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2024-04-26 07:56:11, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001166105 1678 bp mRNA linear PRI 14-JUL-2013
DEFINITION Homo sapiens transcriptional adaptor 2A (TADA2A), transcript
variant 3, mRNA.
ACCESSION NM_001166105
VERSION NM_001166105.1 GI:260656021
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1678)
AUTHORS Pharoah PD, Tsai YY, Ramus SJ, Phelan CM, Goode EL, Lawrenson K,
Buckley M, Fridley BL, Tyrer JP, Shen H, Weber R, Karevan R, Larson
MC, Song H, Tessier DC, Bacot F, Vincent D, Cunningham JM, Dennis
J, Dicks E, Aben KK, Anton-Culver H, Antonenkova N, Armasu SM,
Baglietto L, Bandera EV, Beckmann MW, Birrer MJ, Bloom G, Bogdanova
N, Brenton JD, Brinton LA, Brooks-Wilson A, Brown R, Butzow R,
Campbell I, Carney ME, Carvalho RS, Chang-Claude J, Chen YA, Chen
Z, Chow WH, Cicek MS, Coetzee G, Cook LS, Cramer DW, Cybulski C,
Dansonka-Mieszkowska A, Despierre E, Doherty JA, Dork T, du Bois A,
Durst M, Eccles D, Edwards R, Ekici AB, Fasching PA, Fenstermacher
D, Flanagan J, Gao YT, Garcia-Closas M, Gentry-Maharaj A, Giles G,
Gjyshi A, Gore M, Gronwald J, Guo Q, Halle MK, Harter P, Hein A,
Heitz F, Hillemanns P, Hoatlin M, Hogdall E, Hogdall CK, Hosono S,
Jakubowska A, Jensen A, Kalli KR, Karlan BY, Kelemen LE, Kiemeney
LA, Kjaer SK, Konecny GE, Krakstad C, Kupryjanczyk J, Lambrechts D,
Lambrechts S, Le ND, Lee N, Lee J, Leminen A, Lim BK, Lissowska J,
Lubinski J, Lundvall L, Lurie G, Massuger LF, Matsuo K, McGuire V,
McLaughlin JR, Menon U, Modugno F, Moysich KB, Nakanishi T, Narod
SA, Ness RB, Nevanlinna H, Nickels S, Noushmehr H, Odunsi K, Olson
S, Orlow I, Paul J, Pejovic T, Pelttari LM, Permuth-Wey J, Pike MC,
Poole EM, Qu X, Risch HA, Rodriguez-Rodriguez L, Rossing MA,
Rudolph A, Runnebaum I, Rzepecka IK, Salvesen HB, Schwaab I, Severi
G, Shen H, Shridhar V, Shu XO, Sieh W, Southey MC, Spellman P,
Tajima K, Teo SH, Terry KL, Thompson PJ, Timorek A, Tworoger SS,
van Altena AM, van den Berg D, Vergote I, Vierkant RA, Vitonis AF,
Wang-Gohrke S, Wentzensen N, Whittemore AS, Wik E, Winterhoff B,
Woo YL, Wu AH, Yang HP, Zheng W, Ziogas A, Zulkifli F, Goodman MT,
Hall P, Easton DF, Pearce CL, Berchuck A, Chenevix-Trench G,
Iversen E, Monteiro AN, Gayther SA, Schildkraut JM and Sellers TA.
CONSRTM Australian Cancer Study; Australian Ovarian Cancer Study Group
TITLE GWAS meta-analysis and replication identifies three new
susceptibility loci for ovarian cancer
JOURNAL Nat. Genet. 45 (4), 362-370 (2013)
PUBMED 23535730
REFERENCE 2 (bases 1 to 1678)
AUTHORS Huang,J., Zhang,L., Liu,W., Liao,Q., Shi,T., Xiao,L., Hu,F. and
Qiu,X.
TITLE CCDC134 interacts with hADA2a and functions as a regulator of
hADA2a in acetyltransferase activity, DNA damage-induced apoptosis
and cell cycle arrest
JOURNAL Histochem. Cell Biol. 138 (1), 41-55 (2012)
PUBMED 22644376
REMARK GeneRIF: CCDC134 increased the PCAF-dependent K320 acetylation of
p53 and p53 protein stability in the presence of hADA2a
overexpression.
REFERENCE 3 (bases 1 to 1678)
AUTHORS Ruano,G., Thompson,P.D., Kane,J.P., Pullinger,C.R., Windemuth,A.,
Seip,R.L., Kocherla,M., Holford,T.R. and Wu,A.H.
TITLE Physiogenomic analysis of statin-treated patients: domain-specific
counter effects within the ACACB gene on low-density lipoprotein
cholesterol?
JOURNAL Pharmacogenomics 11 (7), 959-971 (2010)
PUBMED 20602615
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 1678)
AUTHORS Yang,M., Waterman,M.L. and Brachmann,R.K.
TITLE hADA2a and hADA3 are required for acetylation, transcriptional
activity and proliferative effects of beta-catenin
JOURNAL Cancer Biol. Ther. 7 (1), 120-128 (2008)
PUBMED 18059173
REMARK GeneRIF: hADA2a and hADA3 as crucial cofactors of beta-catenin that
are likely involved in the assembly of transactivation-competent
beta-catenin complexes at Wnt target genes.
REFERENCE 5 (bases 1 to 1678)
AUTHORS Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z.,
Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S.,
McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J.,
Dunham,I., Hill,D.E. and Vidal,M.
TITLE hORFeome v3.1: a resource of human open reading frames representing
over 10,000 human genes
JOURNAL Genomics 89 (3), 307-315 (2007)
PUBMED 17207965
REFERENCE 6 (bases 1 to 1678)
AUTHORS Ogryzko,V.V., Kotani,T., Zhang,X., Schiltz,R.L., Howard,T.,
Yang,X.J., Howard,B.H., Qin,J. and Nakatani,Y.
TITLE Histone-like TAFs within the PCAF histone acetylase complex
JOURNAL Cell 94 (1), 35-44 (1998)
PUBMED 9674425
REFERENCE 7 (bases 1 to 1678)
AUTHORS Henriksson,A., Almlof,T., Ford,J., McEwan,I.J., Gustafsson,J.A. and
Wright,A.P.
TITLE Role of the Ada adaptor complex in gene activation by the
glucocorticoid receptor
JOURNAL Mol. Cell. Biol. 17 (6), 3065-3073 (1997)
PUBMED 9154805
REFERENCE 8 (bases 1 to 1678)
AUTHORS Carter,K.C., Wang,L., Shell,B.K., Zamir,I., Berger,S.L. and
Moore,P.A.
TITLE The human transcriptional adaptor genes TADA2L and GCN5L2
colocalize to chromosome 17q12-q21 and display a similar tissue
expression pattern
JOURNAL Genomics 40 (3), 497-500 (1997)
PUBMED 9073520
REFERENCE 9 (bases 1 to 1678)
AUTHORS Wang,L., Mizzen,C., Ying,C., Candau,R., Barlev,N., Brownell,J.,
Allis,C.D. and Berger,S.L.
TITLE Histone acetyltransferase activity is conserved between yeast and
human GCN5 and is required for complementation of growth and
transcriptional activation
JOURNAL Mol. Cell. Biol. 17 (1), 519-527 (1997)
PUBMED 8972232
REFERENCE 10 (bases 1 to 1678)
AUTHORS Candau,R., Moore,P.A., Wang,L., Barlev,N., Ying,C.Y., Rosen,C.A.
and Berger,S.L.
TITLE Identification of human proteins functionally conserved with the
yeast putative adaptors ADA2 and GCN5
JOURNAL Mol. Cell. Biol. 16 (2), 593-602 (1996)
PUBMED 8552087
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CD101741.1 and BC011753.2.
Summary: Many DNA-binding transcriptional activator proteins
enhance the initiation rate of RNA polymerase II-mediated gene
transcription by interacting functionally with the general
transcription machinery bound at the basal promoter. Adaptor
proteins are usually required for this activation, possibly to
acetylate and destabilize nucleosomes, thereby relieving chromatin
constraints at the promoter. The protein encoded by this gene is a
transcriptional activator adaptor and has been found to be part of
the PCAF histone acetylase complex. Several alternatively spliced
transcript variants encoding different isoforms of this gene have
been described, but the full-length nature of some of these
variants has not been determined. [provided by RefSeq, Oct 2009].
Transcript Variant: This variant (3) differs in the 5' UTR compared
to variant 1. Variants 1 and 3 both encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC011753.2, AF064094.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-659 CD101741.1 36-694
660-1678 BC011753.2 607-1625
FEATURES Location/Qualifiers
source 1..1678
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q12-q21"
gene 1..1678
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="transcriptional adaptor 2A"
/db_xref="GeneID:6871"
/db_xref="HGNC:11531"
/db_xref="MIM:602276"
exon 1..64
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 23
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="g"
/db_xref="dbSNP:111492708"
exon 65..186
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 118
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="g"
/db_xref="dbSNP:186419906"
variation 146
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="c"
/db_xref="dbSNP:17138766"
variation 147
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:140453764"
variation 154
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201818113"
misc_feature 156..158
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="upstream in-frame stop codon"
CDS 162..1493
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="isoform a is encoded by transcript variant 3;
transcriptional adaptor 2 alpha; transcriptional adapter
2-alpha; ADA2-like protein"
/codon_start=1
/product="transcriptional adapter 2-alpha isoform a"
/protein_id="NP_001159577.1"
/db_xref="GI:260656022"
/db_xref="CCDS:CCDS11319.1"
/db_xref="GeneID:6871"
/db_xref="HGNC:11531"
/db_xref="MIM:602276"
/translation="
MDRLGPFSNDPSDKPPCRGCSSYLMEPYIKCAECGPPPFFLCLQCFTRGFEYKKHQSDHTYEIMTSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHFINNPLFASTLLNLKQAEEAKTADTAIPFHSTDDPPRPTFDSLLSRDMAGYMPARADFIEEFDNYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKERQRRKKIIRDHGLINLRKFQLMERRYPKEVQDLYETMRRFARIVGPVEHDKFIESHALEFELRREIKRLQEYRTAGITNFCSARTYDHLKKTREEERLKRTMLSEVLQYIQDSSACQQWLRRQADIDSGLSPSIPMASNSGRRSAPPLNLTGLPGTEKLNEKEKELCQMVRLVPGAYLEYKSALLNECNKQGGLRLAQARALIKIDVNKTRKIYDFLIREGYITKG
"
misc_feature 204..353
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="Zinc finger, ZZ type. Zinc finger present in ADA2,
a putative transcriptional adaptor, and related proteins.
The ZZ motif coordinates two zinc ions and most likely
participates in ligand binding or molecular scaffolding;
Region: ZZ_ADA2; cd02335"
/db_xref="CDD:30239"
misc_feature order(210..212,219..221,252..254,261..263,285..287,
294..296,324..326,336..338)
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="Zinc-binding sites [ion binding]; other site"
/db_xref="CDD:30239"
misc_feature order(210..212,219..221,285..287,294..296)
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="zinc cluster 1 [ion binding]; other site"
/db_xref="CDD:30239"
misc_feature order(213..215,243..245,249..251,273..275,279..281)
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="putative charged binding surface; other site"
/db_xref="CDD:30239"
misc_feature 243..1481
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="Histone acetyltransferase complex SAGA/ADA, subunit
ADA2 [Chromatin structure and dynamics]; Region: COG5114"
/db_xref="CDD:34717"
misc_feature order(246..248,297..299,342..344,351..353)
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="putative hydrophobic binding surface; other site"
/db_xref="CDD:30239"
misc_feature order(252..254,261..263,324..326,336..338)
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="zinc cluster 2 [ion binding]; other site"
/db_xref="CDD:30239"
misc_feature 381..515
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
Tandem copies of the domain bind telomeric DNA tandem
repeatsas part of the capping complex. Binding is sequence
dependent for repeats which contain the G/C rich motif
[C2-3 A (CA)1-6]. The domain is...; Region: SANT; cd00167"
/db_xref="CDD:29107"
misc_feature order(384..386,474..479,483..488,492..500,504..512)
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:29107"
misc_feature 1257..1481
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/note="SWIRM domain; Region: SWIRM; pfam04433"
/db_xref="CDD:203011"
variation 169
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:374991405"
variation 170
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:369370248"
variation 177
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:7211875"
variation 179
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace=""
/replace="c"
/db_xref="dbSNP:112855394"
exon 187..293
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 194
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:138178971"
variation 212
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:370683055"
variation 213
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="c"
/db_xref="dbSNP:143836210"
variation 214
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:200118946"
exon 294..353
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 337
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:374099682"
variation 338
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:368270238"
variation 344
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:372228881"
exon 354..445
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 360
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:141037954"
variation 379
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:147950347"
variation 392
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:368442122"
variation 403
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="g"
/replace="t"
/db_xref="dbSNP:369092308"
exon 446..603
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 460
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:148703392"
variation 473
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="g"
/db_xref="dbSNP:373018253"
variation 479
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="g"
/db_xref="dbSNP:186965965"
variation 484
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="t"
/db_xref="dbSNP:147234139"
variation 504
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:1054865"
variation 510
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:17849432"
variation 571
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:187764026"
variation 585
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="c"
/db_xref="dbSNP:78395792"
variation 594
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:34408045"
exon 604..692
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 608
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:199556759"
variation 620
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:143700497"
variation 676
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:374860776"
variation 692
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="g"
/db_xref="dbSNP:377490313"
exon 693..765
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 705
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:375889975"
variation 707
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:144064854"
variation 709
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:367698801"
variation 752
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:148661084"
variation 763
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:142136696"
exon 766..829
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 823
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:367602386"
exon 830..873
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 834
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:150744923"
variation 873
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="t"
/db_xref="dbSNP:371661972"
exon 874..984
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 877
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:184173195"
variation 886
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:376421675"
variation 904
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201607716"
variation 911
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:139151064"
variation 964
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:143994775"
variation 981
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:188630265"
exon 985..1056
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 1010
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:376616299"
exon 1057..1189
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 1063
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:377297752"
variation 1067
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="g"
/db_xref="dbSNP:35001882"
variation 1090
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:200169209"
variation 1102
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:146413054"
variation 1107
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="c"
/db_xref="dbSNP:142392695"
variation 1177
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:149845906"
exon 1190..1233
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 1200
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:145834935"
variation 1214
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="g"
/replace="t"
/db_xref="dbSNP:2522969"
variation 1225
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:117373044"
variation 1231
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="g"
/db_xref="dbSNP:375609348"
exon 1234..1307
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 1240
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:369901141"
variation 1247
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="c"
/db_xref="dbSNP:143738207"
variation 1286
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:150499579"
variation 1293..1294
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace=""
/replace="a"
/db_xref="dbSNP:36089271"
exon 1308..1632
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/inference="alignment:Splign:1.39.8"
variation 1364
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:370986458"
variation 1387
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:373768236"
variation 1396
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:186687337"
variation 1403
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:148115672"
variation 1409
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:142394717"
variation 1479
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:376913298"
variation 1492
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:80260728"
variation 1506
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="t"
/db_xref="dbSNP:370551134"
variation 1514
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:192676041"
variation 1540
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201449135"
variation 1562
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
/replace="c"
/replace="g"
/db_xref="dbSNP:376358646"
polyA_site 1632
/gene="TADA2A"
/gene_synonym="ADA2; ADA2A; hADA2; KL04P; TADA2L"
ORIGIN
acgcaaagcccggaggcgcgcgcgaccggcggctctttggcgcggattagggggtctcggcgagggagtcatcaagctttggtgtatgtgttggccggttctgaagtcttgaagaagctctgctgaggaagaccaaagcagcactcgttgccaattagggaatggaccgtttgggtccctttagcaatgatccctctgataagccaccttgccgaggctgctcctcctacctcatggagccttatatcaagtgtgctgaatgtgggccacctccttttttcctctgcttgcagtgtttcactcgaggctttgagtacaagaaacatcaaagcgatcatacttatgaaataatgacttcagattttcctgtccttgatcccagctggactgctcaagaagaaatggcccttttagaagctgtgatggactgtggctttggaaattggcaggatgtagccaatcaaatgtgcaccaagaccaaggaggagtgtgagaagcactatatgaagcatttcatcaataaccctctgtttgcatctaccctgctgaacctgaaacaagcagaggaagcaaaaactgctgacacagccattccatttcactctacagatgaccctccccgacctacctttgactccttgctttctcgggacatggccgggtacatgccagctcgagcagatttcattgaggaatttgacaattatgcagaatgggacttgagagacattgattttgttgaagatgactcggacattttacatgctctgaagatggctgtggtagatatctatcattccaggttaaaggagagacaaagacgaaaaaaaattataagagaccatggattaatcaaccttagaaagtttcaattaatggaacggcggtatcccaaggaggtccaggacctgtatgaaacaatgaggcgatttgcaagaattgtggggccagtggaacatgacaaattcattgaaagccatgcattggaatttgaactccgaagggaaatcaagaggctccaagaatacaggacagcaggcattaccaatttttgtagtgccagaacctacgatcacctcaagaagacacgggaggaagagcgccttaaacgcactatgctctcagaagttctccagtatatccaggacagtagtgcttgccagcagtggctccgccggcaagctgacattgattccggcctgagtccttccattccaatggcttcgaattcaggtagacggagtgcaccacccttgaacctcactggcctccctggcacagagaagctgaatgaaaaagaaaaggagctctgtcagatggtgaggttggtccctggagcctatttagaatacaaatctgctctattgaacgaatgtaacaagcaaggaggcttaagactggcgcaggcaagagcactcatcaagatagatgtgaacaaaacccggaaaatctatgatttcctcatcagagaaggatacatcactaaaggctaaggctccaagagcttgggatcagaagtcagaagtttggaatgtggtgggtcaaaggacaatatgggtgggcattctggagagttgtttttcagctgaattctcatggtgaaaacaggggaaaggacaaaggaaaccttaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6871 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:6871 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
GeneID:6871 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: TAS
GeneID:6871 -> Molecular function: GO:0003712 [transcription cofactor activity] evidence: TAS
GeneID:6871 -> Molecular function: GO:0004402 [histone acetyltransferase activity] evidence: IDA
GeneID:6871 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:6871 -> Biological process: GO:0001932 [regulation of protein phosphorylation] evidence: IEA
GeneID:6871 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: TAS
GeneID:6871 -> Biological process: GO:0007067 [mitosis] evidence: IEA
GeneID:6871 -> Biological process: GO:0031063 [regulation of histone deacetylation] evidence: IEA
GeneID:6871 -> Biological process: GO:0031647 [regulation of protein stability] evidence: IEA
GeneID:6871 -> Biological process: GO:0043966 [histone H3 acetylation] evidence: IDA
GeneID:6871 -> Biological process: GO:0090043 [regulation of tubulin deacetylation] evidence: IEA
GeneID:6871 -> Cellular component: GO:0000125 [PCAF complex] evidence: IDA
GeneID:6871 -> Cellular component: GO:0005634 [nucleus] evidence: TAS
GeneID:6871 -> Cellular component: GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex] evidence: IEA
GeneID:6871 -> Cellular component: GO:0005694 [chromosome] evidence: IEA
GeneID:6871 -> Cellular component: GO:0072686 [mitotic spindle] evidence: IEA
by
@meso_cacase at
DBCLS
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