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2024-04-20 06:12:36, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001193347 6254 bp mRNA linear PRI 05-JUL-2013
DEFINITION Homo sapiens myocyte enhancer factor 2C (MEF2C), transcript variant
3, mRNA.
ACCESSION NM_001193347
VERSION NM_001193347.1 GI:301069379
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6254)
AUTHORS Del-Aguila,J.L., Beitelshees,A.L., Cooper-Dehoff,R.M.,
Chapman,A.B., Gums,J.G., Bailey,K., Gong,Y., Turner,S.T.,
Johnson,J.A. and Boerwinkle,E.
TITLE Genome-wide association analyses suggest NELL1 influences adverse
metabolic response to HCTZ in African Americans
JOURNAL Pharmacogenomics J. (2013) In press
PUBMED 23400010
REMARK Publication Status: Available-Online prior to print
REFERENCE 2 (bases 1 to 6254)
AUTHORS Mendez-Vigo,B., Martinez-Zapater,J.M. and Alonso-Blanco,C.
TITLE The flowering repressor SVP underlies a novel Arabidopsis thaliana
QTL interacting with the genetic background
JOURNAL PLoS Genet. 9 (1), E1003289 (2013)
PUBMED 23382706
REFERENCE 3 (bases 1 to 6254)
AUTHORS Le Meur,N., Holder-Espinasse,M., Jaillard,S., Goldenberg,A.,
Joriot,S., Amati-Bonneau,P., Guichet,A., Barth,M., Charollais,A.,
Journel,H., Auvin,S., Boucher,C., Kerckaert,J.P., David,V.,
Manouvrier-Hanu,S., Saugier-Veber,P., Frebourg,T., Dubourg,C.,
Andrieux,J. and Bonneau,D.
TITLE MEF2C haploinsufficiency caused by either microdeletion of the
5q14.3 region or mutation is responsible for severe mental
retardation with stereotypic movements, epilepsy and/or cerebral
malformations
JOURNAL J. Med. Genet. 47 (1), 22-29 (2010)
PUBMED 19592390
REMARK GeneRIF: These results strongly suggest that haploinsufficiency of
MEF2C is responsible for severe mental retardation with stereotypic
movements, seizures and/or cerebral malformations.
REFERENCE 4 (bases 1 to 6254)
AUTHORS Zhu,B., Ramachandran,B. and Gulick,T.
TITLE Alternative pre-mRNA splicing governs expression of a conserved
acidic transactivation domain in myocyte enhancer factor 2 factors
of striated muscle and brain
JOURNAL J. Biol. Chem. 280 (31), 28749-28760 (2005)
PUBMED 15834131
REMARK GeneRIF: A conserved pattern of alternative splicing in vertebrate
MEF2 (myocyte enhancer factor 2) genes generates an acidic
activation domain in MEF2 proteins selectively in tissues where
MEF2 target genes are highly expressed. (MEF2)
REFERENCE 5 (bases 1 to 6254)
AUTHORS Zhu,B. and Gulick,T.
TITLE Phosphorylation and alternative pre-mRNA splicing converge to
regulate myocyte enhancer factor 2C activity
JOURNAL Mol. Cell. Biol. 24 (18), 8264-8275 (2004)
PUBMED 15340086
REFERENCE 6 (bases 1 to 6254)
AUTHORS Molkentin,J.D., Li,L. and Olson,E.N.
TITLE Phosphorylation of the MADS-Box transcription factor MEF2C enhances
its DNA binding activity
JOURNAL J. Biol. Chem. 271 (29), 17199-17204 (1996)
PUBMED 8663403
REFERENCE 7 (bases 1 to 6254)
AUTHORS Krainc,D., Haas,M., Ward,D.C., Lipton,S.A., Bruns,G. and Leifer,D.
TITLE Assignment of human myocyte-specific enhancer binding factor 2C
(hMEF2C) to human chromosome 5q14 and evidence that MEF2C is
evolutionarily conserved
JOURNAL Genomics 29 (3), 809-811 (1995)
PUBMED 8575784
REFERENCE 8 (bases 1 to 6254)
AUTHORS Hobson,G.M., Krahe,R., Garcia,E., Siciliano,M.J. and Funanage,V.L.
TITLE Regional chromosomal assignments for four members of the MADS
domain transcription enhancer factor 2 (MEF2) gene family to human
chromosomes 15q26, 19p12, 5q14, and 1q12-q23
JOURNAL Genomics 29 (3), 704-711 (1995)
PUBMED 8575763
REFERENCE 9 (bases 1 to 6254)
AUTHORS McDermott,J.C., Cardoso,M.C., Yu,Y.T., Andres,V., Leifer,D.,
Krainc,D., Lipton,S.A. and Nadal-Ginard,B.
TITLE hMEF2C gene encodes skeletal muscle- and brain-specific
transcription factors
JOURNAL Mol. Cell. Biol. 13 (4), 2564-2577 (1993)
PUBMED 8455629
REFERENCE 10 (bases 1 to 6254)
AUTHORS Leifer,D., Krainc,D., Yu,Y.T., McDermott,J., Breitbart,R.E.,
Heng,J., Neve,R.L., Kosofsky,B., Nadal-Ginard,B. and Lipton,S.A.
TITLE MEF2C, a MADS/MEF2-family transcription factor expressed in a
laminar distribution in cerebral cortex
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (4), 1546-1550 (1993)
PUBMED 7679508
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP231922.1, AL833274.1,
AL833268.1, L08895.1 and AC008525.7.
Summary: This locus encodes a member of the MADS box transcription
enhancer factor 2 (MEF2) family of proteins, which play a role in
myogenesis. The encoded protein, MEF2 polypeptide C, has both
trans-activating and DNA binding activities. This protein may play
a role in maintaining the differentiated state of muscle cells.
Mutations and deletions at this locus have been associated with
severe mental retardation, stereotypic movements, epilepsy, and
cerebral malformation. Alternatively spliced transcript variants
have been described. [provided by RefSeq, Jul 2010].
Transcript Variant: This variant (3) differs in the 5' UTR and has
multiple differences in the coding region but maintains the reading
frame, compared to variant 1. This variant encodes isoform 3, which
is longer than isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AL833268.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-53 BP231922.1 2-54
54-164 AL833274.1 1-111
165-455 AL833268.1 113-403
456-456 L08895.1 428-428
457-1627 AL833268.1 405-1575
1628-3696 L08895.1 1570-3638
3697-3697 AL833268.1 3643-3643
3698-4136 L08895.1 3639-4077
4137-4548 AC008525.7 41254-41665 c
4549-6180 AC008525.7 39622-41253 c
6181-6254 AL833268.1 6128-6201
FEATURES Location/Qualifiers
source 1..6254
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q14.3"
gene 1..6254
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/note="myocyte enhancer factor 2C"
/db_xref="GeneID:4208"
/db_xref="HGNC:6996"
/db_xref="MIM:600662"
exon 1..190
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/inference="alignment:Splign:1.39.8"
exon 191..287
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/inference="alignment:Splign:1.39.8"
exon 288..483
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/inference="alignment:Splign:1.39.8"
STS 292..557
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/standard_name="Mef2c"
/db_xref="UniSTS:143852"
misc_feature 331..333
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/note="upstream in-frame stop codon"
CDS 430..1881
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/note="isoform 3 is encoded by transcript variant 3;
myocyte-specific enhancer factor 2C; MADS box
transcription enhancer factor 2, polypeptide C"
/codon_start=1
/product="myocyte-specific enhancer factor 2C isoform 3"
/protein_id="NP_001180276.1"
/db_xref="GI:301069380"
/db_xref="CCDS:CCDS54878.1"
/db_xref="GeneID:4208"
/db_xref="HGNC:6996"
/db_xref="MIM:600662"
/translation="
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSALNKKENKGCESPDPDSSYALTPRTEEKYKKINEEFDNMIKSHKIPAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT
"
misc_feature 433..663
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/note="MEF2 (myocyte enhancer factor 2)-like/Type II
subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF
(serum response factor) box family of eukaryotic
transcriptional regulators. Binds DNA and exists as hetero
and homo-dimers. Differs from SRF-like/Type I...; Region:
MADS_MEF2_like; cd00265"
/db_xref="CDD:238165"
misc_feature order(433..441,445..447,451..453,466..468,472..474,
484..489,496..501,505..510,517..522,526..531,541..543)
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:238165"
misc_feature order(490..492,511..516,523..528,532..537,544..546,
559..561,565..567,571..573,589..591,595..597,613..615,
622..627,634..636,643..648)
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/note="dimerization interface [polypeptide binding]; other
site"
/db_xref="CDD:238165"
misc_feature 604..606
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/note="putative phosphorylation site [posttranslational
modification]; other site"
/db_xref="CDD:238165"
misc_feature 757..951
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/note="Holliday junction regulator protein family
C-terminal repeat; Region: HJURP_C; pfam12347"
/db_xref="CDD:152782"
exon 484..687
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/inference="alignment:Splign:1.39.8"
STS 632..1074
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/standard_name="Mef2c"
/db_xref="UniSTS:265602"
exon 688..747
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/inference="alignment:Splign:1.39.8"
exon 748..885
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/inference="alignment:Splign:1.39.8"
exon 886..1072
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/inference="alignment:Splign:1.39.8"
STS 899..1067
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/standard_name="MEF2C"
/db_xref="UniSTS:504947"
exon 1073..1120
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/inference="alignment:Splign:1.39.8"
exon 1121..1293
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/inference="alignment:Splign:1.39.8"
STS 1270..1427
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/standard_name="Mef2c"
/db_xref="UniSTS:496803"
exon 1294..1423
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/inference="alignment:Splign:1.39.8"
exon 1424..1559
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/inference="alignment:Splign:1.39.8"
STS 1530..1831
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/standard_name="Mef2c"
/db_xref="UniSTS:265603"
exon 1560..6244
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/inference="alignment:Splign:1.39.8"
STS 2400..2627
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/standard_name="G10647"
/db_xref="UniSTS:17885"
STS 2865..3757
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/standard_name="MEF2C_2028"
/db_xref="UniSTS:280844"
STS 3506..3606
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/standard_name="SGC30054"
/db_xref="UniSTS:69948"
STS 3998..4122
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/standard_name="SGC30495"
/db_xref="UniSTS:62611"
variation 4136
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/replace="a"
/replace="t"
/db_xref="dbSNP:201910863"
variation 4439
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/replace="g"
/replace="t"
/db_xref="dbSNP:1050585"
STS 6130..6192
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
/standard_name="STS-Z40067"
/db_xref="UniSTS:33841"
polyA_site 6244
/gene="MEF2C"
/gene_synonym="C5DELq14.3; DEL5q14.3"
ORIGIN
aagggggcaaagcctcggtcttcatagaaaaggagaggaggcaaacgcagcccaaactggggggtttctcttcaaagccagctggtctggctttattctgcaggaatttttttacctgtcagggtttggacaacaaagccctcagcaggtgctgacgggtacaacttcctggagaagcagaaaggcactggtgccaaagaagagttgcaaactgtgaagtaacttctatgaagagatgaagtaaagaacggaaggcaaatgattgtggcagtaaagaagtgtatgtgcaggaacgaatgcaggaatttgggaactgagctgtgcaagtgctgaagaaggagatttgtttggaggaaacaggaaagagaaagaaaaggaaggaaaaaatacataatttcagggacgagagagagaagaaaaacggggactatggggagaaaaaagattcagattacgaggattatggatgaacgtaacagacaggtgacatttacaaagaggaaatttgggttgatgaagaaggcttatgagctgagcgtgctgtgtgactgtgagattgcgctgatcatcttcaacagcaccaacaagctgttccagtatgccagcaccgacatggacaaagtgcttctcaagtacacggagtacaacgagccgcatgagagccggacaaactcagacatcgtggagacgttgagaaagaagggccttaatggctgtgacagcccagaccccgatgcggacgattccgcattgaacaagaaagaaaacaaaggctgtgaaagccccgatcccgactcctcttatgcactcaccccacgcactgaagaaaaatacaaaaaaattaatgaagaatttgataatatgatcaagagtcataaaattcctgctgttccacctcccaacttcgagatgccagtctccatcccagtgtccagccacaacagtttggtgtacagcaaccctgtcagctcactgggaaaccccaacctattgccactggctcacccttctctgcagaggaatagtatgtctcctggtgtaacacatcgacctccaagtgcaggtaacacaggtggtctgatgggtggagacctcacgtctggtgcaggcaccagtgcagggaacgggtatggcaatccccgaaactcaccaggtctgctggtctcacctggtaacttgaacaagaatatgcaagcaaaatctcctcccccaatgaatttaggaatgaataaccgtaaaccagatctccgagttcttattccaccaggcagcaagaatacgatgccatcagtgaatcaaaggataaataactcccagtcggctcagtcattggctaccccagtggtttccgtagcaactcctactttaccaggacaaggaatgggaggatatccatcagccatttcaacaacatatggtaccgagtactctctgagtagtgcagacctgtcatctctgtctgggtttaacaccgccagcgctcttcaccttggttcagtaactggctggcaacagcaacacctacataacatgccaccatctgccctcagtcagttgggagcttgcactagcactcatttatctcagagttcaaatctctccctgccttctactcaaagcctcaacatcaagtcagaacctgtttctcctcctagagaccgtaccaccaccccttcgagatacccacaacacacgcgccacgaggcggggagatctcctgttgacagcttgagcagctgtagcagttcgtacgacgggagcgaccgagaggatcaccggaacgaattccactcccccattggactcaccagaccttcgccggacgaaagggaaagtccctcagtcaagcgcatgcgactttctgaaggatgggcaacatgatcagattattacttactagtttttttttttttcttgcagtgtgtgtgtgtgctataccttaatggggaaggggggtcgatatgcattatatgtgccgtgtgtggaaaaaaaaaaagtcaggtactctgttttgtaaaagtacttttaaattgcctcagtgatacagtataaagataaacagaaatgctgagataagcttagcacttgagttgtacaacagaacacttgtacaaaatagattttaaggctaacttcttttcactgttgtgctcctttgcaaaatgtatgttacaatagatagtgtcatgttgcaggttcaacgttatttacatgtaaatagacaaaaggaaacatttgccaaaagcggcagatctttactgaaagagagagcagctgttatgcaacatatagaaaaatgtatagatgcttggacagacccggtaatgggtggccattggtaaatgttaggaacacaccaggtcacctgacatcccaagaatgctcacaaacctgcaggcatatcattggcgtatggcactcattaaaaaggatcagagaccattaaaagaggaccatacctattaaaaaaaaatgtggagttggagggctaacatatttaattaaataaataaataaatctgggtctgcatctcttattaaataaaaatataaaaatatgtacattacattttgcttattttcatataaaaggtaagacagagtttgcaaagcatttgtggctttttgtagtttacttaagccaaaatgtgtttttttccccttgatagcttcgctaatattttaaacagtcctgtaaaaaaccaaaaaggactttttgtatagaaagcactaccctaagccatgaagaactccatgctttgctaaccaagataactgttttctctttgtagaagttttgtttttgaaatgtgtatttctaattatataaaatattaagaatcttttaaaaaaatctgtgaaattaacatgcttgtgtatagctttctaatatatataatattatggtaatagcagaagttttgttatcttaatagcgggaggggggtatatttgtgcagttgcacatttgagtaactattttctttctgttttcttttactctgcttacattttataagtttaaggtcagctgtcaaaaggataacctgtggggttagaacatatcacattgcaacaccctaaattgtttttaatacattagcaatctattgggtcaactgacatccattgtatatactagtttctttcatgctatttttattttgttttttgcatttttatcaaatgcagggcccctttctgatctcaccatttcaccatgcatcttggaattcagtaagtgcatatcctaacttgcccatattctaaatcatctggttggttttcagcctagaatttgatacgctttttagaaatatgcccagaatagaaaagctatgttggggcacatgtcctgcaaatatggccctagaaacaagtgatatggaatttacttggtgaataagttataaattcccacagaagaaaaatgtgaaagactgggtgctagacaagaaggaagcaggtaaagggatagttgctttgtcatccgtttttaattattttaactgacccttgacaatcttgtcagcaatataggactgttgaacaatcccggtgtgtcaggacccccaaatgtcacttctgcataaagcatgtatgtcatctattttttcttcaataaagagatttaatagccatttcaagaaatcccataaagaacctctctatgtccctttttttaatttaaaaaaaatgactcttgtctaatattcgtctataagggattaattttcagaccctttaataagtgagtgccataagaaagtcaatatatattgtttaaaagatatttcagtctaggaaagattttccttctcttggaatgtgaagatctgtcgattcatctccaatcatatgcattgacatacacagcaaagaagatataggcagtaatatcaacactgctatatcatgtgtaggacatttcttatccattttttctcttttacttgcatagttgctatgtgtttctcattgtaaaaggctgccgctgggtggcagaagccaagagaccttattaactaggctatatttttcttaacttgatctgaaatccacaattagaccacaatgcacctttggttgtatccataaaggatgctagcctgccttgtactaatgttttatatattaaaaaaaaaaaatctatcaaccatttcatatatatcccactactcaaggtatccatggaacatgaaagaataacatttatgcagaggaaaaacaaaaacatccctgaaaatatacacactcatacacacacacgcacaggggaataaaataagaaaatcattttcctcaccatagacttgatcccatccttacaacccatccttctaacttgatgtgtataaaatatgcaaacatttcacaaatgttctttgtcatttcaaaatactttagtatatcaatatcagtagataccagtgggtgggaaagggtcattacatgaaaatatgaagaaatagccatattagttttttaacctgcaatttgcctcagcaacaaagaaaaagtgaatttttaatgctgaagataaagtaagctaaagtaccagcagaagccttggctatttatagcagttctgacaatagttttataagaacatgaagagaacagaatcacttgaaaatggatgccagtcatctcttgttcccactactgaattcttataaagtggtggcaagatagggaagggataatctgagaatttttaaaagatgatttaatgagaagaagcacaattttgattttgatgagtcactttctgtaaacaatcttggtctatctttacccttataccttatctgtaatttaccatttattgtatttgcaaagctagtatggtttttaatcacagtaaatcctttgtattccagactttagggcagagccctgagggagtattattttacataacccgtcctagagtaacattttaggcaacattcttcattgcaagtaaaagatccataagtggcattttacacggctgcgagtattgttatatctaatcctattttaaaagatttttggtaatatgaagcttgaatactggtaacagtgatgcaatatacgcaagctgcacaacctgtatattgtatgcattgctgcgtggaggctgtttatttcaacctttttaaaaattgtgttttttagtaaaatggcttattttttcccaaaggtggaatttagcattttgtaatgatgaatataaaaatacctgtcatccccagatcatttaaaagttaactaaagtgagaatgaaaaaacaaaattccaagacactttttaaaagaatgtctgccctcacacacttttatggatttgtttttcttacatacccatcttttaacttagagatagcattttttgccctctttattttgttgtttgtttctccagagagtaaacgctttgtagttctttctttaaaaaacattttttttaaagaagaagaagccacttgaaccctcaataaaggctgttgcctaagcatggcatacttcatctgttctcatttgtgccatctgccgtgatgtcgtcacttttatggcgttaatttcctgccactacagatcttttgaagattgctggaatactggtgtctgttagaatgcttcagactacagatgtaattaaaggcttttcttaatatgttttaaccaaagatgtggagcaatccaagccacatatcttctacatcaaatttttccattttggttattttcataatctggtattgcattttgccttccctgttcatacctcaaattgattcatacctcagtttaattcagagaggtcagttaagtgacggattctgttgtggtttgaatgcagtaccagtgttctcttcgagcaaagtagacctgggtcactgtaggcataggacttggattgcttcagatggtttgctgtatcatttttcttctttttcttttcctggggacttgtttccattaaatgagagtaattaaaatcgcttgtaaatgagggcatacaagcatttgcaacaaatattcaaatagaggctcacagcggcataagctggactttgtcgccactagatgacaagatgttataactaagttaaaccacatctgtgtatctcaagggacttaattcagctgtctgtagtgaataaaagtgggaaattttcaaaagtttctcctgctggaaataaggtataatttgtattttgcagacaattcagtaaagttactggctttcttagtgaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4208 -> Molecular function: GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] evidence: IDA
GeneID:4208 -> Molecular function: GO:0000981 [sequence-specific DNA binding RNA polymerase II transcription factor activity] evidence: ISS
GeneID:4208 -> Molecular function: GO:0000983 [RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity] evidence: IDA
GeneID:4208 -> Molecular function: GO:0000987 [core promoter proximal region sequence-specific DNA binding] evidence: IEA
GeneID:4208 -> Molecular function: GO:0001046 [core promoter sequence-specific DNA binding] evidence: IEA
GeneID:4208 -> Molecular function: GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] evidence: IDA
GeneID:4208 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA
GeneID:4208 -> Molecular function: GO:0003680 [AT DNA binding] evidence: IDA
GeneID:4208 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
GeneID:4208 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
GeneID:4208 -> Molecular function: GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:4208 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:4208 -> Molecular function: GO:0033613 [activating transcription factor binding] evidence: IPI
GeneID:4208 -> Molecular function: GO:0035198 [miRNA binding] evidence: IDA
GeneID:4208 -> Molecular function: GO:0042826 [histone deacetylase binding] evidence: IEA
GeneID:4208 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: ISS
GeneID:4208 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IPI
GeneID:4208 -> Molecular function: GO:0071837 [HMG box domain binding] evidence: IEA
GeneID:4208 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:4208 -> Biological process: GO:0000165 [MAPK cascade] evidence: IDA
GeneID:4208 -> Biological process: GO:0000165 [MAPK cascade] evidence: IMP
GeneID:4208 -> Biological process: GO:0001568 [blood vessel development] evidence: ISS
GeneID:4208 -> Biological process: GO:0001649 [osteoblast differentiation] evidence: ISS
GeneID:4208 -> Biological process: GO:0001782 [B cell homeostasis] evidence: ISS
GeneID:4208 -> Biological process: GO:0001947 [heart looping] evidence: ISS
GeneID:4208 -> Biological process: GO:0001958 [endochondral ossification] evidence: ISS
GeneID:4208 -> Biological process: GO:0001974 [blood vessel remodeling] evidence: ISS
GeneID:4208 -> Biological process: GO:0002062 [chondrocyte differentiation] evidence: ISS
GeneID:4208 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
GeneID:4208 -> Biological process: GO:0002467 [germinal center formation] evidence: ISS
GeneID:4208 -> Biological process: GO:0002634 [regulation of germinal center formation] evidence: ISS
GeneID:4208 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:4208 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
GeneID:4208 -> Biological process: GO:0003138 [primary heart field specification] evidence: ISS
GeneID:4208 -> Biological process: GO:0003139 [secondary heart field specification] evidence: ISS
GeneID:4208 -> Biological process: GO:0003151 [outflow tract morphogenesis] evidence: ISS
GeneID:4208 -> Biological process: GO:0003185 [sinoatrial valve morphogenesis] evidence: ISS
GeneID:4208 -> Biological process: GO:0003211 [cardiac ventricle formation] evidence: ISS
GeneID:4208 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:4208 -> Biological process: GO:0006959 [humoral immune response] evidence: ISS
GeneID:4208 -> Biological process: GO:0007399 [nervous system development] evidence: TAS
GeneID:4208 -> Biological process: GO:0007507 [heart development] evidence: IEP
GeneID:4208 -> Biological process: GO:0007507 [heart development] evidence: ISS
GeneID:4208 -> Biological process: GO:0007507 [heart development] evidence: NAS
GeneID:4208 -> Biological process: GO:0007517 [muscle organ development] evidence: TAS
GeneID:4208 -> Biological process: GO:0007519 [skeletal muscle tissue development] evidence: ISS
GeneID:4208 -> Biological process: GO:0007521 [muscle cell fate determination] evidence: ISS
GeneID:4208 -> Biological process: GO:0007611 [learning or memory] evidence: ISS
GeneID:4208 -> Biological process: GO:0009615 [response to virus] evidence: IEP
GeneID:4208 -> Biological process: GO:0010628 [positive regulation of gene expression] evidence: IDA
GeneID:4208 -> Biological process: GO:0010629 [negative regulation of gene expression] evidence: ISS
GeneID:4208 -> Biological process: GO:0010694 [positive regulation of alkaline phosphatase activity] evidence: ISS
GeneID:4208 -> Biological process: GO:0014033 [neural crest cell differentiation] evidence: ISS
GeneID:4208 -> Biological process: GO:0014898 [cardiac muscle hypertrophy in response to stress] evidence: IEA
GeneID:4208 -> Biological process: GO:0014902 [myotube differentiation] evidence: IEP
GeneID:4208 -> Biological process: GO:0021542 [dentate gyrus development] evidence: IEA
GeneID:4208 -> Biological process: GO:0030182 [neuron differentiation] evidence: IEP
GeneID:4208 -> Biological process: GO:0030182 [neuron differentiation] evidence: ISS
GeneID:4208 -> Biological process: GO:0030220 [platelet formation] evidence: ISS
GeneID:4208 -> Biological process: GO:0030224 [monocyte differentiation] evidence: IEA
GeneID:4208 -> Biological process: GO:0030279 [negative regulation of ossification] evidence: IDA
GeneID:4208 -> Biological process: GO:0030318 [melanocyte differentiation] evidence: ISS
GeneID:4208 -> Biological process: GO:0030501 [positive regulation of bone mineralization] evidence: ISS
GeneID:4208 -> Biological process: GO:0030890 [positive regulation of B cell proliferation] evidence: ISS
GeneID:4208 -> Biological process: GO:0033197 [response to vitamin E] evidence: IEA
GeneID:4208 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
GeneID:4208 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
GeneID:4208 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
GeneID:4208 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS
GeneID:4208 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS
GeneID:4208 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS
GeneID:4208 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:4208 -> Biological process: GO:0035690 [cellular response to drug] evidence: ISS
GeneID:4208 -> Biological process: GO:0035984 [cellular response to trichostatin A] evidence: ISS
GeneID:4208 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
GeneID:4208 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
GeneID:4208 -> Biological process: GO:0042100 [B cell proliferation] evidence: ISS
GeneID:4208 -> Biological process: GO:0042692 [muscle cell differentiation] evidence: TAS
GeneID:4208 -> Biological process: GO:0043524 [negative regulation of neuron apoptotic process] evidence: ISS
GeneID:4208 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:4208 -> Biological process: GO:0045652 [regulation of megakaryocyte differentiation] evidence: ISS
GeneID:4208 -> Biological process: GO:0045663 [positive regulation of myoblast differentiation] evidence: IMP
GeneID:4208 -> Biological process: GO:0045666 [positive regulation of neuron differentiation] evidence: ISS
GeneID:4208 -> Biological process: GO:0045669 [positive regulation of osteoblast differentiation] evidence: ISS
GeneID:4208 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
GeneID:4208 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:4208 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:4208 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:4208 -> Biological process: GO:0048643 [positive regulation of skeletal muscle tissue development] evidence: IMP
GeneID:4208 -> Biological process: GO:0048666 [neuron development] evidence: ISS
GeneID:4208 -> Biological process: GO:0048703 [embryonic viscerocranium morphogenesis] evidence: IEA
GeneID:4208 -> Biological process: GO:0050680 [negative regulation of epithelial cell proliferation] evidence: IEA
GeneID:4208 -> Biological process: GO:0050853 [B cell receptor signaling pathway] evidence: ISS
GeneID:4208 -> Biological process: GO:0051145 [smooth muscle cell differentiation] evidence: ISS
GeneID:4208 -> Biological process: GO:0051149 [positive regulation of muscle cell differentiation] evidence: TAS
GeneID:4208 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS
GeneID:4208 -> Biological process: GO:0055012 [ventricular cardiac muscle cell differentiation] evidence: ISS
GeneID:4208 -> Biological process: GO:0060021 [palate development] evidence: IEA
GeneID:4208 -> Biological process: GO:0060025 [regulation of synaptic activity] evidence: ISS
GeneID:4208 -> Biological process: GO:0060045 [positive regulation of cardiac muscle cell proliferation] evidence: ISS
GeneID:4208 -> Biological process: GO:0060297 [regulation of sarcomere organization] evidence: IEA
GeneID:4208 -> Biological process: GO:0060536 [cartilage morphogenesis] evidence: IEA
GeneID:4208 -> Biological process: GO:0061333 [renal tubule morphogenesis] evidence: ISS
GeneID:4208 -> Biological process: GO:0071222 [cellular response to lipopolysaccharide] evidence: ISS
GeneID:4208 -> Biological process: GO:0071277 [cellular response to calcium ion] evidence: ISS
GeneID:4208 -> Biological process: GO:0071300 [cellular response to retinoic acid] evidence: IEA
GeneID:4208 -> Biological process: GO:0071333 [cellular response to glucose stimulus] evidence: IEA
GeneID:4208 -> Biological process: GO:0071374 [cellular response to parathyroid hormone stimulus] evidence: IDA
GeneID:4208 -> Biological process: GO:0071498 [cellular response to fluid shear stress] evidence: ISS
GeneID:4208 -> Biological process: GO:0071560 [cellular response to transforming growth factor beta stimulus] evidence: IDA
GeneID:4208 -> Biological process: GO:0071864 [positive regulation of cell proliferation in bone marrow] evidence: IEA
GeneID:4208 -> Biological process: GO:0072102 [glomerulus morphogenesis] evidence: ISS
GeneID:4208 -> Biological process: GO:0072160 [nephron tubule epithelial cell differentiation] evidence: ISS
GeneID:4208 -> Biological process: GO:0090073 [positive regulation of protein homodimerization activity] evidence: ISS
GeneID:4208 -> Biological process: GO:2000111 [positive regulation of macrophage apoptotic process] evidence: ISS
GeneID:4208 -> Biological process: GO:2000727 [positive regulation of cardiac muscle cell differentiation] evidence: IDA
GeneID:4208 -> Biological process: GO:2000987 [positive regulation of behavioral fear response] evidence: ISS
GeneID:4208 -> Biological process: GO:2001013 [epithelial cell proliferation involved in renal tubule morphogenesis] evidence: ISS
GeneID:4208 -> Biological process: GO:2001016 [positive regulation of skeletal muscle cell differentiation] evidence: IDA
GeneID:4208 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:4208 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:4208 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:4208 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:4208 -> Cellular component: GO:0016607 [nuclear speck] evidence: IDA
GeneID:4208 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA
GeneID:4208 -> Cellular component: GO:0043234 [protein complex] evidence: IDA
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