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2024-04-25 13:37:43, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001178040 6384 bp mRNA linear PRI 16-JUN-2013
DEFINITION Homo sapiens syntaxin 3 (STX3), transcript variant 2, mRNA.
ACCESSION NM_001178040
VERSION NM_001178040.1 GI:295842491
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6384)
AUTHORS Zhu,D., Koo,E., Kwan,E., Kang,Y., Park,S., Xie,H., Sugita,S. and
Gaisano,H.Y.
TITLE Syntaxin-3 regulates newcomer insulin granule exocytosis and
compound fusion in pancreatic beta cells
JOURNAL Diabetologia 56 (2), 359-369 (2013)
PUBMED 23132338
REMARK GeneRIF: In insulin secretion, SYN-3 plays a role in the mediation
of newcomer SG exocytosis and SG-SG fusion that contributes to
biphasic GSIS.
REFERENCE 2 (bases 1 to 6384)
AUTHORS Frank,S.P., Thon,K.P., Bischoff,S.C. and Lorentz,A.
TITLE SNAP-23 and syntaxin-3 are required for chemokine release by mature
human mast cells
JOURNAL Mol. Immunol. 49 (1-2), 353-358 (2011)
PUBMED 21981832
REMARK GeneRIF: STX-3 and SNAP-23 are crucial for the release of all
chemokines in mature human mast cells
REFERENCE 3 (bases 1 to 6384)
AUTHORS Day,P., Riggs,K.A., Hasan,N., Corbin,D., Humphrey,D. and Hu,C.
TITLE Syntaxins 3 and 4 mediate vesicular trafficking of alpha5beta1 and
alpha3beta1 integrins and cancer cell migration
JOURNAL Int. J. Oncol. 39 (4), 863-871 (2011)
PUBMED 21720706
REMARK GeneRIF: siRNA knockdown (KD) of syntaxins 3 and 4 in HeLa cells
reduced cell surface expression of alpha5beta1 and alpha3beta1
integrins
REFERENCE 4 (bases 1 to 6384)
AUTHORS Cepeda,V. and Fraile-Ramos,A.
TITLE A role for the SNARE protein syntaxin 3 in human cytomegalovirus
morphogenesis
JOURNAL Cell. Microbiol. 13 (6), 846-858 (2011)
PUBMED 21371234
REMARK GeneRIF: These results demonstrate a function for STX3 in human
cytomegalovirus morphogenesis, and unravel a new role for this
SNARE protein in late endosomes/lysosomes compartments.
REFERENCE 5 (bases 1 to 6384)
AUTHORS Low,S.H., Vasanji,A., Nanduri,J., He,M., Sharma,N., Koo,M.,
Drazba,J. and Weimbs,T.
TITLE Syntaxins 3 and 4 are concentrated in separate clusters on the
plasma membrane before the establishment of cell polarity
JOURNAL Mol. Biol. Cell 17 (2), 977-989 (2006)
PUBMED 16339081
REFERENCE 6 (bases 1 to 6384)
AUTHORS Martin-Martin,B., Nabokina,S.M., Lazo,P.A. and Mollinedo,F.
TITLE Co-expression of several human syntaxin genes in neutrophils and
differentiating HL-60 cells: variant isoforms and detection of
syntaxin 1
JOURNAL J. Leukoc. Biol. 65 (3), 397-406 (1999)
PUBMED 10080545
REFERENCE 7 (bases 1 to 6384)
AUTHORS Steegmaier,M., Yang,B., Yoo,J.S., Huang,B., Shen,M., Yu,S., Luo,Y.
and Scheller,R.H.
TITLE Three novel proteins of the syntaxin/SNAP-25 family
JOURNAL J. Biol. Chem. 273 (51), 34171-34179 (1998)
PUBMED 9852078
REFERENCE 8 (bases 1 to 6384)
AUTHORS Riento,K., Galli,T., Jansson,S., Ehnholm,C., Lehtonen,E. and
Olkkonen,V.M.
TITLE Interaction of Munc-18-2 with syntaxin 3 controls the association
of apical SNAREs in epithelial cells
JOURNAL J. Cell. Sci. 111 (PT 17), 2681-2688 (1998)
PUBMED 9701566
REFERENCE 9 (bases 1 to 6384)
AUTHORS Galli,T., Zahraoui,A., Vaidyanathan,V.V., Raposo,G., Tian,J.M.,
Karin,M., Niemann,H. and Louvard,D.
TITLE A novel tetanus neurotoxin-insensitive vesicle-associated membrane
protein in SNARE complexes of the apical plasma membrane of
epithelial cells
JOURNAL Mol. Biol. Cell 9 (6), 1437-1448 (1998)
PUBMED 9614185
REFERENCE 10 (bases 1 to 6384)
AUTHORS Delgrossi,M.H., Breuza,L., Mirre,C., Chavrier,P. and Le Bivic,A.
TITLE Human syntaxin 3 is localized apically in human intestinal cells
JOURNAL J. Cell. Sci. 110 (PT 18), 2207-2214 (1997)
PUBMED 9378770
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK125660.1, AP000640.5,
AK297419.1 and AA858058.1.
Summary: The gene is a member of the syntaxin family. The encoded
protein is targeted to the apical membrane of epithelial cells
where it forms clusters and is important in establishing and
maintaining polarity necessary for protein trafficking involving
vesicle fusion and exocytosis. Alternative splicing results in
multiple transcript variants. [provided by RefSeq, May 2010].
Transcript Variant: This variant (2) lacks an exon in the coding
region, which results in a frameshift in the 3' coding region,
compared to variant 1. The resulting protein (isoform 2) is shorter
and has a distinct C-terminus, compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK297419.1, BM801978.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025083, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-250 AK125660.1 1-250
251-251 AP000640.5 94617-94617
252-393 AK125660.1 252-393
394-1964 AK297419.1 1-1571
1965-6356 AP000640.5 140794-145185
6357-6384 AA858058.1 1-28 c
FEATURES Location/Qualifiers
source 1..6384
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q12.1"
gene 1..6384
/gene="STX3"
/gene_synonym="STX3A"
/note="syntaxin 3"
/db_xref="GeneID:6809"
/db_xref="HGNC:11438"
/db_xref="MIM:600876"
exon 1..577
/gene="STX3"
/gene_synonym="STX3A"
/inference="alignment:Splign:1.39.8"
variation 32
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:186433609"
variation 79
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:191329574"
variation 84
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:181815631"
variation 89
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:144281691"
variation 251
/gene="STX3"
/gene_synonym="STX3A"
/replace="g"
/replace="t"
/db_xref="dbSNP:2957223"
variation 279
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:147809952"
variation 290
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:12791844"
variation 373
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:375863784"
misc_feature 395..397
/gene="STX3"
/gene_synonym="STX3A"
/note="upstream in-frame stop codon"
variation 433
/gene="STX3"
/gene_synonym="STX3A"
/replace="g"
/replace="t"
/db_xref="dbSNP:11549443"
variation 499
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:375908830"
variation 510
/gene="STX3"
/gene_synonym="STX3A"
/replace="g"
/replace="t"
/db_xref="dbSNP:201796338"
variation 516
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:200333761"
variation 522
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:368272172"
CDS 548..1381
/gene="STX3"
/gene_synonym="STX3A"
/note="isoform 2 is encoded by transcript variant 2;
syntaxin 3A"
/codon_start=1
/product="syntaxin-3 isoform 2"
/protein_id="NP_001171511.1"
/db_xref="GI:295842492"
/db_xref="CCDS:CCDS53637.1"
/db_xref="GeneID:6809"
/db_xref="HGNC:11438"
/db_xref="MIM:600876"
/translation="
MKDRLEQLKAKQLTQDDDTDAVEIAIDNTAFMDEFFSEIEETRLNIDKISEHVEEAKKLYSIILSAPIPEPKTKDDLEQLTTEIKKRANNVRNKLKSMEKHIEEDEVRSSADLRIRKSQHSVLSRKFVEVMTKYNEAQVDFRERSKGRIQRQLEITGKKTTDEELEEMLESGNPAIFTSGIIDSQISKQALSEIEGRHKDIVRLESSIKELHDMFMDIAMLVENQGEMLDNIELNVMHTVDHVEKARDETKKAVKYQSQARKKLISLQTGVATLVFR
"
misc_feature 641..1090
/gene="STX3"
/gene_synonym="STX3A"
/note="Syntaxin N-terminus domain; syntaxins are nervous
system-specific proteins implicated in the docking of
synaptic vesicles with the presynaptic plasma membrane;
they are a family of receptors for intracellular transport
vesicles; each target membrane may...; Region: SynN;
cd00179"
/db_xref="CDD:29141"
misc_feature order(641..643,653..655,674..676,887..892,899..904,
911..913,920..925,941..943,950..952,1043..1045)
/gene="STX3"
/gene_synonym="STX3A"
/note="nSec1 interaction sites; other site"
/db_xref="CDD:29141"
misc_feature order(734..736,767..769,776..781,800..802,812..814,
821..823,842..844,905..907,920..922,929..931,947..949,
968..973,980..985,989..994,1001..1003,1079..1081)
/gene="STX3"
/gene_synonym="STX3A"
/note="interdomain interaction site; other site"
/db_xref="CDD:29141"
misc_feature order(1019..1051,1076..1090)
/gene="STX3"
/gene_synonym="STX3A"
/note="linker region; other site"
/db_xref="CDD:29141"
misc_feature 1127..1306
/gene="STX3"
/gene_synonym="STX3A"
/note="Soluble NSF (N-ethylmaleimide-sensitive fusion
protein)-Attachment protein (SNAP) REceptor domain; these
alpha-helical motifs form twisted and parallel
heterotetrameric helix bundles; the core complex contains
one helix from a protein that is anchored in...; Region:
t_SNARE; cd00193"
/db_xref="CDD:29155"
misc_feature order(1211..1213,1232..1234,1241..1243)
/gene="STX3"
/gene_synonym="STX3A"
/note="flanking leucine-zipper layers; other site"
/db_xref="CDD:29155"
misc_feature 1220..1222
/gene="STX3"
/gene_synonym="STX3A"
/note="zero layer; other site"
/db_xref="CDD:29155"
variation 558
/gene="STX3"
/gene_synonym="STX3A"
/replace="g"
/replace="t"
/db_xref="dbSNP:371043961"
exon 578..661
/gene="STX3"
/gene_synonym="STX3A"
/inference="alignment:Splign:1.39.8"
variation 591
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:2229915"
variation 593
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:189998019"
variation 601
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:370174495"
variation 625
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:376688869"
variation 634
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:35804634"
exon 662..761
/gene="STX3"
/gene_synonym="STX3A"
/inference="alignment:Splign:1.39.8"
variation 687
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:371596190"
variation 706
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:199724694"
variation 708
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:374509506"
variation 722
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:201820174"
variation 725
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:140285651"
variation 734
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:147225705"
variation 741
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="g"
/db_xref="dbSNP:145044710"
variation 757
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="g"
/db_xref="dbSNP:140824363"
exon 762..836
/gene="STX3"
/gene_synonym="STX3A"
/inference="alignment:Splign:1.39.8"
variation 766
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:143769761"
variation 789
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:372929986"
variation 790
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:144578073"
variation 793
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:369530989"
variation 796
/gene="STX3"
/gene_synonym="STX3A"
/replace="g"
/replace="t"
/db_xref="dbSNP:12282741"
variation 817
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:151157690"
variation 818
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:200311584"
variation 826
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:2228625"
exon 837..904
/gene="STX3"
/gene_synonym="STX3A"
/inference="alignment:Splign:1.39.8"
variation 838
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:148104403"
variation 850
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:79259751"
variation 865
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:142839021"
variation 887
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:374026450"
exon 905..1013
/gene="STX3"
/gene_synonym="STX3A"
/inference="alignment:Splign:1.39.8"
variation 920
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:199896680"
variation 937
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:202134972"
variation 971
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:372990138"
variation 978
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:183505688"
variation 1007
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:201661485"
exon 1014..1087
/gene="STX3"
/gene_synonym="STX3A"
/inference="alignment:Splign:1.39.8"
variation 1030
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:199519154"
variation 1045
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:370179297"
variation 1068
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:373637735"
variation 1087
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:576991"
exon 1088..1222
/gene="STX3"
/gene_synonym="STX3A"
/inference="alignment:Splign:1.39.8"
variation 1137
/gene="STX3"
/gene_synonym="STX3A"
/replace="g"
/replace="t"
/db_xref="dbSNP:368588524"
variation 1139
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:372664488"
variation 1192
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:34900239"
variation 1201
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:371255872"
variation 1202
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:376160845"
variation 1205
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:202002338"
exon 1223..1333
/gene="STX3"
/gene_synonym="STX3A"
/inference="alignment:Splign:1.39.8"
variation 1273
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:377204078"
variation 1296
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:370426130"
variation 1328
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:142968661"
exon 1334..6361
/gene="STX3"
/gene_synonym="STX3A"
/inference="alignment:Splign:1.39.8"
STS 1391..1600
/gene="STX3"
/gene_synonym="STX3A"
/standard_name="SGC35544"
/db_xref="UniSTS:37883"
variation 1456
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:113328109"
variation 1527
/gene="STX3"
/gene_synonym="STX3A"
/replace="g"
/replace="t"
/db_xref="dbSNP:112028314"
variation 1549
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:185985355"
variation 1749
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:191281755"
variation 1808
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:183089906"
variation 1817
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:188373428"
variation 1949
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:17154203"
variation 1995
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="g"
/db_xref="dbSNP:149572486"
variation 2192
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:144367547"
variation 2208
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="t"
/db_xref="dbSNP:498077"
variation 2216
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:76410717"
variation 2225
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:15535"
variation 2251
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:115208854"
variation 2280
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:76903164"
variation 2302
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="a"
/db_xref="dbSNP:75334454"
variation 2302
/gene="STX3"
/gene_synonym="STX3A"
/replace="g"
/replace="t"
/db_xref="dbSNP:2447319"
variation 2362
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:112012200"
variation 2411
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:520851"
variation 2416..2417
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="c"
/db_xref="dbSNP:35824646"
variation 2466
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:510980"
variation 2524
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:61463035"
variation 2646
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:141022527"
variation 2665
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:143178299"
variation 2708
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:190434715"
variation 2768
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:111417259"
variation 2812
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:187750103"
variation 2853
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:192514576"
variation 2854
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:147514115"
STS 2883..3087
/gene="STX3"
/gene_synonym="STX3A"
/standard_name="RH67805"
/db_xref="UniSTS:59457"
variation 2890
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:17511686"
variation 3004
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="g"
/db_xref="dbSNP:184288005"
variation 3060
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="g"
/db_xref="dbSNP:1801585"
variation 3143
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="t"
/db_xref="dbSNP:12790380"
variation 3148
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:140118609"
polyA_signal 3156..3161
/gene="STX3"
/gene_synonym="STX3A"
variation 3172
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:61903590"
variation 3173
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:187655236"
polyA_site 3185
/gene="STX3"
/gene_synonym="STX3A"
variation 3187
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:114965596"
variation 3204
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="g"
/db_xref="dbSNP:79797606"
variation 3208
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="g"
/db_xref="dbSNP:142102987"
variation 3218
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:192861969"
variation 3229
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:12276220"
variation 3241
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:75768611"
variation 3274
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:482356"
variation 3358
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:151181740"
variation 3364
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:184671122"
variation 3385
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:372714139"
variation 3479
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:117506016"
variation 3489..3490
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="atcctctggga"
/db_xref="dbSNP:112607308"
variation 3494..3495
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="ctgggaatcct"
/db_xref="dbSNP:370096293"
variation 3626..3627
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="a"
/db_xref="dbSNP:200407732"
variation 3650
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:139028304"
variation 3651
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:77086274"
variation 3714
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="g"
/db_xref="dbSNP:188824241"
variation 3734
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:71488421"
variation 3746
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="g"
/db_xref="dbSNP:371249929"
variation 3805
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="t"
/db_xref="dbSNP:76227275"
variation 3817
/gene="STX3"
/gene_synonym="STX3A"
/replace="g"
/replace="t"
/db_xref="dbSNP:115456904"
variation 3833
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:75304130"
variation 3894..3895
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="a"
/db_xref="dbSNP:35910556"
variation 3918
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:181581600"
variation 3973
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:75068764"
variation 4060
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:493567"
variation 4187
/gene="STX3"
/gene_synonym="STX3A"
/replace="g"
/replace="t"
/db_xref="dbSNP:184536225"
variation 4229
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:149881123"
variation 4230
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:112302565"
variation 4236
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:76066477"
variation 4322
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:189299452"
variation 4431
/gene="STX3"
/gene_synonym="STX3A"
/replace="g"
/replace="t"
/db_xref="dbSNP:182177716"
variation 4541
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:146502802"
variation 4582
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="g"
/db_xref="dbSNP:75693737"
variation 4607..4608
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="actt"
/db_xref="dbSNP:111282767"
variation 4608..4609
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="actt"
/db_xref="dbSNP:371281921"
variation 4609..4610
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="ttac"
/db_xref="dbSNP:372991382"
variation 4614
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="t"
/db_xref="dbSNP:185966931"
STS 4642..4820
/gene="STX3"
/gene_synonym="STX3A"
/standard_name="A005M15"
/db_xref="UniSTS:12376"
STS 4642..4820
/gene="STX3"
/gene_synonym="STX3A"
/standard_name="G32238"
/db_xref="UniSTS:116841"
variation 4866
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="g"
/db_xref="dbSNP:141138778"
variation 4909
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="t"
/db_xref="dbSNP:190692069"
variation 5109
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="t"
/db_xref="dbSNP:144743079"
variation 5269
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="g"
/db_xref="dbSNP:146721853"
variation 5289..5290
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="a"
/db_xref="dbSNP:201488460"
variation 5314
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:181027738"
variation 5379..5380
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="t"
/db_xref="dbSNP:111375650"
variation 5433
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:111623929"
STS 5536..5625
/gene="STX3"
/gene_synonym="STX3A"
/standard_name="PMC156606P1"
/db_xref="UniSTS:271408"
variation 5610
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:547093"
variation 5655..5656
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="a"
/db_xref="dbSNP:371101239"
variation 5667..5668
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="aa"
/db_xref="dbSNP:72448107"
variation 5672
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:61317138"
variation 5672
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="c"
/db_xref="dbSNP:375835803"
variation 5675
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:143709973"
variation 5676
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:368424383"
variation 5677..5678
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="aacaaac"
/db_xref="dbSNP:72379101"
variation 5677
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:518122"
variation 5678
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:57471515"
variation 5690..5696
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="cttaata"
/db_xref="dbSNP:112792099"
variation 5692..5698
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="taatact"
/db_xref="dbSNP:376226579"
variation 5696..5702
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="acttaat"
/db_xref="dbSNP:71859644"
variation 5696
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="t"
/db_xref="dbSNP:113035425"
variation 5753
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:367957722"
variation 5757
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:185433097"
variation 5840
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="g"
/db_xref="dbSNP:190292141"
variation 5906
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:11825921"
variation 5916..5917
/gene="STX3"
/gene_synonym="STX3A"
/replace=""
/replace="a"
/db_xref="dbSNP:111676707"
variation 5920
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:182724619"
variation 5936
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:79108604"
variation 5963
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:373300329"
variation 6060
/gene="STX3"
/gene_synonym="STX3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:150197655"
variation 6141
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:187416071"
STS 6214..6346
/gene="STX3"
/gene_synonym="STX3A"
/standard_name="D11S4654"
/db_xref="UniSTS:5635"
variation 6224
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="g"
/db_xref="dbSNP:114025228"
variation 6297
/gene="STX3"
/gene_synonym="STX3A"
/replace="a"
/replace="c"
/db_xref="dbSNP:75567003"
polyA_signal 6337..6342
/gene="STX3"
/gene_synonym="STX3A"
polyA_site 6361
/gene="STX3"
/gene_synonym="STX3A"
ORIGIN
agcttgtccccgcctagcaaggagtcggctaagaactggatcctagcgaggagcccggcacagacagcgaatgaccgcagccagacagtcgctcttgctcttcctcggccctgcggcaggatccgccggtgcaggggcctctccccggactccacgcgtgtctggagggctctcgggttagggaagggggctttggagacgccccgggcggccgggcggtggcgggacgcgggccctttaagaaggagcgaggggcgcggccaggtaggggcgggtccagggcggatcagcgctgcgccggcgccggcccgggagccggatttggagcgcgaggcgccggtgggggcggagggggctgcgcggcggaggctcccgtggcctcggacgctcctcctagctagcggccgccgcccgccgccgcctgcgcctccagctccttcgccccggcgggcccggccgccgcttccggcagctcacctgggaagcgctcacctgggacgcgctcacctgggacgcgctacctgcctccgggcgcctgggcttcaggatgaaggaccgtctggagcagctgaaggccaagcagctgacacaggatgatgatactgatgcggttgagattgctatcgacaacacggcttttatggacgagttcttttctgagattgaggaaactcggcttaacattgacaagatctcagaacatgtagaggaggctaagaaactctacagtatcattctctctgcaccgattccagagccaaaaaccaaggatgacctagagcagctcacgactgagattaagaaaagggccaacaacgtccggaacaaactgaagagcatggagaagcatattgaagaagatgaggtcaggtcatcggcagaccttcggattcggaaatcccagcactctgtcctttctcggaagtttgtggaggtgatgaccaaatacaatgaagctcaagtggacttccgagaacgcagcaaagggcgaatccagcggcagctcgaaattactggcaaaaagacaaccgatgaggagctggaggagatgttggagagtggcaacccggccatcttcacttctgggatcattgactcacagatttccaagcaagccctcagtgagattgagggacgacacaaggacattgtgaggctggagagcagcatcaaggagcttcacgacatgtttatggacatcgccatgctggtggagaatcagggtgagatgttagataacatagagttgaatgtcatgcacacagtggaccacgtggagaaggcacgagatgaaacgaaaaaagctgtgaaataccagagtcaggcccggaagaaactgatttcactccagactggtgtggccacccttgtcttcagatgagaatggagtctgaatggccttcctgagagcgagtgcgacccgttcctttgtttccttgcaaccacccttggacctgactcagctaacaatctagccctgggggaatgtgatctacctgatgcgaccctgagttctccccagagcctcctcctgccccaccagctctcaagtaccttttctcctggactgtgtggacccacccagctttcttcctccctgttgtgtgtcagattatgccttgcacttgggaaagctcttgtgagactctcccaaggtgctgtatttttctacctcatggagtattctcccagaaactgcaatgtatttttttaggggagtatctttaacaaagcagaatgattcttctaagtttggcaacaagaaggcttggatctgagtcttctacctggcaggatgccaatcctgtttgttgtccgtatgtcctgaaaacatgagggactggcagatgtcattttggtctaaagagctgacttgtttgaaattcagccttaaattaagctcttagttgttcagcttggggggcaactttgatttttctctgtgttgtagtctctcatatttactcaaggagggaccaggatgatacagtcatctgaggttatgctttgcaaaaggctgacggtatggaatatgtttccatgtctgagtcttagaaactggctgctcattgttagaaagtgatgctttgtgagactattgtcttggggccaaaaataatcagggattttaaattgggcaagggacaaggtgctagaatcctaagctctggaaatatttcatgacactggtgtattcactcatgtgttccagatgtattctaattgtgtatgaaatgtatgtacacataagtgtgtgtgtctcaggaagtaggaaataaaaatggaagctattatgacctcaaaaaaaaaaagccaactttgagctaggataaaaattgggtaaaggacatttgcttacctgcaaatgaatcactgtggaaatgtgatcttcccatatcatcaagaaacttgttttctggatgaatactgggagaataaaatgagaactctggagtgagctaaattgatcccaattaagtttttctgcttagcagacagaaggtataattttttgacaccctttcccacctggtgcctatgctaggcttgtcctgagaacatccctcagtaacttgatattcacatgacctacaggatgtcccatctgcagggctgagtcagttggggaacaccagaggctacacagtagctcttcctgctactcggttaatgagcttggcaggttctttgtctcactgaattcttatcatggaaacagcagcagcagccgctaggaaatcttcaagtgtagtgtctgtgctaacccagtggtaaatcccttagatcccctgctggtctctggcagtctccttgattttgggtaccatgtatattttccgctttgactttaacgctttctaggatagggtaagcacccttaattcaggcactgtccattagcttcctttgcaaaggctacttatggccggtcacaatccagcactcagacagagccaaggcaatatcctcttgcccatggctatgatgtcagacagtggatgggctccagcaacaagagacaaaataactaaaggcctttgctctcctctgacattgaggcctggggcttacagtttggaatacaacatgtgaaggtttttgttgttgtttgtattttttagatgtaaacttgattattttattgctaatttaaaaataaaaatgactttgtattgattgtgaaacggttctggctctgtctcgatgcagaaacacaatgatctggtgccaccatgtggtgatttttattcaggttttagaatgcagttcacacctttttaagccatgtgctggatcagatggttcaaaagtgcaatttttgaacatggtttaactcccacagaatgcagtgtaactatgtttgtgtttcagatttgaggtgttccccccaaaagaatttggttcagtccttgggagtatctggctttaggaggaaatgggggagatctgtcacgatgttatctagaaggtggaatgaccataccaaacatccttttaatctaacttgaatgtctcaccaaaaataacatttctgttggcattctgggtcctagaagccagatccatctcctttttccttctgttgctctcttccttcacaccctcttccatgtccacatgcacttatctccctgcagaatactttttgcgatgatgtttctcatgtattctttctttccttgtctggatgagcagaagaagatcatgatcatgatctgctgtattatccttgcgatcatcttagcttccaccattgggagcatatttgcctgaaaaaggtgagccatctgtggggagggtcagaccttctttcactgacttgaaacctttgtgtcttgggggcactctaggtgccttaatctgggtgggattaggtgctaataatggttagagaaaactaaagaaagggatgtttcagagacagaaaagtgagtgaagaatgaactgttagtaggtagtctgtgggaggaggggggagacagaaggtggcaatctgtcctataacctggtgtggcagaatgctttgtacaggtgaaggatagtgattcctgctaaacagtttgagccttggtatctggaagtgacaaaaagaacaagaattagttcttgcattaggtgcatcttgaactttttggaagagggccggccacacagtaaattcaaattaaatttcttccctttcaaggttaatgaaagttaacacagccttgtatgtagtcctttaccccgggtaagagggatttggtgatcccagccacgaacaccatgctatataatctatgatttttttcctccatttttctgttatctcccacagccctcacagattgatcgactggcatttctaatcctccttccacttctgtggtaccatcacttctccacgcagactcctcatcagcttctcctctttccattatgaaacttcttaagaaacagggcaccaatcaactacttattaagaattatgcaaagaataaacgtatacagaattgggcggaggacagggacagggagtacagatacatagctgattaggcagatggtttaaaggaggactgcagggtagagaagcaagcagagtgggcgcctctttaggaagtgacacagcctgcatgtgcagtatggctgtgaaggggcagatatcatagcacacctaactcaacaggatcttacttgaactgctgtgagttggtcaagtcagggcacttctgctcttcaggctcctctaggtcacacctttgaccaccctacatctgtttcctctttcaggctccagtagtagtcttaaaagtgaagtttatctaaggataagcacatgcctatcttgctcactgctgtgtccccactttttagcacagcgcctgctgcttacaggtactcaaatatctgctgacttaattacttataattaagctcttatttcagtcatggacaaatccttgggtttgactcctaaactctttaaggtaccaatgagaacgtggtttgttactgtcagaggctgtgtaaagccgcttgggaatgggctgatctgcttatgcaaaaatgctaccaacctttcaaaccccattaccacaacatgaaaatttaaagtgctttttctatgggtggtgatggtggagttctagcaacagcctcttaatctgtggagaagatggctggctccaggactgtggttcaataacgaaatacaggcccacaaaataaaataggtttatagcatgactgaactcacacatcagtagaacactctgtgaaccataacaaagaacagataaaggtgtcaagtgagaaaggtgaaatgaggttatcactcacttcacctctcacctgatttgtgttgctagctgaaactgctggccagtaacgtatgtataagaaactgttataggccgggcacggtggctcatgcctgtaatcacagcactttgggaggccaaggcaggtggatcaccagactgaccaacatagtgaaaccccctctctacaaaaaatacaaaaattagccaggcatggtggcttgcacctgtattcccagctacttgggaggctgaggcaggagaattgcttgaatgcaagaggcggaagttgcagtgagccgagatcgcgccactgcactccagcctgggcaacaagagctaaattccatctaaaaaaaaaaaaaaaacaaaaaaaaaaaactgttcttaatacttaatactgtccccaattccattcaaggttcagttgtgttcagctttaaaaccagctatgtgaatgtgagttctagtgcagattatttagtgattatgtaactaaaattgatgaaaaaatcacactatacaactgtgaggagcacacaactgctaagtttgtacttttgaaagtaaattattctttgtttgataccttattttttaagaaagtgggattaaaaatattttggtcagtgctgttttctacccaccttcaaaagccaatggtttgatatttctattaatttgtgcttcctttagttttaataggggatagaagactgcagctggttgggtctggaaaacattaatctgggcaaacggagctggagctatgaggatctgagtcctagggggccctcattcactagcagtaagaatttaagtggtgcatggcacatagcactgtactagattctgcaggggcacaaacatagagccaaacactctccctcttggagaatttcagacccagaaaaggccacgcagttctaacttttgtcatcggttccttttgctaaaaggcaaagggtatgttccttgcctattgtccaacataccccttccaagattgtgagaagatgggtagctgggcatcaataaatattgaatcaattgacctaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6809 -> Molecular function: GO:0005484 [SNAP receptor activity] evidence: IEA
GeneID:6809 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6809 -> Molecular function: GO:0050544 [arachidonic acid binding] evidence: ISS
GeneID:6809 -> Biological process: GO:0006836 [neurotransmitter transport] evidence: IEA
GeneID:6809 -> Biological process: GO:0006886 [intracellular protein transport] evidence: IEA
GeneID:6809 -> Biological process: GO:0006887 [exocytosis] evidence: IEA
GeneID:6809 -> Biological process: GO:0006944 [cellular membrane fusion] evidence: IEA
GeneID:6809 -> Biological process: GO:0031175 [neuron projection development] evidence: ISS
GeneID:6809 -> Cellular component: GO:0005773 [vacuole] evidence: TAS
GeneID:6809 -> Cellular component: GO:0005911 [cell-cell junction] evidence: IDA
GeneID:6809 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:6809 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IDA
GeneID:6809 -> Cellular component: GO:0030426 [growth cone] evidence: ISS
GeneID:6809 -> Cellular component: GO:0031201 [SNARE complex] evidence: ISS
GeneID:6809 -> Cellular component: GO:0042581 [specific granule] evidence: IDA
GeneID:6809 -> Cellular component: GO:0042582 [azurophil granule] evidence: IDA
GeneID:6809 -> Cellular component: GO:0043005 [neuron projection] evidence: ISS
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