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2024-03-29 14:47:19, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001191               2386 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens BCL2-like 1 (BCL2L1), transcript variant 2, mRNA.
ACCESSION   NM_001191
VERSION     NM_001191.2  GI:20336333
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2386)
  AUTHORS   Casanelles,E., Gozzelino,R., Marques-Fernandez,F.,
            Iglesias-Guimarais,V., Garcia-Belinchon,M., Sanchez-Osuna,M.,
            Sole,C., Moubarak,R.S., Comella,J.X. and Yuste,V.J.
  TITLE     NF-kappaB activation fails to protect cells to TNFalpha-induced
            apoptosis in the absence of Bcl-xL, but not Mcl-1, Bcl-2 or Bcl-w
  JOURNAL   Biochim. Biophys. Acta 1833 (5), 1085-1095 (2013)
   PUBMED   23369735
  REMARK    GeneRIF: This indicates that TNFalpha-induced apoptosis in
            SR-IkappaBalpha-overexpressing cells relies on the protein levels
            of Bcl-xL.
REFERENCE   2  (bases 1 to 2386)
  AUTHORS   Rahmani,M., Aust,M.M., Attkisson,E., Williams,D.C. Jr.,
            Ferreira-Gonzalez,A. and Grant,S.
  TITLE     Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K
            inhibition-induced apoptosis in human myeloid leukemia cells
            through a GSK3- and Bim-dependent mechanism
  JOURNAL   Cancer Res. 73 (4), 1340-1351 (2013)
   PUBMED   23243017
  REMARK    GeneRIF: Findings suggest that inhibiton of Bcl-2, Bcl-xL and PI3K,
            and release of Bim from Bcl-2/Bcl-xL and GSK3alpha/beta culminating
            in Bax/Bak activation and apoptosis.
REFERENCE   3  (bases 1 to 2386)
  AUTHORS   Todt,F., Cakir,Z., Reichenbach,F., Youle,R.J. and Edlich,F.
  TITLE     The C-terminal helix of Bcl-x(L) mediates Bax retrotranslocation
            from the mitochondria
  JOURNAL   Cell Death Differ. 20 (2), 333-342 (2013)
   PUBMED   23079612
  REMARK    GeneRIF: the importance of the C-terminal membrane anchor of Bcl-xL
            for both Bax and Bcl-xL retrotranslocation.
REFERENCE   4  (bases 1 to 2386)
  AUTHORS   Geng,X., Huang,C., Qin,Y., McCombs,J.E., Yuan,Q., Harry,B.L.,
            Palmer,A.E., Xia,N.S. and Xue,D.
  TITLE     Hepatitis B virus X protein targets Bcl-2 proteins to increase
            intracellular calcium, required for virus replication and cell
            death induction
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 109 (45), 18471-18476 (2012)
   PUBMED   23091012
  REMARK    GeneRIF: HBx targets Bcl-2 proteins through its BH3-like motif to
            promote cytosolic calcium elevation, cell death, and viral
            replication.
REFERENCE   5  (bases 1 to 2386)
  AUTHORS   Zhan,Z., He,K., Zhu,D., Jiang,D., Huang,Y.H., Li,Y., Sun,C. and
            Jin,Y.H.
  TITLE     Phosphorylation of Rad9 at serine 328 by cyclin A-Cdk2 triggers
            apoptosis via interfering Bcl-xL
  JOURNAL   PLoS ONE 7 (9), E44923 (2012)
   PUBMED   23028682
  REMARK    GeneRIF: cyclin A-Cdk2 regulates apoptosis through a mechanism that
            involves Rad9phosphorylation
REFERENCE   6  (bases 1 to 2386)
  AUTHORS   Broome,H.E., Dargan,C.M., Krajewski,S. and Reed,J.C.
  TITLE     Expression of Bcl-2, Bcl-x, and Bax after T cell activation and
            IL-2 withdrawal
  JOURNAL   J. Immunol. 155 (5), 2311-2317 (1995)
   PUBMED   7650367
REFERENCE   7  (bases 1 to 2386)
  AUTHORS   Sedlak,T.W., Oltvai,Z.N., Yang,E., Wang,K., Boise,L.H.,
            Thompson,C.B. and Korsmeyer,S.J.
  TITLE     Multiple Bcl-2 family members demonstrate selective dimerizations
            with Bax
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (17), 7834-7838 (1995)
   PUBMED   7644501
REFERENCE   8  (bases 1 to 2386)
  AUTHORS   Jaattela,M., Benedict,M., Tewari,M., Shayman,J.A. and Dixit,V.M.
  TITLE     Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and
            activation of phospholipase A2 in breast carcinoma cells
  JOURNAL   Oncogene 10 (12), 2297-2305 (1995)
   PUBMED   7540278
REFERENCE   9  (bases 1 to 2386)
  AUTHORS   Yang,E., Zha,J., Jockel,J., Boise,L.H., Thompson,C.B. and
            Korsmeyer,S.J.
  TITLE     Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax
            and promotes cell death
  JOURNAL   Cell 80 (2), 285-291 (1995)
   PUBMED   7834748
REFERENCE   10 (bases 1 to 2386)
  AUTHORS   Boise,L.H., Gonzalez-Garcia,M., Postema,C.E., Ding,L., Lindsten,T.,
            Turka,L.A., Mao,X., Nunez,G. and Thompson,C.B.
  TITLE     bcl-x, a bcl-2-related gene that functions as a dominant regulator
            of apoptotic cell death
  JOURNAL   Cell 74 (4), 597-608 (1993)
   PUBMED   8358789
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z23116.1.
            On Apr 28, 2002 this sequence version replaced gi:4502380.
            
            Summary: The protein encoded by this gene belongs to the BCL-2
            protein family. BCL-2 family members form hetero- or homodimers and
            act as anti- or pro-apoptotic regulators that are involved in a
            wide variety of cellular activities. The proteins encoded by this
            gene are located at the outer mitochondrial membrane, and have been
            shown to regulate outer mitochondrial membrane channel (VDAC)
            opening. VDAC regulates mitochondrial membrane potential, and thus
            controls the production of reactive oxygen species and release of
            cytochrome C by mitochondria, both of which are the potent inducers
            of cell apoptosis. Two alternatively spliced transcript variants,
            which encode distinct isoforms, have been reported. The longer
            isoform acts as an apoptotic inhibitor and the shorter form acts as
            an apoptotic activator. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) is also known as bcl-xS or
            bcl-x beta. It lacks an exon within the coding region when compared
            to variant 1. The translation remains in-frame, and results in a
            shorter isoform (2) that lacks an internal segment, as compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX386023.2, AK290968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2386
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..2386
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /note="BCL2-like 1"
                     /db_xref="GeneID:598"
                     /db_xref="HGNC:992"
                     /db_xref="HPRD:02497"
                     /db_xref="MIM:600039"
     exon            1..236
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /inference="alignment:Splign:1.39.8"
     exon            237..741
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /inference="alignment:Splign:1.39.8"
     STS             273..348
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /standard_name="PMC92563P3"
                     /db_xref="UniSTS:273621"
     misc_feature    316..318
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /note="upstream in-frame stop codon"
     STS             328..902
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /standard_name="Bcl2l"
                     /db_xref="UniSTS:141168"
     STS             364..899
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /standard_name="PMC196230P1"
                     /db_xref="UniSTS:271802"
     CDS             367..879
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /note="isoform 2 is encoded by transcript variant 2;
                     bcl-2-like protein 1; apoptosis regulator Bcl-X; protein
                     phosphatase 1, regulatory subunit 52"
                     /codon_start=1
                     /product="bcl-2-like protein 1 isoform 2"
                     /protein_id="NP_001182.1"
                     /db_xref="GI:4502381"
                     /db_xref="CCDS:CCDS13188.1"
                     /db_xref="GeneID:598"
                     /db_xref="HGNC:992"
                     /db_xref="HPRD:02497"
                     /db_xref="MIM:600039"
                     /translation="
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
"
     misc_feature    367..>741
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /note="apoptosis regulator; Region: bcl-2; TIGR00865"
                     /db_xref="CDD:162075"
     misc_feature    367..447
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /note="Bcl-2 homology region 4; Region: BH4; pfam02180"
                     /db_xref="CDD:145370"
     misc_feature    376..438
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07817.1);
                     Region: BH4"
     misc_feature    490..492
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:00253"
     misc_feature    511..513
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by PLK3; propagated from
                     UniProtKB/Swiss-Prot (Q07817.1); phosphorylation site"
     misc_feature    547..552
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Cleavage, by caspase-1; propagated from
                     UniProtKB/Swiss-Prot (Q07817.1); cleavage site"
     misc_feature    547..549
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:00977"
     misc_feature    550..552
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by CDK1; propagated from
                     UniProtKB/Swiss-Prot (Q07817.1); phosphorylation site"
     misc_feature    <607..>741
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /note="Apoptosis regulator proteins of the Bcl-2 family,
                     named after B-cell lymphoma 2. This alignment model spans
                     what have been described as Bcl-2 homology regions BH1,
                     BH2, BH3, and BH4. Many members of this family have an
                     additional C-terminal transmembrane...; Region:
                     Bcl-2_like; cl02575"
                     /db_xref="CDD:207655"
     misc_feature    622..666
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07817.1);
                     Region: BH3"
     misc_feature    634..660
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /note="BH3; other site"
                     /db_xref="CDD:132900"
     variation       405
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11550474"
     variation       495
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11550476"
     variation       556
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11550473"
     STS             652..875
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /standard_name="PMC316415P1"
                     /db_xref="UniSTS:272987"
     exon            742..2370
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /inference="alignment:Splign:1.39.8"
     variation       854
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11550472"
     variation       1004
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11550475"
     variation       1031
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:10861"
     variation       1793
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3208680"
     variation       1812
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3208681"
     variation       1813
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3208682"
     variation       1817
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3208683"
     variation       1826
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3208684"
     STS             2085..2369
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
                     /standard_name="RH25072"
                     /db_xref="UniSTS:90736"
     polyA_signal    2347..2352
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
     polyA_site      2370
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L;
                     BCLX; BCLXL; BCLXS; PPP1R52"
ORIGIN      
ggaggaggaagcaagcgagggggctggttcctgagcttcgcaattcctgtgtcgccttctgggctcccagcctgccgggtcgcatgatccctccggccggagctggtttttttgccagccaccgcgaggccggctgagttaccggcatccccgcagccacctcctctcccgacctgtgatacaaaagatcttccgggggctgcacctgcctgcctttgcctaaggcggatttgaatctctttctctcccttcagaatcttatcttggctttggatcttagaagagaatcactaaccagagacgagactcagtgagtgagcaggtgttttggacaatggactggttgagcccatccctattataaaaatgtctcagagcaaccgggagctggtggttgactttctctcctacaagctttcccagaaaggatacagctggagtcagtttagtgatgtggaagagaacaggactgaggccccagaagggactgaatcggagatggagacccccagtgccatcaatggcaacccatcctggcacctggcagacagccccgcggtgaatggagccactggccacagcagcagtttggatgcccgggaggtgatccccatggcagcagtaaagcaagcgctgagggaggcaggcgacgagtttgaactgcggtaccggcgggcattcagtgacctgacatcccagctccacatcaccccagggacagcatatcagagctttgaacaggatacttttgtggaactctatgggaacaatgcagcagccgagagccgaaagggccaggaacgcttcaaccgctggttcctgacgggcatgactgtggccggcgtggttctgctgggctcactcttcagtcggaaatgaccagacactgaccatccactctaccctcccacccccttctctgctccaccacatcctccgtccagccgccattgccaccaggagaaccactacatgcagcccatgcccacctgcccatcacagggttgggcccagatctggtcccttgcagctagttttctagaatttatcacacttctgtgagacccccacacctcagttcccttggcctcagaattcacaaaatttccacaaaatctgtccaaaggaggctggcaggtatggaagggtttgtggctgggggcaggagggccctacctgattggtgcaacccttaccccttagcctccctgaaaatgtttttctgccagggagcttgaaagttttcagaacctcttccccagaaaggagactagattgcctttgttttgatgtttgtggcctcagaattgatcattttccccccactctccccacactaacctgggttccctttccttccatccctaccccctaagagccatttaggggccacttttgactagggattcaggctgcttgggataaagatgcaaggaccaggactccctcctcacctctggactggctagagtcctcactcccagtccaaatgtcctccagaagcctctggctagaggccagccccacccaggagggagggggctatagctacaggaagcaccccatgccaaagctagggtggcccttgcagttcagcaccaccctagtcccttcccctccctggctcccatgaccatactgagggaccaactgggcccaagacagatgccccagagctgtttatggcctcagctgcctcacttcctacaagagcagcctgtggcatctttgccttgggctgctcctcatggtgggttcaggggactcagccctgaggtgaaagggagctatcaggaacagctatgggagccccagggtcttccctacctcaggcaggaagggcaggaaggagagcctgctgcatggggtggggtagggctgactagaagggccagtcctgcctggccaggcagatctgtgccccatgcctgtccagcctgggcagccaggctgccaaggccagagtggcctggccaggagctcttcaggcctccctctctcttctgctccacccttggcctgtctcatccccaggggtcccagccaccccgggctctctgctgtacatatttgagactagtttttattccttgtgaagatgatatactatttttgttaagcgtgtctgtatttatgtgtgaggagctgctggcttgcagtgcgcgtgcacgtggagagctggtgcccggagattggacggcctgatgctccctcccctgccctggtccagggaagctggccgagggtcctggctcctgaggggcatctgcccctcccccaacccccaccccacacttgttccagctctttgaaatagtctgtgtgaaggtgaaagtgcagttcagtaataaactgtgtttactcagtgaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:598 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:598 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI
            GeneID:598 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
            GeneID:598 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA
            GeneID:598 -> Molecular function: GO:0051434 [BH3 domain binding] evidence: IPI
            GeneID:598 -> Biological process: GO:0000910 [cytokinesis] evidence: IMP
            GeneID:598 -> Biological process: GO:0001541 [ovarian follicle development] evidence: IEA
            GeneID:598 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
            GeneID:598 -> Biological process: GO:0001836 [release of cytochrome c from mitochondria] evidence: IDA
            GeneID:598 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:598 -> Biological process: GO:0007093 [mitotic cell cycle checkpoint] evidence: IMP
            GeneID:598 -> Biological process: GO:0007281 [germ cell development] evidence: IEA
            GeneID:598 -> Biological process: GO:0007283 [spermatogenesis] evidence: IEA
            GeneID:598 -> Biological process: GO:0008283 [cell proliferation] evidence: IEA
            GeneID:598 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IEA
            GeneID:598 -> Biological process: GO:0008584 [male gonad development] evidence: IEA
            GeneID:598 -> Biological process: GO:0008637 [apoptotic mitochondrial changes] evidence: TAS
            GeneID:598 -> Biological process: GO:0009566 [fertilization] evidence: IEA
            GeneID:598 -> Biological process: GO:0010507 [negative regulation of autophagy] evidence: TAS
            GeneID:598 -> Biological process: GO:0019050 [suppression by virus of host apoptotic process] evidence: IDA
            GeneID:598 -> Biological process: GO:0034097 [response to cytokine stimulus] evidence: IDA
            GeneID:598 -> Biological process: GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] evidence: TAS
            GeneID:598 -> Biological process: GO:0040007 [growth] evidence: IEA
            GeneID:598 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
            GeneID:598 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA
            GeneID:598 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IMP
            GeneID:598 -> Biological process: GO:0043524 [negative regulation of neuron apoptotic process] evidence: IEA
            GeneID:598 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:598 -> Biological process: GO:0046898 [response to cycloheximide] evidence: IEA
            GeneID:598 -> Biological process: GO:0046902 [regulation of mitochondrial membrane permeability] evidence: IDA
            GeneID:598 -> Biological process: GO:0051881 [regulation of mitochondrial membrane potential] evidence: IDA
            GeneID:598 -> Biological process: GO:0060154 [cellular process regulating host cell cycle in response to virus] evidence: IEA
            GeneID:598 -> Biological process: GO:0071230 [cellular response to amino acid stimulus] evidence: IEA
            GeneID:598 -> Biological process: GO:0071312 [cellular response to alkaloid] evidence: IEA
            GeneID:598 -> Biological process: GO:0071480 [cellular response to gamma radiation] evidence: IEA
            GeneID:598 -> Biological process: GO:0090005 [negative regulation of establishment of protein localization to plasma membrane] evidence: IDA
            GeneID:598 -> Biological process: GO:0090201 [negative regulation of release of cytochrome c from mitochondria] evidence: IC
            GeneID:598 -> Biological process: GO:0090201 [negative regulation of release of cytochrome c from mitochondria] evidence: IDA
            GeneID:598 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS
            GeneID:598 -> Biological process: GO:1900118 [negative regulation of execution phase of apoptosis] evidence: IDA
            GeneID:598 -> Biological process: GO:1902230 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] evidence: IDA
            GeneID:598 -> Biological process: GO:2000811 [negative regulation of anoikis] evidence: IMP
            GeneID:598 -> Biological process: GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] evidence: TAS
            GeneID:598 -> Biological process: GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] evidence: IDA
            GeneID:598 -> Biological process: GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway] evidence: TAS
            GeneID:598 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:598 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
            GeneID:598 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: NAS
            GeneID:598 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: TAS
            GeneID:598 -> Cellular component: GO:0005813 [centrosome] evidence: IDA
            GeneID:598 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
            GeneID:598 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
            GeneID:598 -> Cellular component: GO:0031965 [nuclear membrane] evidence: IEA
            GeneID:598 -> Cellular component: GO:0097136 [Bcl-2 family protein complex] evidence: IDA

by @meso_cacase at DBCLS
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