2024-03-28 20:49:14, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001199163 1507 bp mRNA linear PRI 15-JUN-2013 DEFINITION Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 5 (PSMC5), transcript variant 2, mRNA. ACCESSION NM_001199163 VERSION NM_001199163.1 GI:312596880 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1507) AUTHORS Inostroza-Nieves,Y., Venkatraman,P. and Zavala-Ruiz,Z. TITLE Role of Sug1, a 19S proteasome ATPase, in the transcription of MHC I and the atypical MHC II molecules, HLA-DM and HLA-DO JOURNAL Immunol. Lett. 147 (1-2), 67-74 (2012) PUBMED 22771340 REMARK GeneRIF: Sug1 plays a critical role in transcription of MHC class I, and the MHC class II-like molecules, HLA-DM and HLA-DO. REFERENCE 2 (bases 1 to 1507) AUTHORS Wang,X.H., Zhang,L., Mitch,W.E., LeDoux,J.M., Hu,J. and Du,J. TITLE Caspase-3 cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity JOURNAL J. Biol. Chem. 285 (28), 21249-21257 (2010) PUBMED 20424172 REMARK GeneRIF: Caspase-3 cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity REFERENCE 3 (bases 1 to 1507) AUTHORS Koues,O.I., Dudley,R.K., Mehta,N.T. and Greer,S.F. TITLE The 19S proteasome positively regulates histone methylation at cytokine inducible genes JOURNAL Biochim. Biophys. Acta 1789 (11-12), 691-701 (2009) PUBMED 19660582 REMARK GeneRIF: Findings show that Sug1 is crucial for regulating histone H3K4me3 and H3R17me2 at the cytokine inducible MHC-II and CIITA promoters. REFERENCE 4 (bases 1 to 1507) AUTHORS Kaneko,T., Hamazaki,J., Iemura,S., Sasaki,K., Furuyama,K., Natsume,T., Tanaka,K. and Murata,S. TITLE Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones JOURNAL Cell 137 (5), 914-925 (2009) PUBMED 19490896 REFERENCE 5 (bases 1 to 1507) AUTHORS Ferry,C., Gianni,M., Lalevee,S., Bruck,N., Plassat,J.L., Raska,I. Jr., Garattini,E. and Rochette-Egly,C. TITLE SUG-1 plays proteolytic and non-proteolytic roles in the control of retinoic acid target genes via its interaction with SRC-3 JOURNAL J. Biol. Chem. 284 (12), 8127-8135 (2009) PUBMED 19144644 REMARK GeneRIF: SUG-1 has a unique role in linking the transcription and degradation processes via its ability to interact with SRC-3. REFERENCE 6 (bases 1 to 1507) AUTHORS Akiyama,K., Yokota,K., Kagawa,S., Shimbara,N., DeMartino,G.N., Slaughter,C.A., Noda,C. and Tanaka,K. TITLE cDNA cloning of a new putative ATPase subunit p45 of the human 26S proteasome, a homolog of yeast transcriptional factor Sug1p JOURNAL FEBS Lett. 363 (1-2), 151-156 (1995) PUBMED 7729537 REFERENCE 7 (bases 1 to 1507) AUTHORS Lee,J.W., Ryan,F., Swaffield,J.C., Johnston,S.A. and Moore,D.D. TITLE Interaction of thyroid-hormone receptor with a conserved transcriptional mediator JOURNAL Nature 374 (6517), 91-94 (1995) PUBMED 7870181 REFERENCE 8 (bases 1 to 1507) AUTHORS Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D. TITLE Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor JOURNAL Mol. Endocrinol. 9 (2), 243-254 (1995) PUBMED 7776974 REFERENCE 9 (bases 1 to 1507) AUTHORS Dubiel,W., Ferrell,K., Pratt,G. and Rechsteiner,M. TITLE Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family JOURNAL J. Biol. Chem. 267 (32), 22699-22702 (1992) PUBMED 1429620 REFERENCE 10 (bases 1 to 1507) AUTHORS Nelbock,P., Dillon,P.J., Perkins,A. and Rosen,C.A. TITLE A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator JOURNAL Science 248 (4963), 1650-1653 (1990) PUBMED 2194290 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA056321.1, BC001932.1 and AI193169.1. Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK290758.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-480 DA056321.1 1-480 481-1487 BC001932.1 297-1303 1488-1507 AI193169.1 1-20 c FEATURES Location/Qualifiers source 1..1507 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="17" /map="17q23.3" gene 1..1507 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /note="proteasome (prosome, macropain) 26S subunit, ATPase, 5" /db_xref="GeneID:5705" /db_xref="HGNC:9552" /db_xref="MIM:601681" exon 1..240 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /inference="alignment:Splign:1.39.8" variation 95 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:182284542" variation 208 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:186941288" variation 209 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="t" /db_xref="dbSNP:139627174" misc_feature 226..228 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /note="upstream in-frame stop codon" CDS 241..1437 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /note="isoform 2 is encoded by transcript variant 2; thyroid receptor interactor 1; proteasome subunit p45; MSUG1 protein; Tat-binding protein homolog 10; proteasome 26S ATPase subunit 5; 26S protease regulatory subunit 8; proteasome 26S subunit ATPase 5; thyroid hormone receptor-interacting protein 1; 26S proteasome AAA-ATPase subunit RPT6" /codon_start=1 /product="26S protease regulatory subunit 8 isoform 2" /protein_id="NP_001186092.1" /db_xref="GI:312596881" /db_xref="CCDS:CCDS56043.1" /db_xref="GeneID:5705" /db_xref="HGNC:9552" /db_xref="MIM:601681" /translation="
MELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
" misc_feature 241..1428 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /note="ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]; Region: RPT1; COG1222" /db_xref="CDD:224143" misc_feature 670..1173 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /note="The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009" /db_xref="CDD:99707" misc_feature 784..807 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /note="Walker A motif; other site" /db_xref="CDD:99707" misc_feature order(787..810,961..963,1102..1104) /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:99707" misc_feature 949..966 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /note="Walker B motif; other site" /db_xref="CDD:99707" misc_feature 1144..1146 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /note="arginine finger; other site" /db_xref="CDD:99707" exon 241..312 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /inference="alignment:Splign:1.39.8" variation 252 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:367952890" variation 259 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="c" /db_xref="dbSNP:138422324" variation 279 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="t" /db_xref="dbSNP:200470216" variation 288 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="t" /db_xref="dbSNP:372693739" variation 299 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="t" /db_xref="dbSNP:200165127" exon 313..382 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /inference="alignment:Splign:1.39.8" exon 383..480 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /inference="alignment:Splign:1.39.8" variation 426 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="c" /db_xref="dbSNP:372235083" variation 441 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:374448804" variation 444 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="c" /db_xref="dbSNP:368371685" variation 468 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:201733814" exon 481..537 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /inference="alignment:Splign:1.39.8" exon 538..768 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /inference="alignment:Splign:1.39.8" variation 555 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="g" /db_xref="dbSNP:141233223" variation 609 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="t" /db_xref="dbSNP:368691895" variation 618 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:374525393" variation 629 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="t" /db_xref="dbSNP:1802130" variation 632 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="t" /db_xref="dbSNP:201173463" variation 645 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:199705459" variation 649 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="g" /db_xref="dbSNP:146976250" variation 653 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="t" /db_xref="dbSNP:200364182" variation 691 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:202169906" variation 720 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="t" /db_xref="dbSNP:201585705" variation 732 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="t" /db_xref="dbSNP:370586480" exon 769..895 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /inference="alignment:Splign:1.39.8" variation 792 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:138131935" STS 819..1355 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /standard_name="PMC113761P5" /db_xref="UniSTS:270256" variation 837 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:138950745" variation 853 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="t" /db_xref="dbSNP:143717913" variation 871 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:968719" exon 896..1086 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /inference="alignment:Splign:1.39.8" variation 897 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:201676701" variation 941 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="t" /db_xref="dbSNP:148086513" variation 962 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="t" /db_xref="dbSNP:1802131" variation 988 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="t" /db_xref="dbSNP:11543211" variation 995 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:80345213" variation 1012 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:1050708" variation 1036 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="t" /db_xref="dbSNP:150616906" variation 1056 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="t" /db_xref="dbSNP:13030" exon 1087..1185 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /inference="alignment:Splign:1.39.8" variation 1116 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="g" /db_xref="dbSNP:1050740" variation 1124 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="t" /db_xref="dbSNP:374419165" variation 1125 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:368192353" variation 1182 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:371740165" exon 1186..1296 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /inference="alignment:Splign:1.39.8" variation 1248 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="g" /db_xref="dbSNP:377085708" exon 1297..1383 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /inference="alignment:Splign:1.39.8" variation 1308 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:1131321" STS 1333..1462 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /standard_name="SGC30177" /db_xref="UniSTS:12005" exon 1384..1495 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /inference="alignment:Splign:1.39.8" variation 1400 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:146352219" variation 1441 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:376370493" variation 1454 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="c" /replace="t" /db_xref="dbSNP:370922627" polyA_signal 1465..1470 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" variation 1466 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="g" /db_xref="dbSNP:373633732" polyA_site 1484 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" variation 1490 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" /replace="a" /replace="c" /db_xref="dbSNP:115733234" polyA_site 1495 /gene="PSMC5" /gene_synonym="p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1" ORIGIN
ggtgagtcagggcaaggctgggagaggaagacgcggtagaagcggagtgagtgagggaagcgatgggcgcgggaatggccggcccacgggtcgcaggagacgggacgccagtcctttggctccgttccgctggctccttcgtcagtactgacacctcgggcttgtagagcacttcacgcagtgcaaagcgccccccgtctatatcatatcgcctctcggtcctcctaaaagtcgtatgagatggagctggaggaggggaaggcaggcagcggactccgccaatattatctgtccaagattgaagaactccagctgattgtgaatgataagagccaaaacctccggaggctgcaggcacagaggaacgaactaaatgctaaagttcgcctattgcgggaggagctacagctgctgcaggagcagggctcctatgtgggggaagtagtccgggccatggataagaagaaagtgttggtcaaggtacatcctgaaggtaaatttgttgtagacgtggacaaaaacattgacatcaatgatgtgacacccaattgccgggtggctctaaggaatgacagctacactctgcacaagatcctgcccaacaaggtagacccattagtgtcactgatgatggtggagaaagtaccagattcaacttatgagatgattggtggactggacaaacagatcaaggagatcaaagaagtgatcgagctgcctgttaagcatcctgagctcttcgaagcactgggcattgctcagcccaagggagtgctgctgtatggacctccaggcactgggaagacactgttggcccgggctgtggctcatcatacggactgtacctttattcgtgtctctggctctgaactggtacagaaattcataggggaaggggcaagaatggtgagggagctgtttgtcatggcacgggaacatgctccatctatcatcttcatggacgaaatcgactccatcggctcctcgcggctggaggggggttctggaggggacagtgaagtgcagcgcacgatgctggagttgctcaaccagctcgacggctttgaggccaccaagaacatcaaggttatcatggctactaataggattgatatcctggactcggcactgcttcgcccagggcgcattgacagaaaaattgaattcccaccccccaatgaggaggcccggctggacattttgaagattcattctcggaagatgaacctgacccgggggatcaacctgagaaaaattgctgagctcatgccaggagcatcaggggctgaagtgaagggcgtgtgcacagaagctggcatgtatgccctgcgagaacggcgagtccatgtcactcaggaggactttgagatggcagtagccaaggtcatgcagaaggacagtgagaaaaacatgtccatcaagaaattatggaagtgagtggacagcctttgtgtgtatctctccaataaagctctgtgggccaagtcctctaggaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:5705 -> Molecular function: GO:0003712 [transcription cofactor activity] evidence: TAS GeneID:5705 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:5705 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA GeneID:5705 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI GeneID:5705 -> Molecular function: GO:0016887 [ATPase activity] evidence: ISS GeneID:5705 -> Molecular function: GO:0016887 [ATPase activity] evidence: TAS GeneID:5705 -> Molecular function: GO:0017025 [TBP-class protein binding] evidence: IEA GeneID:5705 -> Molecular function: GO:0031531 [thyrotropin-releasing hormone receptor binding] evidence: IPI GeneID:5705 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS GeneID:5705 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS GeneID:5705 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS GeneID:5705 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS GeneID:5705 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS GeneID:5705 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: TAS GeneID:5705 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS GeneID:5705 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:5705 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS GeneID:5705 -> Biological process: GO:0010467 [gene expression] evidence: TAS GeneID:5705 -> Biological process: GO:0016032 [viral process] evidence: TAS GeneID:5705 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS GeneID:5705 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS GeneID:5705 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS GeneID:5705 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS GeneID:5705 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS GeneID:5705 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS GeneID:5705 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS GeneID:5705 -> Biological process: GO:0043069 [negative regulation of programmed cell death] evidence: NAS GeneID:5705 -> Biological process: GO:0043161 [proteasomal ubiquitin-dependent protein catabolic process] evidence: IDA GeneID:5705 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS GeneID:5705 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IEA GeneID:5705 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: NAS GeneID:5705 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS GeneID:5705 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS GeneID:5705 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS GeneID:5705 -> Cellular component: GO:0000502 [proteasome complex] evidence: IDA GeneID:5705 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:5705 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS GeneID:5705 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA GeneID:5705 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:5705 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:5705 -> Cellular component: GO:0022624 [proteasome accessory complex] evidence: ISS GeneID:5705 -> Cellular component: GO:0031410 [cytoplasmic vesicle] evidence: IDA GeneID:5705 -> Cellular component: GO:0031595 [nuclear proteasome complex] evidence: IEA
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