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2024-04-20 03:33:50, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001168298            2672 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens chemokine (C-X-C motif) receptor 2 (CXCR2), transcript
            variant 2, mRNA.
ACCESSION   NM_001168298
VERSION     NM_001168298.1  GI:269973858
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2672)
  AUTHORS   Zeng,Z., Shaffer,J.R., Wang,X., Feingold,E., Weeks,D.E., Lee,M.,
            Cuenco,K.T., Wendell,S.K., Weyant,R.J., Crout,R., McNeil,D.W. and
            Marazita,M.L.
  TITLE     Genome-wide association studies of pit-and-fissure- and
            smooth-surface caries in permanent dentition
  JOURNAL   J. Dent. Res. 92 (5), 432-437 (2013)
   PUBMED   23470693
REFERENCE   2  (bases 1 to 2672)
  AUTHORS   Ravindran,A., Sawant,K.V., Sarmiento,J., Navarro,J. and
            Rajarathnam,K.
  TITLE     Chemokine CXCL1 dimer is a potent agonist for the CXCR2 receptor
  JOURNAL   J. Biol. Chem. 288 (17), 12244-12252 (2013)
   PUBMED   23479735
  REMARK    GeneRIF: Chemokine CXCL1 dimer is a potent agonist for the CXCR2
            receptor.
REFERENCE   3  (bases 1 to 2672)
  AUTHORS   Saintigny,P., Massarelli,E., Lin,S., Ahn,Y.H., Chen,Y., Goswami,S.,
            Erez,B., O'Reilly,M.S., Liu,D., Lee,J.J., Zhang,L., Ping,Y.,
            Behrens,C., Solis Soto,L.M., Heymach,J.V., Kim,E.S., Herbst,R.S.,
            Lippman,S.M., Wistuba,I.I., Hong,W.K., Kurie,J.M. and Koo,J.S.
  TITLE     CXCR2 expression in tumor cells is a poor prognostic factor and
            promotes invasion and metastasis in lung adenocarcinoma
  JOURNAL   Cancer Res. 73 (2), 571-582 (2013)
   PUBMED   23204236
  REMARK    GeneRIF: CXCR2 axis gene expression profiles in human NSCLC cell
            lines and lung adenocarcinomas defined a cluster driven by CXCL5
            and associated with smoking, poor prognosis, and RAS pathway
            activation.
REFERENCE   4  (bases 1 to 2672)
  AUTHORS   Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee
            JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K,
            Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z,
            Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN,
            Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A,
            Boucher G, Brand S, Buning C, Cohain A, Cichon S, D'Amato M, De
            Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson
            LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas
            J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH,
            Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees
            CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W,
            Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M,
            Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber
            S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M,
            Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier
            RJ, Zeissig S, Zhang B, Zhang CK, Zhao H, Silverberg MS, Annese V,
            Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD,
            Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC and
            Cho JH.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   5  (bases 1 to 2672)
  AUTHORS   Dwyer,J., Hebda,J.K., Le Guelte,A., Galan-Moya,E.M., Smith,S.S.,
            Azzi,S., Bidere,N. and Gavard,J.
  TITLE     Glioblastoma cell-secreted interleukin-8 induces brain endothelial
            cell permeability via CXCR2
  JOURNAL   PLoS ONE 7 (9), E45562 (2012)
   PUBMED   23029099
  REMARK    GeneRIF: Glioblastoma cell-secreted interleukin-8 induces brain
            endothelial cell permeability via CXCR2.
REFERENCE   6  (bases 1 to 2672)
  AUTHORS   Morris,S.W., Nelson,N., Valentine,M.B., Shapiro,D.N., Look,A.T.,
            Kozlosky,C.J., Beckmann,M.P. and Cerretti,D.P.
  TITLE     Assignment of the genes encoding human interleukin-8 receptor types
            1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35
  JOURNAL   Genomics 14 (3), 685-691 (1992)
   PUBMED   1427896
REFERENCE   7  (bases 1 to 2672)
  AUTHORS   Lee,J., Horuk,R., Rice,G.C., Bennett,G.L., Camerato,T. and
            Wood,W.I.
  TITLE     Characterization of two high affinity human interleukin-8 receptors
  JOURNAL   J. Biol. Chem. 267 (23), 16283-16287 (1992)
   PUBMED   1379593
REFERENCE   8  (bases 1 to 2672)
  AUTHORS   Murphy,P.M. and Tiffany,H.L.
  TITLE     Cloning of complementary DNA encoding a functional human
            interleukin-8 receptor
  JOURNAL   Science 253 (5025), 1280-1283 (1991)
   PUBMED   1891716
REFERENCE   9  (bases 1 to 2672)
  AUTHORS   Holmes,W.E., Lee,J., Kuang,W.J., Rice,G.C. and Wood,W.I.
  TITLE     Structure and functional expression of a human interleukin-8
            receptor
  JOURNAL   Science 253 (5025), 1278-1280 (1991)
   PUBMED   1840701
REFERENCE   10 (bases 1 to 2672)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J. Biol. Chem. 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA674925.1, AC124768.4 and
            AJ710879.1.
            
            Summary: The protein encoded by this gene is a member of the
            G-protein-coupled receptor family. This protein is a receptor for
            interleukin 8 (IL8). It binds to IL8 with high affinity, and
            transduces the signal through a G-protein activated second
            messenger system. This receptor also binds to chemokine (C-X-C
            motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth
            stimulating activity, and has been shown to be a major component
            required for serum-dependent melanoma cell growth. This receptor
            mediates neutrophil migration to sites of inflammation. The
            angiogenic effects of IL8 in intestinal microvascular endothelial
            cells are found to be mediated by this receptor. Knockout studies
            in mice suggested that this receptor controls the positioning of
            oligodendrocyte precursors in developing spinal cord by arresting
            their migration. This gene, IL8RA, a gene encoding another high
            affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB,
            form a gene cluster in a region mapped to chromosome 2q33-q36.
            Alternatively spliced variants, encoding the same protein, have
            been identified. [provided by RefSeq, Nov 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA674925.1, CN836893.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-580               DA674925.1         1-580
            581-2526            AC124768.4         70772-72717
            2527-2672           AJ710879.1         1-146
FEATURES             Location/Qualifiers
     source          1..2672
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..2672
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /note="chemokine (C-X-C motif) receptor 2"
                     /db_xref="GeneID:3579"
                     /db_xref="HGNC:6027"
                     /db_xref="MIM:146928"
     exon            1..70
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="alignment:Splign:1.39.8"
     exon            71..133
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    91..93
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /note="upstream in-frame stop codon"
     variation       97
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201034122"
     variation       104
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201979333"
     exon            134..185
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="alignment:Splign:1.39.8"
     variation       148
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201877059"
     variation       150
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200242599"
     variation       152
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201386473"
     variation       158
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199650637"
     variation       179
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200485079"
     exon            186..2662
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="alignment:Splign:1.39.8"
     variation       199
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:55781915"
     variation       204
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201205999"
     CDS             211..1293
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /note="interleukin 8 receptor, beta; interleukin 8
                     receptor B; CXCR2 gene for IL8 receptor type B;
                     interleukin 8 receptor type 2; chemokine (CXC) receptor 2;
                     high affinity interleukin-8 receptor B; GRO/MGSA receptor;
                     interleukin-8 receptor type B; CXC-R2; CXCR-2; IL-8R B;
                     IL-8 receptor type 2"
                     /codon_start=1
                     /product="C-X-C chemokine receptor type 2"
                     /protein_id="NP_001161770.1"
                     /db_xref="GI:269973859"
                     /db_xref="CCDS:CCDS2408.1"
                     /db_xref="GeneID:3579"
                     /db_xref="HGNC:6027"
                     /db_xref="MIM:146928"
                     /translation="
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
"
     misc_feature    355..435
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P25025.2);
                     transmembrane region"
     misc_feature    427..1152
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /note="7 transmembrane receptor (rhodopsin family);
                     Region: 7tm_1; pfam00001"
                     /db_xref="CDD:200918"
     misc_feature    463..525
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P25025.2);
                     transmembrane region"
     misc_feature    571..636
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P25025.2);
                     transmembrane region"
     misc_feature    700..759
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P25025.2);
                     transmembrane region"
     misc_feature    835..903
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P25025.2);
                     transmembrane region"
     misc_feature    964..1029
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P25025.2);
                     transmembrane region"
     misc_feature    1093..1155
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P25025.2);
                     transmembrane region"
     variation       227
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:139809702"
     variation       228
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201134932"
     variation       240
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369575199"
     variation       247
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371161134"
     variation       253
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55672388"
     variation       272
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199905091"
     variation       285
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200836817"
     variation       297
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148935180"
     variation       300
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142762038"
     variation       311
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191559601"
     STS             317..743
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="PMC135988P2"
                     /db_xref="UniSTS:270788"
     variation       318
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201373363"
     variation       319
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75759064"
     variation       329
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200402782"
     variation       345
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:183812193"
     variation       346
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55678589"
     variation       351
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141285974"
     variation       374
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199770538"
     variation       391
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574748"
     variation       414
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201294973"
     variation       415
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368269858"
     variation       433
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199633255"
     variation       444
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150483744"
     variation       445
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149364972"
     variation       448
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138773569"
     variation       453
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372364370"
     variation       454
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201754155"
     STS             460..905
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="PMC310709P2"
                     /db_xref="UniSTS:272638"
     variation       480
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200819332"
     variation       482
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199535002"
     variation       484
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142747099"
     variation       523
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201513058"
     STS             529..1164
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="PMC155779P2"
                     /db_xref="UniSTS:271353"
     STS             529..778
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="PMC155779P3"
                     /db_xref="UniSTS:271354"
     variation       529
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200115845"
     variation       558
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147368052"
     variation       576
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201382541"
     variation       606
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199919394"
     variation       618
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376503094"
     variation       619
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369839517"
     variation       640
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141722043"
     variation       643
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201114751"
     STS             666..1188
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="IL8R-1"
                     /db_xref="UniSTS:251622"
     variation       666
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375690914"
     variation       668
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55799208"
     variation       681
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146545386"
     variation       685
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200940650"
     variation       686
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368809767"
     variation       692
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:202076117"
     variation       711
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200386344"
     variation       736
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199906283"
     variation       738
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201535541"
     variation       741
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201960181"
     variation       760
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200409575"
     variation       768
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201476763"
     variation       769
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199777583"
     variation       794
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200413041"
     variation       804
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201063764"
     variation       805
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201694058"
     variation       813
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199692849"
     variation       826
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200627519"
     variation       840
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143703189"
     variation       852
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:202054642"
     variation       860
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199822657"
     variation       861
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200776607"
     variation       873
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141723765"
     variation       879
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2228414"
     variation       887
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141096894"
     variation       897
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201979852"
     variation       903
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138670528"
     variation       904
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201103729"
     variation       916
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:10201766"
     variation       917
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144013681"
     variation       921
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201499279"
     variation       931
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61733608"
     variation       943
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200332183"
     variation       953
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61733609"
     variation       961
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373547007"
     variation       962
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199561988"
     variation       966
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17844699"
     STS             975..1164
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="PMC155779P1"
                     /db_xref="UniSTS:271352"
     variation       978
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11574750"
     variation       996
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230054"
     variation       1059
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200911312"
     variation       1064
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201881186"
     variation       1069
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201264119"
     variation       1073
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199642674"
     variation       1075
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200726461"
     variation       1076
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186640530"
     variation       1086
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199873547"
     variation       1087..1088
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:34747313"
     variation       1090
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141145934"
     variation       1091
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2228413"
     variation       1094
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200127100"
     variation       1107
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13306439"
     variation       1120
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373633146"
     variation       1123
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201271219"
     variation       1144..1145
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:36094489"
     variation       1146
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45606837"
     variation       1152
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143174409"
     variation       1153
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200906463"
     variation       1175
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201872950"
     variation       1178
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200182920"
     variation       1201
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201481173"
     variation       1205
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199632317"
     variation       1206
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17844701"
     variation       1227
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201578768"
     variation       1232
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199534482"
     variation       1244
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146279580"
     variation       1246
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200600788"
     variation       1247
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201772068"
     variation       1248
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141985893"
     variation       1251
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11574751"
     variation       1253
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370921619"
     variation       1256
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200917361"
     STS             1269..1468
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="RH69171"
                     /db_xref="UniSTS:15270"
     variation       1269
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201890292"
     variation       1285
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:150629039"
     variation       1288
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373447323"
     variation       1290
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201280885"
     variation       1292
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201597594"
     STS             1297..1499
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="STS-L19593"
                     /db_xref="UniSTS:37178"
     variation       1299
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370198012"
     variation       1308
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199886410"
     variation       1317
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200811589"
     variation       1318
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200375313"
     variation       1323
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200327176"
     variation       1330
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200366084"
     variation       1340
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374087831"
     STS             1346..1562
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="SHGC-35278"
                     /db_xref="UniSTS:8485"
     variation       1362
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202145285"
     variation       1366
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191445302"
     variation       1389
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201610228"
     variation       1407
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202138860"
     variation       1420
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1126579"
     variation       1429
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201301122"
     variation       1444
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199662489"
     variation       1449
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200910303"
     variation       1463
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201580582"
     variation       1477
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199529314"
     variation       1481
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:184907766"
     variation       1487
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200661535"
     variation       1493
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201497688"
     variation       1501
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200083985"
     variation       1528
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:375176823"
     variation       1538
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200713198"
     variation       1589
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201358180"
     variation       1592
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199960281"
     variation       1615
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201255939"
     variation       1624
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202122610"
     variation       1631
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13306441"
     variation       1640
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200944263"
     variation       1644
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202081724"
     variation       1648
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17844765"
     variation       1652
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1126580"
     variation       1660
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:56176202"
     variation       1666
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144937879"
     variation       1676
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201975844"
     variation       1678
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200358732"
     variation       1679..1680
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:11384701"
     variation       1693
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201616246"
     variation       1694
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199720972"
     variation       1700
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56153350"
     variation       1701
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201060551"
     variation       1702
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199684776"
     variation       1704
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200622623"
     variation       1712
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189221075"
     variation       1716
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199863372"
     variation       1767
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200661022"
     variation       1768
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201984059"
     variation       1773
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:56092703"
     variation       1792
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200097337"
     variation       1808
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:55829498"
     variation       1809
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:56175425"
     variation       1816
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201220752"
     variation       1821
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201986384"
     variation       1822
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199944797"
     variation       1847
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201100780"
     variation       1851
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202141075"
     variation       1852
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55638099"
     variation       1853
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200999393"
     variation       1871
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202200545"
     variation       1877
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200317880"
     variation       1888
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201256811"
     variation       1892
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199540825"
     variation       1924
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55647070"
     variation       1927
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200255470"
     variation       1935
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201156584"
     variation       1956
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199725306"
     variation       1974
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201006994"
     variation       1984
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201645636"
     variation       1985
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199632962"
     variation       1989
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185395115"
     variation       2015
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201889090"
     variation       2018
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199869170"
     variation       2020
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200954784"
     variation       2030
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201972373"
     variation       2031
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200083187"
     variation       2037
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201363519"
     variation       2081
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:55868412"
     variation       2095
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201963170"
     variation       2104
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200257699"
     variation       2131
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148989011"
     variation       2137
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201872518"
     variation       2146
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200180099"
     variation       2163
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201377420"
     variation       2175
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17844705"
     variation       2178
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200480096"
     variation       2181
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201754329"
     variation       2187
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199528804"
     variation       2188
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200594925"
     variation       2200
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201770115"
     variation       2232
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199764281"
     variation       2240
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55824260"
     variation       2245
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:17844706"
     variation       2272
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17844707"
     variation       2276
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56035337"
     variation       2347
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201107545"
     STS             2364..2548
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /standard_name="RH78907"
                     /db_xref="UniSTS:35029"
     variation       2364
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202047158"
     variation       2365
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199884990"
     variation       2379
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200811552"
     variation       2405
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201795975"
     variation       2438
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200077824"
     variation       2439
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11574752"
     variation       2441
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375016461"
     variation       2442
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201967136"
     variation       2445
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:72955950"
     variation       2447..2448
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace=""
                     /replace="cttaatgc"
                     /db_xref="dbSNP:148832762"
     variation       2447
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201473254"
     variation       2520
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:147749945"
     variation       2521
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200153685"
     variation       2544
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201283841"
     variation       2558
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199647047"
     variation       2565
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200784640"
     variation       2586
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201741488"
     variation       2611
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199516582"
     variation       2639
                     /gene="CXCR2"
                     /gene_synonym="CD182; CDw128b; CMKAR2; IL8R2; IL8RA;
                     IL8RB"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:181068104"
ORIGIN      
aagcagtggtgatagctgagaatatgcagccgttttctccttcctgggtacagtgctattctgcctagagctctgactaccacccaaccttgaggcacagtgaagacatcggtggccactccaataacagcaggtcacagctgctcttctggaggtgtcctacaggtgaaaagcccagcgacccagtcaggatttaagtttacctcaaaaatggaagattttaacatggagagtgacagctttgaagatttctggaaaggtgaagatcttagtaattacagttacagctctaccctgcccccttttctactagatgccgccccatgtgaaccagaatccctggaaatcaacaagtattttgtggtcattatctatgccctggtattcctgctgagcctgctgggaaactccctcgtgatgctggtcatcttatacagcagggtcggccgctccgtcactgatgtctacctgctgaacctagccttggccgacctactctttgccctgaccttgcccatctgggccgcctccaaggtgaatggctggatttttggcacattcctgtgcaaggtggtctcactcctgaaggaagtcaacttctatagtggcatcctgctactggcctgcatcagtgtggaccgttacctggccattgtccatgccacacgcacactgacccagaagcgctacttggtcaaattcatatgtctcagcatctggggtctgtccttgctcctggccctgcctgtcttacttttccgaaggaccgtctactcatccaatgttagcccagcctgctatgaggacatgggcaacaatacagcaaactggcggatgctgttacggatcctgccccagtcctttggcttcatcgtgccactgctgatcatgctgttctgctacggattcaccctgcgtacgctgtttaaggcccacatggggcagaagcaccgggccatgcgggtcatctttgctgtcgtcctcatcttcctgctctgctggctgccctacaacctggtcctgctggcagacaccctcatgaggacccaggtgatccaggagacctgtgagcgccgcaatcacatcgaccgggctctggatgccaccgagattctgggcatccttcacagctgcctcaaccccctcatctacgccttcattggccagaagtttcgccatggactcctcaagattctagctatacatggcttgatcagcaaggactccctgcccaaagacagcaggccttcctttgttggctcttcttcagggcacacttccactactctctaagacctcctgcctaagtgcagccccgtggggttcctcccttctcttcacagtcacattccaagcctcatgtccactggttcttcttggtctcagtgtcaatgcagcccccattgtggtcacaggaagtagaggaggccacgttcttactagtttcccttgcatggtttagaaagcttgccctggtgcctcaccccttgccataattactatgtcatttgctggagctctgcccatcctgcccctgagcccatggcactctatgttctaagaagtgaaaatctacactccagtgagacagctctgcatactcattaggatggctagtatcaaaagaaagaaaatcaggctggccaacggggtgaaaccctgtctctactaaaaatacaaaaaaaaaaaaaaattagccgggcgtggtggtgagtgcctgtaatcacagctacttgggaggctgagatgggagaatcacttgaacccgggaggcagaggttgcagtgagccgagattgtgcccctgcactccagcctgagcgacagtgagactctgtctcagtccatgaagatgtagaggagaaactggaactctcgagcgttgctgggggggattgtaaaatggtgtgaccactgcagaagacagtatggcagctttcctcaaaacttcagacatagaattaacacatgatcctgcaattccacttataggaattgacccacaagaaatgaaagcagggacttgaacccatatttgtacaccaatattcatagcagcttattcacaagacccaaaaggcagaagcaacccaaatgttcatcaatgaatgaatgaatggctaagcaaaatgtgatatgtacctaacgaagtatccttcagcctgaaagaggaatgaagtactcatacatgttacaacacggacgaaccttgaaaactttatgctaagtgaaataagccagacatcaacagataaatagtttatgattccacctacatgaggtactgagagtgaacaaatttacagagacagaaagcagaacagtgattaccagggactgaggggaggggagcatgggaagtgacggtttaatgggcacagggtttatgtttaggatgttgaaaaagttctgcagataaacagtagtgatagttgtaccgcaatgtgacttaatgccactaaattgacacttaaaaatggtttaaatggtcaattttgttatgtatattttatatcaatttaaaaaaaaacctgagccccaaaaggtattttaatcaccaaggctgattaaaccaaggctagaaccacctgcctatattttttgttaaatgatttcattcaatatcttttttttaataaaccatttttacttgggtgtttataaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3579 -> Molecular function: GO:0004871 [signal transducer activity] evidence: IDA
            GeneID:3579 -> Molecular function: GO:0004918 [interleukin-8 receptor activity] evidence: IDA
            GeneID:3579 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:3579 -> Molecular function: GO:0016494 [C-X-C chemokine receptor activity] evidence: IDA
            GeneID:3579 -> Molecular function: GO:0019959 [interleukin-8 binding] evidence: IPI
            GeneID:3579 -> Biological process: GO:0002407 [dendritic cell chemotaxis] evidence: TAS
            GeneID:3579 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:3579 -> Biological process: GO:0006935 [chemotaxis] evidence: IDA
            GeneID:3579 -> Biological process: GO:0006954 [inflammatory response] evidence: TAS
            GeneID:3579 -> Biological process: GO:0006968 [cellular defense response] evidence: IDA
            GeneID:3579 -> Biological process: GO:0007165 [signal transduction] evidence: IDA
            GeneID:3579 -> Biological process: GO:0007166 [cell surface receptor signaling pathway] evidence: IDA
            GeneID:3579 -> Biological process: GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] evidence: IDA
            GeneID:3579 -> Biological process: GO:0007204 [elevation of cytosolic calcium ion concentration] evidence: IEA
            GeneID:3579 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IDA
            GeneID:3579 -> Biological process: GO:0030593 [neutrophil chemotaxis] evidence: IDA
            GeneID:3579 -> Biological process: GO:0031623 [receptor internalization] evidence: IDA
            GeneID:3579 -> Biological process: GO:0038112 [interleukin-8-mediated signaling pathway] evidence: IDA
            GeneID:3579 -> Biological process: GO:0042119 [neutrophil activation] evidence: IDA
            GeneID:3579 -> Cellular component: GO:0005622 [intracellular] evidence: IDA
            GeneID:3579 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:3579 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
            GeneID:3579 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
            GeneID:3579 -> Cellular component: GO:0016020 [membrane] evidence: IDA
            GeneID:3579 -> Cellular component: GO:0042629 [mast cell granule] evidence: IDA

by @meso_cacase at DBCLS
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