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2024-03-29 07:13:31, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001168235            6643 bp    mRNA    linear   PRI 07-OCT-2012
DEFINITION  Homo sapiens FRAS1 related extracellular matrix 3 (FREM3), mRNA.
ACCESSION   NM_001168235 XM_001127662 XM_001720656 XM_094074
VERSION     NM_001168235.1  GI:270265870
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6643)
  AUTHORS   Shi,C., Zhang,K., Wang,X., Shen,Y. and Xu,Q.
  TITLE     A study of the combined effects of the EHD3 and FREM3 genes in
            patients with major depressive disorder
  JOURNAL   Am. J. Med. Genet. B Neuropsychiatr. Genet. 159B (3), 336-342
            (2012)
   PUBMED   22337703
  REMARK    GeneRIF: The combined effect of the EHD3 and FREM3 genes may play
            an important role in developing major depressive disorder.
REFERENCE   2  (bases 1 to 6643)
  AUTHORS   Smyth,I., Du,X., Taylor,M.S., Justice,M.J., Beutler,B. and
            Jackson,I.J.
  TITLE     The extracellular matrix gene Frem1 is essential for the normal
            adhesion of the embryonic epidermis
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (37), 13560-13565 (2004)
   PUBMED   15345741
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139713.1, AW953229.1, DN831271.1, AI184955.1, DR731220.1,
            DR007885.1, BE223071.1 and R44783.1.
            On or before Dec 5, 2009 this sequence version replaced
            gi:169166903, gi:169167210, gi:169166333.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4867              AC139713.1         154821-159687       c
            4868-5470           AW953229.1         11-613
            5471-5840           DN831271.1         110-479
            5841-6028           AI184955.1         141-328             c
            6029-6124           DR731220.1         1-96                c
            6125-6230           DR007885.1         39-144
            6231-6600           BE223071.1         132-501             c
            6601-6643           R44783.1           1-43                c
FEATURES             Location/Qualifiers
     source          1..6643
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..6643
                     /gene="FREM3"
                     /note="FRAS1 related extracellular matrix 3"
                     /db_xref="GeneID:166752"
                     /db_xref="HGNC:25172"
                     /db_xref="MIM:608946"
     CDS             1..6420
                     /gene="FREM3"
                     /note="FRAS1-related extracellular matrix protein 3"
                     /codon_start=1
                     /product="FRAS1-related extracellular matrix protein 3
                     precursor"
                     /protein_id="NP_001161707.1"
                     /db_xref="GI:270265871"
                     /db_xref="CCDS:CCDS54808.1"
                     /db_xref="GeneID:166752"
                     /db_xref="HGNC:25172"
                     /db_xref="MIM:608946"
                     /translation="
MAGASRHPTGTPRQLLVALACLLLSRPALQGRASSLGTEPDPALYLPARGALDGTRPDGPSVLIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLDALPRLKGALSPRRFPCTFGPRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEKLRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDGPLPKYGRLVDAVGAPLPRGKGVDCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEGQDAGSAGVLVREHFQLLVRIRGGAENTPPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQGYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDNLEEVKMAAVRGLRHGQLVVFGAPAGCKYFTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQVNQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVFVGESFIVYEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGARVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRLTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLISYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYVLNEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQIILSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLLQMPMGAVLGEPNKTTIFIEDTITDCKQSACSSFD
"
     sig_peptide     1..90
                     /gene="FREM3"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     91..6417
                     /gene="FREM3"
                     /product="FRAS1-related extracellular matrix protein 3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C091.2)"
     misc_feature    853..1239
                     /gene="FREM3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C091.2);
                     Region: CSPG 1"
     misc_feature    1240..1572
                     /gene="FREM3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C091.2);
                     Region: CSPG 2"
     misc_feature    1573..2049
                     /gene="FREM3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C091.2);
                     Region: CSPG 3"
     misc_feature    2050..2433
                     /gene="FREM3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C091.2);
                     Region: CSPG 4"
     misc_feature    2434..2766
                     /gene="FREM3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C091.2);
                     Region: CSPG 5"
     misc_feature    2767..3165
                     /gene="FREM3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C091.2);
                     Region: CSPG 6"
     misc_feature    3166..3522
                     /gene="FREM3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C091.2);
                     Region: CSPG 7"
     misc_feature    3523..3861
                     /gene="FREM3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C091.2);
                     Region: CSPG 8"
     misc_feature    3862..4215
                     /gene="FREM3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C091.2);
                     Region: CSPG 9"
     misc_feature    4216..4554
                     /gene="FREM3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C091.2);
                     Region: CSPG 10"
     misc_feature    4555..4908
                     /gene="FREM3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C091.2);
                     Region: CSPG 11"
     misc_feature    4909..5289
                     /gene="FREM3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C091.2);
                     Region: CSPG 12"
     misc_feature    5344..5586
                     /gene="FREM3"
                     /note="Calx-beta domain; Region: Calx-beta; cl02522"
                     /db_xref="CDD:207627"
     misc_feature    5656..5952
                     /gene="FREM3"
                     /note="Calx-beta domain; Region: Calx-beta; cl02522"
                     /db_xref="CDD:207627"
     misc_feature    6031..6315
                     /gene="FREM3"
                     /note="Calx-beta domain; Region: Calx-beta; pfam03160"
                     /db_xref="CDD:202559"
     exon            1..5185
                     /gene="FREM3"
                     /inference="alignment:Splign:1.39.8"
     STS             4955..5119
                     /gene="FREM3"
                     /standard_name="SHGC-59692"
                     /db_xref="UniSTS:60676"
     exon            5186..5275
                     /gene="FREM3"
                     /inference="alignment:Splign:1.39.8"
     exon            5276..5422
                     /gene="FREM3"
                     /inference="alignment:Splign:1.39.8"
     exon            5423..5653
                     /gene="FREM3"
                     /inference="alignment:Splign:1.39.8"
     exon            5654..5779
                     /gene="FREM3"
                     /inference="alignment:Splign:1.39.8"
     exon            5780..6028
                     /gene="FREM3"
                     /inference="alignment:Splign:1.39.8"
     exon            6029..6178
                     /gene="FREM3"
                     /inference="alignment:Splign:1.39.8"
     exon            6179..6624
                     /gene="FREM3"
                     /inference="alignment:Splign:1.39.8"
     variation       6416
                     /gene="FREM3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1497622"
ORIGIN      
atggcgggggcttctcggcacccgactgggacgccccggcagctccttgtggcgctcgcctgcctgctcttgagtcgccccgcgctgcagggacgggcatcctcacttgggaccgagcccgacccggcgctttacctgcccgcccggggtgcgcttgacggcactcgccccgacggccccagcgtgctgattgccaaccctggactccgggtgcccctgggtcgttccctttggctcgacccgctccgggatctggtgattggagtgcagccgggggaccggtgcgaagtcacggtactggacgccctgccgcggctcaagggcgcgctctccccgcgccgcttcccctgcaccttcgggccccgccaagtccagtacactcacttcggctcccacagccccggacgcgcccgggtgctgctgcagctgcgctacgacgccccgactcacactctggtgctgcccttcacgctggcggtggacttggtcttctcccagctggagctggtgacgcgtaacaggcctttggtagtggagaagctgcgaagctggagccgcgccatagacaggagagtgctggacttcgcctccctgaagtctggagccacggccacccgcaggtgccggcttaccccacttcctcacgaggacggccccctgcccaagtacgggcgcttggtggacgcggtgggggcccctctccccaggggcaagggcgtagactgtgaggctttcctccgtgctggggtgcgctatcagcacacagccacctcctcgcccaaccgtgactacgtgcccatgatggtggagctgctggggcctgagggccaagacgctgggtccgcgggtgtgctggtccgcgagcacttccagctgctcgtgaggatccgcggcggagccgagaacacaccgcccaggcccagcttcatggccacgatgatgatggaggtggatccactggtgctgacagccctgacgcctgacgcactggccgcggaggacgtcgagtcagaccctggtgacctggtgttcaacattctgaacgcccccactcacccaccagggcacccggggcaacagggctacgtggtcagcaccgacgaccctctagggcttccagtctccttcttcacccagcaggagctgagggagctgaagattgcctatcagccccctgcagagaactcccatggggagcgcctctttcagctggagctggaggtggtggacggagacggcgccgcctcagacccctttgccttcatggtgacagtgaaatccatgaatactctggtcccagtggctagccataacaggggacttgtgctttttgaaggtcagtcaaggcccttgtccagcacccacagcattcctatcagtgataaagataacctggaagaggtgaaaatggctgcagtcaggggcttgagacatgggcagctggtggtgtttggggcacctgctgggtgcaagtatttcacaccagcggacctggcagcagggcgagtggtgtatcagcatgatggcagcaacacctacagtgacaatatcatcttccggatggaggacgggcaccaccaagtggacttcctctttcccctcaccatcctacctgtggatgatgaaccaccaatggtcaatactaacacaggactctcactcactgaagggcaggtggtccagatctctccctttgtactgagtgctactgatattgactctgaggactcaaccatccactttgtgctggagaaccagcccctaaaaggaaatgaggaagagcctcagtgggagttggcccctggttcctcccactcaggccactacctgggggacctgttgctgcagcaggctgaactacctctctcaactgaagatgaagactggcactacatggaaaaggaagggctttatgagaaagtggtgactgagtggctacagagagacataatggaagggagactcttctaccgccatcttggaccacacagccctcaatctgtaatggtccagctggctttccatgtgcaggatgaccatgacccacccaatctctccaaacagcacattttcaccatcaaggtccaaccagtggatatactgagtccacagctgtatccaggaactacactagaaatgactgtacaagaataccaactcactcacttccagaagaatttcctccgatacattgaccaggactctgatgaccagaacctatggtacaccctactgacactcccgactgacacagatggcaaccaccaagtccgggctggagaaattgtgctcactgattcaccagacacactcatcatgcactttacccaagcccaggtaaatcagcataaagttgcctaccagcctccacagaaattgggtattgcaccacgggttgtgcagtttacttaccaggtggaagatgctgcaggcaatagcgtgccaggcacattcacattattcctgcaacctgtggacaaccagcccccagaagtcaccaacagaggctttgctatcttagagggaggcagctttaacctcagcagtaatgagctgcatgttacagacccagacacagacattgaccaaattgtcttcatattagtccggggtccccaacatggacacttgcagtactttaaaagatgtatggtcccaggggaatctttcatgcaagctgatgttattaacgggagtgtctcttaccagcatggcagagaccagacgactaccagtgacactttccatctggaagtaagtgatggggtgcaccatatacccatcaccatcccaatttctgtgcatcccaatgtggctaacagaagtcctaggatctctctcagaagtagttcattattggatgtttctatagacgtactagagaataaagccactgaaattaccatgggtgtcatccatggcaaaaggaaggatgtaggtgacttgatgctgtctttcattgtaaaggacagccccaaactgggcactattctggtaaatggtttgcccacagaacgattcacccaagaggatctcatcaatgggagagtagcctatgcccacactgcaggtgaagttggttttcaaaagcagcacgatgccttcagcctcatcctctccaaagattcttaccaatgggtagtggggaatagcataatagagaaagtacaggtacaagtaactgtgctgcctgtggacaatgtgggacccaaggtcttcgtcggggagtccttcattgtctatgaaggtgagaagaactccttgaccttacaacatctccatgttgaagatgtggacactcatcaagatgaactcctctgcacagtgactagtcagccagcctctggctacctggaaaagattgcatcagctcctggttcaaaaatgtcccagtctggtagccctatcagtgctttctccctcagagatatccaagtgaggcatatcaattatgtacagagtattcacaagggagtagagccacaagaggaccaattcaccttttattgctctgatggcatcaacttctccccaaatgtcttcttccctataatcatcctacccaccaatgatgagcagcctaaactttttgcccatgagtttaaggtactagaggggatgagcctggtcatagacacccagctgcttaatggagcagatgctgacctgccaccaaatgagctccactttcaactcacagccctccctcggcatggacgaatcatacagcagctggctacaggcagccagcccatccacagcttcaccctcaaggagatccaggaggcctccaccattgtgtatgagcatgatgactcagagacaaaagaggacagttttgaggtctggctgagtgacggcaagcacacaacccacaggaaggtacccattgtagtgaccctagtggatgatgaaactcctcacctgactgtcaacaatgggctgaaggtagagaaaggacactctgagatcatcacaaatcggatcctcaaggccacagatcttgactcagatgataaaagcctcagttttgtcctccattctgggcctcaacaagggcttctacagaggctgagaaaacccagaggagaagtgaggaacaatcttactctgggaatgaactttacccaggatgagattaacagaggcctcatctgctatatccacacaggccaagaagggattgttgacattatcaagtttgatgttactgatggggttaacactttgacagaccactacttctatgtcaccattggcaacttagacagcgtcttccctgaggtaatcagcaaaaggatcaccttgatagaaggtgccagagtgacccttaccaacaatctgcttaccaacagtgacatcaacagctctgatgaacatcactttagcattacacgggctccaagcctgggtcacttagaaagttctgactatgctggggaacccattgcctctttcactcaacttcaattggctagcaacaaaatatcctatgtccatacttcaaatgatgagaaaaagatggacagcttcgaatttcaagtgatcggcgaactctaccctgtgttcagaaccttcaggatcttcatcactgatgtggataataagaaacctatcttgaccatccatagactaacactacagaaagaggatagccaactgatcactctccttgagttgacagtggaagacagtgataccccagatgaccttattctctttaccatcacccaggtccccatgcatggcaagattttgtacaatggtagccgtcccgtgaccactttcaccaagcaagacctgaacaagaacctgattagctacaagcatgacggcagtgagaccactgaagatagtttctccttgactgtgacagacggcactcacactgatttctatgtcctaccagacactgccctggcgacacacaaacctcaagtaatgagggtccagataagatcattagacaataggcttccccagattactaccaacaggggtgccccagccttgaagcgccttcacactggacacatgggcttcctgattaccagcaagtctctgaaggcagaagatcaggacagtccccacaggcttctgaagtataaagtgaccagaggaccagagcatggcttcattatcaaaactggccttggaaaccagagcactcgagtgtttacacaagctgacattgatgagatgaagatatcctatgtcttgaatgagggcagcaacgcatcaaaggacatcttctatttctctgttgaagacaatggaggaaataaactaacaaatcagcctttccatctaaactgggcttggatttgtttggagaaagagtactacattgtggatgaagattccacattcttagaagtgacccttacacgcagaggataccttggagaaacatcatttatcagcattggtaccaaagatgaaactgcaaaaaaagacaaagatttcaaatggaagaccaataaacagatccagttcaatcctggacagactacagccacatggagggtgagaattatacctgacaatgaatatgagacttcagagaccttccagatcattctgtctgaacctctcatggctgtactggagtttccagaaatggcaacggttgaaattgtagaccctggagatgaatcaacagtttatattccagaggcggaatacaaaatagaagaggacattggggaacttttgattccagtaagacgatctggagatgcaagccaggaactaatcgtcatttgctccacacgtcaaggttctgccacaggcacgatttcttccacagtgttattctctgattacatctcacgtccagaagaccacaccagcatcctccactttgacaagaatgagacacagaagacctgccaggtcctgatcattgatgactccctttatgaagaggaggaatccttcagcgtttcacttaggctgccagtgggaggacagctgggagccagattccccaccactaaggtgactattctggctgatcgttatgatgaacctgtcctgcactttggggatgctgaatatcacgtcaatgaaagtgctcgctacgtggaggtttgtgtttggagaagaggcactgatctttcccaaccatcatccatcgccgtgcgctccagaaagtcagagcaggagtcagcagaagctggaacagattatgttggtatcagccgaaacctggactttgctccaggcgtgcgcatgcagacattccaagtgaccatccttgatgacctgggacagcctaccttggaaggcccagagaagtttgaattacttcttcagatgcctatgggtgcagtgcttggagaaccaaataaaactaccattttcatcgaggacaccatcacggactgtaagcagagtgcttgtagttcctttgattgaaagactttaagagggaaaaaaacagccaagatatgtctcctaacaacagaatgaaactctactgtttatagatcttagcaattctgggatatcagtgatattgtactgtcattggtgttatattctggtgatatgtggaaatgtaatttatatgactgcatggagatagaaatatatatacctagaaaacattgagcccacaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:166752 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:166752 -> Biological process: GO:0007154 [cell communication] evidence: IEA
            GeneID:166752 -> Biological process: GO:0007155 [cell adhesion] evidence: IEA
            GeneID:166752 -> Cellular component: GO:0005604 [basement membrane] evidence: IEA
            GeneID:166752 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
            GeneID:166752 -> Cellular component: GO:0031012 [extracellular matrix] evidence: TAS

by @meso_cacase at DBCLS
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