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2020-10-26 19:31:51, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001174167            5072 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens spleen tyrosine kinase (SYK), transcript variant 3,
            mRNA.
ACCESSION   NM_001174167 NR_024155
VERSION     NM_001174167.1  GI:293332584
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5072)
  AUTHORS   Yu,S., Huang,H., Iliuk,A., Wang,W.H., Jayasundera,K.B., Tao,W.A.,
            Post,C.B. and Geahlen,R.L.
  TITLE     Syk inhibits the activity of protein kinase A by phosphorylating
            tyrosine 330 of the catalytic subunit
  JOURNAL   J. Biol. Chem. 288 (15), 10870-10881 (2013)
   PUBMED   23447535
  REMARK    GeneRIF: PKA is a novel substrate of Syk, and its phosphorylation
            on Tyr-330 inhibits its participation in downstream signaling
            pathways.
REFERENCE   2  (bases 1 to 5072)
  AUTHORS   Kim,Y., Kong,M. and Lee,C.
  TITLE     Association of intronic sequence variant in the gene encoding
            spleen tyrosine kinase with susceptibility to vascular dementia
  JOURNAL   World J. Biol. Psychiatry 14 (3), 220-226 (2013)
   PUBMED   23480133
REFERENCE   3  (bases 1 to 5072)
  AUTHORS   Vallieres,F. and Girard,D.
  TITLE     IL-21 enhances phagocytosis in mononuclear phagocyte cells:
            identification of spleen tyrosine kinase as a novel molecular
            target of IL-21
  JOURNAL   J. Immunol. 190 (6), 2904-2912 (2013)
   PUBMED   23396946
  REMARK    GeneRIF: Spleen tyrosine kinase (Syk) is a novel and important
            target of interleukin (IL)-21 for enhancing phagocytosis.
REFERENCE   4  (bases 1 to 5072)
  AUTHORS   Hussain,A., Mohammad,D.K., Gustafsson,M.O., Uslu,M., Hamasy,A.,
            Nore,B.F., Mohamed,A.J. and Smith,C.I.
  TITLE     Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK
            (spleen tyrosine kinase) fusion kinase is dependent on adapter
            SLP-76 and on the adapter function of the kinases SYK and ZAP70
  JOURNAL   J. Biol. Chem. 288 (10), 7338-7350 (2013)
   PUBMED   23293025
  REMARK    GeneRIF: Data indicate that the intracellular signaling of ITK-SYK
            requires both SLP-76 and the adapter function of SYK/ZAP-70
            kinases.
REFERENCE   5  (bases 1 to 5072)
  AUTHORS   Romero-Camarero,I., Jiang,X., Natkunam,Y., Lu,X.,
            Vicente-Duenas,C., Gonzalez-Herrero,I., Flores,T., Garcia,J.L.,
            McNamara,G., Kunder,C., Zhao,S., Segura,V., Fontan,L.,
            Martinez-Climent,J.A., Garcia-Criado,F.J., Theis,J.D., Dogan,A.,
            Campos-Sanchez,E., Green,M.R., Alizadeh,A.A., Cobaleda,C.,
            Sanchez-Garcia,I. and Lossos,I.S.
  TITLE     Germinal centre protein HGAL promotes lymphoid hyperplasia and
            amyloidosis via BCR-mediated Syk activation
  JOURNAL   Nat Commun 4, 1338 (2013)
   PUBMED   23299888
  REMARK    GeneRIF: the germinal centre protein human germinal
            centre-associated lymphoma regulates B-cell receptor signalling in
            B-lymphocytes which, without appropriate control, may lead to
            B-cell lymphoproliferation.
REFERENCE   6  (bases 1 to 5072)
  AUTHORS   Chan,A.C., Iwashima,M., Turck,C.W. and Weiss,A.
  TITLE     ZAP-70: a 70 kd protein-tyrosine kinase that associates with the
            TCR zeta chain
  JOURNAL   Cell 71 (4), 649-662 (1992)
   PUBMED   1423621
REFERENCE   7  (bases 1 to 5072)
  AUTHORS   Hutchcroft,J.E., Harrison,M.L. and Geahlen,R.L.
  TITLE     Association of the 72-kDa protein-tyrosine kinase PTK72 with the B
            cell antigen receptor
  JOURNAL   J. Biol. Chem. 267 (12), 8613-8619 (1992)
   PUBMED   1569106
REFERENCE   8  (bases 1 to 5072)
  AUTHORS   Yannoukakos,D., Meyer,H.E., Vasseur,C., Driancourt,C., Wajcman,H.
            and Bursaux,E.
  TITLE     Three regions of erythrocyte band 3 protein are phosphorylated on
            tyrosines: characterization of the phosphorylation sites by solid
            phase sequencing combined with capillary electrophoresis
  JOURNAL   Biochim. Biophys. Acta 1066 (1), 70-76 (1991)
   PUBMED   2065070
REFERENCE   9  (bases 1 to 5072)
  AUTHORS   Yannoukakos,D., Vasseur,C., Piau,J.P., Wajcman,H. and Bursaux,E.
  TITLE     Phosphorylation sites in human erythrocyte band 3 protein
  JOURNAL   Biochim. Biophys. Acta 1061 (2), 253-266 (1991)
   PUBMED   1998697
REFERENCE   10 (bases 1 to 5072)
  AUTHORS   Kim,J.W., Sim,S.S., Kim,U.H., Nishibe,S., Wahl,M.I., Carpenter,G.
            and Rhee,S.G.
  TITLE     Tyrosine residues in bovine phospholipase C-gamma phosphorylated by
            the epidermal growth factor receptor in vitro
  JOURNAL   J. Biol. Chem. 265 (7), 3940-3943 (1990)
   PUBMED   1689310
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA948098.1, AK290927.1,
            BC011399.1, BC001645.2, AL354862.12 and W33104.1.
            On Apr 3, 2010 this sequence version replaced gi:205277437.
            
            Summary: This gene encodes a member of the family of non-receptor
            type Tyr protein kinases. This protein is widely expressed in
            hematopoietic cells and is involved in coupling activated
            immunoreceptors to downstream signaling events that mediate diverse
            cellular responses, including proliferation, differentiation, and
            phagocytosis. It is thought to be a modulator of epithelial cell
            growth and a potential tumour suppressor in human breast
            carcinomas. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Mar 2010].
            
            Transcript Variant: This variant (3) contains an alternate 5'
            terminal exon compared to variant 1, which introduces an upstream
            open reading frame (uORF) with a weak Kozak signal, making
            translation of the downstream primary ORF (with a strong Kozak
            signal) encoding isoform 1 likely by leaky scanning or
            re-initiation. Variants 1 and 3 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X73568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-558               DA948098.1         1-558
            559-1694            AK290927.1         460-1595
            1695-2429           BC011399.1         1532-2266
            2430-2708           BC001645.2         2379-2657
            2709-4930           AL354862.12        145283-147504
            4931-5072           W33104.1           1-142               c
FEATURES             Location/Qualifiers
     source          1..5072
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22"
     gene            1..5072
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="spleen tyrosine kinase"
                     /db_xref="GeneID:6850"
                     /db_xref="HGNC:11491"
                     /db_xref="MIM:600085"
     exon            1..157
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       18
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200232305"
     variation       21
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:182564913"
     variation       62
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201489782"
     variation       65
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199683437"
     variation       72
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188032492"
     variation       108
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201659462"
     variation       116
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199772310"
     variation       117
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200895917"
     variation       132
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201777939"
     variation       137
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200009952"
     variation       151
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200748020"
     exon            158..615
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       170
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200237145"
     variation       178
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201338526"
     variation       186
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201341126"
     variation       187
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200373424"
     misc_feature    193..195
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="upstream in-frame stop codon"
     CDS             199..2106
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 3;
                     tyrosine-protein kinase SYK"
                     /codon_start=1
                     /product="tyrosine-protein kinase SYK isoform 1"
                     /protein_id="NP_001167638.1"
                     /db_xref="GI:293332585"
                     /db_xref="CCDS:CCDS6688.1"
                     /db_xref="GeneID:6850"
                     /db_xref="HGNC:11491"
                     /db_xref="MIM:600085"
                     /translation="
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
"
     misc_feature    235..546
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="N-terminal Src homology 2 (SH2) domain found in
                     Zeta-chain-associated protein kinase 70 (ZAP-70) and
                     Spleen tyrosine kinase (Syk) proteins; Region:
                     SH2_N-SH2_Zap70_Syk_like; cd09938"
                     /db_xref="CDD:198191"
     misc_feature    order(262..264,322..324,385..387,391..393)
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198191"
     misc_feature    280..282
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    328..330
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P43405.1); phosphorylation site"
     misc_feature    337..339
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    order(388..390,424..429,433..435,490..495)
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198191"
     misc_feature    520..699
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P43405.1);
                     Region: Interdomain A"
     misc_feature    589..591
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    688..984
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="C-terminal Src homology 2 (SH2) domain found in
                     Spleen tyrosine kinase (Syk) proteins; Region:
                     SH2_C-SH2_Syk_like; cd10401"
                     /db_xref="CDD:198264"
     misc_feature    order(721..723,781..783,787..789,841..843,847..849)
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198264"
     misc_feature    802..804
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P43405.1); phosphorylation site"
     misc_feature    order(844..846,880..882,889..891,946..948)
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198264"
     misc_feature    964..966
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    976..1308
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P43405.1);
                     Region: Interdomain B"
     misc_feature    1081..1083
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P43405.1); phosphorylation site"
     misc_feature    1084..1086
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1087..1089
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P43405.1); phosphorylation site"
     misc_feature    1144..1146
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P43405.1); phosphorylation site"
     misc_feature    1147..1149
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1153..1155
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P43405.1); phosphorylation site"
     misc_feature    1165..1167
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by LYN; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1231..1233
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1240..1242
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1246..1248
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P43405.1); phosphorylation site"
     misc_feature    1252..1254
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1288..1290
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1318..2076
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="Protein tyrosine kinase; Region: Pkinase_Tyr;
                     pfam07714"
                     /db_xref="CDD:203736"
     misc_feature    1321..2091
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Spleen tyrosine kinase; Region: PTKc_Syk; cd05116"
                     /db_xref="CDD:133247"
     misc_feature    order(1327..1341,1351..1353,1396..1398,1402..1404,
                     1495..1497,1540..1551,1558..1563,1678..1680,1690..1695,
                     1699..1701,1732..1734,1789..1803,1828..1830,1930..1932)
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="active site"
                     /db_xref="CDD:133247"
     misc_feature    order(1327..1332,1351..1353,1396..1398,1402..1404,
                     1495..1497,1540..1551,1558..1563,1690..1695,1699..1701,
                     1729..1734)
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:133247"
     misc_feature    1333..1335
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P43405.1); phosphorylation site"
     misc_feature    1348..1350
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1648..1650
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    order(1678..1680,1690..1692,1789..1803,1828..1830,
                     1930..1932)
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:133247"
     misc_feature    1717..1719
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1729..1809
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:133247"
     misc_feature    1771..1773
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1774..1776
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1786..1788
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    1933..1935
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P43405.1); phosphorylation site"
     misc_feature    1942..1944
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    2083..2085
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    2086..2088
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     misc_feature    2089..2091
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P43405.1); phosphorylation site"
     variation       202
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201301123"
     variation       210
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199823436"
     variation       211
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146743944"
     variation       215
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201350143"
     variation       225
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201458538"
     variation       226
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199606629"
     variation       249
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200626943"
     variation       263
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140421546"
     variation       264
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139401525"
     variation       279
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200577589"
     variation       295
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201364101"
     STS             299..523
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /standard_name="STS-S80267"
                     /db_xref="UniSTS:70625"
     variation       327
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35758162"
     variation       332
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:16906862"
     variation       333
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201774526"
     variation       345
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:140490837"
     variation       351
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200928765"
     variation       360
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150440676"
     variation       361
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200078199"
     variation       369
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371908826"
     variation       390
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138271353"
     variation       392
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149603234"
     variation       410
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:146786995"
     variation       413
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200175081"
     variation       420
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139316651"
     variation       426
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202064642"
     variation       429
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200362424"
     variation       440
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201374653"
     variation       449
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199818587"
     variation       454
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201455170"
     variation       457
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201177148"
     variation       461
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78791900"
     variation       468
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199646361"
     variation       488
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200223184"
     variation       509
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200453337"
     variation       526
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202043759"
     variation       527
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375028044"
     variation       534
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143342183"
     variation       608
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200097669"
     variation       612
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142980255"
     exon            616..776
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       627
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199932327"
     variation       630
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370551918"
     variation       637
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373730562"
     variation       672
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200921683"
     variation       705
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147347882"
     variation       742
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200476529"
     variation       768
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:148413110"
     variation       771
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201529865"
     exon            777..915
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       825
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202000893"
     variation       843
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201867954"
     variation       885
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199938327"
     variation       886
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200498885"
     variation       905
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201857010"
     variation       906
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200087795"
     exon            916..994
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       930
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201907766"
     variation       935
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184127752"
     variation       957
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34489331"
     variation       973
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201538038"
     variation       982
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:112619650"
     variation       985
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199886319"
     exon            995..1044
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       1014
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201662709"
     variation       1016
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139520862"
     variation       1017
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55920107"
     variation       1020
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200859639"
     variation       1042
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377620701"
     variation       1043
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201994789"
     variation       1044
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199908671"
     exon            1045..1113
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       1056
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200313175"
     variation       1061
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143341039"
     variation       1103
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201228592"
     exon            1114..1201
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       1119
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146732805"
     variation       1130
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199612745"
     variation       1135
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200684262"
     variation       1136
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201840933"
     variation       1137
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199745532"
     variation       1164
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200697355"
     variation       1184
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201358181"
     exon            1202..1379
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       1202
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139388374"
     variation       1205
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200099811"
     variation       1207
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144168552"
     variation       1211
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56071116"
     variation       1217
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200994798"
     variation       1219
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200409467"
     variation       1242
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142936514"
     variation       1254
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41274652"
     variation       1255
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200167353"
     variation       1256
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201479078"
     variation       1257
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377587992"
     variation       1263
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2290890"
     variation       1273
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200418715"
     variation       1279
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201460357"
     variation       1298
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199772052"
     variation       1305
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376461830"
     variation       1310
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369986984"
     variation       1311
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151053124"
     variation       1321
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201179887"
     variation       1341
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:67128367"
     exon            1380..1589
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       1392
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375613854"
     variation       1402
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79190821"
     variation       1416
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202093746"
     STS             1431..1687
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /standard_name="SYK-1"
                     /db_xref="UniSTS:513716"
     variation       1432
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201438493"
     variation       1467
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200930117"
     variation       1491
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141000507"
     variation       1494
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202166418"
     variation       1500
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2290888"
     variation       1506
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201416422"
     variation       1515
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202191431"
     variation       1516
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200202947"
     variation       1536
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2290887"
     variation       1554
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199712945"
     variation       1563
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143304676"
     exon            1590..1779
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       1607
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201930376"
     variation       1623
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200072255"
     variation       1629
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56285406"
     variation       1630
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201724218"
     variation       1642
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200456955"
     variation       1646
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147125933"
     variation       1683
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200991736"
     variation       1695
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2306042"
     variation       1719
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2306041"
     variation       1725
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201341572"
     variation       1728
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202069669"
     variation       1731
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200251333"
     variation       1737
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34231418"
     variation       1743
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2306040"
     variation       1756
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200320837"
     exon            1780..1920
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       1791
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200628553"
     variation       1808
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371627100"
     variation       1815
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201650753"
     variation       1821
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201516360"
     variation       1836
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201065688"
     variation       1853
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199801793"
     variation       1857
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141667926"
     variation       1908
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200957611"
     variation       1919
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201765057"
     exon            1921..2033
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     variation       1923
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201336985"
     variation       1944
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139024468"
     variation       1945
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369492720"
     variation       1968
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149469439"
     variation       2005
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200438123"
     variation       2031
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201360872"
     exon            2034..5066
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /inference="alignment:Splign:1.39.8"
     STS             2039..2786
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /standard_name="SYK_1884"
                     /db_xref="UniSTS:281037"
     variation       2049
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202024803"
     variation       2050
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200612476"
     variation       2055
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374945682"
     variation       2056
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139348511"
     variation       2061
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:145685109"
     variation       2079
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200834108"
     variation       2081
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150998279"
     variation       2094
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201364356"
     variation       2097
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200148300"
     variation       2100
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200682995"
     variation       2108
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201520390"
     variation       2109
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199607948"
     variation       2132
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201191948"
     variation       2140
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201001425"
     variation       2147
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202243160"
     variation       2176
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200070739"
     variation       2201
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201179148"
     variation       2205
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202035242"
     variation       2206
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191082286"
     variation       2223
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201474800"
     variation       2240
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202088785"
     variation       2287
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200443955"
     variation       2294
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201367588"
     variation       2295
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113175204"
     variation       2306
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200786369"
     variation       2307
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201177252"
     variation       2321
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199644752"
     variation       2326
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56139234"
     variation       2332
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1804251"
     variation       2346
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201615361"
     variation       2355
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200080967"
     variation       2371
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200817268"
     variation       2372
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182865904"
     variation       2394
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187420975"
     variation       2427
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199888968"
     variation       2428
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201168587"
     variation       2430
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1049164"
     STS             2436..2576
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /standard_name="WI-18899"
                     /db_xref="UniSTS:28988"
     variation       2448
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199927091"
     STS             2463..2592
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /standard_name="RH69035"
                     /db_xref="UniSTS:21128"
     variation       2497
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200937477"
     variation       2521
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202179400"
     variation       2523
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200478377"
     variation       2526
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41309340"
     variation       2546
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201184094"
     variation       2556
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202018238"
     variation       2572
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:14979"
     variation       2576
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1804252"
     variation       2579
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201236332"
     variation       2580
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41313849"
     variation       2606..2607
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34237652"
     variation       2620
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:3087507"
     polyA_signal    2622..2627
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
     variation       2628
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113304691"
     variation       2642
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201054834"
     variation       2643
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3087508"
     variation       2649
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3087506"
     polyA_site      2653
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
     variation       2664
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199807708"
     variation       2709..2710
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:113920845"
     variation       2709
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200854897"
     variation       2712
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:57651872"
     variation       2713
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201993887"
     variation       2742
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199584610"
     variation       2744
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113580142"
     variation       2753
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201935229"
     variation       2764
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200082519"
     variation       2794
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200996064"
     variation       2811
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:192822491"
     variation       2820
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201640049"
     variation       2823
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199893313"
     variation       2824
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201228319"
     variation       2839
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202208832"
     variation       2852
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200250756"
     variation       2858
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200788246"
     variation       2865
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201901573"
     variation       2917
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200306296"
     variation       2964
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201170015"
     variation       2965
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199593787"
     variation       2971
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200233293"
     variation       2993
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201530364"
     variation       3003
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199757614"
     variation       3010
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200639366"
     variation       3018
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201656525"
     variation       3019
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140271666"
     variation       3037
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200271297"
     variation       3039
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201996237"
     variation       3052
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199910798"
     variation       3053
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201033897"
     variation       3065
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201904421"
     variation       3071
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200062335"
     variation       3078
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:158688"
     variation       3097
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201766681"
     variation       3112
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184864847"
     variation       3121
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201197144"
     variation       3125
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202205240"
     variation       3169
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200418572"
     variation       3170
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201475559"
     variation       3171
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376917555"
     variation       3174
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202172624"
     variation       3176
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12344755"
     variation       3202
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:158687"
     variation       3233
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199614233"
     variation       3235
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:74847439"
     variation       3244
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138070207"
     variation       3258
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:10512203"
     variation       3260
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113367349"
     variation       3296
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200684900"
     variation       3298
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201846169"
     variation       3303
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:158686"
     variation       3304
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200678129"
     variation       3306
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201507403"
     variation       3322
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199954919"
     variation       3324
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201129087"
     variation       3336
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202170530"
     variation       3349
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200092376"
     variation       3354
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201067892"
     STS             3359..3447
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     variation       3361
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202049478"
     variation       3368
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200169491"
     variation       3369
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201483217"
     variation       3370
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:202087399"
     STS             3378..3488
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /standard_name="D10S275"
                     /db_xref="UniSTS:147992"
     variation       3386
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:192259837"
     variation       3389
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201450125"
     variation       3425
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199763889"
     variation       3426
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200961449"
     variation       3447
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201471258"
     variation       3465
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199623121"
     variation       3471
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200404562"
     variation       3472
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:158685"
     variation       3480
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200068159"
     variation       3482
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200689319"
     variation       3487
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138672587"
     variation       3502
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183960220"
     variation       3506
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189425165"
     variation       3519
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142720783"
     variation       3520
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199842566"
     variation       3528
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201341496"
     variation       3538
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201770050"
     variation       3551
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199924149"
     variation       3552..3556
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace=""
                     /replace="aactt"
                     /db_xref="dbSNP:368223574"
     variation       3552
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200933262"
     variation       3554
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202178674"
     variation       3559
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200488395"
     variation       3631
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201111768"
     variation       3632
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:5021552"
     variation       3652
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202189825"
     variation       3655
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371047374"
     variation       3656
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115363876"
     variation       3674
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192548937"
     variation       3677
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199783989"
     variation       3686
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184355645"
     variation       3707
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201058837"
     variation       3720
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:189146244"
     variation       3732
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199768164"
     variation       3745
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:181141508"
     variation       3752
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201774920"
     variation       3776
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186279193"
     variation       3782
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200592316"
     variation       3790
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201934148"
     variation       3808
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200079558"
     variation       3820
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112868894"
     variation       3887
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201711043"
     variation       3907
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199822713"
     variation       3910
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201323598"
     variation       3927
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202054985"
     variation       3931
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200437396"
     variation       3939
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:17568705"
     variation       3940
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201899168"
     variation       3956
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200311317"
     variation       3974
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201177408"
     variation       3978..3979
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:35758629"
     variation       3993
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199604777"
     variation       4004
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200219989"
     variation       4020
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201716941"
     variation       4026
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199714639"
     variation       4072
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148015317"
     variation       4073
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200634194"
     variation       4079
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201655256"
     variation       4085
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199537078"
     variation       4088
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371399205"
     variation       4090
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200782311"
     variation       4100
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201768739"
     variation       4111
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199976134"
     variation       4141
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200655648"
     variation       4169
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202076504"
     variation       4177
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:10217275"
     variation       4179
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200864082"
     variation       4180
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:111798674"
     variation       4193
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201771764"
     variation       4196
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199911137"
     variation       4200
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200984283"
     variation       4205
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202058374"
     variation       4209
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200440991"
     variation       4234
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115781501"
     variation       4241
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202241782"
     variation       4252
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200430210"
     variation       4253
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201413796"
     variation       4279
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199603436"
     variation       4287
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200481350"
     variation       4306
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201775735"
     variation       4312
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199695443"
     variation       4336
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200815743"
     variation       4343
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114553487"
     variation       4352
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199914885"
     variation       4358
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200680066"
     variation       4368
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201514338"
     variation       4382
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199958969"
     variation       4415
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200795833"
     variation       4429
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73650275"
     variation       4498
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368631722"
     variation       4499
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200073109"
     variation       4507
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201185795"
     variation       4509
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202006211"
     variation       4533
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13559"
     variation       4535
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:72729087"
     variation       4541
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201467820"
     variation       4543
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202131391"
     variation       4550
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200305022"
     variation       4565
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201342619"
     variation       4603
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199804824"
     variation       4614
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200863208"
     variation       4615
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201618755"
     variation       4621
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199633431"
     variation       4622
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:117866558"
     variation       4624
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201616726"
     variation       4631
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199774700"
     variation       4636
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141926409"
     variation       4657
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201639704"
     variation       4658
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199863553"
     variation       4672
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201200597"
     variation       4695
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201761264"
     variation       4721
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199956562"
     variation       4722
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200907814"
     variation       4736
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202165739"
     variation       4744
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200362937"
     variation       4751
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201255894"
     variation       4766
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202010594"
     variation       4773
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200244210"
     variation       4776
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201537770"
     variation       4783
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199792221"
     variation       4787
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200278333"
     variation       4790
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:189965276"
     variation       4791
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199848843"
     variation       4809
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200863059"
     variation       4843
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367775503"
     STS             4847..4982
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /standard_name="RH91425"
                     /db_xref="UniSTS:84312"
     variation       4868
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201987311"
     variation       4875
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199576591"
     STS             4885..5018
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /standard_name="D9S2062"
                     /db_xref="UniSTS:2175"
     variation       4909
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77417541"
     variation       4931
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:8773"
     variation       4971
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200056866"
     variation       4995
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150672706"
     variation       5021
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201710784"
     variation       5024
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199868385"
     variation       5027
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201205439"
     variation       5030
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202207011"
     variation       5033
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200425328"
     polyA_signal    5037..5042
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
     polyA_site      5066
                     /gene="SYK"
                     /gene_synonym="p72-Syk"
ORIGIN      
actctggcttgttgatgcctgtcttgtgctttctctctgtttcagctgttttccttttaagatactcctctcagatttgtgtgcttcttcccttcccacattctatactgcccagcgcctgggattccagatctgcgtttgaatccaggaaagggaggtggacacctgcgcaggtgtgtgccctccggcccctgaagcatggccagcagcggcatggctgacagcgccaaccacctgcccttctttttcggcaacatcacccgggaggaggcagaagattacctggtccaggggggcatgagtgatgggctttatttgctgcgccagagccgcaactacctgggtggcttcgccctgtccgtggcccacgggaggaaggcacaccactacaccatcgagcgggagctgaatggcacctacgccatcgccggtggcaggacccatgccagccccgccgacctctgccactaccactcccaggagtctgatggcctggtctgcctcctcaagaagcccttcaaccggccccaaggggtgcagcccaagactgggccctttgaggatttgaaggaaaacctcatcagggaatatgtgaagcagacatggaacctgcagggtcaggctctggagcaggccatcatcagtcagaagcctcagctggagaagctgatcgctaccacagcccatgaaaaaatgccttggttccatggaaaaatctctcgggaagaatctgagcaaattgtcctgataggatcaaagacaaatggaaagttcctgatccgagccagagacaacaacggctcctacgccctgtgcctgctgcacgaagggaaggtgctgcactatcgcatcgacaaagacaagacagggaagctctccatccccgagggaaagaagttcgacacgctctggcagctagtcgagcattattcttataaagcagatggtttgttaagagttcttactgtcccatgtcaaaaaatcggcacacagggaaatgttaattttggaggccgtccacaacttccaggttcccatcctgcgacttggtcagcgggtggaataatctcaagaatcaaatcatactccttcccaaagcctggccacagaaagtcctcccctgcccaagggaaccggcaagagagtactgtgtcattcaatccgtatgagccagaacttgcaccctgggctgcagacaaaggcccccagagagaagccctacccatggacacagaggtgtacgagagcccctacgcggaccccgaggagatcaggcccaaggaggtttacctggaccgaaagctgctgacgctggaagacaaagaactgggctctggtaattttggaactgtgaaaaagggctactaccaaatgaaaaaagttgtgaaaaccgtggctgtgaaaatactgaaaaacgaggccaatgaccccgctcttaaagatgagttattagcagaagcaaatgtcatgcagcagctggacaacccgtacatcgtgcggatgatcgggatatgcgaggccgagtcctggatgctggttatggagatggcagaacttggtcccctcaataagtatttgcagcagaacagacatgtcaaggataagaacatcatagaactggttcatcaggtttccatgggcatgaagtacttggaggagagcaattttgtgcacagagatctggctgcaagaaatgtgttgctagttacccaacattacgccaagatcagtgatttcggactttccaaagcactgcgtgctgatgaaaactactacaaggcccagacccatggaaagtggcctgtcaagtggtacgctccggaatgcatcaactactacaagttctccagcaaaagcgatgtctggagctttggagtgttgatgtgggaagcattctcctatgggcagaagccatatcgagggatgaaaggaagtgaagtcaccgctatgttagagaaaggagagcggatggggtgccctgcagggtgtccaagagagatgtacgatctcatgaatctgtgctggacatacgatgtggaaaacaggcccggattcgcagcagtggaactgcggctgcgcaattactactatgacgtggtgaactaaccgctcccgcacctgtcggtggctgcctttgatcacaggagcaatcacaggaaaatgtatccagaggaattgattgtcagccacctccctctgccagtcgggagagccaggcttggatggaacatgcccacaacttgtcacccaaagcctgtcccaggactcaccctccacaaagcaaaggcagtcccgggagaaaagacggatggcaggatccaaggggctagctggatttgtttgttttcttgtctgtgtgattttcatacaggttatttttacgatctgtttccaaatccctttcatgtctttccacttctctgggtcccggggtgcatttgttactcatcgggcccagggacattgcagagtggcctagagcactctcaccccaagcggccttttccaaatgcccaaggatgccttagcatgtgactcctgaagggaaggcaaaggcagaggaatttggctgcttctacggccatgagactgatccctggccactgaaaagctttcctgacaataaaaatgttttgaggctttaaaaagaaaatcaagtttgaccagtgcagtttctaagcatgtagccagttaaggaaagaaagaaagaaaaaaaaaaaaggcctggatactgcttttgctgtctctgttatgagatggaagacttacatgtttgtgataaaaggggaccatgagaatgaattggcttggcttactttccccctgaaatcctctctcctgcagactgtcttgaagacctggtgactggtaaataaagccctgcatggaggctgcacagcaggggcaagaggcccatcccccagcatctcactgaggacagcttcaggctgccttcctctgaacgtggtccacaccttcctctcctccacagagagggtgccgccagaatcccctgtcgctttctgtgtctgcaatggggggcagcacagggatcaaagccatctaaagagtttccaaagaaagtattaattcagaacaagccaaagaccctgagcctcaccacaaacaggccttttggagtgtgaatttgagttgaagatacaagatcggagaatgattttctggtcttaactaatcctcatcttcatgtttgatctttaagaagtcatcacccattgatttcagttttgctgtacctcttgaaagttaaagagacatctcagcactttaggaggccgaggcgggtggatcacttgaggtaaggagtttgagactagcctggccaatatggtaaaaccccatctctactaaaaatacaaaaattagccgggcatggtggcatgtgtctgtagtcccagctactcgggaggctgaggcaggagaatcgcttgaacccaggaaacggaggtcgcagtgagccaagatcatgccactgcactccagcttgggcatcacagcgagactctgtcaaaacaaacaaacaaaaaaacaacttaaagaggtaatttagccatcattcttatgccagcagatataaataaacttggacccatctggtcttcagctaaacctgagacattttaaagtgcatggacagccatggacagcaggccctcctctaacaggggatgcaaggcatggagaaagacaatcagtacccaagctcagccacagaagacaggagtcactcatataacttgtgtttagaagtttttggtagccacgcacactttctgaaatcacactatctggtggtttaatcatatttttaaagacagaatccctgagtgctgagcagattctcaaaacacatttagaatccctgaaattagaaagatcaatgacaaaatatctgtcagccaggccacaaacaggtgtaaaattatgaaaggagtggttggatgtgccaagtttggtaaagtggtgactgcatctgagaaagaggctgtgaggctgaactcttggtggcttccttctgtaacttccagagggagtcttcaacacaggccccgtgctcgtaggaatacggtagcacctatgtaggaagtgcgtggagttttctgtcttctttctgtgtgatttttggcctttttatcagcacttctcccctcccaggagcctggggatgccaaacatccagaatgtgatgggacaagatgggggcaggggcctcacctccctgcagaggtccggccaggtctccttgtccctggacaatctcctgagcctctctgcttggtggagcaggcacctgtgtgcagaattcccactgtggccagcacgaggaagtcttttctagtgaaaatgtgtcttgtggtcaggaataattatcctttcccctgtagccaccaaggagggcaaatagagaaaggtaacctaattgaaggattggtcatgtgaaaagggctacatttgggaagctgggaaaggcctccaggcttctagagcagctagcttgggctggattctcatacccaggctgccccttggattgttctacccaagcttttccctggggtctgggctcactccataaggtaaggtgccttttaccttatggtccttctttagcaggtaacaaaggagcatcaggggcaggctgccctggtggcatcacactggctagtgaggccgtgaatatcttgtcccccagcagggccgacagtttctatcacagaaaacagtgtgttcagtggtgaaaatcgttgcatgcatgttttcatctgagcgtgtccttctcccatactccctatcagccagccctgcctgtagctgctgtatggtgattgcacttggacatcagtccaatgactgcaagtcggcctggattttcacttgcagaggctacagctgcattgtcaggtctcccagccctgcagagagctccctccactggttagcagtgtgttgtgttttccattcatttcagaagagctacattgtgtcactggacatttttaaaaactgtgatttttaataaaaatttaaaatttgctttgtgatgaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:6850 -> Molecular function: GO:0004672 [protein kinase activity] evidence: NAS
            GeneID:6850 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: EXP
            GeneID:6850 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: TAS
            GeneID:6850 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: IDA
            GeneID:6850 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: TAS
            GeneID:6850 -> Molecular function: GO:0004716 [receptor signaling protein tyrosine kinase activity] evidence: IEA
            GeneID:6850 -> Molecular function: GO:0005178 [integrin binding] evidence: IPI
            GeneID:6850 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:6850 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:6850 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IEA
            GeneID:6850 -> Biological process: GO:0001525 [angiogenesis] evidence: IEA
            GeneID:6850 -> Biological process: GO:0001945 [lymph vessel development] evidence: ISS
            GeneID:6850 -> Biological process: GO:0002250 [adaptive immune response] evidence: ISS
            GeneID:6850 -> Biological process: GO:0002281 [macrophage activation involved in immune response] evidence: ISS
            GeneID:6850 -> Biological process: GO:0002283 [neutrophil activation involved in immune response] evidence: ISS
            GeneID:6850 -> Biological process: GO:0002366 [leukocyte activation involved in immune response] evidence: ISS
            GeneID:6850 -> Biological process: GO:0002554 [serotonin secretion by platelet] evidence: ISS
            GeneID:6850 -> Biological process: GO:0006468 [protein phosphorylation] evidence: ISS
            GeneID:6850 -> Biological process: GO:0007159 [leukocyte cell-cell adhesion] evidence: IDA
            GeneID:6850 -> Biological process: GO:0007167 [enzyme linked receptor protein signaling pathway] evidence: IEA
            GeneID:6850 -> Biological process: GO:0007229 [integrin-mediated signaling pathway] evidence: ISS
            GeneID:6850 -> Biological process: GO:0007229 [integrin-mediated signaling pathway] evidence: NAS
            GeneID:6850 -> Biological process: GO:0007257 [activation of JUN kinase activity] evidence: IEA
            GeneID:6850 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
            GeneID:6850 -> Biological process: GO:0008283 [cell proliferation] evidence: TAS
            GeneID:6850 -> Biological process: GO:0009887 [organ morphogenesis] evidence: TAS
            GeneID:6850 -> Biological process: GO:0010543 [regulation of platelet activation] evidence: ISS
            GeneID:6850 -> Biological process: GO:0018108 [peptidyl-tyrosine phosphorylation] evidence: IEA
            GeneID:6850 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
            GeneID:6850 -> Biological process: GO:0019370 [leukotriene biosynthetic process] evidence: IEA
            GeneID:6850 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
            GeneID:6850 -> Biological process: GO:0030593 [neutrophil chemotaxis] evidence: IDA
            GeneID:6850 -> Biological process: GO:0032928 [regulation of superoxide anion generation] evidence: ISS
            GeneID:6850 -> Biological process: GO:0033630 [positive regulation of cell adhesion mediated by integrin] evidence: ISS
            GeneID:6850 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
            GeneID:6850 -> Biological process: GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] evidence: TAS
            GeneID:6850 -> Biological process: GO:0042742 [defense response to bacterium] evidence: ISS
            GeneID:6850 -> Biological process: GO:0043306 [positive regulation of mast cell degranulation] evidence: IEA
            GeneID:6850 -> Biological process: GO:0043313 [regulation of neutrophil degranulation] evidence: ISS
            GeneID:6850 -> Biological process: GO:0043366 [beta selection] evidence: IEA
            GeneID:6850 -> Biological process: GO:0045087 [innate immune response] evidence: ISS
            GeneID:6850 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:6850 -> Biological process: GO:0045401 [positive regulation of interleukin-3 biosynthetic process] evidence: IEA
            GeneID:6850 -> Biological process: GO:0045425 [positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process] evidence: IEA
            GeneID:6850 -> Biological process: GO:0045579 [positive regulation of B cell differentiation] evidence: IEA
            GeneID:6850 -> Biological process: GO:0045588 [positive regulation of gamma-delta T cell differentiation] evidence: IEA
            GeneID:6850 -> Biological process: GO:0045780 [positive regulation of bone resorption] evidence: ISS
            GeneID:6850 -> Biological process: GO:0046638 [positive regulation of alpha-beta T cell differentiation] evidence: IEA
            GeneID:6850 -> Biological process: GO:0046641 [positive regulation of alpha-beta T cell proliferation] evidence: IEA
            GeneID:6850 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IEA
            GeneID:6850 -> Biological process: GO:0048514 [blood vessel morphogenesis] evidence: ISS
            GeneID:6850 -> Biological process: GO:0050715 [positive regulation of cytokine secretion] evidence: IEA
            GeneID:6850 -> Biological process: GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] evidence: IEA
            GeneID:6850 -> Biological process: GO:0050764 [regulation of phagocytosis] evidence: ISS
            GeneID:6850 -> Biological process: GO:0050850 [positive regulation of calcium-mediated signaling] evidence: IEA
            GeneID:6850 -> Biological process: GO:0050853 [B cell receptor signaling pathway] evidence: ISS
            GeneID:6850 -> Biological process: GO:0070372 [regulation of ERK1 and ERK2 cascade] evidence: ISS
            GeneID:6850 -> Biological process: GO:0071226 [cellular response to molecule of fungal origin] evidence: ISS
            GeneID:6850 -> Biological process: GO:0090237 [regulation of arachidonic acid secretion] evidence: ISS
            GeneID:6850 -> Biological process: GO:0090330 [regulation of platelet aggregation] evidence: ISS
            GeneID:6850 -> Cellular component: GO:0005829 [cytosol] evidence: IC
            GeneID:6850 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:6850 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:6850 -> Cellular component: GO:0019815 [B cell receptor complex] evidence: IEA
            GeneID:6850 -> Cellular component: GO:0032009 [early phagosome] evidence: ISS
            GeneID:6850 -> Cellular component: GO:0042101 [T cell receptor complex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001167638 -> EC 2.7.10.2

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.