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2024-04-26 07:17:18, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001190481 8292 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens claspin (CLSPN), transcript variant 2, mRNA.
ACCESSION NM_001190481
VERSION NM_001190481.1 GI:299522983
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8292)
AUTHORS Sato,K., Sundaramoorthy,E., Rajendra,E., Hattori,H.,
Jeyasekharan,A.D., Ayoub,N., Schiess,R., Aebersold,R.,
Nishikawa,H., Sedukhina,A.S., Wada,H., Ohta,T. and
Venkitaraman,A.R.
TITLE A DNA-damage selective role for BRCA1 E3 ligase in claspin
ubiquitylation, CHK1 activation, and DNA repair
JOURNAL Curr. Biol. 22 (18), 1659-1666 (2012)
PUBMED 22863316
REMARK GeneRIF: findings identify claspin as an in vivo substrate for the
BRCA1 E3 ligase and suggest that its modification selectively
triggers CHK1 activation for the homology-directed repair of a
subset of genotoxic lesions
REFERENCE 2 (bases 1 to 8292)
AUTHORS Liu,S., Song,N. and Zou,L.
TITLE The conserved C terminus of Claspin interacts with Rad9 and
promotes rapid activation of Chk1
JOURNAL Cell Cycle 11 (14), 2711-2716 (2012)
PUBMED 22732499
REMARK GeneRIF: The conserved C terminus of Claspin interacts with Rad9
and ensures timely activation of the ATR-Chk1 pathway.
REFERENCE 3 (bases 1 to 8292)
AUTHORS Benevolo,M., Musio,A., Vocaturo,A., Dona,M.G., Rollo,F.,
Terrenato,I., Carosi,M., Pescarmona,E., Vocaturo,G. and
Mottolese,M.
TITLE Claspin as a biomarker of human papillomavirus-related high grade
lesions of uterine cervix
JOURNAL J Transl Med 10, 132 (2012)
PUBMED 22731782
REMARK GeneRIF: analysis of claspin expression could be clinically
relevant in the diagnosis of HPV-related cervical lesions, in
particular when applied to cervico-vaginal cytology
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 8292)
AUTHORS Yoshimura,A., Akita,M., Hosono,Y., Abe,T., Kobayashi,M.,
Yamamoto,K., Tada,S., Seki,M. and Enomoto,T.
TITLE Functional relationship between Claspin and Rad17
JOURNAL Biochem. Biophys. Res. Commun. 414 (2), 298-303 (2011)
PUBMED 21945441
REMARK GeneRIF: the functions of Claspin and the functional relationship
between Claspin and Rad17 were studied.
REFERENCE 5 (bases 1 to 8292)
AUTHORS Izawa,N., Wu,W., Sato,K., Nishikawa,H., Kato,A., Boku,N., Itoh,F.
and Ohta,T.
TITLE HERC2 Interacts with Claspin and regulates DNA origin firing and
replication fork progression
JOURNAL Cancer Res. 71 (17), 5621-5625 (2011)
PUBMED 21775519
REMARK GeneRIF: In the presence of BRCA1, endogenous HERC2 interacts with
Claspin, a protein essential for G(2)-M checkpoint activation and
replication fork stability.
REFERENCE 6 (bases 1 to 8292)
AUTHORS Sorensen,C.S., Syljuasen,R.G., Lukas,J. and Bartek,J.
TITLE ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and
Cdc25A in the absence of DNA damage
JOURNAL Cell Cycle 3 (7), 941-945 (2004)
PUBMED 15190204
REFERENCE 7 (bases 1 to 8292)
AUTHORS Lin,S.Y., Li,K., Stewart,G.S. and Elledge,S.J.
TITLE Human Claspin works with BRCA1 to both positively and negatively
regulate cell proliferation
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (17), 6484-6489 (2004)
PUBMED 15096610
REMARK GeneRIF: determination of properties of both a tumor suppressor and
an oncogene
REFERENCE 8 (bases 1 to 8292)
AUTHORS Chini,C.C. and Chen,J.
TITLE Human claspin is required for replication checkpoint control
JOURNAL J. Biol. Chem. 278 (32), 30057-30062 (2003)
PUBMED 12766152
REMARK GeneRIF: Claspin has a potentially critical role in replication
checkpoint control in mammalian cells
REFERENCE 9 (bases 1 to 8292)
AUTHORS Zou,L. and Elledge,S.J.
TITLE Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
JOURNAL Science 300 (5625), 1542-1548 (2003)
PUBMED 12791985
REFERENCE 10 (bases 1 to 8292)
AUTHORS Kumagai,A. and Dunphy,W.G.
TITLE Claspin, a novel protein required for the activation of Chk1 during
a DNA replication checkpoint response in Xenopus egg extracts
JOURNAL Mol. Cell 6 (4), 839-849 (2000)
PUBMED 11090622
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AF297866.1, BC115025.1,
BC137279.1 and AL354864.16.
Summary: The product of this gene is an essential upstream
regulator of checkpoint kinase 1 and triggers a checkpoint arrest
of the cell cycle in response to replicative stress or DNA damage.
The protein is also required for efficient DNA replication during a
normal S phase. Multiple transcript variants encoding different
isoforms have been found for this gene. [provided by RefSeq, Jun
2010].
Transcript Variant: This variant (2) lacks an alternate in-frame
exon in the central coding region, compared to variant 1. The
resulting isoform (2) lacks an internal segment, compared to
isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC115025.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1417 AF297866.1 1-1417
1418-2678 BC115025.1 1411-2671
2679-4109 BC137279.1 2850-4280
4110-8292 AL354864.16 77956-82138
FEATURES Location/Qualifiers
source 1..8292
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p34.2"
gene 1..8292
/gene="CLSPN"
/note="claspin"
/db_xref="GeneID:63967"
/db_xref="HGNC:19715"
/db_xref="MIM:605434"
exon 1..104
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
misc_feature 54..56
/gene="CLSPN"
/note="upstream in-frame stop codon"
CDS 81..3908
/gene="CLSPN"
/note="isoform 2 is encoded by transcript variant 2;
hClaspin; claspin homolog"
/codon_start=1
/product="claspin isoform 2"
/protein_id="NP_001177410.1"
/db_xref="GI:299522984"
/db_xref="CCDS:CCDS53297.1"
/db_xref="GeneID:63967"
/db_xref="HGNC:19715"
/db_xref="MIM:605434"
/translation="
MTGEVGSEVHLEINDPNVISQEEADSPSDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEEGSELSKGTTRKERKAARLSKEALKQLHSETQRLIRESALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSSKYQSSHHKEIIDTANTTEMNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEGEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDSFVILEPETNRGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIGSTIPSYQPCNRQTGRGTSFFPTAGGFRSPSPGLFRASLVSSASKSSGKLSEPSLPIEDSQDLYNASPEPKTLFLGAGDFQFCLEDDTQSQLLDADGFLNVRNHRNQYQALKPRLPLASMDENAMDANMDELLDLCTGKFTSQAEKHLPRKSDKKENMEELLNLCSGKFTSQDASTPASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADGDLHSDGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKSLLRNPFEAIRPGSAQQVKTGSLLNQPKAVLQKLAALSDHNPSAPRNSRNFVFHTLSPVKAEAAKESSKSQVKKRGPSFMTSPSPKHLKTDDSTSGLTRSIFKYLES
"
exon 105..213
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 214..662
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 663..824
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 825..902
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
variation 852
/gene="CLSPN"
/replace="a"
/replace="g"
/db_xref="dbSNP:35435909"
exon 903..975
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 976..1084
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 1085..1659
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 1660..1916
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 1917..2095
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 2096..2160
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 2161..2360
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 2361..2515
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 2516..2742
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
variation 2562
/gene="CLSPN"
/replace="a"
/replace="c"
/db_xref="dbSNP:34390044"
exon 2743..2854
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 2855..2930
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 2931..3031
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 3032..3196
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 3197..3318
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 3319..3446
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 3447..3552
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 3553..3635
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 3636..3797
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
variation 3727
/gene="CLSPN"
/replace="c"
/replace="t"
/db_xref="dbSNP:35490896"
exon 3798..8292
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
STS 4217..4816
/gene="CLSPN"
/standard_name="PMC156606P1"
/db_xref="UniSTS:271408"
STS 4298..5758
/gene="CLSPN"
/standard_name="GDB:312794"
/db_xref="UniSTS:30247"
STS 4353..5756
/gene="CLSPN"
/standard_name="L17971"
/db_xref="UniSTS:43966"
STS 4378..4799
/gene="CLSPN"
/standard_name="G38154"
/db_xref="UniSTS:53341"
variation 4657
/gene="CLSPN"
/replace="g"
/replace="t"
/db_xref="dbSNP:1062047"
STS 4751..4820
/gene="CLSPN"
/standard_name="D1S1423"
/db_xref="UniSTS:149619"
STS 5128..5251
/gene="CLSPN"
/standard_name="RH91339"
/db_xref="UniSTS:88492"
STS 5280..5419
/gene="CLSPN"
/standard_name="SHGC-37119"
/db_xref="UniSTS:32226"
polyA_signal 5414..5419
/gene="CLSPN"
STS 5426..6474
/gene="CLSPN"
/standard_name="D11S1910"
/db_xref="UniSTS:149174"
polyA_site 5436
/gene="CLSPN"
variation 5615
/gene="CLSPN"
/replace="c"
/replace="t"
/db_xref="dbSNP:609070"
STS 5738..5859
/gene="CLSPN"
/standard_name="G44334"
/db_xref="UniSTS:95121"
variation 5771
/gene="CLSPN"
/replace="c"
/replace="t"
/db_xref="dbSNP:620296"
STS 5800..6579
/gene="CLSPN"
/standard_name="RH36905"
/db_xref="UniSTS:87932"
STS 7020..7167
/gene="CLSPN"
/standard_name="L17791"
/db_xref="UniSTS:42740"
STS 7298..7367
/gene="CLSPN"
/standard_name="D1S1423"
/db_xref="UniSTS:149619"
polyA_signal 8270..8275
/gene="CLSPN"
polyA_site 8292
/gene="CLSPN"
ORIGIN
gacggcgggagccgctgctctccggctgagggaatcagagacagctccgtccctagtggagcgcaggggaggcagaagtcatgacaggcgaggtgggttctgaggttcacctagaaatcaatgacccaaacgtcatttcacaagaggaagcagatagtccttcagatagtggacagggcagctatgaaacaattggacccttgagtgaaggagattcagatgaagagatatttgtaagtaagaagttgaaaaacaggaaggttctacaagacagtgattccgaaacagaggacacaaatgcctctccagagaaaactacctatgacagtgccgaggaggaaaataaagagaatttatatgctgggaaaaatacaaaaatcaaaaggatttacaaaactgtggcagacagtgatgaaagttacatggaaaagtctttgtatcaggaaaatcttgaagcgcaagtgaaaccttgcttagagctgagtcttcagtctggaaactctacagactttaccactgacagaaagagttccaaaaagcacatacatgataaagaaggaactgcaggaaaagcaaaagtaaaatcaaaaagaagacttgagaaagaggagagaaaaatggaaaaaattagacagctaaaaaagaaggaaacaaaaaaccaggaagatgatgtagaacagccatttaatgacagtggctgtcttcttgtggataaagacctttttgaaactgggttggaggatgaaaataactctccattggaagatgaagagtcattagaatcaataagagcagctgtaaaaaacaaagtaaaaaagcacaagaaaaaagaaccatctttggagagtggggtccattcatttgaggaaggaagtgagttatcaaaaggaaccacgaggaaggaaagaaaggcagccagattaagtaaagaagcattaaaacaactgcatagtgagactcagcgccttattcgagagtctgcactgaaccttccatatcatatgcctgagaataaaaccattcatgatttcttcaaacgtaaaccccggcccacttgccacggaaatgccatggcactattgaagtcatctaaatatcagtcaagccatcacaaagaaatcatagacactgcaaatactactgaaatgaacagtgatcaccatagtaaaggttctgagcagacaacaggtgcagaaaatgaagtggaaactaatgcactccctgtagtttcaaaggaaacccagatcattactggatcagatgagtcttgcaggaaggatttggtaaaaaatgaagagctagaaattcaggagaaacagaagcagagtgacattagaccttcacctggggacagctcagtgttgcaacaggaatccaacttcctcgggaacaatcacagtgaggaatgtcaggttggagggcttgtagcatttgaacctcatgccctggagggtgaaggcccccaaaatccagaagaaacagatgagaaagtggaagagcctgagcagcaaaataaatcatcagcagttgggccacctgaaaaagtgagacggtttactctggatagacttaagcaactgggagtagatgtttccattaaaccacggctaggtgctgatgaagattcctttgtgatacttgaacctgaaaccaacagaggtgaaaagcttcaggtgttaaaagctaaactgcaagaagcaatgaaactccgaaggtttgaggagcgccagaagcgccaagcactgtttaaattagataatgaagatgggtttgaggaagaggaggaggaagaggaagaaatgacagatgagtctgaggaagatggagaagagaaggtagagaaagaagagaaagaggaagaactagaggaagaggaggagaaagaagaggaggaggaagaagaaggaaatcaggagactgcagaattccttcttagtagtgaagaaatagaaacaaaagatgaaaaagaaatggataaagaaaataatgatggcagtagtgaaattggcaaggcagttggcttcctctctgttcccaagtctctctcatcagattctactttacttctgtttaaggacagctcttccaagatgggttactttcctactgaagaaaaatcagaaacagatgaaaactcaggcaagcagcctagcaaactggatgaggatgattcatgttcattgctaacaaaggagagcagccacaatagcagctttgagctgattggctccacgattccatcctatcagccttgcaacagacaaacaggccgtgggaccagttttttccctacagcaggaggattcagatctccttcccctgggctatttcgagccagtttggtcagctcagcttctaagagttcagggaaactgtctgagccttcacttcccatagaggattcccaggatctgtataacgcctccccagagcctaagacacttttcctaggagcaggagacttccagttctgtttagaagatgacactcagagccaactgttggatgcagatgggttcttaaatgttagaaaccacaggaatcagtaccaagctttgaagcctcgattgccattggccagtatggatgagaatgccatggatgccaacatggatgagctgttggatttgtgtactggaaagttcacatctcaggctgaaaaacatctacccaggaagagtgacaagaaagagaacatggaggaacttctgaacctttgttcaggaaaattcacttctcaggatgcctccactccagcctcatcagagttaaataaacaggagaaggagagcagcatgggtgatccaatggaagaagcacttgctctttgctcaggctcttttcccacagacaaggaagaggaagacgaggaggaggaatttggagactttcggcttgtttcaaatgataatgagtttgatagtgatgaggatgaacacagtgactctggtaatgatctggcactggaagaccatgaagatgatgatgaagaagaactcctgaagcgatctgagaagttgaaaaggcaaatgaggttgaggaaatacctggaggatgaggcagaggtgtcaggaagtgatgtgggaagcgaagatgagtatgatggggaagaaattgatgaatatgaagaggacgtaattgatgaagtacttccttctgatgaggaactgcagagtcaaatcaagaaaatacacatgaaaactatgttggatgatgataagcgacagctacgtttataccaagagaggtaccttgctgatggggatctgcacagcgatggtcctgggcgaatgaggaagtttcgatggaaaaacatagatgatgcttcccagatggacttgttccacagagactctgatgatgatcagactgaagaacagcttgatgagtcagaagccaggtggaggaaggagcgaattgaacgagagcagtggcttcgggacatggcacagcaggggaaaattacagctgaagaagaagaagaaattggggaggacagtcagtttatgatactggccaagaaagttacagccaaagcactgcagaagaatgccagtcgccctatggttattcaggaatcaaagtctttgctcagaaatccttttgaagccatcagaccaggaagtgctcaacaggtgaagacaggctcactgctaaaccagcccaaagctgtgcttcagaaactggctgctctctctgaccataaccccagtgctcctcgaaattcaagaaactttgtctttcatacactttctcctgtcaaggctgaggcggcaaaggaatcgtctaagtctcaggtaaagaaaaggggtccatctttcatgacttctccttcacctaagcacctcaaaacagatgatagcacttcaggattgacgcgaagcatcttcaaatatttggagagctaacaccatcaaaggtgccaaaatctacattgagactgctttgagaagtttctagcactgaaagttggaattgacactccagccaatgatccttccttctttcataatcaatgcaataagattgcagacagaaattccagtgatttctactgcacagctctggacatctcttttcctagtattattccctgaattggccactgatttcaattctgcagtatttacaacatcaacaactcatggaatacttgggtgaggtttcctttttttttttttttttaagatgggagtctcactctgttgcccagcttggagtgcagtggcgtgatctcggctcaccacaatctctgcctcccaggttcaagcgattctcctccttcagcctcccgagtagctgggattacaggcatgtgccaatacgcccagctaatttttgtatttttagtagagacggggtttcaccatgttggccaggctggtcttgaactcctgacctcaaatgatccatccacctcggccccacaaagtgctggtcacatgcatgagtcactgcacctggccttgggttaggtttcacttcctccattagacatttgacattttattgtagcagctttctgggttaatatctctttgtgattgatagaagtggttggaagaggaagagtagggaaaagtgtgacattacagattaaacagtgaaaatcagtaccataatgactcctttacacccatgagatacgtaccatgatgaccagggctcggtgaaagaaagatttctttttttttttttgagatagtctcactttgttgcccagtctggagtgcagtggcgcaatctcggctcacggcaacctctgcctcccgggttcaagtgattctcctgtctcagcctcccaagtagctgggactacaggtgcatgccaccacacctggctaatttttgtatttttagtggagacagggagtcaccatgttggccaggctggtctcgatctcctgacctcaagtgatccagctgcctcagcctcccaaagtgctgagattacaggcgtgagccactgtgcccagccaaaagaacgatttcttagatggaggacctaggaaccaacagatgggctgctgtattactcttacccctttcattttcctgtatgcttcttcccaaggcagcatcaaattttgaattaatttttgctgcttaataaggacttaaactggtacccaagtcagaaagactctgcctctaattttctggggcttggggatgaagataaagtgttacacccagtgtttgtccaccacagtctgtggggcagagagacccttcctgggactgaattctcaatttgaagcactgttgttcaaagatctcccttctgggtctgacaagaagaaacataacccttatttattgcattcttctggcttacatacattgccctcactaatcaatggacatttcagcatttcattactaattttgagagaaggccaccatggaatttaataaaaatattattgaagagaattgccatcattctccattttccctgaactaccacaagcttctcagaattttagacaaatgtttttcccctcagaactgagcatcagtgctgctttggaaaaacattccatgtgaatactgtggtttcagtgtcaggacctgtacttgggcagttggaagagagtgtgccagttttttactgggagatgggaacaccaatttaattgatgcaattaggttgtaggttttttacagtttttcttttcttttctttttctttttcttttcttttcttttctttttttttttttgagacataggctggctctgtcacctaggctggaatacaatggcatgatctcggcttactgcaacctccgcctcctaggttcaagcaattctgcctcggcctcccaaatagcagggattacaggcacctgccaccactcccagctaattttttgtatttttattagagatgaggtttcgccatgttggccaggctggtcttgaactcctgacctgaggtgatccacccgtctcggcctcccaaagtgctgggattataggcatgagccaccgcacccggccggttttctacagttttctaatactcaagatgttgactttgacaatacttatgtttgtatacttgtaatcttataatggggaaaatgtgtataaagatgttttaatatgtatgtagtttttcaataaatcttaatgccttgaagggaagatttgctgtccagcttgaatgctcattcttgggtcagtgcctgtctaaccttgaggagcatttcattttcaggttatctccatcccagggaaaccctctgggtctaaactgagaagctgctgcaattgtcccctcactggcttctcagtcctagtgaattgatcaagttaacttaccaagtggtttgggttcagctcaggtgaagaggataattgagtttacataaatggtaccttctattatagctctttgtttaaaaaacttattttttagagacagtctcattctgttgcccaggttagagtgcagtggcacaatcatagctcactgtacccttgaactcctgggcttcagcatcctccttcctcaacctttggaatagctgggccacattacaggcatatgccaccatgcccagctaattattttattttagtagagacagggtcttgctgtgttgccccagctgatcttgaactcctggcctcaagtaatcctcccaccttggcctcccaaaatgctggggtcacaggctcagccaccatgcccagcctgttacagctttgattggcctttctctttagctaagtttgtatgtacttcattttatccatgggttcaagatacatgtttttgcctctttctttgaactctctaaacagttcccaaggcaaagtagcccttgctgggcaaaagagaactgagcaggaaggctagatatttcttccctcttgtttccctacatgtcttttgaggagagatagaaaagacaattggaattgacaactgaggataagaaaattcagccaggtccggtggctcacgccagcactttaggagactgaggtgggtgcattgcttgaactcaggagttcgagaccagcctgggaaacatggtgaaatcccaactctaaaaaaaaaaaaaaaaagaaaaaaaaaagaaaattagtgcctgagaaatccagggagaaaatggtttctgggctgggcgtggtggcttatgcctgtaatctcagcactttgggaggctgaggcagctggatcacctaaggtcaggagttggagaccagactgaccaacaaggtgaaaccccgtctctactaaaaatacaaaaatcagccaggcttggtggtggcaggtgcctgtagtcccagctacttgggaggctgagacaagagaattgcttgaacctgggaggcagaggttgcagtgagccgagatcacgccactgctctccagcatgggcgacagagtgagactccctctcaaaaaaaaaaagaaagaaagaaaatggtttctgattgaggctcctgggagaaagcactctttggagaaagaaaacttgagtcaaactctgggttacttttccttatgccaggatggctgctataaagtaagctaagccttgatcttggtaacaggattgacatggacagtttcaatctgacccatatgccctttgcccaaagcactgagccagcagcatcagttatgttttaatgaaattgaagccccaggacctgccactatggctctgaggaggactcagcttcactagcttggaaattacatatttggagggatgagagcccatgagtgtgggagatagggtaggctcagtgtcagtgtttttgtttcttccttgttccatacacttgagtagggatacatggtattaacctctttaaacaggtctctaatttcatctcattaattcacagttgcacagccatactagggtctcttccataaaccataagattttattcaccaaagctctagagacaaggtactcagatctctgtggcatccctcattttctcaactgcttctctacaaacttctcctcactttgagagtttctaatgctcaggctgggagactttttagggggtgtttttggtttttatctcctagggttatgtctaatcactcttgtggcatcctgtcctgggatttgtgctcctaaggatagaggagagtatttctgggaggagtgttcccatgatactatttgattatgtcatccttgagatggtattgtatcttctacccttatatcctactcatcgcctggcacacagcttggaatgtagtggtgcctaccacagtttgaataaataacactacacctttca
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:63967 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:63967 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:63967 -> Molecular function: GO:0010997 [anaphase-promoting complex binding] evidence: IPI
GeneID:63967 -> Biological process: GO:0000077 [DNA damage checkpoint] evidence: IMP
GeneID:63967 -> Biological process: GO:0006260 [DNA replication] evidence: TAS
GeneID:63967 -> Biological process: GO:0006281 [DNA repair] evidence: IEA
GeneID:63967 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:63967 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
GeneID:63967 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:63967 -> Biological process: GO:0018105 [peptidyl-serine phosphorylation] evidence: IDA
GeneID:63967 -> Biological process: GO:0031572 [G2 DNA damage checkpoint] evidence: IDA
GeneID:63967 -> Biological process: GO:0032147 [activation of protein kinase activity] evidence: IDA
GeneID:63967 -> Biological process: GO:0033314 [mitotic DNA replication checkpoint] evidence: IMP
GeneID:63967 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
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