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2024-04-19 12:00:51, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001195573 9921 bp mRNA linear PRI 24-JUN-2013
DEFINITION Homo sapiens dicer 1, ribonuclease type III (DICER1), transcript
variant 3, mRNA.
ACCESSION NM_001195573
VERSION NM_001195573.1 GI:307133774
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 9921)
AUTHORS Redfern,A.D., Colley,S.M., Beveridge,D.J., Ikeda,N., Epis,M.R.,
Li,X., Foulds,C.E., Stuart,L.M., Barker,A., Russell,V.J.,
Ramsay,K., Kobelke,S.J., Li,X., Hatchell,E.C., Payne,C.,
Giles,K.M., Messineo,A., Gatignol,A., Lanz,R.B., O'Malley,B.W. and
Leedman,P.J.
TITLE RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer
are SRA binding nuclear receptor coregulators
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (16), 6536-6541 (2013)
PUBMED 23550157
REMARK GeneRIF: RISC proteins PACT, TRBP, and Dicer, together with PKR,
are steroid receptor RNA activator-binding nuclear receptor
coregulators that are recruited to the promoters of
hormone-regulated genes and regulate the expression of downstream
target genes.
REFERENCE 2 (bases 1 to 9921)
AUTHORS Vincenzi,B., Zoccoli,A., Schiavon,G., Iuliani,M., Pantano,F.,
Dell'aquila,E., Ratta,R., Muda,A.O., Perrone,G., Brunelli,C.,
Correale,P., Riva,E., Russo,A., Loupakis,F., Falcone,A., Santini,D.
and Tonini,G.
TITLE Dicer and Drosha expression and response to Bevacizumab-based
therapy in advanced colorectal cancer patients
JOURNAL Eur. J. Cancer 49 (6), 1501-1508 (2013)
PUBMED 23266047
REMARK GeneRIF: Data indicate that tumour sample showed a significantly
higher Drosha expression versus normal mucosa, while Dicer levels
did not differ.
REFERENCE 3 (bases 1 to 9921)
AUTHORS Velez Edwards,D.R., Naj,A.C., Monda,K., North,K.E., Neuhouser,M.,
Magvanjav,O., Kusimo,I., Vitolins,M.Z., Manson,J.E.,
O'Sullivan,M.J., Rampersaud,E. and Edwards,T.L.
TITLE Gene-environment interactions and obesity traits among
postmenopausal African-American and Hispanic women in the Women's
Health Initiative SHARe Study
JOURNAL Hum. Genet. 132 (3), 323-336 (2013)
PUBMED 23192594
REFERENCE 4 (bases 1 to 9921)
AUTHORS Oshlag,J.Z., Devasthanam,A.S. and Tomasi,T.B.
TITLE Mild hyperthermia enhances the expression and induces oscillations
in the Dicer protein
JOURNAL Int J Hyperthermia 29 (1), 51-61 (2013)
PUBMED 23311378
REMARK GeneRIF: Heat-induced regulation of Dicer expression occurs
primarily post- transcriptionally, and the expression levels of
Dicer protein are increased and often oscillate in response to
fever-range hyperthermia in multiple mouse and human cells
REFERENCE 5 (bases 1 to 9921)
AUTHORS Li,X., Tian,X., Zhang,B., Zhang,Y. and Chen,J.
TITLE Variation in dicer gene is associated with increased survival in
T-cell lymphoma
JOURNAL PLoS ONE 7 (12), E51640 (2012)
PUBMED 23251602
REMARK GeneRIF: Dicer rs3742330 is associated with T cell lymphoma
survival.
REFERENCE 6 (bases 1 to 9921)
AUTHORS Provost,P., Dishart,D., Doucet,J., Frendewey,D., Samuelsson,B. and
Radmark,O.
TITLE Ribonuclease activity and RNA binding of recombinant human Dicer
JOURNAL EMBO J. 21 (21), 5864-5874 (2002)
PUBMED 12411504
REMARK GeneRIF: cloning and expression of the 218 kDa human Dicer, and
characterization of its ribonuclease activity and dsRNA-binding
properties
REFERENCE 7 (bases 1 to 9921)
AUTHORS Tabara,H., Yigit,E., Siomi,H. and Mello,C.C.
TITLE The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a
DExH-box helicase to direct RNAi in C. elegans
JOURNAL Cell 109 (7), 861-871 (2002)
PUBMED 12110183
REFERENCE 8 (bases 1 to 9921)
AUTHORS Suk,K., Kim,S., Kim,Y.H., Oh,S.H., Lee,M.K., Kim,K.W., Kim,H.D. and
Seo,Y.S.
TITLE Identification of a novel human member of the DEAD box protein
family
JOURNAL Biochim. Biophys. Acta 1501 (1), 63-69 (2000)
PUBMED 10727850
REFERENCE 9 (bases 1 to 9921)
AUTHORS Matsuda,S., Ichigotani,Y., Okuda,T., Irimura,T., Nakatsugawa,S. and
Hamaguchi,M.
TITLE Molecular cloning and characterization of a novel human gene
(HERNA) which encodes a putative RNA-helicase
JOURNAL Biochim. Biophys. Acta 1490 (1-2), 163-169 (2000)
PUBMED 10786632
REFERENCE 10 (bases 1 to 9921)
AUTHORS Provost,P., Samuelsson,B. and Radmark,O.
TITLE Interaction of 5-lipoxygenase with cellular proteins
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (5), 1881-1885 (1999)
PUBMED 10051563
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL356017.3, HM595745.1 and
AL390254.6.
Summary: This gene encodes a protein possessing an RNA helicase
motif containing a DEXH box in its amino terminus and an RNA motif
in the carboxy terminus. The encoded protein functions as a
ribonuclease and is required by the RNA interference and small
temporal RNA (stRNA) pathways to produce the active small RNA
component that represses gene expression. Alternative splicing
results in multiple transcript variants. [provided by RefSeq, Sep
2010].
Transcript Variant: This variant (3) lacks an exon in the coding
region, which results in a frameshift and an early stop codon,
compared to variant 1. Variant 3 encodes isoform 2 (also called
t-Dicer), is shorter and has a distinct C-terminus, compared to
isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: HM595745.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-36 AL356017.3 56223-56258 c
37-5657 HM595745.1 1-5621
5658-9921 AL390254.6 9498-13761
FEATURES Location/Qualifiers
source 1..9921
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q32.13"
gene 1..9921
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/note="dicer 1, ribonuclease type III"
/db_xref="GeneID:23405"
/db_xref="HGNC:17098"
/db_xref="MIM:606241"
exon 1..189
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
misc_feature 43..45
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/note="upstream in-frame stop codon"
CDS 46..5535
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/EC_number="3.1.26.-"
/note="isoform 2 is encoded by transcript variant 3;
K12H4.8-LIKE; helicase-moi; dicer 1, double-stranded
RNA-specific endoribonuclease; helicase with RNAse motif;
endoribonuclease Dicer; helicase MOI; Dicer1, Dcr-1
homolog"
/codon_start=1
/product="endoribonuclease Dicer isoform 2"
/protein_id="NP_001182502.1"
/db_xref="GI:307133775"
/db_xref="CCDS:CCDS55941.1"
/db_xref="GeneID:23405"
/db_xref="HGNC:17098"
/db_xref="MIM:606241"
/translation="
MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFSRNGKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSNLEVNASWTKERWNQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLVFDECHLAILDHPYREIMKLCENCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPFTDRSGLYERLLMELEEALNFINDCNISVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTFLRKIHALCEEHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDEDEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYIMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSVDTGETDIDPVMDDDDVFPPYVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPDGTFYSTLYLPINSPLRASIVGPPMSCVRLAERVVALICCEKLHKIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRDSYPRPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFMLSLQMLELITRLHQYIFSHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSLPADFRYPNLDFGWKKSIDSKSFISISNSSSAENDNYCKHSTIVPENAAHQGANRTSSLENHDQMSVNCRTLLSESPGKLHVEVSADLTAINGLSYNQNLANGSYDLANRDFCQGNQLNYYKQEIPVQPTTSYSIQNLYSYENQPQPSDECTLLSNKYLDGNANKSTSDGSPVMAVMPGTTDTIQVLKGRMDSEQSPSIGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYVVNQDKSNTDKWEKDEMTKDCMLANGKLDEDYEEEDEEEESLMWRAPKEEADYEDDFLEYDQEHIRFIDNMLMGSGAFVKKISLSPFSTTDSAYEWKMPKKSSLGSMPFSSDFEDFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGVDTGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKRTDREKALCPTRENFNSQQKNLSVSCAAASVASSRSSVLKDSEYGCLKIPPRCMFDHPDADKTLNHLISGFENFEKKINYRFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSEKSFLQMYPVPLCENCLKWNQKLPNLARLRELTTGRSESLWK
"
misc_feature 217..672
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/note="DEAD-like helicases superfamily. A diverse family
of proteins involved in ATP-dependent RNA or DNA
unwinding. This domain contains the ATP-binding region;
Region: DEXDc; cd00046"
/db_xref="CDD:28927"
misc_feature 244..258
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:28927"
misc_feature 568..579
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UPY3.3);
Region: DECH box"
misc_feature 568..579
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/note="putative Mg++ binding site [ion binding]; other
site"
/db_xref="CDD:28927"
misc_feature 811..1830
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UPY3.3);
Region: Required for interaction with PRKRA and TARBP2"
misc_feature 1282..1284
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UPY3.3); phosphorylation site"
misc_feature 1288..1290
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UPY3.3); phosphorylation site"
misc_feature <1375..1704
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/note="Helicase superfamily c-terminal domain; associated
with DEXDc-, DEAD-, and DEAH-box proteins, yeast
initiation factor 4A, Ski2p, and Hepatitis C virus NS3
helicases; this domain is found in a wide variety of
helicases and helicase related proteins; may...; Region:
HELICc; cd00079"
/db_xref="CDD:28960"
misc_feature order(1390..1401,1489..1494,1600..1608)
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/note="nucleotide binding region [chemical binding]; other
site"
/db_xref="CDD:28960"
misc_feature order(1624..1626,1687..1689,1699..1701)
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/note="ATP-binding site [chemical binding]; other site"
/db_xref="CDD:28960"
misc_feature 1933..2211
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/note="Double stranded RNA binding domain; Region:
dsRNA_bind; pfam03368"
/db_xref="CDD:190615"
misc_feature 2701..3069
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/note="PAZ domain, dicer_like subfamily. Dicer is an RNAse
involved in cleaving dsRNA in the RNA interference
pathway. It generates dsRNAs which are approximately 20 bp
long (siRNAs), which in turn target hydrolysis of
homologous RNAs. PAZ domains are named...; Region:
PAZ_dicer_like; cd02843"
/db_xref="CDD:30328"
misc_feature order(2890..2892,2929..2931,2947..2949,2959..2961,
3013..3015,3037..3039,3043..3045)
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/note="nucleic acid-binding interface [nucleotide
binding]; other site"
/db_xref="CDD:30328"
misc_feature 3091..3093
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UPY3.3); phosphorylation site"
misc_feature 3922..>4143
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/note="dsRNA-specific ribonuclease [Transcription];
Region: Rnc; COG0571"
/db_xref="CDD:30916"
misc_feature 3931..>4173
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/note="RIBOc. Ribonuclease III C terminal domain. This
group consists of eukaryotic, bacterial and archeal
ribonuclease III (RNAse III) proteins. RNAse III is a
double stranded RNA-specific endonuclease. Prokaryotic
RNAse III is important in...; Region: RIBOc; cd00593"
/db_xref="CDD:29697"
misc_feature order(3982..3987,3994..3999,4006..4008,4015..4020,
4027..4032,4036..4044,4072..4074)
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/note="dimerization interface [polypeptide binding]; other
site"
/db_xref="CDD:29697"
misc_feature order(3982..3984,3991..3993,4003..4005)
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/note="active site"
/db_xref="CDD:29697"
misc_feature 5086..>5340
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/note="RIBOc. Ribonuclease III C terminal domain. This
group consists of eukaryotic, bacterial and archeal
ribonuclease III (RNAse III) proteins. RNAse III is a
double stranded RNA-specific endonuclease. Prokaryotic
RNAse III is important in...; Region: RIBOc; cd00593"
/db_xref="CDD:29697"
misc_feature order(5149..5154,5161..5166,5173..5175,5182..5187,
5194..5199,5203..5211,5239..5241)
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/note="dimerization interface [polypeptide binding]; other
site"
/db_xref="CDD:29697"
misc_feature order(5149..5151,5158..5160,5170..5172)
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/note="active site"
/db_xref="CDD:29697"
exon 190..352
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 353..483
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 484..618
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 619..779
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 780..948
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 949..1421
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 1422..1554
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 1555..1797
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 1798..1952
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 1953..2085
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 2086..2161
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 2162..2301
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 2302..2481
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 2482..2695
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 2696..2849
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 2850..3032
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 3033..3138
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 3139..3314
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 3315..4095
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 4096..4251
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 4252..5140
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
STS 4684..5174
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/standard_name="Dicer1"
/db_xref="UniSTS:498692"
exon 5141..5409
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 5410..5485
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
exon 5486..9921
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/inference="alignment:Splign:1.39.8"
STS 6008..6166
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/standard_name="RH47658"
/db_xref="UniSTS:14968"
variation 6102
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1063608"
variation 6115
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1063609"
STS 6326..7068
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/standard_name="DICER1_2299"
/db_xref="UniSTS:280643"
STS 6628..6813
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/standard_name="RH98980"
/db_xref="UniSTS:92622"
STS 6628..6746
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/standard_name="RH78640"
/db_xref="UniSTS:92621"
variation 9537
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11556997"
STS 9616..9851
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/standard_name="Cda1bd03"
/db_xref="UniSTS:92027"
STS 9681..9913
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/standard_name="A003B15"
/db_xref="UniSTS:34468"
STS 9846..9914
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
/standard_name="D14S892E"
/db_xref="UniSTS:153948"
polyA_signal 9901..9906
/gene="DICER1"
/gene_synonym="DCR1; Dicer; HERNA; MNG1"
ORIGIN
taagctgtgctagaacaaaaatgcaatgaaagaaacactggatgaatgaaaagccctgctttgcaacccctcagcatggcaggcctgcagctcatgacccctgcttcctcaccaatgggtcctttctttggactgccatggcaacaagaagcaattcatgataacatttatacgccaagaaaatatcaggttgaactgcttgaagcagctctggatcataataccatcgtctgtttaaacactggctcagggaagacatttattgcagtactactcactaaagagctgtcctatcagatcaggggagacttcagcagaaatggaaaaaggacggtgttcttggtcaactctgcaaaccaggttgctcaacaagtgtcagctgtcagaactcattcagatctcaaggttggggaatactcaaacctagaagtaaatgcatcttggacaaaagagagatggaaccaagagtttactaagcaccaggttctcattatgacttgctatgtcgccttgaatgttttgaaaaatggttacttatcactgtcagacattaaccttttggtgtttgatgagtgtcatcttgcaatcctagaccacccctatcgagaaattatgaagctctgtgaaaattgtccatcatgtcctcgcattttgggactaactgcttccattttaaatgggaaatgtgatccagaggaattggaagaaaagattcagaaactagagaaaattcttaagagtaatgctgaaactgcaactgacctggtggtcttagacaggtatacttctcagccatgtgagattgtggtggattgtggaccatttactgacagaagtgggctttatgaaagactgctgatggaattagaagaagcacttaattttatcaatgattgtaatatatctgtacattcaaaagaaagagattctactttaatttcgaaacagatactatcagactgtcgtgccgtattggtagttctgggaccctggtgtgcagataaagtagctggaatgatggtaagagaactacagaaatacatcaaacatgagcaagaggagctgcacaggaaatttttattgtttacagacactttcctaaggaaaatacatgcactatgtgaagagcacttctcacctgcctcacttgacctgaaatttgtaactcctaaagtaatcaaactgctcgaaatcttacgcaaatataaaccatatgagcgacagcagtttgaaagcgttgagtggtataataatagaaatcaggataattatgtgtcatggagtgattctgaggatgatgatgaggatgaagaaattgaagaaaaagagaagccagagacaaattttccttctccttttaccaacattttgtgcggaattatttttgtggaaagaagatacacagcagttgtcttaaacagattgataaaggaagctggcaaacaagatccagagctggcttatatcagtagcaatttcataactggacatggcattgggaagaatcagcctcgcaacaaacagatggaagcagaattcagaaaacaggaagaggtacttaggaaatttcgagcacatgagaccaacctgcttattgcaacaagtattgtagaagagggtgttgatataccaaaatgcaacttggtggttcgttttgatttgcccacagaatatcgatcctatgttcaatctaaaggaagagcaagggcacccatctctaattatataatgttagcggatacagacaaaataaaaagttttgaagaagaccttaaaacctacaaagctattgaaaagatcttgagaaacaagtgttccaagtcggttgatactggtgagactgacattgatcctgtcatggatgatgatgacgttttcccaccatatgtgttgaggcctgacgatggtggtccacgagtcacaatcaacacggccattggacacatcaatagatactgtgctagattaccaagtgatccgtttactcatctagctcctaaatgcagaacccgagagttgcctgatggtacattttattcaactctttatctgccaattaactcacctcttcgagcctccattgttggtccaccaatgagctgtgtacgattggctgaaagagttgtagctctcatttgctgtgagaaactgcacaaaattggcgaactggatgaccatttgatgccagttgggaaagagactgttaaatatgaagaggagcttgatttgcatgatgaagaagagaccagtgttccaggaagaccaggttccacgaaacgaaggcagtgctacccaaaagcaattccagagtgtttgagggatagttatcccagacctgatcagccctgttacctgtatgtgataggaatggttttaactacacctttacctgatgaactcaactttagaaggcggaagctctatcctcctgaagataccacaagatgctttggaatactgacggccaaacccatacctcagattccacactttcctgtgtacacacgctctggagaggttaccatatccattgagttgaagaagtctggtttcatgttgtctctacaaatgcttgagttgattacaagacttcaccagtatatattctcacatattcttcggcttgaaaaacctgcactagaatttaaacctacagacgctgattcagcatactgtgttctacctcttaatgttgttaatgactccagcactttggatattgactttaaattcatggaagatattgagaagtctgaagctcgcataggcattcccagtacaaagtatacaaaagaaacaccctttgtttttaaattagaagattaccaagatgccgttatcattccaagatatcgcaattttgatcagcctcatcgattttatgtagctgatgtgtacactgatcttaccccactcagtaaatttccttcccctgagtatgaaacttttgcagaatattataaaacaaagtacaaccttgacctaaccaatctcaaccagccactgctggatgtggaccacacatcttcaagacttaatcttttgacacctcgacatttgaatcagaaggggaaagcgcttcctttaagcagtgctgagaagaggaaagccaaatgggaaagtctgcagaataaacagatactggttccagaactctgtgctatacatccaattccagcatcactgtggagaaaagctgtttgtctccccagcatactttatcgccttcactgccttttgactgcagaggagctaagagcccagactgccagcgatgctggcgtgggagtcagatcacttcctgcggattttagataccctaacttagacttcgggtggaaaaaatctattgacagcaaatctttcatctcaatttctaactcctcttcagctgaaaatgataattactgtaagcacagcacaattgtccctgaaaatgctgcacatcaaggtgctaatagaacctcctctctagaaaatcatgaccaaatgtctgtgaactgcagaacgttgctcagcgagtcccctggtaagctccacgttgaagtttcagcagatcttacagcaattaatggtctttcttacaatcaaaatctcgccaatggcagttatgatttagctaacagagacttttgccaaggaaatcagctaaattactacaagcaggaaatacccgtgcaaccaactacctcatattccattcagaatttatacagttacgagaaccagccccagcccagcgatgaatgtactctcctgagtaataaataccttgatggaaatgctaacaaatctacctcagatggaagtcctgtgatggccgtaatgcctggtacgacagacactattcaagtgctcaagggcaggatggattctgagcagagcccttctattgggtactcctcaaggactcttggccccaatcctggacttattcttcaggctttgactctgtcaaacgctagtgatggatttaacctggagcggcttgaaatgcttggcgactcctttttaaagcatgccatcaccacatatctattttgcacttaccctgatgcgcatgagggccgcctttcatatatgagaagcaaaaaggtcagcaactgtaatctgtatcgccttggaaaaaagaagggactacccagccgcatggtggtgtcaatatttgatccccctgtgaattggcttcctcctggttatgtagtaaatcaagacaaaagcaacacagataaatgggaaaaagatgaaatgacaaaagactgcatgctggcgaatggcaaactggatgaggattacgaggaggaggatgaggaggaggagagcctgatgtggagggctccgaaggaagaggctgactatgaagatgatttcctggagtatgatcaggaacatatcagatttatagataatatgttaatggggtcaggagcttttgtaaagaaaatctctctttctcctttttcaaccactgattctgcatatgaatggaaaatgcccaaaaaatcctccttaggtagtatgccattttcatcagattttgaggattttgactacagctcttgggatgcaatgtgctatctggatcctagcaaagctgttgaagaagatgactttgtggtggggttctggaatccatcagaagaaaactgtggtgttgacacgggaaagcagtccatttcttacgacttgcacactgagcagtgtattgctgacaaaagcatagcggactgtgtggaagccctgctgggctgctatttaaccagctgtggggagagggctgctcagcttttcctctgttcactggggctgaaggtgctcccggtaattaaaaggactgatcgggaaaaggccctgtgccctactcgggagaatttcaacagccaacaaaagaacctttcagtgagctgtgctgctgcttctgtggccagttcacgctcttctgtattgaaagactcggaatatggttgtttgaagattccaccaagatgtatgtttgatcatccagatgcagataaaacactgaatcaccttatatcggggtttgaaaattttgaaaagaaaatcaactacagattcaagaataaggcttaccttctccaggcttttacacatgcctcctaccactacaatactatcactgattgttaccagcgcttagaattcctgggagatgcgattttggactacctcataaccaagcacctttatgaagacccgcggcagcactccccgggggtcctgacagacctgcggtctgccctggtcaacaacaccatctttgcatcgctggctgtaaagtacgactaccacaagtacttcaaagctgtctctcctgagctcttccatgtcattgatgactttgtgcagtttcagcttgagaagaatgaaatgcaaggaatggattctgagaaaagttttctgcaaatgtaccccgttcccctgtgcgagaattgcttgaaatggaaccagaaactgccaaatttagcccggctgagagaacttacgacgggaaggtcagagtcactgtggaagtagtaggaaaggggaaatttaaaggtgttggtcgaagttacaggattgccaaatctgcagcagcaagaagagccctccgaagcctcaaagctaatcaacctcaggttcccaatagctgaaaccgctttttaaaattcaaaacaagaaacaaaacaaaaaaaattaaggggaaaattatttaaatcggaaaggaagacttaaagttgttagtgagtggaatgaattgaaggcagaatttaaagtttggttgataacaggatagataacagaataaaacatttaacatatgtataaaattttggaactaattgtagttttagttttttgcgcaaacacaatcttatcttctttcctcacttctgctttgtttaaatcacaagagtgctttaatgatgacatttagcaagtgctcaaaataattgacaggttttgtttttttttttttgagtttatgtcagctttgcttagtgttagaaggccatggagcttaaacctccagcagtccctaggatgatgtagattcttctccatctctccgtgtgtgcagtagtgccagtcctgcagtagttgataagctgaatagaaagataaggttttcgagaggagaagtgcgccaatgttgtcttttctttccacgttatactgtgtaaggtgatgttcccggtcgctgttgcacctgatagtaagggacagatttttaatgaacattggctggcatgttggtgaatcacattttagttttctgatgccacatagtcttgcataaaaaagggttcttgccttaaaagtgaaaccttcatggatagtctttaatctctgatctttttggaacaaactgttttacattcctttcattttattatgcattagacgttgagacagcgtgatacttacaactcactagtatagttgtaacttattacaggatcatactaaaatttctgtcatatgtatactgaagacattttaaaaaccagaatatgtagtctacggatattttttatcataaaaatgatctttggctaaacaccccattttactaaagtcctcctgccaggtagttcccactgatggaaatgtttatggcaaataattttgccttctaggctgttgctctaacaaaataaaccttagacatatcacacctaaaatatgctgcagattttataattgattggttacttatttaagaagcaaaacacagcacctttacccttagtctcctcacataaatttcttactatacttttcataatgttgcatgcatatttcacctaccaaagctgtgctgttaatgccgtgaaagtttaacgtttgcgataaactgccgtaattttgatacatctgtgatttaggtcattaatttagataaactagctcattatttccatctttggaaaaggaaaaaaaaaaaaacttctttaggcatttgcctaagtttctttaattagacttgtaggcactcttcacttaaatacctcagttcttcttttcttttgcatgcatttttcccctgtttggtgctatgtttatgtattatgcttgaaattttaatttttttttttttgcactgtaactataatacctcttaatttacctttttaaaagctgtgggtcagtcttgcactcccatcaacataccagtagaggtttgctgcaatttgccccgttaattatgcttgaagtttaagaaagctgagcagaggtgtctcatatttcccagcacatgattctgaacttgatgcttcgtggaatgctgcatttatatgtaagtgacatttgaatactgtccttcctgctttatctgcatcatccacccacagagaaatgcctctgtgcgagtgcaccgacagaaaactgtcagctctgctttctaaggaaccctgagtgaggggggtattaagcttctccagtgttttttgttgtctccaatcttaaacttaaattgagatctaaattattaaacgagtttttgagcaaattaggtgacttgttttaaaaatatttaattccgatttggaaccttagatgtctatttgattttttaaaaaaccttaatgtaagatatgaccagttaaaacaaagcaattcttgaattatataactgtaaaagtgtgcagttaacaaggctggatgtgaattttattctgagggtgatttgtgatcaagtttaatcacaaatctcttaatatttataaactacctgatgccaggagcttagggctttgcattgtgtctaatacattgatcccagtgttacgggattctcttgattcctggcaccaaaatcagattgttttcacagttatgattcccagtgggagaaaaatgcctcaatatatttgtaaccttaagaagagtatttttttgttaatactaagatgttcaaacttagacatgattaggtcatacattctcaggggttcaaatttccttctaccattcaaatgttttatcaacagcaaacttcagccgtttcactttttgttggagaaaaatagtagattttaatttgactcacagtttgaagcattctgtgatcccctggttactgagttaaaaaataaaaaagtacgagttagacatatgaaatggttatgaacgcttttgtgctgctgatttttaatgctgtaaagttttcctgtgtttagcttgttgaaatgttttgcatctgtcaattaaggaaaaaaaaaatcactctatgttgccccactttagagccctgtgtgccaccctgtgttcctgtgattgcaatgtgagaccgaatgtaatatggaaaacctaccagtggggtgtggttgtgccctgagcacgtgtgtaaaggactggggaggcgtgtcttgaaaaagcaactgcagaaattccttatgatgattgtgtgcaagttagttaacatgaaccttcatttgtaaattttttaaaatttcttttataatatgctttccgcagtcctaactatgctgcgttttataatagctttttcccttctgttctgttcatgtagcacagataagcattgcacttggtaccatgctttacctcatttcaagaaaatatgcttaacagagaggaaaaaaatgtggtttggccttgctgctgttttgatttatggaatttgaaaaagataattataatgcctgcaatgtgtcatatactcgcacaacttaaataggtcatttttgtctgtggcatttttactgtttgtgaaagtatgaaacagatttgttaactgaactcttaattatgtttttaaaatgtttgttatatttcttttcttttttcttttatattacgtgaagtgatgaaatttagaatgacctctaacactcctgtaattgtcttttaaaatactgatatttttatttgttaataatactttgccctcagaaagattctgataccctgccttgacaacatgaaacttgaggctgctttggttcatgaatccaggtgttcccccggcagtcggcttcttcagtcgctccctggaggcaggtgggcactgcagaggatcactggaatccagatcgagcgcagttcatgcacaaggccccgttgatttaaaatattggatcttgctctgttagggtgtctaatccctttacacaagattgaagccaccaaactgagaccttgatacctttttttaactgcatctgaaattatgttaagagtctttaacccatttgcattatctgcagaagagaaactcatgtcatgtttattacctatatggttgttttaattacatttgaataattatatttttccaaccactgattacttttcaggaatttaattatttccagataaatttctttattttatattgtacatgaaaagttttaaagatatgtttaagaccaagactattaaaatgatttttaaagttgttggagacgccaatagcaatatctaggaaatttgcattgagaccattgtattttccactagcagtgaaaatgatttttcacaactaacttgtaaatatattttaatcattacttctttttttctagtccatttttatttggacatcaaccacagacaatttaaattttatagatgcactaagaattcactgcagcagcaggttacatagcaaaaatgcaaaggtgaacaggaagtaaatttctggcttttctgctgtaaatagtgaaggaaaattactaaaatcaagtaaaactaatgcatattatttgattgacaataaaatatttaccatcacatgctgcagctgttttttaaggaacatgatgtcattcattcatacagtaatcatgctgcagaaatttgcagtctgcaccttatggatcacaattacctttagttgttttttttgtaataattgtagccaagtaaatctccaataaagttatcgtctgttca
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:23405 -> Molecular function: GO:0003725 [double-stranded RNA binding] evidence: IDA
GeneID:23405 -> Molecular function: GO:0004525 [ribonuclease III activity] evidence: IDA
GeneID:23405 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:23405 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:23405 -> Molecular function: GO:0008026 [ATP-dependent helicase activity] evidence: IEA
GeneID:23405 -> Molecular function: GO:0035198 [miRNA binding] evidence: IEA
GeneID:23405 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:23405 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: ISS
GeneID:23405 -> Biological process: GO:0001525 [angiogenesis] evidence: IEA
GeneID:23405 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:23405 -> Biological process: GO:0009791 [post-embryonic development] evidence: IEA
GeneID:23405 -> Biological process: GO:0010070 [zygote asymmetric cell division] evidence: IEA
GeneID:23405 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:23405 -> Biological process: GO:0010626 [negative regulation of Schwann cell proliferation] evidence: ISS
GeneID:23405 -> Biological process: GO:0014040 [positive regulation of Schwann cell differentiation] evidence: ISS
GeneID:23405 -> Biological process: GO:0019827 [stem cell maintenance] evidence: IEA
GeneID:23405 -> Biological process: GO:0021522 [spinal cord motor neuron differentiation] evidence: IEA
GeneID:23405 -> Biological process: GO:0021675 [nerve development] evidence: ISS
GeneID:23405 -> Biological process: GO:0021889 [olfactory bulb interneuron differentiation] evidence: IEA
GeneID:23405 -> Biological process: GO:0021987 [cerebral cortex development] evidence: IEA
GeneID:23405 -> Biological process: GO:0030324 [lung development] evidence: IEA
GeneID:23405 -> Biological process: GO:0030422 [production of siRNA involved in RNA interference] evidence: IDA
GeneID:23405 -> Biological process: GO:0030423 [targeting of mRNA for destruction involved in RNA interference] evidence: IMP
GeneID:23405 -> Biological process: GO:0031054 [pre-miRNA processing] evidence: IDA
GeneID:23405 -> Biological process: GO:0031069 [hair follicle morphogenesis] evidence: IEA
GeneID:23405 -> Biological process: GO:0031643 [positive regulation of myelination] evidence: ISS
GeneID:23405 -> Biological process: GO:0032290 [peripheral nervous system myelin formation] evidence: ISS
GeneID:23405 -> Biological process: GO:0035116 [embryonic hindlimb morphogenesis] evidence: IEA
GeneID:23405 -> Biological process: GO:0035196 [production of miRNAs involved in gene silencing by miRNA] evidence: ISS
GeneID:23405 -> Biological process: GO:0035264 [multicellular organism growth] evidence: IEA
GeneID:23405 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
GeneID:23405 -> Biological process: GO:0045069 [regulation of viral genome replication] evidence: IEA
GeneID:23405 -> Biological process: GO:0045664 [regulation of neuron differentiation] evidence: IEA
GeneID:23405 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:23405 -> Biological process: GO:0048536 [spleen development] evidence: IEA
GeneID:23405 -> Biological process: GO:0048713 [regulation of oligodendrocyte differentiation] evidence: IEA
GeneID:23405 -> Biological process: GO:0048754 [branching morphogenesis of an epithelial tube] evidence: IEA
GeneID:23405 -> Biological process: GO:0048812 [neuron projection morphogenesis] evidence: ISS
GeneID:23405 -> Biological process: GO:0051225 [spindle assembly] evidence: IEA
GeneID:23405 -> Biological process: GO:0051607 [defense response to virus] evidence: IEA
GeneID:23405 -> Biological process: GO:0051726 [regulation of cell cycle] evidence: IEA
GeneID:23405 -> Biological process: GO:0055013 [cardiac muscle cell development] evidence: IEA
GeneID:23405 -> Biological process: GO:0060119 [inner ear receptor cell development] evidence: IEA
GeneID:23405 -> Biological process: GO:0060576 [intestinal epithelial cell development] evidence: IEA
GeneID:23405 -> Biological process: GO:0070173 [regulation of enamel mineralization] evidence: IEA
GeneID:23405 -> Biological process: GO:0071335 [hair follicle cell proliferation] evidence: IEA
GeneID:23405 -> Biological process: GO:2000630 [positive regulation of miRNA metabolic process] evidence: IEA
GeneID:23405 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:23405 -> Cellular component: GO:0016442 [RNA-induced silencing complex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001182502 -> EC 3.1.26.-
by
@meso_cacase at
DBCLS
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