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2024-04-25 01:48:48, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001193306 1371 bp mRNA linear PRI 02-JUN-2013
DEFINITION Homo sapiens formyl peptide receptor 1 (FPR1), transcript variant
1, mRNA.
ACCESSION NM_001193306
VERSION NM_001193306.1 GI:300863093
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1371)
AUTHORS Zhou,C., Zhou,Y., Wang,J., Feng,Y., Wang,H., Xue,J., Chen,Y.,
Ye,R.D. and Wang,M.W.
TITLE V101L of human formyl peptide receptor 1 (FPR1) increases receptor
affinity and augments the antagonism mediated by cyclosporins
JOURNAL Biochem. J. 451 (2), 245-255 (2013)
PUBMED 23373827
REMARK GeneRIF: haplotypic variation in FPR1, especially the SNP p.V101L,
alters the receptor's response to cyclosporins
REFERENCE 2 (bases 1 to 1371)
AUTHORS Schneider,E.H., Weaver,J.D., Gaur,S.S., Tripathi,B.K.,
Jesaitis,A.J., Zelenka,P.S., Gao,J.L. and Murphy,P.M.
TITLE The leukocyte chemotactic receptor FPR1 is functionally expressed
on human lens epithelial cells
JOURNAL J. Biol. Chem. 287 (48), 40779-40792 (2012)
PUBMED 23012360
REMARK GeneRIF: FPR1 is functionally expressed on human lens epithelial
cells.
REFERENCE 3 (bases 1 to 1371)
AUTHORS Mitchell,M.J. and King,M.R.
TITLE Shear-induced resistance to neutrophil activation via the formyl
peptide receptor
JOURNAL Biophys. J. 102 (8), 1804-1814 (2012)
PUBMED 22768936
REMARK GeneRIF: physiological shear forces alter neutrophil activation via
FP
REFERENCE 4 (bases 1 to 1371)
AUTHORS Gemperle,C., Schmid,M., Herova,M., Marti-Jaun,J., Wuest,S.J.,
Loretz,C. and Hersberger,M.
TITLE Regulation of the formyl peptide receptor 1 (FPR1) gene in primary
human macrophages
JOURNAL PLoS ONE 7 (11), E50195 (2012)
PUBMED 23185575
REMARK GeneRIF: The expression of the formyl peptide receptor 1 (FPR1)
gene in primary human macrophages is regulated by cytokines and
bacterial ligands.
REFERENCE 5 (bases 1 to 1371)
AUTHORS Miettinen,H.M.
TITLE Regulation of human formyl peptide receptor 1 synthesis: role of
single nucleotide polymorphisms, transcription factors, and
inflammatory mediators
JOURNAL PLoS ONE 6 (12), E28712 (2011)
PUBMED 22174875
REMARK GeneRIF: The expression of FPR1 in myeloid cells is developmentally
regulated, and the differentiated cells are equipped for immediate
response to microbial infections.
REFERENCE 6 (bases 1 to 1371)
AUTHORS Perez,H.D., Holmes,R., Kelly,E., McClary,J., Chou,Q. and
Andrews,W.H.
TITLE Cloning of the gene coding for a human receptor for formyl
peptides. Characterization of a promoter region and evidence for
polymorphic expression
JOURNAL Biochemistry 31 (46), 11595-11599 (1992)
PUBMED 1445895
REFERENCE 7 (bases 1 to 1371)
AUTHORS Graves,V., Gabig,T., McCarthy,L., Strour,E.F., Leemhuis,T. and
English,D.
TITLE Simultaneous mobilization of Mac-1 (CD11b/CD18) and formyl peptide
chemoattractant receptors in human neutrophils
JOURNAL Blood 80 (3), 776-787 (1992)
PUBMED 1322204
REMARK Erratum:[Blood 1993 Mar 15;81(6):1668]
REFERENCE 8 (bases 1 to 1371)
AUTHORS Bao,L., Gerard,N.P., Eddy,R.L. Jr., Shows,T.B. and Gerard,C.
TITLE Mapping of genes for the human C5a receptor (C5AR), human FMLP
receptor (FPR), and two FMLP receptor homologue orphan receptors
(FPRH1, FPRH2) to chromosome 19
JOURNAL Genomics 13 (2), 437-440 (1992)
PUBMED 1612600
REFERENCE 9 (bases 1 to 1371)
AUTHORS Murphy,P.M., Ozcelik,T., Kenney,R.T., Tiffany,H.L., McDermott,D.
and Francke,U.
TITLE A structural homologue of the N-formyl peptide receptor.
Characterization and chromosome mapping of a peptide
chemoattractant receptor family
JOURNAL J. Biol. Chem. 267 (11), 7637-7643 (1992)
PUBMED 1373134
REFERENCE 10 (bases 1 to 1371)
AUTHORS Murphy,P.M. and McDermott,D.
TITLE Functional expression of the human formyl peptide receptor in
Xenopus oocytes requires a complementary human factor
JOURNAL J. Biol. Chem. 266 (19), 12560-12567 (1991)
PUBMED 1712023
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC018755.3.
Summary: This gene encodes a G protein-coupled receptor of
mammalian phagocytic cells that is a member of the G-protein
coupled receptor 1 family. The protein mediates the response of
phagocytic cells to invasion of the host by microorganisms and is
important in host defense and inflammation.[provided by RefSeq, Jul
2010].
Transcript Variant: This variant (1) represents the longer
transcript. Both variants 1 and 2 encode the same protein.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: DT217150.1, DB488002.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025084, ERS025088 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-84 AC018755.3 178963-179046 c
85-135 AC018755.3 177352-177402 c
136-1371 AC018755.3 172919-174154 c
FEATURES Location/Qualifiers
source 1..1371
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.4"
gene 1..1371
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/note="formyl peptide receptor 1"
/db_xref="GeneID:2357"
/db_xref="HGNC:3826"
/db_xref="MIM:136537"
exon 1..84
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/inference="alignment:Splign:1.39.8"
exon 85..135
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/inference="alignment:Splign:1.39.8"
misc_feature 102..104
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/note="upstream in-frame stop codon"
exon 136..1371
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/inference="alignment:Splign:1.39.8"
CDS 147..1199
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/note="fMLP receptor; N-formylpeptide chemoattractant
receptor"
/codon_start=1
/product="fMet-Leu-Phe receptor"
/protein_id="NP_001180235.1"
/db_xref="GI:300863094"
/db_xref="CCDS:CCDS12839.1"
/db_xref="GeneID:2357"
/db_xref="HGNC:3826"
/db_xref="MIM:136537"
/translation="
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
"
misc_feature 228..296
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21462.3);
transmembrane region"
misc_feature 315..1049
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/note="7 transmembrane receptor (rhodopsin family);
Region: 7tm_1; pfam00001"
/db_xref="CDD:200918"
misc_feature 330..395
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21462.3);
transmembrane region"
misc_feature 447..509
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21462.3);
transmembrane region"
misc_feature 567..632
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21462.3);
transmembrane region"
misc_feature 762..824
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21462.3);
transmembrane region"
misc_feature 873..944
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21462.3);
transmembrane region"
misc_feature 1002..1061
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21462.3);
transmembrane region"
variation 178
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:5030878"
variation 447
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/replace="c"
/replace="g"
/db_xref="dbSNP:2070745"
variation 494
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:5030879"
variation 692
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/replace="a"
/replace="c"
/db_xref="dbSNP:2070746"
variation 714
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/replace="a"
/replace="t"
/db_xref="dbSNP:5030880"
variation 722
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:1042229"
STS 1041..1195
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/standard_name="RH17955"
/db_xref="UniSTS:82329"
variation 1183
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/replace="a"
/replace="c"
/db_xref="dbSNP:867228"
variation 1274
/gene="FPR1"
/gene_synonym="FMLP; FPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:867341"
polyA_signal 1349..1354
/gene="FPR1"
/gene_synonym="FMLP; FPR"
ORIGIN
aatcattagagcctgagtcactctccccaggagacccagacctagaactacccagagcaagaccacagctggtgaacagtccagcctgtctccagttggactagccacaattcaagtgcttgaaaaccacatgtggagcagacaagatggagacaaattcctctctccccacgaacatctctggagggacacctgctgtatctgctggctatctcttcctggatatcatcacttatctggtatttgcagtcacctttgtcctcggggtcctgggcaacgggcttgtgatctgggtggctggattccggatgacacacacagtcaccaccatcagttacctgaacctggccgtggctgacttctgtttcacctccactttgccattcttcatggtcaggaaggccatgggaggacattggcctttcggctggttcctgtgcaaattcgtctttaccatagtggacatcaacttgttcggaagtgtcttcctgatcgccctcattgctctggaccgctgtgtttgcgtcctgcatccagtctggacccagaaccaccgcaccgtgagcctggccaagaaggtgatcattgggccctgggtgatggctctgctcctcacattgccagttatcattcgtgtgactacagtacctggtaaaacggggacagtagcctgcacttttaacttttcgccctggaccaacgaccctaaagagaggataaatgtggccgttgccatgttgacggtgagaggcatcatccggttcatcattggcttcagcgcacccatgtccatcgttgctgtcagttatgggcttattgccaccaagatccacaagcaaggcttgattaagtccagtcgtcccttacgggtcctctcctttgtcgcagcagccttttttctctgctggtccccatatcaggtggtggcccttatagccacagtcagaatccgtgagttattgcaaggcatgtacaaagaaattggtattgcagtggatgtgacaagtgccctggccttcttcaacagctgcctcaaccccatgctctatgtcttcatgggccaggacttccgggagaggctgatccacgcccttcccgccagtctggagagggccctgaccgaggactcaacccaaaccagtgacacagctaccaattctactttaccttctgcagaggtggagttacaggcaaagtgaggagggagctgggggacactttcgagctcccagctccagcttcgtctcaccttgagttaggctgagccacaggcatttcctgcttattttaggattacccactcatcagaaaaaaaaaaaaaagcctttgtgtcccctgatttggggagaataaacagatatgagtttatta
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2357 -> Molecular function: GO:0004872 [receptor activity] evidence: TAS
GeneID:2357 -> Molecular function: GO:0004982 [N-formyl peptide receptor activity] evidence: IDA
GeneID:2357 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:2357 -> Biological process: GO:0000187 [activation of MAPK activity] evidence: TAS
GeneID:2357 -> Biological process: GO:0006928 [cellular component movement] evidence: TAS
GeneID:2357 -> Biological process: GO:0006935 [chemotaxis] evidence: IEA
GeneID:2357 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:2357 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: TAS
GeneID:2357 -> Biological process: GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] evidence: TAS
GeneID:2357 -> Biological process: GO:0007263 [nitric oxide mediated signal transduction] evidence: TAS
GeneID:2357 -> Cellular component: GO:0005768 [endosome] evidence: TAS
GeneID:2357 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:2357 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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