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2024-03-29 07:27:21, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001193350            6446 bp    mRNA    linear   PRI 05-JUL-2013
DEFINITION  Homo sapiens myocyte enhancer factor 2C (MEF2C), transcript variant
            6, mRNA.
ACCESSION   NM_001193350
VERSION     NM_001193350.1  GI:301069385
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6446)
  AUTHORS   Del-Aguila,J.L., Beitelshees,A.L., Cooper-Dehoff,R.M.,
            Chapman,A.B., Gums,J.G., Bailey,K., Gong,Y., Turner,S.T.,
            Johnson,J.A. and Boerwinkle,E.
  TITLE     Genome-wide association analyses suggest NELL1 influences adverse
            metabolic response to HCTZ in African Americans
  JOURNAL   Pharmacogenomics J. (2013) In press
   PUBMED   23400010
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 6446)
  AUTHORS   Mendez-Vigo,B., Martinez-Zapater,J.M. and Alonso-Blanco,C.
  TITLE     The flowering repressor SVP underlies a novel Arabidopsis thaliana
            QTL interacting with the genetic background
  JOURNAL   PLoS Genet. 9 (1), E1003289 (2013)
   PUBMED   23382706
REFERENCE   3  (bases 1 to 6446)
  AUTHORS   Le Meur,N., Holder-Espinasse,M., Jaillard,S., Goldenberg,A.,
            Joriot,S., Amati-Bonneau,P., Guichet,A., Barth,M., Charollais,A.,
            Journel,H., Auvin,S., Boucher,C., Kerckaert,J.P., David,V.,
            Manouvrier-Hanu,S., Saugier-Veber,P., Frebourg,T., Dubourg,C.,
            Andrieux,J. and Bonneau,D.
  TITLE     MEF2C haploinsufficiency caused by either microdeletion of the
            5q14.3 region or mutation is responsible for severe mental
            retardation with stereotypic movements, epilepsy and/or cerebral
            malformations
  JOURNAL   J. Med. Genet. 47 (1), 22-29 (2010)
   PUBMED   19592390
  REMARK    GeneRIF: These results strongly suggest that haploinsufficiency of
            MEF2C is responsible for severe mental retardation with stereotypic
            movements, seizures and/or cerebral malformations.
REFERENCE   4  (bases 1 to 6446)
  AUTHORS   Zhu,B., Ramachandran,B. and Gulick,T.
  TITLE     Alternative pre-mRNA splicing governs expression of a conserved
            acidic transactivation domain in myocyte enhancer factor 2 factors
            of striated muscle and brain
  JOURNAL   J. Biol. Chem. 280 (31), 28749-28760 (2005)
   PUBMED   15834131
  REMARK    GeneRIF: A conserved pattern of alternative splicing in vertebrate
            MEF2 (myocyte enhancer factor 2) genes generates an acidic
            activation domain in MEF2 proteins selectively in tissues where
            MEF2 target genes are highly expressed. (MEF2)
REFERENCE   5  (bases 1 to 6446)
  AUTHORS   Zhu,B. and Gulick,T.
  TITLE     Phosphorylation and alternative pre-mRNA splicing converge to
            regulate myocyte enhancer factor 2C activity
  JOURNAL   Mol. Cell. Biol. 24 (18), 8264-8275 (2004)
   PUBMED   15340086
REFERENCE   6  (bases 1 to 6446)
  AUTHORS   Molkentin,J.D., Li,L. and Olson,E.N.
  TITLE     Phosphorylation of the MADS-Box transcription factor MEF2C enhances
            its DNA binding activity
  JOURNAL   J. Biol. Chem. 271 (29), 17199-17204 (1996)
   PUBMED   8663403
REFERENCE   7  (bases 1 to 6446)
  AUTHORS   Krainc,D., Haas,M., Ward,D.C., Lipton,S.A., Bruns,G. and Leifer,D.
  TITLE     Assignment of human myocyte-specific enhancer binding factor 2C
            (hMEF2C) to human chromosome 5q14 and evidence that MEF2C is
            evolutionarily conserved
  JOURNAL   Genomics 29 (3), 809-811 (1995)
   PUBMED   8575784
REFERENCE   8  (bases 1 to 6446)
  AUTHORS   Hobson,G.M., Krahe,R., Garcia,E., Siciliano,M.J. and Funanage,V.L.
  TITLE     Regional chromosomal assignments for four members of the MADS
            domain transcription enhancer factor 2 (MEF2) gene family to human
            chromosomes 15q26, 19p12, 5q14, and 1q12-q23
  JOURNAL   Genomics 29 (3), 704-711 (1995)
   PUBMED   8575763
REFERENCE   9  (bases 1 to 6446)
  AUTHORS   McDermott,J.C., Cardoso,M.C., Yu,Y.T., Andres,V., Leifer,D.,
            Krainc,D., Lipton,S.A. and Nadal-Ginard,B.
  TITLE     hMEF2C gene encodes skeletal muscle- and brain-specific
            transcription factors
  JOURNAL   Mol. Cell. Biol. 13 (4), 2564-2577 (1993)
   PUBMED   8455629
REFERENCE   10 (bases 1 to 6446)
  AUTHORS   Leifer,D., Krainc,D., Yu,Y.T., McDermott,J., Breitbart,R.E.,
            Heng,J., Neve,R.L., Kosofsky,B., Nadal-Ginard,B. and Lipton,S.A.
  TITLE     MEF2C, a MADS/MEF2-family transcription factor expressed in a
            laminar distribution in cerebral cortex
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 90 (4), 1546-1550 (1993)
   PUBMED   7679508
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC377336.1, DC377710.1,
            BC026341.1, L08895.1, AL833268.1 and AC008525.7.
            
            Summary: This locus encodes a member of the MADS box transcription
            enhancer factor 2 (MEF2) family of proteins, which play a role in
            myogenesis. The encoded protein, MEF2 polypeptide C, has both
            trans-activating and DNA binding activities. This protein may play
            a role in maintaining the differentiated state of muscle cells.
            Mutations and deletions at this locus have been associated with
            severe mental retardation, stereotypic movements, epilepsy, and
            cerebral malformation. Alternatively spliced transcript variants
            have been described. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (6) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 6 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 DC377336.1         1-8
            9-240               DC377710.1         1-232
            241-874             BC026341.1         16-649
            875-1104            L08895.1           625-854
            1105-1726           BC026341.1         880-1501
            1727-3888           L08895.1           1477-3638
            3889-3889           AL833268.1         3643-3643
            3890-4328           L08895.1           3639-4077
            4329-4740           AC008525.7         41254-41665         c
            4741-6372           AC008525.7         39622-41253         c
            6373-6446           AL833268.1         6128-6201
FEATURES             Location/Qualifiers
     source          1..6446
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.3"
     gene            1..6446
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /note="myocyte enhancer factor 2C"
                     /db_xref="GeneID:4208"
                     /db_xref="HGNC:6996"
                     /db_xref="MIM:600662"
     exon            1..512
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /inference="alignment:Splign:1.39.8"
     exon            513..705
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /inference="alignment:Splign:1.39.8"
     STS             514..779
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /standard_name="Mef2c"
                     /db_xref="UniSTS:143852"
     misc_feature    553..555
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /note="upstream in-frame stop codon"
     CDS             652..2073
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /note="isoform 1 is encoded by transcript variant 6;
                     myocyte-specific enhancer factor 2C; MADS box
                     transcription enhancer factor 2, polypeptide C"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2C isoform 1"
                     /protein_id="NP_001180279.1"
                     /db_xref="GI:301069386"
                     /db_xref="CCDS:CCDS47245.1"
                     /db_xref="GeneID:4208"
                     /db_xref="HGNC:6996"
                     /db_xref="MIM:600662"
                     /translation="
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT
"
     misc_feature    655..885
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; Region:
                     MADS_MEF2_like; cd00265"
                     /db_xref="CDD:238165"
     misc_feature    order(655..663,667..669,673..675,688..690,694..696,
                     706..711,718..723,727..732,739..744,748..753,763..765)
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     misc_feature    661..663
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (Q06413.1); acetylation site"
     misc_feature    order(712..714,733..738,745..750,754..759,766..768,
                     781..783,787..789,793..795,811..813,817..819,835..837,
                     844..849,856..858,865..870)
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238165"
     misc_feature    826..828
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /note="putative phosphorylation site [posttranslational
                     modification]; other site"
                     /db_xref="CDD:238165"
     misc_feature    934..1119
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; Region: HJURP_C; pfam12347"
                     /db_xref="CDD:152782"
     misc_feature    997..999
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (Q06413.1); acetylation site"
     misc_feature    1006..1008
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (Q06413.1); acetylation site"
     misc_feature    1351..1353
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (Q06413.1); acetylation site"
     misc_feature    1366..1368
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (Q06413.1); acetylation site"
     misc_feature    1405..1407
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (Q06413.1); acetylation site"
     misc_feature    1441..1443
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (Q06413.1); acetylation site"
     misc_feature    1462..1485
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q06413.1);
                     Region: Beta domain"
     misc_feature    1528..1530
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by MAPK14; propagated from
                     UniProtKB/Swiss-Prot (Q06413.1); phosphorylation site"
     misc_feature    1549..1551
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by MAPK14; propagated from
                     UniProtKB/Swiss-Prot (Q06413.1); phosphorylation site"
     misc_feature    1753..1848
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q06413.1);
                     Region: Transcription repressor"
     misc_feature    1837..1839
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by CDK5; propagated from
                     UniProtKB/Swiss-Prot (Q06413.1); phosphorylation site"
     misc_feature    1906..1908
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by MAPK7; propagated from
                     UniProtKB/Swiss-Prot (Q06413.1); phosphorylation site"
     misc_feature    1945..1950
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="Cleavage (Probable); propagated from
                     UniProtKB/Swiss-Prot (Q06413.1); cleavage site"
     exon            706..909
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /inference="alignment:Splign:1.39.8"
     STS             854..1242
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /standard_name="Mef2c"
                     /db_xref="UniSTS:265602"
     exon            910..1053
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /inference="alignment:Splign:1.39.8"
     STS             925..990
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /standard_name="Mef2c"
                     /db_xref="UniSTS:498478"
     exon            1054..1240
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /inference="alignment:Splign:1.39.8"
     STS             1067..1235
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /standard_name="MEF2C"
                     /db_xref="UniSTS:504947"
     exon            1241..1288
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /inference="alignment:Splign:1.39.8"
     exon            1289..1461
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /inference="alignment:Splign:1.39.8"
     STS             1438..1619
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /standard_name="Mef2c"
                     /db_xref="UniSTS:496803"
     exon            1462..1485
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /inference="alignment:Splign:1.39.8"
     exon            1486..1615
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /inference="alignment:Splign:1.39.8"
     exon            1616..1751
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /inference="alignment:Splign:1.39.8"
     STS             1722..2023
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /standard_name="Mef2c"
                     /db_xref="UniSTS:265603"
     exon            1752..6436
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /inference="alignment:Splign:1.39.8"
     STS             2592..2819
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /standard_name="G10647"
                     /db_xref="UniSTS:17885"
     STS             3057..3949
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /standard_name="MEF2C_2028"
                     /db_xref="UniSTS:280844"
     STS             3698..3798
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /standard_name="SGC30054"
                     /db_xref="UniSTS:69948"
     STS             4190..4314
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /standard_name="SGC30495"
                     /db_xref="UniSTS:62611"
     variation       4328
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201910863"
     variation       4631
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1050585"
     STS             6322..6384
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
                     /standard_name="STS-Z40067"
                     /db_xref="UniSTS:33841"
     polyA_site      6436
                     /gene="MEF2C"
                     /gene_synonym="C5DELq14.3; DEL5q14.3"
ORIGIN      
gagctgttctccttttcccattcgtcttctgtcacttccttcctggacgcagttttctggacgagtctggttacttttaatccgaccggccgctgagagccactttctcctcctcctcctcctcctccttctcttcctcctccttcttcctcctcctcctcctcttccgagcggcctcggcgcgcgcgaatgcgcggccccgcgccccccccctcgcgcgcgctcccctcgcgcgcgcgcacacacgcacacatcgtctccagctctctgctcgctctgctcgcagtcacagacacttgagcacacgcgtacacccagacatcttcgggctgctattggattgactttgaaggttctgtgtgggtcgccgtggctgcatgtttgaatcaggtggagaagcacttcaacgctggacgaagtaaagattattgttgttattttttttttctctctctctctctcttaagaaaggaaaatatcccaaggactaatctgatcgggtcttccttcatgaacgaatgcaggaatttgggaactgagctgtgcaagtgctgaagaaggagatttgtttggaggaaacaggaaagagaaagaaaaggaaggaaaaaatacataatttcagggacgagagagagaagaaaaacggggactatggggagaaaaaagattcagattacgaggattatggatgaacgtaacagacaggtgacatttacaaagaggaaatttgggttgatgaagaaggcttatgagctgagcgtgctgtgtgactgtgagattgcgctgatcatcttcaacagcaccaacaagctgttccagtatgccagcaccgacatggacaaagtgcttctcaagtacacggagtacaacgagccgcatgagagccggacaaactcagacatcgtggagacgttgagaaagaagggccttaatggctgtgacagcccagaccccgatgcggacgattccgtaggtcacagccctgagtctgaggacaagtacaggaaaattaacgaagatattgatctaatgatcagcaggcaaagattgtgtgctgttccacctcccaacttcgagatgccagtctccatcccagtgtccagccacaacagtttggtgtacagcaaccctgtcagctcactgggaaaccccaacctattgccactggctcacccttctctgcagaggaatagtatgtctcctggtgtaacacatcgacctccaagtgcaggtaacacaggtggtctgatgggtggagacctcacgtctggtgcaggcaccagtgcagggaacgggtatggcaatccccgaaactcaccaggtctgctggtctcacctggtaacttgaacaagaatatgcaagcaaaatctcctcccccaatgaatttaggaatgaataaccgtaaaccagatctccgagttcttattccaccaggcagcaagaatacgatgccatcagtgtctgaggatgtcgacctgcttttgaatcaaaggataaataactcccagtcggctcagtcattggctaccccagtggtttccgtagcaactcctactttaccaggacaaggaatgggaggatatccatcagccatttcaacaacatatggtaccgagtactctctgagtagtgcagacctgtcatctctgtctgggtttaacaccgccagcgctcttcaccttggttcagtaactggctggcaacagcaacacctacataacatgccaccatctgccctcagtcagttgggagcttgcactagcactcatttatctcagagttcaaatctctccctgccttctactcaaagcctcaacatcaagtcagaacctgtttctcctcctagagaccgtaccaccaccccttcgagatacccacaacacacgcgccacgaggcggggagatctcctgttgacagcttgagcagctgtagcagttcgtacgacgggagcgaccgagaggatcaccggaacgaattccactcccccattggactcaccagaccttcgccggacgaaagggaaagtccctcagtcaagcgcatgcgactttctgaaggatgggcaacatgatcagattattacttactagtttttttttttttcttgcagtgtgtgtgtgtgctataccttaatggggaaggggggtcgatatgcattatatgtgccgtgtgtggaaaaaaaaaaagtcaggtactctgttttgtaaaagtacttttaaattgcctcagtgatacagtataaagataaacagaaatgctgagataagcttagcacttgagttgtacaacagaacacttgtacaaaatagattttaaggctaacttcttttcactgttgtgctcctttgcaaaatgtatgttacaatagatagtgtcatgttgcaggttcaacgttatttacatgtaaatagacaaaaggaaacatttgccaaaagcggcagatctttactgaaagagagagcagctgttatgcaacatatagaaaaatgtatagatgcttggacagacccggtaatgggtggccattggtaaatgttaggaacacaccaggtcacctgacatcccaagaatgctcacaaacctgcaggcatatcattggcgtatggcactcattaaaaaggatcagagaccattaaaagaggaccatacctattaaaaaaaaatgtggagttggagggctaacatatttaattaaataaataaataaatctgggtctgcatctcttattaaataaaaatataaaaatatgtacattacattttgcttattttcatataaaaggtaagacagagtttgcaaagcatttgtggctttttgtagtttacttaagccaaaatgtgtttttttccccttgatagcttcgctaatattttaaacagtcctgtaaaaaaccaaaaaggactttttgtatagaaagcactaccctaagccatgaagaactccatgctttgctaaccaagataactgttttctctttgtagaagttttgtttttgaaatgtgtatttctaattatataaaatattaagaatcttttaaaaaaatctgtgaaattaacatgcttgtgtatagctttctaatatatataatattatggtaatagcagaagttttgttatcttaatagcgggaggggggtatatttgtgcagttgcacatttgagtaactattttctttctgttttcttttactctgcttacattttataagtttaaggtcagctgtcaaaaggataacctgtggggttagaacatatcacattgcaacaccctaaattgtttttaatacattagcaatctattgggtcaactgacatccattgtatatactagtttctttcatgctatttttattttgttttttgcatttttatcaaatgcagggcccctttctgatctcaccatttcaccatgcatcttggaattcagtaagtgcatatcctaacttgcccatattctaaatcatctggttggttttcagcctagaatttgatacgctttttagaaatatgcccagaatagaaaagctatgttggggcacatgtcctgcaaatatggccctagaaacaagtgatatggaatttacttggtgaataagttataaattcccacagaagaaaaatgtgaaagactgggtgctagacaagaaggaagcaggtaaagggatagttgctttgtcatccgtttttaattattttaactgacccttgacaatcttgtcagcaatataggactgttgaacaatcccggtgtgtcaggacccccaaatgtcacttctgcataaagcatgtatgtcatctattttttcttcaataaagagatttaatagccatttcaagaaatcccataaagaacctctctatgtccctttttttaatttaaaaaaaatgactcttgtctaatattcgtctataagggattaattttcagaccctttaataagtgagtgccataagaaagtcaatatatattgtttaaaagatatttcagtctaggaaagattttccttctcttggaatgtgaagatctgtcgattcatctccaatcatatgcattgacatacacagcaaagaagatataggcagtaatatcaacactgctatatcatgtgtaggacatttcttatccattttttctcttttacttgcatagttgctatgtgtttctcattgtaaaaggctgccgctgggtggcagaagccaagagaccttattaactaggctatatttttcttaacttgatctgaaatccacaattagaccacaatgcacctttggttgtatccataaaggatgctagcctgccttgtactaatgttttatatattaaaaaaaaaaaatctatcaaccatttcatatatatcccactactcaaggtatccatggaacatgaaagaataacatttatgcagaggaaaaacaaaaacatccctgaaaatatacacactcatacacacacacgcacaggggaataaaataagaaaatcattttcctcaccatagacttgatcccatccttacaacccatccttctaacttgatgtgtataaaatatgcaaacatttcacaaatgttctttgtcatttcaaaatactttagtatatcaatatcagtagataccagtgggtgggaaagggtcattacatgaaaatatgaagaaatagccatattagttttttaacctgcaatttgcctcagcaacaaagaaaaagtgaatttttaatgctgaagataaagtaagctaaagtaccagcagaagccttggctatttatagcagttctgacaatagttttataagaacatgaagagaacagaatcacttgaaaatggatgccagtcatctcttgttcccactactgaattcttataaagtggtggcaagatagggaagggataatctgagaatttttaaaagatgatttaatgagaagaagcacaattttgattttgatgagtcactttctgtaaacaatcttggtctatctttacccttataccttatctgtaatttaccatttattgtatttgcaaagctagtatggtttttaatcacagtaaatcctttgtattccagactttagggcagagccctgagggagtattattttacataacccgtcctagagtaacattttaggcaacattcttcattgcaagtaaaagatccataagtggcattttacacggctgcgagtattgttatatctaatcctattttaaaagatttttggtaatatgaagcttgaatactggtaacagtgatgcaatatacgcaagctgcacaacctgtatattgtatgcattgctgcgtggaggctgtttatttcaacctttttaaaaattgtgttttttagtaaaatggcttattttttcccaaaggtggaatttagcattttgtaatgatgaatataaaaatacctgtcatccccagatcatttaaaagttaactaaagtgagaatgaaaaaacaaaattccaagacactttttaaaagaatgtctgccctcacacacttttatggatttgtttttcttacatacccatcttttaacttagagatagcattttttgccctctttattttgttgtttgtttctccagagagtaaacgctttgtagttctttctttaaaaaacattttttttaaagaagaagaagccacttgaaccctcaataaaggctgttgcctaagcatggcatacttcatctgttctcatttgtgccatctgccgtgatgtcgtcacttttatggcgttaatttcctgccactacagatcttttgaagattgctggaatactggtgtctgttagaatgcttcagactacagatgtaattaaaggcttttcttaatatgttttaaccaaagatgtggagcaatccaagccacatatcttctacatcaaatttttccattttggttattttcataatctggtattgcattttgccttccctgttcatacctcaaattgattcatacctcagtttaattcagagaggtcagttaagtgacggattctgttgtggtttgaatgcagtaccagtgttctcttcgagcaaagtagacctgggtcactgtaggcataggacttggattgcttcagatggtttgctgtatcatttttcttctttttcttttcctggggacttgtttccattaaatgagagtaattaaaatcgcttgtaaatgagggcatacaagcatttgcaacaaatattcaaatagaggctcacagcggcataagctggactttgtcgccactagatgacaagatgttataactaagttaaaccacatctgtgtatctcaagggacttaattcagctgtctgtagtgaataaaagtgggaaattttcaaaagtttctcctgctggaaataaggtataatttgtattttgcagacaattcagtaaagttactggctttcttagtgaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:4208 -> Molecular function: GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] evidence: IDA
            GeneID:4208 -> Molecular function: GO:0000981 [sequence-specific DNA binding RNA polymerase II transcription factor activity] evidence: ISS
            GeneID:4208 -> Molecular function: GO:0000983 [RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:4208 -> Molecular function: GO:0000987 [core promoter proximal region sequence-specific DNA binding] evidence: IEA
            GeneID:4208 -> Molecular function: GO:0001046 [core promoter sequence-specific DNA binding] evidence: IEA
            GeneID:4208 -> Molecular function: GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] evidence: IDA
            GeneID:4208 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA
            GeneID:4208 -> Molecular function: GO:0003680 [AT DNA binding] evidence: IDA
            GeneID:4208 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
            GeneID:4208 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:4208 -> Molecular function: GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:4208 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:4208 -> Molecular function: GO:0033613 [activating transcription factor binding] evidence: IPI
            GeneID:4208 -> Molecular function: GO:0035198 [miRNA binding] evidence: IDA
            GeneID:4208 -> Molecular function: GO:0042826 [histone deacetylase binding] evidence: IEA
            GeneID:4208 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: ISS
            GeneID:4208 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IPI
            GeneID:4208 -> Molecular function: GO:0071837 [HMG box domain binding] evidence: IEA
            GeneID:4208 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IMP
            GeneID:4208 -> Biological process: GO:0000165 [MAPK cascade] evidence: IDA
            GeneID:4208 -> Biological process: GO:0000165 [MAPK cascade] evidence: IMP
            GeneID:4208 -> Biological process: GO:0001568 [blood vessel development] evidence: ISS
            GeneID:4208 -> Biological process: GO:0001649 [osteoblast differentiation] evidence: ISS
            GeneID:4208 -> Biological process: GO:0001782 [B cell homeostasis] evidence: ISS
            GeneID:4208 -> Biological process: GO:0001947 [heart looping] evidence: ISS
            GeneID:4208 -> Biological process: GO:0001958 [endochondral ossification] evidence: ISS
            GeneID:4208 -> Biological process: GO:0001974 [blood vessel remodeling] evidence: ISS
            GeneID:4208 -> Biological process: GO:0002062 [chondrocyte differentiation] evidence: ISS
            GeneID:4208 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
            GeneID:4208 -> Biological process: GO:0002467 [germinal center formation] evidence: ISS
            GeneID:4208 -> Biological process: GO:0002634 [regulation of germinal center formation] evidence: ISS
            GeneID:4208 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
            GeneID:4208 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
            GeneID:4208 -> Biological process: GO:0003138 [primary heart field specification] evidence: ISS
            GeneID:4208 -> Biological process: GO:0003139 [secondary heart field specification] evidence: ISS
            GeneID:4208 -> Biological process: GO:0003151 [outflow tract morphogenesis] evidence: ISS
            GeneID:4208 -> Biological process: GO:0003185 [sinoatrial valve morphogenesis] evidence: ISS
            GeneID:4208 -> Biological process: GO:0003211 [cardiac ventricle formation] evidence: ISS
            GeneID:4208 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:4208 -> Biological process: GO:0006959 [humoral immune response] evidence: ISS
            GeneID:4208 -> Biological process: GO:0007399 [nervous system development] evidence: TAS
            GeneID:4208 -> Biological process: GO:0007507 [heart development] evidence: IEP
            GeneID:4208 -> Biological process: GO:0007507 [heart development] evidence: ISS
            GeneID:4208 -> Biological process: GO:0007507 [heart development] evidence: NAS
            GeneID:4208 -> Biological process: GO:0007517 [muscle organ development] evidence: TAS
            GeneID:4208 -> Biological process: GO:0007519 [skeletal muscle tissue development] evidence: ISS
            GeneID:4208 -> Biological process: GO:0007521 [muscle cell fate determination] evidence: ISS
            GeneID:4208 -> Biological process: GO:0007611 [learning or memory] evidence: ISS
            GeneID:4208 -> Biological process: GO:0009615 [response to virus] evidence: IEP
            GeneID:4208 -> Biological process: GO:0010628 [positive regulation of gene expression] evidence: IDA
            GeneID:4208 -> Biological process: GO:0010629 [negative regulation of gene expression] evidence: ISS
            GeneID:4208 -> Biological process: GO:0010694 [positive regulation of alkaline phosphatase activity] evidence: ISS
            GeneID:4208 -> Biological process: GO:0014033 [neural crest cell differentiation] evidence: ISS
            GeneID:4208 -> Biological process: GO:0014898 [cardiac muscle hypertrophy in response to stress] evidence: IEA
            GeneID:4208 -> Biological process: GO:0014902 [myotube differentiation] evidence: IEP
            GeneID:4208 -> Biological process: GO:0021542 [dentate gyrus development] evidence: IEA
            GeneID:4208 -> Biological process: GO:0030182 [neuron differentiation] evidence: IEP
            GeneID:4208 -> Biological process: GO:0030182 [neuron differentiation] evidence: ISS
            GeneID:4208 -> Biological process: GO:0030220 [platelet formation] evidence: ISS
            GeneID:4208 -> Biological process: GO:0030224 [monocyte differentiation] evidence: IEA
            GeneID:4208 -> Biological process: GO:0030279 [negative regulation of ossification] evidence: IDA
            GeneID:4208 -> Biological process: GO:0030318 [melanocyte differentiation] evidence: ISS
            GeneID:4208 -> Biological process: GO:0030501 [positive regulation of bone mineralization] evidence: ISS
            GeneID:4208 -> Biological process: GO:0030890 [positive regulation of B cell proliferation] evidence: ISS
            GeneID:4208 -> Biological process: GO:0033197 [response to vitamin E] evidence: IEA
            GeneID:4208 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
            GeneID:4208 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
            GeneID:4208 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
            GeneID:4208 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS
            GeneID:4208 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS
            GeneID:4208 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS
            GeneID:4208 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
            GeneID:4208 -> Biological process: GO:0035690 [cellular response to drug] evidence: ISS
            GeneID:4208 -> Biological process: GO:0035984 [cellular response to trichostatin A] evidence: ISS
            GeneID:4208 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
            GeneID:4208 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
            GeneID:4208 -> Biological process: GO:0042100 [B cell proliferation] evidence: ISS
            GeneID:4208 -> Biological process: GO:0042692 [muscle cell differentiation] evidence: TAS
            GeneID:4208 -> Biological process: GO:0043524 [negative regulation of neuron apoptotic process] evidence: ISS
            GeneID:4208 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:4208 -> Biological process: GO:0045652 [regulation of megakaryocyte differentiation] evidence: ISS
            GeneID:4208 -> Biological process: GO:0045663 [positive regulation of myoblast differentiation] evidence: IMP
            GeneID:4208 -> Biological process: GO:0045666 [positive regulation of neuron differentiation] evidence: ISS
            GeneID:4208 -> Biological process: GO:0045669 [positive regulation of osteoblast differentiation] evidence: ISS
            GeneID:4208 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:4208 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:4208 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
            GeneID:4208 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
            GeneID:4208 -> Biological process: GO:0048643 [positive regulation of skeletal muscle tissue development] evidence: IMP
            GeneID:4208 -> Biological process: GO:0048666 [neuron development] evidence: ISS
            GeneID:4208 -> Biological process: GO:0048703 [embryonic viscerocranium morphogenesis] evidence: IEA
            GeneID:4208 -> Biological process: GO:0050680 [negative regulation of epithelial cell proliferation] evidence: IEA
            GeneID:4208 -> Biological process: GO:0050853 [B cell receptor signaling pathway] evidence: ISS
            GeneID:4208 -> Biological process: GO:0051145 [smooth muscle cell differentiation] evidence: ISS
            GeneID:4208 -> Biological process: GO:0051149 [positive regulation of muscle cell differentiation] evidence: TAS
            GeneID:4208 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS
            GeneID:4208 -> Biological process: GO:0055012 [ventricular cardiac muscle cell differentiation] evidence: ISS
            GeneID:4208 -> Biological process: GO:0060021 [palate development] evidence: IEA
            GeneID:4208 -> Biological process: GO:0060025 [regulation of synaptic activity] evidence: ISS
            GeneID:4208 -> Biological process: GO:0060045 [positive regulation of cardiac muscle cell proliferation] evidence: ISS
            GeneID:4208 -> Biological process: GO:0060297 [regulation of sarcomere organization] evidence: IEA
            GeneID:4208 -> Biological process: GO:0060536 [cartilage morphogenesis] evidence: IEA
            GeneID:4208 -> Biological process: GO:0061333 [renal tubule morphogenesis] evidence: ISS
            GeneID:4208 -> Biological process: GO:0071222 [cellular response to lipopolysaccharide] evidence: ISS
            GeneID:4208 -> Biological process: GO:0071277 [cellular response to calcium ion] evidence: ISS
            GeneID:4208 -> Biological process: GO:0071300 [cellular response to retinoic acid] evidence: IEA
            GeneID:4208 -> Biological process: GO:0071333 [cellular response to glucose stimulus] evidence: IEA
            GeneID:4208 -> Biological process: GO:0071374 [cellular response to parathyroid hormone stimulus] evidence: IDA
            GeneID:4208 -> Biological process: GO:0071498 [cellular response to fluid shear stress] evidence: ISS
            GeneID:4208 -> Biological process: GO:0071560 [cellular response to transforming growth factor beta stimulus] evidence: IDA
            GeneID:4208 -> Biological process: GO:0071864 [positive regulation of cell proliferation in bone marrow] evidence: IEA
            GeneID:4208 -> Biological process: GO:0072102 [glomerulus morphogenesis] evidence: ISS
            GeneID:4208 -> Biological process: GO:0072160 [nephron tubule epithelial cell differentiation] evidence: ISS
            GeneID:4208 -> Biological process: GO:0090073 [positive regulation of protein homodimerization activity] evidence: ISS
            GeneID:4208 -> Biological process: GO:2000111 [positive regulation of macrophage apoptotic process] evidence: ISS
            GeneID:4208 -> Biological process: GO:2000727 [positive regulation of cardiac muscle cell differentiation] evidence: IDA
            GeneID:4208 -> Biological process: GO:2000987 [positive regulation of behavioral fear response] evidence: ISS
            GeneID:4208 -> Biological process: GO:2001013 [epithelial cell proliferation involved in renal tubule morphogenesis] evidence: ISS
            GeneID:4208 -> Biological process: GO:2001016 [positive regulation of skeletal muscle cell differentiation] evidence: IDA
            GeneID:4208 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:4208 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:4208 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:4208 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:4208 -> Cellular component: GO:0016607 [nuclear speck] evidence: IDA
            GeneID:4208 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA
            GeneID:4208 -> Cellular component: GO:0043234 [protein complex] evidence: IDA

by @meso_cacase at DBCLS
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