtgggggaagtagtccgggccatggataagaagaaagtgttggtcaaggtacatcctgaaggtaaatttgttgtagacgtggacaaaaacattgacatcaatgatgtgacacccaattgccgggtggctctaaggaatgacagctacactctgcacaagatcctgcccaacaaggtagacccattagtgtcactgatgatggtggagaaagtaccagattcaacttatgagatgattggtggactggacaaacagatcaaggagatcaaagaagtgatcgagctgcctgttaagcatcctgagctcttcgaagcactgggcattgctcagcccaagggagtgctgctgtatggacctccaggcactgggaagacactgttggcccgggctgtggctcatcatacggactgtacctttattcgtgtctctggctctgaactggtacagaaattcataggggaaggggcaagaatggtgagggagctgtttgtcatggcacgggaacatgctccatctatcatcttcatggacgaaatcgactccatcggctcctcgcggctggaggggggttctggaggggacagtgaagtgcagcgcacgatgctggagttgctcaaccagctcgacggctttgaggccaccaagaacatcaaggttatcatggctactaataggattgatatcctggactcggcactgcttcgcccagggcgcattgacagaaaaattgaattcccaccccccaatgaggaggcccggctggacattttgaagattcattctcggaagatgaacctgacccgggggatcaacctgagaaaaattgctgagctcatgccaggagcatcaggggctgaagtgaagggcgtgtgcacagaagctggcatgtatgccctgcgagaacggcgagtccatgtcactcaggaggactttgagatggcagtagccaaggtcatgcagaaggacagtgagaaaaacatgtccatcaagaaattatggaagtgagtggacagcctttgtgtgtatctctccaataaagctctgtgggccaagtcctctaggaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5705 -> Molecular function: GO:0003712 [transcription cofactor activity] evidence: TAS
            GeneID:5705 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5705 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:5705 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
            GeneID:5705 -> Molecular function: GO:0016887 [ATPase activity] evidence: ISS
            GeneID:5705 -> Molecular function: GO:0016887 [ATPase activity] evidence: TAS
            GeneID:5705 -> Molecular function: GO:0017025 [TBP-class protein binding] evidence: IEA
            GeneID:5705 -> Molecular function: GO:0031531 [thyrotropin-releasing hormone receptor binding] evidence: IPI
            GeneID:5705 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
            GeneID:5705 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
            GeneID:5705 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
            GeneID:5705 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
            GeneID:5705 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
            GeneID:5705 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: TAS
            GeneID:5705 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
            GeneID:5705 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:5705 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
            GeneID:5705 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:5705 -> Biological process: GO:0016032 [viral process] evidence: TAS
            GeneID:5705 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
            GeneID:5705 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
            GeneID:5705 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
            GeneID:5705 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
            GeneID:5705 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
            GeneID:5705 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
            GeneID:5705 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
            GeneID:5705 -> Biological process: GO:0043069 [negative regulation of programmed cell death] evidence: NAS
            GeneID:5705 -> Biological process: GO:0043161 [proteasomal ubiquitin-dependent protein catabolic process] evidence: IDA
            GeneID:5705 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:5705 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IEA
            GeneID:5705 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: NAS
            GeneID:5705 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5705 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5705 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5705 -> Cellular component: GO:0000502 [proteasome complex] evidence: IDA
            GeneID:5705 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:5705 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:5705 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:5705 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:5705 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:5705 -> Cellular component: GO:0022624 [proteasome accessory complex] evidence: ISS
            GeneID:5705 -> Cellular component: GO:0031410 [cytoplasmic vesicle] evidence: IDA
            GeneID:5705 -> Cellular component: GO:0031595 [nuclear proteasome complex] evidence: IEA

by @meso_cacase at DBCLS
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