LOCUS       NM_001185056            2431 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens claudin 11 (CLDN11), transcript variant 2, mRNA.
ACCESSION   NM_001185056
VERSION     NM_001185056.1  GI:297374749
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2431)
  AUTHORS   Chiba,K., Yamaguchi,K., Ando,M., Miyake,H. and Fujisawa,M.
  TITLE     Expression pattern of testicular claudin-11 in infertile men
  JOURNAL   Urology 80 (5), 1161 (2012)
   PUBMED   22951003
  REMARK    GeneRIF: disorganization of claudin-11 expression in Sertoli cells
            might be one of the factors involved in the impairment of
            spermatogenesis.
REFERENCE   2  (bases 1 to 2431)
  AUTHORS   Katsushima,K., Shinjo,K., Natsume,A., Ohka,F., Fujii,M., Osada,H.,
            Sekido,Y. and Kondo,Y.
  TITLE     Contribution of microRNA-1275 to Claudin11 protein suppression via
            a polycomb-mediated silencing mechanism in human glioma stem-like
            cells
  JOURNAL   J. Biol. Chem. 287 (33), 27396-27406 (2012)
   PUBMED   22736761
  REMARK    GeneRIF: Treatment with 3-deazaneplanocin A, an inhibitor of H3K27
            methyltransferase, attenuated CLDN11 induction by serum stimulation
            in parallel with sustained miR-1275 expression
REFERENCE   3  (bases 1 to 2431)
  AUTHORS   Kote-Jarai,Z., Olama,A.A., Giles,G.G., Severi,G., Schleutker,J.,
            Weischer,M., Campa,D., Riboli,E., Key,T., Gronberg,H., Hunter,D.J.,
            Kraft,P., Thun,M.J., Ingles,S., Chanock,S., Albanes,D., Hayes,R.B.,
            Neal,D.E., Hamdy,F.C., Donovan,J.L., Pharoah,P., Schumacher,F.,
            Henderson,B.E., Stanford,J.L., Ostrander,E.A., Sorensen,K.D.,
            Dork,T., Andriole,G., Dickinson,J.L., Cybulski,C., Lubinski,J.,
            Spurdle,A., Clements,J.A., Chambers,S., Aitken,J., Gardiner,R.A.,
            Thibodeau,S.N., Schaid,D., John,E.M., Maier,C., Vogel,W.,
            Cooney,K.A., Park,J.Y., Cannon-Albright,L., Brenner,H., Habuchi,T.,
            Zhang,H.W., Lu,Y.J., Kaneva,R., Muir,K., Benlloch,S.,
            Leongamornlert,D.A., Saunders,E.J., Tymrakiewicz,M., Mahmud,N.,
            Guy,M., O'Brien,L.T., Wilkinson,R.A., Hall,A.L., Sawyer,E.J.,
            Dadaev,T., Morrison,J., Dearnaley,D.P., Horwich,A., Huddart,R.A.,
            Khoo,V.S., Parker,C.C., Van As,N., Woodhouse,C.J., Thompson,A.,
            Christmas,T., Ogden,C., Cooper,C.S., Lophatonanon,A., Southey,M.C.,
            Hopper,J.L., English,D.R., Wahlfors,T., Tammela,T.L., Klarskov,P.,
            Nordestgaard,B.G., Roder,M.A., Tybjaerg-Hansen,A., Bojesen,S.E.,
            Travis,R., Canzian,F., Kaaks,R., Wiklund,F., Aly,M., Lindstrom,S.,
            Diver,W.R., Gapstur,S., Stern,M.C., Corral,R., Virtamo,J., Cox,A.,
            Haiman,C.A., Le Marchand,L., Fitzgerald,L., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Orntoft,T.F., Borre,M., Meyer,A., Serth,J.,
            Yeager,M., Berndt,S.I., Marthick,J.R., Patterson,B.,
            Wokolorczyk,D., Batra,J., Lose,F., McDonnell,S.K., Joshi,A.D.,
            Shahabi,A., Rinckleb,A.E., Ray,A., Sellers,T.A., Lin,H.Y.,
            Stephenson,R.A., Farnham,J., Muller,H., Rothenbacher,D.,
            Tsuchiya,N., Narita,S., Cao,G.W., Slavov,C., Mitev,V., Easton,D.F.
            and Eeles,R.A.
  CONSRTM   UK Genetic Prostate Cancer Study Collaborators/British Association
            of Urological Surgeons' Section of Oncology; UK ProtecT Study
            Collaborators, The Australian Prostate Cancer BioResource;
            PRACTICAL Consortium
  TITLE     Seven prostate cancer susceptibility loci identified by a
            multi-stage genome-wide association study
  JOURNAL   Nat. Genet. 43 (8), 785-791 (2011)
   PUBMED   21743467
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2431)
  AUTHORS   Awsare,N.S., Martin,T.A., Haynes,M.D., Matthews,P.N. and Jiang,W.G.
  TITLE     Claudin-11 decreases the invasiveness of bladder cancer cells
  JOURNAL   Oncol. Rep. 25 (6), 1503-1509 (2011)
   PUBMED   21468549
  REMARK    GeneRIF: claudin-11 may have a role in preventing cancer
            progression and may serve as a therapeutic target in reducing
            metastasis
REFERENCE   5  (bases 1 to 2431)
  AUTHORS   Nah,W.H., Lee,J.E., Park,H.J., Park,N.C. and Gye,M.C.
  TITLE     Claudin-11 expression increased in spermatogenic defect in human
            testes
  JOURNAL   Fertil. Steril. 95 (1), 385-388 (2011)
   PUBMED   20850723
  REMARK    GeneRIF: late spermatogenic wave may negatively regulate claudin-11
            gene activation and the subcellular localization of claudin-11 in
            Sertoli cells, thus altering the blood testis barrier in the human
            testis
REFERENCE   6  (bases 1 to 2431)
  AUTHORS   Kniesel,U. and Wolburg,H.
  TITLE     Tight junctions of the blood-brain barrier
  JOURNAL   Cell. Mol. Neurobiol. 20 (1), 57-76 (2000)
   PUBMED   10690502
  REMARK    Review article
REFERENCE   7  (bases 1 to 2431)
  AUTHORS   Gow,A., Southwood,C.M., Li,J.S., Pariali,M., Riordan,G.P.,
            Brodie,S.E., Danias,J., Bronstein,J.M., Kachar,B. and
            Lazzarini,R.A.
  TITLE     CNS myelin and sertoli cell tight junction strands are absent in
            Osp/claudin-11 null mice
  JOURNAL   Cell 99 (6), 649-659 (1999)
   PUBMED   10612400
REFERENCE   8  (bases 1 to 2431)
  AUTHORS   Shafit-Zagardo,B., Kress,Y., Zhao,M.L. and Lee,S.C.
  TITLE     A novel microtubule-associated protein-2 expressed in
            oligodendrocytes in multiple sclerosis lesions
  JOURNAL   J. Neurochem. 73 (6), 2531-2537 (1999)
   PUBMED   10582615
REFERENCE   9  (bases 1 to 2431)
  AUTHORS   Bronstein,J.M., Popper,P., Micevych,P.E. and Farber,D.B.
  TITLE     Isolation and characterization of a novel oligodendrocyte-specific
            protein
  JOURNAL   Neurology 47 (3), 772-778 (1996)
   PUBMED   8797478
REFERENCE   10 (bases 1 to 2431)
  AUTHORS   Bronstein,J.M., Kozak,C.A., Chen,X.N., Wu,S., Danciger,M.,
            Korenberg,J.R. and Farber,D.B.
  TITLE     Chromosomal localization of murine and human
            oligodendrocyte-specific protein genes
  JOURNAL   Genomics 34 (2), 255-257 (1996)
   PUBMED   8661061
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA258090.1 and AC008041.5.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. The protein encoded by this gene is a major
            component of central nervous system (CNS) myelin and plays an
            important role in regulating proliferation and migration of
            oligodendrocytes. Mouse studies showed that the gene deficiency
            results in deafness and loss of the Sertoli cell epithelial
            phenotype in the testis. This protein is a tight junction protein
            at the human blood-testis barrier (BTB), and the BTB disruption is
            related to a dysfunction of this gene. Alternatively spliced
            transcript variants encoding different isoforms have been
            identified.[provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (2) has an alternate 5' exon,
            resulting in a downstream in-frame AUG start codon, as compared to
            variant 1. The resulting isoform (2) has a shorter N-terminus, as
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA258090.1, BX397382.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-496               DA258090.1         1-496
            497-2431            AC008041.5         17075-19009
FEATURES             Location/Qualifiers
     source          1..2431
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.2-q26.3"
     gene            1..2431
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /note="claudin 11"
                     /db_xref="GeneID:5010"
                     /db_xref="HGNC:8514"
                     /db_xref="MIM:601326"
     exon            1..98
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /inference="alignment:Splign:1.39.8"
     variation       31
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:73163838"
     variation       49
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143055849"
     misc_feature    83..85
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /note="upstream in-frame stop codon"
     exon            99..263
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /inference="alignment:Splign:1.39.8"
     variation       103
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367974397"
     variation       120
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148297542"
     CDS             125..496
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; oligodendrocyte transmembrane protein;
                     claudin-11; oligodendrocyte-specific protein"
                     /codon_start=1
                     /product="claudin-11 isoform 2 precursor"
                     /protein_id="NP_001171985.1"
                     /db_xref="GI:297374750"
                     /db_xref="GeneID:5010"
                     /db_xref="HGNC:8514"
                     /db_xref="MIM:601326"
                     /translation="

MIAASVLGLPAILLLLTVLPCIRMGQEPGVAKYRRAQLAGVLLILLALCALVATIWFPVCAHRETTIVSFGYSLYAGWIGAVLCLVGGCVILCCAGDAQAFGENRFYYTAGSSSPTHAKSAHV

"
     sig_peptide     125..199
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     variation       154
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:141421186"
     variation       208
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150789369"
     variation       260
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371649486"
     exon            264..2431
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /inference="alignment:Splign:1.39.8"
     variation       271
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138100932"
     variation       272
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143763226"
     variation       294..295
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34124448"
     variation       312
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146493095"
     variation       326
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377105856"
     variation       385
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375051671"
     variation       454
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369096350"
     variation       458
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372554090"
     variation       467
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144303681"
     variation       477
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375624085"
     variation       478
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140975891"
     variation       490
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200665065"
     variation       507
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369963006"
     variation       508
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374008151"
     variation       520
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:373002112"
     variation       586
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:192477349"
     variation       637..638
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace=""
                     /replace="ttt"
                     /db_xref="dbSNP:10620799"
     variation       730
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:60306951"
     variation       764
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:6770844"
     variation       848
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369372951"
     variation       863
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374137538"
     variation       871
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace=""
                     /replace="t"
                     /replace="ttt"
                     /db_xref="dbSNP:11322219"
     variation       1117
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144763446"
     variation       1176
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:75747180"
     variation       1273
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:71306669"
     variation       1286
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146584959"
     variation       1302
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:77614151"
     variation       1410
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116573207"
     variation       1434
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114923460"
     variation       1460
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:184479005"
     variation       1500
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:76935838"
     variation       1626
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:141295233"
     variation       1643
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13973"
     STS             1694..1821
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /standard_name="SHGC-77525"
                     /db_xref="UniSTS:21761"
     variation       1697
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143257986"
     variation       1727
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79247818"
     polyA_signal    1814..1819
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
     variation       1826
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188703062"
     polyA_site      1839
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
     variation       1893
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:199859109"
     variation       1995
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192810780"
     variation       1996
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74578076"
     variation       1997
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184973915"
     variation       2010
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189444465"
     variation       2083
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77575392"
     variation       2088
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141576986"
     variation       2139
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191573902"
     variation       2160
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150475064"
     variation       2324
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138487700"
ORIGIN      

atcttttggtgtccggacatggccttggcactgtagcatgtggacagccagtgccatggatttcagaacctgcattgccagttgactgcctgctttgtgctacgtgcaggcctgccgcgccctgatgattgctgcctcggtcctgggtctgccggccattttactgctgctgactgttcttccctgcatccggatgggccaggagcccggtgtggctaagtacaggcgggcccagctggctggtgttttgctcattctgctggctctctgcgcccttgttgccaccatctggttccctgtgtgcgcccaccgtgagaccaccatcgtgagctttggctactccctgtatgcaggctggattggtgctgtgctgtgcctcgtgggtggctgtgtcatcctctgctgcgctggagatgcccaggcctttggtgaaaaccgtttctactacactgcgggctctagctccccgactcatgcgaagagtgcccacgtataagagggctgcccggctgcccacagaggtgctgtagatgctgggcccagggccctaggtttgctcgtcacagtgtggggaagcccattcctctgccaggctctaaagccaaaggtctagaaaagcatcctgtctggcattttgtagtcttaacttctccccatttcccccatcttttggttgccttaaaagaaatctctagctcagataatgcccagacatttttttcccttggtgttgcccctattagctcttttcttgggcattcttttgctgtttattaaaaatatattatatatattttgtttctttaaatttcaaatgttttgcaaacatcactgagttaggtgggggtggggaagagaaatacaagatacttttttttttttttttttttttttttttttaaatagggcctcactctgttgctcaggctggagtgcggtggtgtgatctcggctcatgtagcctcaacctccccggctcaagtgatcctcctgcctcagcctcccaagtagctgggactacaggcgttcactactacacccagctaatttttaagttttttatagagatgagggctccctatgttgcccaggttggtctcgaactcctggactcaaagtatcctcccgcctcggcctcccaaagtgttgggattataggagtgagccaccacaccggccaagatgcttttcaaactgatacagatgacaatgggagcctcataaagatggcttttgtttcttcccttcaaggtcatttacttgtacgagacagaaaaagatagcattggggacatgggatgggggagggagggcaatagtggaacgaactttccatgggaaactttcccttttgtaagttgagggccaggggtagggatattttttagtttgtgattttacatttatctgtacatactttttcaagattgatcatttttataaccatggttttcctgaaatcctcaattcatcaatatgaaggaaatgaaccacatagactttatgcaataaataacagtgcaagtgagtataactctaactgatgttccacaaaacatttttgatttcaggtttgtatgatgtagtttttaatcgtacattttcatatgcttcaaactaacacatttttaaagctttcccccacttttctctctatttgtattgttagccatcttgaagtgatgttgtttaacataaattgtactgttgaatttggctttacgggtgtaaacactgatggtatatcagtatctgagaccccaaactctccaaatactgatggtgcattttattcttgaagtgaaatctgtgcaataaaataacagactgtctgcaaaactggccttcaatcttctgttgtatccagaggtatcattattgatttaaaaaaatctcattaatctctactggtaatttatagggaatctgatcagtgattcaagaacaagtaattctgcattgccttgaataattaaaaagttatattttattcacggtattgcagtggtaatttgtggtcatgaaagcataacctcagtgctctctaggtttcttaagtggggtgactttatggcatctttaatcatcgatcaatgggcagcaatcagaaacaaagttctcagcattatgcagttaatgtccttcatctacttctaacacttagtaaaggaattgattggctaggtataaaaagagaattaacgaaacctattttattggatctttaagtaataatatctaaatacatttcgttcaaacatacatatgtagctgtttggacattttggacaaagacacattgagttgatttttatttgtttttctgttccagaaacttcatcaagttacgggcctggtctaagaaaacacattgcaatctattttggcagacttctttcaaataaaatactaatttcattagctgatagta

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5010 -> Molecular function: GO:0005198 [structural molecule activity] evidence: IEA
            GeneID:5010 -> Molecular function: GO:0042802 [identical protein binding] evidence: ISS
            GeneID:5010 -> Biological process: GO:0007283 [spermatogenesis] evidence: IEA
            GeneID:5010 -> Biological process: GO:0008366 [axon ensheathment] evidence: IEA
            GeneID:5010 -> Biological process: GO:0016338 [calcium-independent cell-cell adhesion] evidence: ISS
            GeneID:5010 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
            GeneID:5010 -> Cellular component: GO:0005923 [tight junction] evidence: ISS
            GeneID:5010 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA