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2024-04-24 00:49:16, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001193424 3148 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens suppressor of variegation 3-9 homolog 2 (Drosophila)
(SUV39H2), transcript variant 1, mRNA.
ACCESSION NM_001193424
VERSION NM_001193424.1 GI:301171587
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3148)
AUTHORS Syreeni,A., El-Osta,A., Forsblom,C., Sandholm,N., Parkkonen,M.,
Tarnow,L., Parving,H.H., McKnight,A.J., Maxwell,A.P., Cooper,M.E.
and Groop,P.H.
CONSRTM FinnDiane Study Group
TITLE Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and
the risk of diabetes complications in patients with type 1 diabetes
JOURNAL Diabetes 60 (11), 3073-3080 (2011)
PUBMED 21896933
REMARK GeneRIF: genetic association studies in a Finnish population with
type I diabetes: The minor T allele of exonic SNP rs17353856 in
SUV39H2 is associated with diabetic retinopathy (in a larger
meta-analysis); thus an genetic variation may be protective.
REFERENCE 2 (bases 1 to 3148)
AUTHORS Benlhabib,H. and Mendelson,C.R.
TITLE Epigenetic regulation of surfactant protein A gene (SP-A)
expression in fetal lung reveals a critical role for Suv39h
methyltransferases during development and hypoxia
JOURNAL Mol. Cell. Biol. 31 (10), 1949-1958 (2011)
PUBMED 21402781
REMARK GeneRIF: findings suggest that Suv39H1 and Suv39H2 are key
hypoxia-induced methyltransferases; their decline in fetal lung
during late gestation is critical for epigenetic changes resulting
in the developmental induction of SP-A
REFERENCE 3 (bases 1 to 3148)
AUTHORS Sun,X.J., Xu,P.F., Zhou,T., Hu,M., Fu,C.T., Zhang,Y., Jin,Y.,
Chen,Y., Chen,S.J., Huang,Q.H., Liu,T.X. and Chen,Z.
TITLE Genome-wide survey and developmental expression mapping of
zebrafish SET domain-containing genes
JOURNAL PLoS ONE 3 (1), E1499 (2008)
PUBMED 18231586
REMARK GeneRIF: The SUV39H2 gene is found in tetrapods (e.g., human, mouse
and frog) but not in zebrafish, suggesting that this gene is
generated by a tetrapod lineage-specific gene duplication event.
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 3148)
AUTHORS Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
Jurisica,I. and Li,S.S.
TITLE Systematic identification of SH3 domain-mediated human
protein-protein interactions by peptide array target screening
JOURNAL Proteomics 7 (11), 1775-1785 (2007)
PUBMED 17474147
REFERENCE 5 (bases 1 to 3148)
AUTHORS Yoon,K.A., Hwangbo,B., Kim,I.J., Park,S., Kim,H.S., Kee,H.J.,
Lee,J.E., Jang,Y.K., Park,J.G. and Lee,J.S.
TITLE Novel polymorphisms in the SUV39H2 histone methyltransferase and
the risk of lung cancer
JOURNAL Carcinogenesis 27 (11), 2217-2222 (2006)
PUBMED 16774942
REMARK GeneRIF: a novel SUV39H2 polymorphism may have a role in lung
cancer susceptibility for smokers
GeneRIF: Observational study of gene-disease association and
gene-environment interaction. (HuGE Navigator)
REFERENCE 6 (bases 1 to 3148)
AUTHORS Frontelo,P., Leader,J.E., Yoo,N., Potocki,A.C., Crawford,M.,
Kulik,M. and Lechleider,R.J.
TITLE Suv39h histone methyltransferases interact with Smads and cooperate
in BMP-induced repression
JOURNAL Oncogene 23 (30), 5242-5251 (2004)
PUBMED 15107829
REFERENCE 7 (bases 1 to 3148)
AUTHORS Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
TITLE The DNA sequence and comparative analysis of human chromosome 10
JOURNAL Nature 429 (6990), 375-381 (2004)
PUBMED 15164054
REFERENCE 8 (bases 1 to 3148)
AUTHORS Ait-Si-Ali,S., Guasconi,V., Fritsch,L., Yahi,H., Sekhri,R.,
Naguibneva,I., Robin,P., Cabon,F., Polesskaya,A. and
Harel-Bellan,A.
TITLE A Suv39h-dependent mechanism for silencing S-phase genes in
differentiating but not in cycling cells
JOURNAL EMBO J. 23 (3), 605-615 (2004)
PUBMED 14765126
REFERENCE 9 (bases 1 to 3148)
AUTHORS O'Carroll,D., Scherthan,H., Peters,A.H., Opravil,S., Haynes,A.R.,
Laible,G., Rea,S., Schmid,M., Lebersorger,A., Jerratsch,M.,
Sattler,L., Mattei,M.G., Denny,P., Brown,S.D., Schweizer,D. and
Jenuwein,T.
TITLE Isolation and characterization of Suv39h2, a second histone H3
methyltransferase gene that displays testis-specific expression
JOURNAL Mol. Cell. Biol. 20 (24), 9423-9433 (2000)
PUBMED 11094092
REFERENCE 10 (bases 1 to 3148)
AUTHORS Rea,S., Eisenhaber,F., O'Carroll,D., Strahl,B.D., Sun,Z.W.,
Schmid,M., Opravil,S., Mechtler,K., Ponting,C.P., Allis,C.D. and
Jenuwein,T.
TITLE Regulation of chromatin structure by site-specific histone H3
methyltransferases
JOURNAL Nature 406 (6796), 593-599 (2000)
PUBMED 10949293
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DB040298.1 and BC007754.2.
Transcript Variant: This variant (1) represents the longest
transcript, and encodes the longest isoform (1).
##Evidence-Data-START##
RNAseq introns :: single sample supports all introns ERS025084,
ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-580 DB040298.1 1-580
581-3148 BC007754.2 526-3093
FEATURES Location/Qualifiers
source 1..3148
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10p13"
gene 1..3148
/gene="SUV39H2"
/gene_synonym="KMT1B"
/note="suppressor of variegation 3-9 homolog 2
(Drosophila)"
/db_xref="GeneID:79723"
/db_xref="HGNC:17287"
/db_xref="MIM:606503"
exon 1..137
/gene="SUV39H2"
/gene_synonym="KMT1B"
/inference="alignment:Splign:1.39.8"
misc_feature 92..94
/gene="SUV39H2"
/gene_synonym="KMT1B"
/note="upstream in-frame stop codon"
variation 102
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:375333545"
CDS 107..1339
/gene="SUV39H2"
/gene_synonym="KMT1B"
/EC_number="2.1.1.43"
/note="isoform 1 is encoded by transcript variant 1;
histone-lysine N-methyltransferase SUV39H2; H3-K9-HMTase
2; su(var)3-9 homolog 2; lysine N-methyltransferase 1B;
histone H3-K9 methyltransferase 2"
/codon_start=1
/product="histone-lysine N-methyltransferase SUV39H2
isoform 1"
/protein_id="NP_001180353.1"
/db_xref="GI:301171588"
/db_xref="CCDS:CCDS53494.1"
/db_xref="GeneID:79723"
/db_xref="HGNC:17287"
/db_xref="MIM:606503"
/translation="
MAAVGAEARGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKDMEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLKPAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPGISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN
"
misc_feature 245..385
/gene="SUV39H2"
/gene_synonym="KMT1B"
/note="Chromatin organization modifier (chromo) domain is
a conserved region of around 50 amino acids found in a
variety of chromosomal proteins, which appear to play a
role in the functional organization of the eukaryotic
nucleus. Experimental evidence...; Region: CHROMO;
cd00024"
/db_xref="CDD:28908"
misc_feature order(245..247,302..304,308..310,317..319,329..331,
341..343,353..358)
/gene="SUV39H2"
/gene_synonym="KMT1B"
/note="histone binding site; other site"
/db_xref="CDD:28908"
misc_feature 539..832
/gene="SUV39H2"
/gene_synonym="KMT1B"
/note="Pre-SET motif; Region: Pre-SET; pfam05033"
/db_xref="CDD:203156"
misc_feature 854..1225
/gene="SUV39H2"
/gene_synonym="KMT1B"
/note="SET (Su(var)3-9, Enhancer-of-zeste, Trithorax)
domain; Region: SET; smart00317"
/db_xref="CDD:197649"
misc_feature 1247..1249
/gene="SUV39H2"
/gene_synonym="KMT1B"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9H5I1.2); phosphorylation site"
misc_feature 1256..1258
/gene="SUV39H2"
/gene_synonym="KMT1B"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9H5I1.2); phosphorylation site"
misc_feature 1268..1270
/gene="SUV39H2"
/gene_synonym="KMT1B"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9H5I1.2); phosphorylation site"
exon 138..283
/gene="SUV39H2"
/gene_synonym="KMT1B"
/inference="alignment:Splign:1.39.8"
variation 214
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="g"
/replace="t"
/db_xref="dbSNP:369200305"
variation 225
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="c"
/db_xref="dbSNP:373386573"
exon 284..955
/gene="SUV39H2"
/gene_synonym="KMT1B"
/inference="alignment:Splign:1.39.8"
variation 373
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:148153307"
variation 394
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:376764262"
variation 396
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:140852434"
variation 450
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:144521316"
variation 454
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:3740112"
variation 468..469
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace=""
/replace="c"
/db_xref="dbSNP:35348245"
variation 473
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:372163934"
variation 485
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:201043867"
variation 498
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="g"
/db_xref="dbSNP:138508980"
variation 506
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="c"
/db_xref="dbSNP:45473500"
variation 514
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:150726093"
STS 587..1086
/gene="SUV39H2"
/gene_synonym="KMT1B"
/standard_name="MARC_27758-27759:1034860367:1"
/db_xref="UniSTS:269123"
STS 598..921
/gene="SUV39H2"
/gene_synonym="KMT1B"
/standard_name="ksks283"
/db_xref="UniSTS:514323"
variation 625
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:138078553"
variation 651
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="g"
/db_xref="dbSNP:149546848"
variation 661
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="g"
/replace="t"
/db_xref="dbSNP:200539708"
variation 668
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="c"
/db_xref="dbSNP:376480219"
variation 859
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:368991744"
variation 887
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:375736366"
variation 889
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:199654065"
variation 925
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:144034230"
exon 956..1102
/gene="SUV39H2"
/gene_synonym="KMT1B"
/inference="alignment:Splign:1.39.8"
variation 1015
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:190174096"
variation 1027
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:183140822"
variation 1028
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:148667087"
variation 1072
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:17353856"
variation 1078
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:369186882"
variation 1093
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:147278353"
exon 1103..1232
/gene="SUV39H2"
/gene_synonym="KMT1B"
/inference="alignment:Splign:1.39.8"
variation 1147
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="g"
/db_xref="dbSNP:61730323"
variation 1172
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:369793867"
exon 1233..3142
/gene="SUV39H2"
/gene_synonym="KMT1B"
/inference="alignment:Splign:1.39.8"
variation 1308
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:199727444"
variation 1318
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="g"
/replace="t"
/db_xref="dbSNP:144605484"
variation 1334
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:201395473"
variation 1358
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="g"
/db_xref="dbSNP:375126181"
variation 1394
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:368830300"
variation 1430
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:113301024"
variation 1451
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:373511332"
variation 1466
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="c"
/db_xref="dbSNP:11547181"
variation 1487
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:373567048"
variation 1498
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="c"
/db_xref="dbSNP:180989547"
variation 1502
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace=""
/replace="g"
/db_xref="dbSNP:375028927"
STS 1621..1742
/gene="SUV39H2"
/gene_synonym="KMT1B"
/standard_name="RH48597"
/db_xref="UniSTS:71892"
variation 1679
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="g"
/db_xref="dbSNP:116910335"
variation 1692
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="c"
/db_xref="dbSNP:75420442"
polyA_signal 1854..1859
/gene="SUV39H2"
/gene_synonym="KMT1B"
variation 1873..1875
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace=""
/replace="aat"
/db_xref="dbSNP:367684066"
polyA_site 1874
/gene="SUV39H2"
/gene_synonym="KMT1B"
polyA_site 1890
/gene="SUV39H2"
/gene_synonym="KMT1B"
polyA_signal 1899..1904
/gene="SUV39H2"
/gene_synonym="KMT1B"
variation 1911..1914
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace=""
/replace="aatt"
/db_xref="dbSNP:371874353"
polyA_site 1916
/gene="SUV39H2"
/gene_synonym="KMT1B"
polyA_site 1927
/gene="SUV39H2"
/gene_synonym="KMT1B"
variation 2024
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:142967205"
variation 2081
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="g"
/replace="t"
/db_xref="dbSNP:185218421"
variation 2143
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:41284455"
variation 2234
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:11594111"
variation 2305
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:190438184"
variation 2421
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:181251834"
variation 2559
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="g"
/replace="t"
/db_xref="dbSNP:61843036"
variation 2696
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:75516757"
variation 2718
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:376829730"
variation 2776
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:150828159"
variation 2901
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="g"
/replace="t"
/db_xref="dbSNP:139176971"
variation 2965
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:11259385"
STS 3004..3086
/gene="SUV39H2"
/gene_synonym="KMT1B"
/standard_name="L18426"
/db_xref="UniSTS:34648"
STS 3005..3084
/gene="SUV39H2"
/gene_synonym="KMT1B"
/standard_name="D5S1597E"
/db_xref="UniSTS:151019"
STS 3006..3108
/gene="SUV39H2"
/gene_synonym="KMT1B"
/standard_name="D11S2921"
/db_xref="UniSTS:152074"
STS 3008..3077
/gene="SUV39H2"
/gene_synonym="KMT1B"
/standard_name="D1S1423"
/db_xref="UniSTS:149619"
variation 3045
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="g"
/replace="t"
/db_xref="dbSNP:186353154"
variation 3063
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:191603474"
variation 3064
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:371491790"
variation 3083
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="c"
/replace="g"
/db_xref="dbSNP:183557434"
variation 3131
/gene="SUV39H2"
/gene_synonym="KMT1B"
/replace="a"
/replace="t"
/db_xref="dbSNP:79193913"
ORIGIN
aacaagccccggcccccaagtcccgcgcgggccggccaggggcggggcgtcgggccagctgagctatcccgtcagaccgcgccagtttgaatgaaagctctacaagatggcggcggtcggggccgaggcgcgaggagcttggtgtgtgccttgcctagtttcacttgatactcttcaggaattatgtagaaaagaaaagctcacatgtaaatcgattggaatcaccaaaaggaatctaaacaattatgaggtggaatacttgtgtgactacaaggtagtaaaggatatggaatattatcttgtaaaatggaaaggatggccagattctacaaatacttgggaacctttgcaaaatctgaagtgcccgttactgcttcagcaattctctaatgacaagcataattatttatctcaggtaaagaaaggcaaagcaataactccaaaagacaataacaaaactttgaaacctgccattgctgagtacattgtgaagaaggctaaacaaaggatagctctgcagagatggcaagatgaactcaacagaagaaagaatcataaaggaatgatatttgttgaaaatactgttgatttagagggcccaccttcagacttctattacattaacgaatacaaaccagctcctggaatcagcttagtcaatgaagctacctttggttgttcatgcacagattgcttctttcaaaaatgttgtcctgctgaagctggagttcttttggcttataataaaaaccaacaaattaaaatcccacctggtactcccatctatgaatgcaactcaaggtgtcagtgtggtcctgattgtcccaataggattgtacaaaaaggcacacagtattcgctttgcatctttcgaactagcaatggacgtggctggggtgtaaagacccttgtgaagattaaaagaatgagttttgtcatggaatatgttggagaggtaatcacaagtgaagaagctgaaagacgaggacagttctatgacaacaagggaatcacgtatctctttgatctggactatgagtctgatgaattcacagtggatgcggctcgatacggcaatgtgtctcattttgtgaatcacagctgtgacccaaatcttcaggtgttcaatgttttcattgataacctcgatactcgtcttccccgaatagcattgttttccacaagaaccataaatgctggagaagagctgacttttgattatcaaatgaaaggttctggagatatatcttcagattctattgaccacagcccagccaaaaagagggtcagaacagtatgtaaatgtggagctgtgacttgcagaggttacctcaactgaactttttcaggaaatagagctgatgattataatatttttttcctaatgttaacatttttaaaaatacatatttgggactcttattatcaaggttctacctatgttaatttacaattcatgtttcaagacatttgccaaatgtattaccgatgcctctgaaaagggggtcactgggtctcatagactgatatgaagtcgacatatttatagtgcttagagaccaaactaatggaaggcagactatttacagcttagtatatgtgtacttaagtctatgtgaacagagaaatgcctcccgtagtgtttgaaagcgttaagctgataatgtaattaacaactgctgagagatcaaagattcaacttgccatacacctcaaattcggagaaacagttaatttgggcaaatctacagttctgtttttgctactctattgtcattcctgtttaatactcactgtacttgtatttgagacaaataggtgatactgaattttatactgttttctacttttccattaaaacattggcacctcaatgataaagaaatttaaggtataaaattaaatgtaaaaattaatttcagcttcatttcgtatttcgaagcaatctagactgttgtgatgagtgtatgtctgaacctgtaattcttaaaagacttcttaatcttctagaagaaaaatctccgaagagctctctctagaagtccaaaatggctagccattatgcttctttgaaaggacatgataatgggaccaggatggttttttggagtaccaagcaaggggaatggagcactttaagggcgcctgttagtaacatgaattggaaatctgtgtcgagtacctctgatctaaacggtaaaacaagctgcctggagagcagctgtacctaacaatactgtaatgtacattaacattacagcctctcaatttcaggcaggtgtaacagttcctttccaccagatttaatatttttatacttcctgcaggttcttcttaaaaagtaatctatatttttgaactgatacttgttttatacataaattttttttagatgtgataaagctaaacttggccaaagtgtgtgcctgaattattagacctttttattagtcaacctacgaagactaaaatagaatatattagttttcaagggagtgggaggcttccaacatagtattgaatctcaggaaaaactattctttcatgtctgattctgagatttctaattgtgttgtgaaaatgataaatgcagcaaatctagctttcagtattcctaatttttacctaagctcattgctccaggctttgattacctaaaataagcttggataaaattgaaccaacttcaagaatgcagcacttcttaatctttagctctttcttgggagaagctagactttattcattatattgctatgacaacttcactctttcataatatataggataaattgtttacatgattggaccctcagattctgttaaccaaaattgcagaatggggggccaggcctgtgtggtggctcacacctgtgatcccagcactttgggaggctgaggtaggaggatcacgtgaggtcgggagttcaagaccagcctggccatcatggtgaaaccctgtctctactgaaaatacaaaaattagccgggcgtggtggcacacgcctgtagtcccagctactcaggaggctgaggcaggagaatcacttgaattcaggaggcggaggttgcagtgagccaagatcataccactgcactgcagcctgagtgacacagtaagactgtctccaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:79723 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
GeneID:79723 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:79723 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:79723 -> Molecular function: GO:0046974 [histone methyltransferase activity (H3-K9 specific)] evidence: IDA
GeneID:79723 -> Biological process: GO:0006333 [chromatin assembly or disassembly] evidence: IMP
GeneID:79723 -> Biological process: GO:0006338 [chromatin remodeling] evidence: IDA
GeneID:79723 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:79723 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
GeneID:79723 -> Biological process: GO:0007140 [male meiosis] evidence: IEA
GeneID:79723 -> Biological process: GO:0030154 [cell differentiation] evidence: IEA
GeneID:79723 -> Cellular component: GO:0000775 [chromosome, centromeric region] evidence: IEA
GeneID:79723 -> Cellular component: GO:0000785 [chromatin] evidence: IDA
GeneID:79723 -> Cellular component: GO:0005720 [nuclear heterochromatin] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001180353 -> EC 2.1.1.43
by
@meso_cacase at
DBCLS
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