GGRNA Home | Help | Advanced search

2024-03-29 13:54:36, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001190943            1334 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens tumor necrosis factor (ligand) superfamily, member 10
            (TNFSF10), transcript variant 3, mRNA.
ACCESSION   NM_001190943
VERSION     NM_001190943.1  GI:300193033
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1334)
  AUTHORS   Stagg,H.W., Bowen,K.A., Sawant,D.A., Rodriguez,M., Tharakan,B. and
            Childs,E.W.
  TITLE     Tumor necrosis factor-related apoptosis-inducing ligand promotes
            microvascular endothelial cell hyperpermeability through
            phosphatidylinositol 3-kinase pathway
  JOURNAL   Am. J. Surg. 205 (4), 419-425 (2013)
   PUBMED   23375756
  REMARK    GeneRIF: TRAIL-induced microvascular hyperpermeability is
            phosphatidylinositol 3-kinase (PI3K)-dependent and may be mediated
            by caspase-3 cleavage of the endothelial adherens junctional
            complex.
REFERENCE   2  (bases 1 to 1334)
  AUTHORS   Zhang,N., Wang,X., Huo,Q., Li,X., Wang,H., Schneider,P., Hu,G. and
            Yang,Q.
  TITLE     The oncogene metadherin modulates the apoptotic pathway based on
            the tumor necrosis factor superfamily member TRAIL (Tumor Necrosis
            Factor-related Apoptosis-inducing Ligand) in breast cancer
  JOURNAL   J. Biol. Chem. 288 (13), 9396-9407 (2013)
   PUBMED   23408429
  REMARK    GeneRIF: oncogene metadherin modulates the apoptotic pathway based
            on the tumor necrosis factor superfamily member TRAIL (Tumor
            Necrosis Factor-related Apoptosis-inducing Ligand) in breast cancer
REFERENCE   3  (bases 1 to 1334)
  AUTHORS   Levidou,G., Thymara,I., Saetta,A.A., Papanastasiou,P.,
            Pavlopoulos,P., Sakellariou,S., Fragkou,P., Patsouris,E. and
            Korkolopoulou,P.
  TITLE     TRAIL and osteoprotegerin (OPG) expression in bladder urothelial
            carcinoma: correlation with clinicopathological parameters and
            prognosis
  JOURNAL   Pathology 45 (2), 138-144 (2013)
   PUBMED   23277172
  REMARK    GeneRIF: OPG and TRAIL are frequently expressed and coexpressed in
            bladder urothelial carcinomas, supporting the involvement of OPG in
            the resistance to TRAIL-driven apoptosis.
REFERENCE   4  (bases 1 to 1334)
  AUTHORS   Spes,A., Sobotic,B., Turk,V. and Turk,B.
  TITLE     Cysteine cathepsins are not critical for TRAIL- and CD95-induced
            apoptosis in several human cancer cell lines
  JOURNAL   Biol. Chem. 393 (12), 1417-1431 (2012)
   PUBMED   23667901
  REMARK    GeneRIF: Data indicate that cysteine cathepsins are not required
            for the TRAIL- and CD95-mediated apoptosis in various human cancer
            cell lines.
REFERENCE   5  (bases 1 to 1334)
  AUTHORS   Grunert,M., Gottschalk,K., Kapahnke,J., Gundisch,S., Kieser,A. and
            Jeremias,I.
  TITLE     The adaptor protein FADD and the initiator caspase-8 mediate
            activation of NF-kappaB by TRAIL
  JOURNAL   Cell Death Dis 3, E414 (2012)
   PUBMED   23096115
  REMARK    GeneRIF: FADD and the initiator caspase-8 mediate activation of
            NF-kappaB by TRAIL.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1334)
  AUTHORS   Pan,G., Ni,J., Wei,Y.F., Yu,G., Gentz,R. and Dixit,V.M.
  TITLE     An antagonist decoy receptor and a death domain-containing receptor
            for TRAIL
  JOURNAL   Science 277 (5327), 815-818 (1997)
   PUBMED   9242610
REFERENCE   7  (bases 1 to 1334)
  AUTHORS   Pan,G., O'Rourke,K., Chinnaiyan,A.M., Gentz,R., Ebner,R., Ni,J. and
            Dixit,V.M.
  TITLE     The receptor for the cytotoxic ligand TRAIL
  JOURNAL   Science 276 (5309), 111-113 (1997)
   PUBMED   9082980
REFERENCE   8  (bases 1 to 1334)
  AUTHORS   Marsters,S.A., Pitti,R.M., Donahue,C.J., Ruppert,S., Bauer,K.D. and
            Ashkenazi,A.
  TITLE     Activation of apoptosis by Apo-2 ligand is independent of FADD but
            blocked by CrmA
  JOURNAL   Curr. Biol. 6 (6), 750-752 (1996)
   PUBMED   8793301
REFERENCE   9  (bases 1 to 1334)
  AUTHORS   Pitti,R.M., Marsters,S.A., Ruppert,S., Donahue,C.J., Moore,A. and
            Ashkenazi,A.
  TITLE     Induction of apoptosis by Apo-2 ligand, a new member of the tumor
            necrosis factor cytokine family
  JOURNAL   J. Biol. Chem. 271 (22), 12687-12690 (1996)
   PUBMED   8663110
REFERENCE   10 (bases 1 to 1334)
  AUTHORS   Wiley,S.R., Schooley,K., Smolak,P.J., Din,W.S., Huang,C.P.,
            Nicholl,J.K., Sutherland,G.R., Smith,T.D., Rauch,C., Smith,C.A. et
            al.
  TITLE     Identification and characterization of a new member of the TNF
            family that induces apoptosis
  JOURNAL   Immunity 3 (6), 673-682 (1995)
   PUBMED   8777713
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007919.18 and AC016938.24.
            
            Summary: The protein encoded by this gene is a cytokine that
            belongs to the tumor necrosis factor (TNF) ligand family. This
            protein preferentially induces apoptosis in transformed and tumor
            cells, but does not appear to kill normal cells although it is
            expressed at a significant level in most normal tissues. This
            protein binds to several members of TNF receptor superfamily
            including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3,
            TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity
            of this protein may be modulated by binding to the decoy receptors
            TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot
            induce apoptosis. The binding of this protein to its receptors has
            been shown to trigger the activation of MAPK8/JNK, caspase 8, and
            caspase 3. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2010].
            
            Transcript Variant: This variant (3) lacks multiple 3' exons, but
            has an alternate 3' exon, as compared to variant 1. The resulting
            isoform (3) is very short and has a different C-terminus, as
            compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK309200.1, DA398853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025083, ERS025089 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AC007919.18        4049-4271           c
            224-1334            AC016938.24        37606-38716         c
FEATURES             Location/Qualifiers
     source          1..1334
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26"
     gene            1..1334
                     /gene="TNFSF10"
                     /gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
                     /note="tumor necrosis factor (ligand) superfamily, member
                     10"
                     /db_xref="GeneID:8743"
                     /db_xref="HGNC:11925"
                     /db_xref="MIM:603598"
     exon            1..223
                     /gene="TNFSF10"
                     /gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    17..19
                     /gene="TNFSF10"
                     /gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
                     /note="upstream in-frame stop codon"
     CDS             92..289
                     /gene="TNFSF10"
                     /gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
                     /note="isoform 3 is encoded by transcript variant 3; Apo-2
                     ligand; TNF-related apoptosis inducing ligand TRAIL; tumor
                     necrosis factor (ligand) family, member 10; tumor necrosis
                     factor apoptosis-inducing ligand splice variant delta;
                     chemokine tumor necrosis factor ligand superfamily member
                     10"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     10 isoform 3"
                     /protein_id="NP_001177872.1"
                     /db_xref="GI:300193034"
                     /db_xref="GeneID:8743"
                     /db_xref="HGNC:11925"
                     /db_xref="MIM:603598"
                     /translation="
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQFAENDCQRLMSGQQTGSLLPS
"
     variation       140
                     /gene="TNFSF10"
                     /gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11545817"
     exon            224..1334
                     /gene="TNFSF10"
                     /gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
                     /inference="alignment:Splign:1.39.8"
     variation       1127
                     /gene="TNFSF10"
                     /gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200047251"
ORIGIN      
atttcctcactgactataaaagaatagagaaggaagggcttcagtgaccggctgcctggctgacttacagcagtcagactctgacaggatcatggctatgatggaggtccaggggggacccagcctgggacagacctgcgtgctgatcgtgatcttcacagtgctcctgcagtctctctgtgtggctgtaacttacgtgtactttaccaacgagctgaagcagtttgcagaaaatgattgccagagactaatgtctgggcagcagacagggtcattgctgccatcttgaagtctaccttgctgagtctaccctgctgacctcaagccccatcaaggactggttgaccctggcctagacaaccaccgtgtttgtaacagcaccaagagcagtcaccatggaaatccacttttcagaaccaagggcttctggagctgaagaacaggcacccagtgcaagagctttcttttcagaggcacgcaaatgaaaataatccccacacgctaccttctgcccccaatgcccaagtgtggttagttagagaatatagcctcagcctatgatatgctgcaggaaactcatattttgaagtggaaaggatgggaggaggcgggggagacgtatcgtattaattatcattcttggaataaccacagcacctcacgtcaacccgccatgtgtctagtcaccagcattggccaagttctataggagaaactaccaaaattcatgatgcaagaaacatgtgagggtggagagagtgactggggcttcctctctggatttctattgttcagaaatcaatatttatgcataaaaaggtctagaaagagaaacaccaaaatgacaatgtgatctctagatggtatgattatgggtactttttttcctttttatttttctatattttacaaattttctacagggaatgttataaaaatatccatgctatccatgtataattttcatacagatttaaagaacacagcatttttatatagtcttatgagaaaacaaccatactcaaaattatgcacacacacagtctgatctcacccctgtaaacaagagatatcatccaaaggttaagtaggaggtgagaatatagctgctattagtggttgttttgttttgtttttgtgatttacttatttagtttttggagggttttttttttcttttagaaaagtgttctttacttttccatgcttccctgcttgcctgtgtatcctgaatgtatccaggctttataaactcctgggtaataatgtagctacattaacttgttaacctcccatccacttatacccaggaccttactcaattttccaggttc
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:8743 -> Molecular function: GO:0005102 [receptor binding] evidence: TAS
            GeneID:8743 -> Molecular function: GO:0005125 [cytokine activity] evidence: IEA
            GeneID:8743 -> Molecular function: GO:0005164 [tumor necrosis factor receptor binding] evidence: IEA
            GeneID:8743 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:8743 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:8743 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:8743 -> Biological process: GO:0006917 [induction of apoptosis] evidence: TAS
            GeneID:8743 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: TAS
            GeneID:8743 -> Biological process: GO:0006955 [immune response] evidence: IEA
            GeneID:8743 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:8743 -> Biological process: GO:0007267 [cell-cell signaling] evidence: TAS
            GeneID:8743 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IDA
            GeneID:8743 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IEP
            GeneID:8743 -> Biological process: GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: IDA
            GeneID:8743 -> Biological process: GO:0090200 [positive regulation of release of cytochrome c from mitochondria] evidence: IDA
            GeneID:8743 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
            GeneID:8743 -> Biological process: GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] evidence: IDA
            GeneID:8743 -> Biological process: GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand] evidence: TAS
            GeneID:8743 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS
            GeneID:8743 -> Cellular component: GO:0005615 [extracellular space] evidence: IEA
            GeneID:8743 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.