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2024-03-28 18:07:47, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001185157            1820 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens interleukin 24 (IL24), transcript variant 4, mRNA.
ACCESSION   NM_001185157
VERSION     NM_001185157.1  GI:297632403
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1820)
  AUTHORS   Tian,H., Li,L., Zhang,B., Di,J., Chen,F., Li,H., Liu,J., Pei,D. and
            Zheng,J.
  TITLE     Critical role of lysine 123 in the ubiquitin-mediated degradation
            of MDA-7/IL-24
  JOURNAL   J. Interferon Cytokine Res. 32 (12), 575-582 (2012)
   PUBMED   23078624
  REMARK    GeneRIF: Data suggest that IL24 is ubiquitinated and degraded by
            26S proteasomes; data from site-directed mutagenesis study suggest
            that lysine 123 is the major internal lysine involved in
            ubiquitination of IL24; K123R mutant promotes apoptosis of HeLa
            cells.
REFERENCE   2  (bases 1 to 1820)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   3  (bases 1 to 1820)
  AUTHORS   Bosanquet,D.C., Harding,K.G., Ruge,F., Sanders,A.J. and Jiang,W.G.
  TITLE     Expression of IL-24 and IL-24 receptors in human wound tissues and
            the biological implications of IL-24 on keratinocytes
  JOURNAL   Wound Repair Regen 20 (6), 896-903 (2012)
   PUBMED   23110359
  REMARK    GeneRIF: IL-24 appears to promote wound chronicity via its
            inhibitory effect on the migratory behavior of human keratinocytes,
            mediated through an AKT-dependent pathway.
REFERENCE   4  (bases 1 to 1820)
  AUTHORS   Allen,M., Pratscher,B., Krepler,C., Frei,K., Schofer,C.,
            Pehamberger,H., Muller,M. and Lucas,T.
  TITLE     Alternative splicing of IL-24 in melanocytes by deletion of exons 3
            and 5
  JOURNAL   Int. J. Immunogenet. 32 (6), 375-378 (2005)
   PUBMED   16313301
REFERENCE   5  (bases 1 to 1820)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci. 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   6  (bases 1 to 1820)
  AUTHORS   Allen,M., Pratscher,B., Roka,F., Krepler,C., Wacheck,V.,
            Schofer,C., Pehamberger,H., Muller,M. and Lucas,T.
  TITLE     Loss of novel mda-7 splice variant (mda-7s) expression is
            associated with metastatic melanoma
  JOURNAL   J. Invest. Dermatol. 123 (3), 583-588 (2004)
   PUBMED   15304100
  REMARK    GeneRIF: mda-7s expression is linked to a non-metastatic phenotype
REFERENCE   7  (bases 1 to 1820)
  AUTHORS   Huang,E.Y., Madireddi,M.T., Gopalkrishnan,R.V., Leszczyniecka,M.,
            Su,Z., Lebedeva,I.V., Kang,D., Jiang,H., Lin,J.J., Alexandre,D.,
            Chen,Y., Vozhilla,N., Mei,M.X., Christiansen,K.A., Sivo,F.,
            Goldstein,N.I., Mhashilkar,A.B., Chada,S., Huberman,E., Pestka,S.
            and Fisher,P.B.
  TITLE     Genomic structure, chromosomal localization and expression profile
            of a novel melanoma differentiation associated (mda-7) gene with
            cancer specific growth suppressing and apoptosis inducing
            properties
  JOURNAL   Oncogene 20 (48), 7051-7063 (2001)
   PUBMED   11704829
REFERENCE   8  (bases 1 to 1820)
  AUTHORS   Su,Z.Z., Madireddi,M.T., Lin,J.J., Young,C.S., Kitada,S.,
            Reed,J.C., Goldstein,N.I. and Fisher,P.B.
  TITLE     The cancer growth suppressor gene mda-7 selectively induces
            apoptosis in human breast cancer cells and inhibits tumor growth in
            nude mice
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (24), 14400-14405 (1998)
   PUBMED   9826712
REFERENCE   9  (bases 1 to 1820)
  AUTHORS   Jiang,H., Su,Z.Z., Lin,J.J., Goldstein,N.I., Young,C.S. and
            Fisher,P.B.
  TITLE     The melanoma differentiation associated gene mda-7 suppresses
            cancer cell growth
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 93 (17), 9160-9165 (1996)
   PUBMED   8799171
REFERENCE   10 (bases 1 to 1820)
  AUTHORS   Jiang,H., Lin,J.J., Su,Z.Z., Goldstein,N.I. and Fisher,P.B.
  TITLE     Subtraction hybridization identifies a novel melanoma
            differentiation associated gene, mda-7, modulated during human
            melanoma differentiation, growth and progression
  JOURNAL   Oncogene 11 (12), 2477-2486 (1995)
   PUBMED   8545104
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP222545.1 and AY641441.1.
            
            Summary: This gene encodes a member of the IL10 family of
            cytokines. It was identified as a gene induced during terminal
            differentiation in melanoma cells. The protein encoded by this gene
            can induce apoptosis selectively in various cancer cells.
            Overexpression of this gene leads to elevated expression of several
            GADD family genes, which correlates with the induction of
            apoptosis. The phosphorylation of mitogen-activated protein kinase
            14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are
            found to be induced by this gene in melanoma cells, but not in
            normal immortal melanocytes. Alternatively spliced transcript
            variants encoding distinct isoforms have been reported. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (4, also known as IL-24 delE5)
            uses an alternate in-frame splice site in the 5' coding region, and
            lacks an alternate in-frame exon in the central coding region,
            compared to variant 1, resulting in an isoform (4) that is shorter
            than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY641441.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025084, ERS025088 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BP222545.1         1-1
            2-1820              AY641441.1         1-1819
FEATURES             Location/Qualifiers
     source          1..1820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1820
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /note="interleukin 24"
                     /db_xref="GeneID:11009"
                     /db_xref="HGNC:11346"
                     /db_xref="MIM:604136"
     exon            1..173
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /inference="alignment:Splign:1.39.8"
     exon            174..319
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    270..272
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /note="upstream in-frame stop codon"
     CDS             276..740
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; IL-4-induced secreted protein; suppression of
                     tumorigenicity 16 (melanoma differentiation);
                     melanocyte-associated Mda-7; melanoma
                     differentiation-associated gene 7 protein"
                     /codon_start=1
                     /product="interleukin-24 isoform 4 precursor"
                     /protein_id="NP_001172086.1"
                     /db_xref="GI:297632404"
                     /db_xref="CCDS:CCDS53466.1"
                     /db_xref="GeneID:11009"
                     /db_xref="HGNC:11346"
                     /db_xref="MIM:604136"
                     /translation="
MNFQQRLQSLWTLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL
"
     sig_peptide     276..431
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
     mat_peptide     432..737
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /product="interleukin-24 isoform 4"
     exon            320..518
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /inference="alignment:Splign:1.39.8"
     exon            519..581
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /inference="alignment:Splign:1.39.8"
     exon            582..656
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /inference="alignment:Splign:1.39.8"
     exon            657..1820
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /inference="alignment:Splign:1.39.8"
     STS             867..1695
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /standard_name="IL24_765"
                     /db_xref="UniSTS:277377"
     polyA_signal    1132..1137
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
     polyA_site      1150
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
     variation       complement(1236)
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1063304"
     STS             1307..1479
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /standard_name="SHGC-76250"
                     /db_xref="UniSTS:58289"
     polyA_signal    1525..1530
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
     polyA_site      1546
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /note="This is an internal polyA site. The 3'-most polyA
                     site has not yet been determined."
ORIGIN      
gcttgcctgcaaacctttacttctgaaatgacttccacggctgggacgggaaccttccacccacagctatgcctctgattggtgaatggtgaaggtgcctgtctaacttttctgtaaaaagaaccagctgcctccaggcagccagccctcaagcatcacttacaggaccagagggacaagacatgactgtgatgaggagctgctttcgccaatttaacaccaagaagaattgaggctgcttgggaggaaggccaggaggaacacgagactgagagatgaattttcaacagaggctgcaaagcctgtggactttagccagcagacccttctgccctcctttgctggcgacagcctctcaaatgcagatggttgtgctcccttgcctgggttttaccctgcttctctggagccaggtatcaggggcccagggccaagaattccactttgggccctgccaagtgaagggggttgttccccagaaactgtgggaagccttctgggctgtgaaagacactatgcaagctcaggataacatcacgagtgcccggctgctgcagcaggaggttctgcagaacgtctcgcaagaaaatgagatgttttccatcagagacagtgcacacaggcggtttctgctattccggagagcattcaaacagttggacgtagaagcagctctgaccaaagcccttggggaagtggacattcttctgacctggatgcagaaattctacaagctctgaatgtctagaccaggacctccctccccctggcactggtttgttccctgtgtcatttcaaacagtctcccttcctatgctgttcactggacacttcacgcccttggccatgggtcccattcttggcccaggattattgtcaaagaagtcattctttaagcagcgccagtgacagtcagggaaggtgcctctggatgctgtgaagagtctacagagaagattcttgtatttattacaactctatttaattaatgtcagtatttcaactgaagttctatttatttgtgagactgtaagttacatgaaggcagcagaatattgtgccccatgcttctttacccctcacaatccttgccacagtgtggggcagtggatgggtgcttagtaagtacttaataaactgtggtgctttttttggcctgtctttggattgttaaaaaacagagagggatgcttggatgtaaaactgaacttcagagcatgaaaatcacactgtcttctgatatctgcagggacagagcattggggtgggggtaaggtgcatctgtttgaaaagtaaacgataaaatgtggattaaagtgcccagcacaaagcagatcctcaataaacatttcatttcccacccacactcgccagctcaccccatcatccctttcccttggtgccctccttttttttttatcctagtcattcttccctaatcttccacttgagtgtcaagctgaccttgctgatggtgacattgcacctggatgtactatccaatctgtgatgacattccctgctaataaaagacaacataactcaagtctggcagactttcttctctatttctggatgaatgcccagtgagactgtgttgtacagctagaaaaggccttcttcccaatagcaaggctgtgcatctagcctcaagctctggctgaactttgtggtcgacatcaatctaaagatacagtgtctgactataaccttgttccaaaaacctaggcaaagagtatatgtaggaggtgggatatcacttccatgacataagtgctattgcagagccgtggccacccaggaactcctgactgctttcc
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:11009 -> Molecular function: GO:0005125 [cytokine activity] evidence: IEA
            GeneID:11009 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:11009 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IEA
            GeneID:11009 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IEA
            GeneID:11009 -> Biological process: GO:0030336 [negative regulation of cell migration] evidence: IEA
            GeneID:11009 -> Biological process: GO:0033136 [serine phosphorylation of STAT3 protein] evidence: IEA
            GeneID:11009 -> Biological process: GO:0042060 [wound healing] evidence: IEA
            GeneID:11009 -> Biological process: GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein] evidence: IEA
            GeneID:11009 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
            GeneID:11009 -> Biological process: GO:0071222 [cellular response to lipopolysaccharide] evidence: IEA
            GeneID:11009 -> Biological process: GO:0071353 [cellular response to interleukin-4] evidence: IEA
            GeneID:11009 -> Cellular component: GO:0005615 [extracellular space] evidence: IEA
            GeneID:11009 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IEA

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