2024-03-29 07:13:31, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001168235 6643 bp mRNA linear PRI 07-OCT-2012 DEFINITION Homo sapiens FRAS1 related extracellular matrix 3 (FREM3), mRNA. ACCESSION NM_001168235 XM_001127662 XM_001720656 XM_094074 VERSION NM_001168235.1 GI:270265870 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6643) AUTHORS Shi,C., Zhang,K., Wang,X., Shen,Y. and Xu,Q. TITLE A study of the combined effects of the EHD3 and FREM3 genes in patients with major depressive disorder JOURNAL Am. J. Med. Genet. B Neuropsychiatr. Genet. 159B (3), 336-342 (2012) PUBMED 22337703 REMARK GeneRIF: The combined effect of the EHD3 and FREM3 genes may play an important role in developing major depressive disorder. REFERENCE 2 (bases 1 to 6643) AUTHORS Smyth,I., Du,X., Taylor,M.S., Justice,M.J., Beutler,B. and Jackson,I.J. TITLE The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (37), 13560-13565 (2004) PUBMED 15345741 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC139713.1, AW953229.1, DN831271.1, AI184955.1, DR731220.1, DR007885.1, BE223071.1 and R44783.1. On or before Dec 5, 2009 this sequence version replaced gi:169166903, gi:169167210, gi:169166333. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-4867 AC139713.1 154821-159687 c 4868-5470 AW953229.1 11-613 5471-5840 DN831271.1 110-479 5841-6028 AI184955.1 141-328 c 6029-6124 DR731220.1 1-96 c 6125-6230 DR007885.1 39-144 6231-6600 BE223071.1 132-501 c 6601-6643 R44783.1 1-43 c FEATURES Location/Qualifiers source 1..6643 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="4" /map="4q31.21" gene 1..6643 /gene="FREM3" /note="FRAS1 related extracellular matrix 3" /db_xref="GeneID:166752" /db_xref="HGNC:25172" /db_xref="MIM:608946" CDS 1..6420 /gene="FREM3" /note="FRAS1-related extracellular matrix protein 3" /codon_start=1 /product="FRAS1-related extracellular matrix protein 3 precursor" /protein_id="NP_001161707.1" /db_xref="GI:270265871" /db_xref="CCDS:CCDS54808.1" /db_xref="GeneID:166752" /db_xref="HGNC:25172" /db_xref="MIM:608946" /translation="
MAGASRHPTGTPRQLLVALACLLLSRPALQGRASSLGTEPDPALYLPARGALDGTRPDGPSVLIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLDALPRLKGALSPRRFPCTFGPRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEKLRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDGPLPKYGRLVDAVGAPLPRGKGVDCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEGQDAGSAGVLVREHFQLLVRIRGGAENTPPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQGYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDNLEEVKMAAVRGLRHGQLVVFGAPAGCKYFTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQVNQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVFVGESFIVYEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGARVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRLTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLISYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYVLNEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQIILSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLLQMPMGAVLGEPNKTTIFIEDTITDCKQSACSSFD
" sig_peptide 1..90 /gene="FREM3" /inference="COORDINATES: ab initio prediction:SignalP:4.0" mat_peptide 91..6417 /gene="FREM3" /product="FRAS1-related extracellular matrix protein 3" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P0C091.2)" misc_feature 853..1239 /gene="FREM3" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P0C091.2); Region: CSPG 1" misc_feature 1240..1572 /gene="FREM3" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P0C091.2); Region: CSPG 2" misc_feature 1573..2049 /gene="FREM3" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P0C091.2); Region: CSPG 3" misc_feature 2050..2433 /gene="FREM3" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P0C091.2); Region: CSPG 4" misc_feature 2434..2766 /gene="FREM3" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P0C091.2); Region: CSPG 5" misc_feature 2767..3165 /gene="FREM3" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P0C091.2); Region: CSPG 6" misc_feature 3166..3522 /gene="FREM3" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P0C091.2); Region: CSPG 7" misc_feature 3523..3861 /gene="FREM3" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P0C091.2); Region: CSPG 8" misc_feature 3862..4215 /gene="FREM3" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P0C091.2); Region: CSPG 9" misc_feature 4216..4554 /gene="FREM3" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P0C091.2); Region: CSPG 10" misc_feature 4555..4908 /gene="FREM3" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P0C091.2); Region: CSPG 11" misc_feature 4909..5289 /gene="FREM3" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P0C091.2); Region: CSPG 12" misc_feature 5344..5586 /gene="FREM3" /note="Calx-beta domain; Region: Calx-beta; cl02522" /db_xref="CDD:207627" misc_feature 5656..5952 /gene="FREM3" /note="Calx-beta domain; Region: Calx-beta; cl02522" /db_xref="CDD:207627" misc_feature 6031..6315 /gene="FREM3" /note="Calx-beta domain; Region: Calx-beta; pfam03160" /db_xref="CDD:202559" exon 1..5185 /gene="FREM3" /inference="alignment:Splign:1.39.8" STS 4955..5119 /gene="FREM3" /standard_name="SHGC-59692" /db_xref="UniSTS:60676" exon 5186..5275 /gene="FREM3" /inference="alignment:Splign:1.39.8" exon 5276..5422 /gene="FREM3" /inference="alignment:Splign:1.39.8" exon 5423..5653 /gene="FREM3" /inference="alignment:Splign:1.39.8" exon 5654..5779 /gene="FREM3" /inference="alignment:Splign:1.39.8" exon 5780..6028 /gene="FREM3" /inference="alignment:Splign:1.39.8" exon 6029..6178 /gene="FREM3" /inference="alignment:Splign:1.39.8" exon 6179..6624 /gene="FREM3" /inference="alignment:Splign:1.39.8" variation 6416 /gene="FREM3" /replace="a" /replace="g" /db_xref="dbSNP:1497622" ORIGIN
atggcgggggcttctcggcacccgactgggacgccccggcagctccttgtggcgctcgcctgcctgctcttgagtcgccccgcgctgcagggacgggcatcctcacttgggaccgagcccgacccggcgctttacctgcccgcccggggtgcgcttgacggcactcgccccgacggccccagcgtgctgattgccaaccctggactccgggtgcccctgggtcgttccctttggctcgacccgctccgggatctggtgattggagtgcagccgggggaccggtgcgaagtcacggtactggacgccctgccgcggctcaagggcgcgctctccccgcgccgcttcccctgcaccttcgggccccgccaagtccagtacactcacttcggctcccacagccccggacgcgcccgggtgctgctgcagctgcgctacgacgccccgactcacactctggtgctgcccttcacgctggcggtggacttggtcttctcccagctggagctggtgacgcgtaacaggcctttggtagtggagaagctgcgaagctggagccgcgccatagacaggagagtgctggacttcgcctccctgaagtctggagccacggccacccgcaggtgccggcttaccccacttcctcacgaggacggccccctgcccaagtacgggcgcttggtggacgcggtgggggcccctctccccaggggcaagggcgtagactgtgaggctttcctccgtgctggggtgcgctatcagcacacagccacctcctcgcccaaccgtgactacgtgcccatgatggtggagctgctggggcctgagggccaagacgctgggtccgcgggtgtgctggtccgcgagcacttccagctgctcgtgaggatccgcggcggagccgagaacacaccgcccaggcccagcttcatggccacgatgatgatggaggtggatccactggtgctgacagccctgacgcctgacgcactggccgcggaggacgtcgagtcagaccctggtgacctggtgttcaacattctgaacgcccccactcacccaccagggcacccggggcaacagggctacgtggtcagcaccgacgaccctctagggcttccagtctccttcttcacccagcaggagctgagggagctgaagattgcctatcagccccctgcagagaactcccatggggagcgcctctttcagctggagctggaggtggtggacggagacggcgccgcctcagacccctttgccttcatggtgacagtgaaatccatgaatactctggtcccagtggctagccataacaggggacttgtgctttttgaaggtcagtcaaggcccttgtccagcacccacagcattcctatcagtgataaagataacctggaagaggtgaaaatggctgcagtcaggggcttgagacatgggcagctggtggtgtttggggcacctgctgggtgcaagtatttcacaccagcggacctggcagcagggcgagtggtgtatcagcatgatggcagcaacacctacagtgacaatatcatcttccggatggaggacgggcaccaccaagtggacttcctctttcccctcaccatcctacctgtggatgatgaaccaccaatggtcaatactaacacaggactctcactcactgaagggcaggtggtccagatctctccctttgtactgagtgctactgatattgactctgaggactcaaccatccactttgtgctggagaaccagcccctaaaaggaaatgaggaagagcctcagtgggagttggcccctggttcctcccactcaggccactacctgggggacctgttgctgcagcaggctgaactacctctctcaactgaagatgaagactggcactacatggaaaaggaagggctttatgagaaagtggtgactgagtggctacagagagacataatggaagggagactcttctaccgccatcttggaccacacagccctcaatctgtaatggtccagctggctttccatgtgcaggatgaccatgacccacccaatctctccaaacagcacattttcaccatcaaggtccaaccagtggatatactgagtccacagctgtatccaggaactacactagaaatgactgtacaagaataccaactcactcacttccagaagaatttcctccgatacattgaccaggactctgatgaccagaacctatggtacaccctactgacactcccgactgacacagatggcaaccaccaagtccgggctggagaaattgtgctcactgattcaccagacacactcatcatgcactttacccaagcccaggtaaatcagcataaagttgcctaccagcctccacagaaattgggtattgcaccacgggttgtgcagtttacttaccaggtggaagatgctgcaggcaatagcgtgccaggcacattcacattattcctgcaacctgtggacaaccagcccccagaagtcaccaacagaggctttgctatcttagagggaggcagctttaacctcagcagtaatgagctgcatgttacagacccagacacagacattgaccaaattgtcttcatattagtccggggtccccaacatggacacttgcagtactttaaaagatgtatggtcccaggggaatctttcatgcaagctgatgttattaacgggagtgtctcttaccagcatggcagagaccagacgactaccagtgacactttccatctggaagtaagtgatggggtgcaccatatacccatcaccatcccaatttctgtgcatcccaatgtggctaacagaagtcctaggatctctctcagaagtagttcattattggatgtttctatagacgtactagagaataaagccactgaaattaccatgggtgtcatccatggcaaaaggaaggatgtaggtgacttgatgctgtctttcattgtaaaggacagccccaaactgggcactattctggtaaatggtttgcccacagaacgattcacccaagaggatctcatcaatgggagagtagcctatgcccacactgcaggtgaagttggttttcaaaagcagcacgatgccttcagcctcatcctctccaaagattcttaccaatgggtagtggggaatagcataatagagaaagtacaggtacaagtaactgtgctgcctgtggacaatgtgggacccaaggtcttcgtcggggagtccttcattgtctatgaaggtgagaagaactccttgaccttacaacatctccatgttgaagatgtggacactcatcaagatgaactcctctgcacagtgactagtcagccagcctctggctacctggaaaagattgcatcagctcctggttcaaaaatgtcccagtctggtagccctatcagtgctttctccctcagagatatccaagtgaggcatatcaattatgtacagagtattcacaagggagtagagccacaagaggaccaattcaccttttattgctctgatggcatcaacttctccccaaatgtcttcttccctataatcatcctacccaccaatgatgagcagcctaaactttttgcccatgagtttaaggtactagaggggatgagcctggtcatagacacccagctgcttaatggagcagatgctgacctgccaccaaatgagctccactttcaactcacagccctccctcggcatggacgaatcatacagcagctggctacaggcagccagcccatccacagcttcaccctcaaggagatccaggaggcctccaccattgtgtatgagcatgatgactcagagacaaaagaggacagttttgaggtctggctgagtgacggcaagcacacaacccacaggaaggtacccattgtagtgaccctagtggatgatgaaactcctcacctgactgtcaacaatgggctgaaggtagagaaaggacactctgagatcatcacaaatcggatcctcaaggccacagatcttgactcagatgataaaagcctcagttttgtcctccattctgggcctcaacaagggcttctacagaggctgagaaaacccagaggagaagtgaggaacaatcttactctgggaatgaactttacccaggatgagattaacagaggcctcatctgctatatccacacaggccaagaagggattgttgacattatcaagtttgatgttactgatggggttaacactttgacagaccactacttctatgtcaccattggcaacttagacagcgtcttccctgaggtaatcagcaaaaggatcaccttgatagaaggtgccagagtgacccttaccaacaatctgcttaccaacagtgacatcaacagctctgatgaacatcactttagcattacacgggctccaagcctgggtcacttagaaagttctgactatgctggggaacccattgcctctttcactcaacttcaattggctagcaacaaaatatcctatgtccatacttcaaatgatgagaaaaagatggacagcttcgaatttcaagtgatcggcgaactctaccctgtgttcagaaccttcaggatcttcatcactgatgtggataataagaaacctatcttgaccatccatagactaacactacagaaagaggatagccaactgatcactctccttgagttgacagtggaagacagtgataccccagatgaccttattctctttaccatcacccaggtccccatgcatggcaagattttgtacaatggtagccgtcccgtgaccactttcaccaagcaagacctgaacaagaacctgattagctacaagcatgacggcagtgagaccactgaagatagtttctccttgactgtgacagacggcactcacactgatttctatgtcctaccagacactgccctggcgacacacaaacctcaagtaatgagggtccagataagatcattagacaataggcttccccagattactaccaacaggggtgccccagccttgaagcgccttcacactggacacatgggcttcctgattaccagcaagtctctgaaggcagaagatcaggacagtccccacaggcttctgaagtataaagtgaccagaggaccagagcatggcttcattatcaaaactggccttggaaaccagagcactcgagtgtttacacaagctgacattgatgagatgaagatatcctatgtcttgaatgagggcagcaacgcatcaaaggacatcttctatttctctgttgaagacaatggaggaaataaactaacaaatcagcctttccatctaaactgggcttggatttgtttggagaaagagtactacattgtggatgaagattccacattcttagaagtgacccttacacgcagaggataccttggagaaacatcatttatcagcattggtaccaaagatgaaactgcaaaaaaagacaaagatttcaaatggaagaccaataaacagatccagttcaatcctggacagactacagccacatggagggtgagaattatacctgacaatgaatatgagacttcagagaccttccagatcattctgtctgaacctctcatggctgtactggagtttccagaaatggcaacggttgaaattgtagaccctggagatgaatcaacagtttatattccagaggcggaatacaaaatagaagaggacattggggaacttttgattccagtaagacgatctggagatgcaagccaggaactaatcgtcatttgctccacacgtcaaggttctgccacaggcacgatttcttccacagtgttattctctgattacatctcacgtccagaagaccacaccagcatcctccactttgacaagaatgagacacagaagacctgccaggtcctgatcattgatgactccctttatgaagaggaggaatccttcagcgtttcacttaggctgccagtgggaggacagctgggagccagattccccaccactaaggtgactattctggctgatcgttatgatgaacctgtcctgcactttggggatgctgaatatcacgtcaatgaaagtgctcgctacgtggaggtttgtgtttggagaagaggcactgatctttcccaaccatcatccatcgccgtgcgctccagaaagtcagagcaggagtcagcagaagctggaacagattatgttggtatcagccgaaacctggactttgctccaggcgtgcgcatgcagacattccaagtgaccatccttgatgacctgggacagcctaccttggaaggcccagagaagtttgaattacttcttcagatgcctatgggtgcagtgcttggagaaccaaataaaactaccattttcatcgaggacaccatcacggactgtaagcagagtgcttgtagttcctttgattgaaagactttaagagggaaaaaaacagccaagatatgtctcctaacaacagaatgaaactctactgtttatagatcttagcaattctgggatatcagtgatattgtactgtcattggtgttatattctggtgatatgtggaaatgtaatttatatgactgcatggagatagaaatatatatacctagaaaacattgagcccacaaaaaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:166752 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA GeneID:166752 -> Biological process: GO:0007154 [cell communication] evidence: IEA GeneID:166752 -> Biological process: GO:0007155 [cell adhesion] evidence: IEA GeneID:166752 -> Cellular component: GO:0005604 [basement membrane] evidence: IEA GeneID:166752 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA GeneID:166752 -> Cellular component: GO:0031012 [extracellular matrix] evidence: TAS
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