2024-04-18 19:14:01, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001165975 3107 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens phosphodiesterase 1B, calmodulin-dependent (PDE1B), transcript variant 2, mRNA. ACCESSION NM_001165975 VERSION NM_001165975.2 GI:342187232 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3107) AUTHORS Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V., Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S. CONSRTM DREAM investigators TITLE Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study JOURNAL Diabetes Care 33 (10), 2250-2253 (2010) PUBMED 20628086 REMARK GeneRIF: Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) REFERENCE 2 (bases 1 to 3107) AUTHORS Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C., Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R., Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A., Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C., Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S., Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N., Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D. CONSRTM ASCOT investigators; NORDIL investigators; BRIGHT Consortium TITLE Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip JOURNAL Am. J. Hum. Genet. 85 (5), 628-642 (2009) PUBMED 19913121 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 3 (bases 1 to 3107) AUTHORS Vandeput,F., Wolda,S.L., Krall,J., Hambleton,R., Uher,L., McCaw,K.N., Radwanski,P.B., Florio,V. and Movsesian,M.A. TITLE Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes JOURNAL J. Biol. Chem. 282 (45), 32749-32757 (2007) PUBMED 17726023 REFERENCE 4 (bases 1 to 3107) AUTHORS Bender,A.T. and Beavo,J.A. TITLE PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte JOURNAL Proc. Natl. Acad. Sci. U.S.A. 103 (2), 460-465 (2006) PUBMED 16407168 REMARK GeneRIF: PDE1B2 regulates a subset of phenotypic changes that occur upon phorbol-12-myristate-13-acetate-induced differentiation and likely also plays a role in differentiated macrophages by regulating agonist-stimulated cGMP levels REFERENCE 5 (bases 1 to 3107) AUTHORS Bender,A.T., Ostenson,C.L., Wang,E.H. and Beavo,J.A. TITLE Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation JOURNAL Proc. Natl. Acad. Sci. U.S.A. 102 (2), 497-502 (2005) PUBMED 15625104 REMARK GeneRIF: Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation. REFERENCE 6 (bases 1 to 3107) AUTHORS Yu,J., Wolda,S.L., Frazier,A.L., Florio,V.A., Martins,T.J., Snyder,P.B., Harris,E.A., McCaw,K.N., Farrell,C.A., Steiner,B., Bentley,J.K., Beavo,J.A., Ferguson,K. and Gelinas,R. TITLE Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1 JOURNAL Cell. Signal. 9 (7), 519-529 (1997) PUBMED 9419816 REFERENCE 7 (bases 1 to 3107) AUTHORS Spence,S., Rena,G., Sullivan,M., Erdogan,S. and Houslay,M.D. TITLE Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase JOURNAL Biochem. J. 321 (PT 1), 157-163 (1997) PUBMED 9003415 REFERENCE 8 (bases 1 to 3107) AUTHORS Jiang,X., Li,J., Paskind,M. and Epstein,P.M. TITLE Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (20), 11236-11241 (1996) PUBMED 8855339 REFERENCE 9 (bases 1 to 3107) AUTHORS Loughney,K., Martins,T.J., Harris,E.A., Sadhu,K., Hicks,J.B., Sonnenburg,W.K., Beavo,J.A. and Ferguson,K. TITLE Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases JOURNAL J. Biol. Chem. 271 (2), 796-806 (1996) PUBMED 8557689 REFERENCE 10 (bases 1 to 3107) AUTHORS Repaske,D.R., Swinnen,J.V., Jin,S.L., Van Wyk,J.J. and Conti,M. TITLE A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase JOURNAL J. Biol. Chem. 267 (26), 18683-18688 (1992) PUBMED 1326532 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX538092.1, BP342896.1 and BC032226.1. On Jul 30, 2011 this sequence version replaced gi:260166686. Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]. Transcript Variant: This variant (2) contains an alternate 5' terminal exon (with an AUG codon) compared to variant 1. This results in a shorter isoform (2) with a distinct N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ401609.1, AK302931.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025084 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-96 BX538092.1 1-96 97-605 BP342896.1 76-584 606-2364 BX538092.1 509-2267 2365-3107 BC032226.1 2450-3192 FEATURES Location/Qualifiers source 1..3107 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="12" /map="12q13" gene 1..3107 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /note="phosphodiesterase 1B, calmodulin-dependent" /db_xref="GeneID:5153" /db_xref="HGNC:8775" /db_xref="MIM:171891" exon 1..194 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 97 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:10747699" variation 101 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:376202872" variation 129 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:111971905" CDS 142..1692 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /EC_number="3.1.4.17" /note="isoform 2 is encoded by transcript variant 2; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B; calmodulin-stimulated phosphodiesterase PDE1B1; cam-PDE 1B; 63 kDa Cam-PDE" /codon_start=1 /product="calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 2" /protein_id="NP_001159447.1" /db_xref="GI:260166687" /db_xref="CCDS:CCDS53800.1" /db_xref="GeneID:5153" /db_xref="HGNC:8775" /db_xref="MIM:171891" /translation="
MANPVPVQRSHLQGPILRLRYMVKQLENGEINIEELKKNLEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD
" misc_feature 310..492 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /note="3'5'-cyclic nucleotide phosphodiesterase N-terminal; Region: PDEase_I_N; pfam08499" /db_xref="CDD:203961" misc_feature 745..1440 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /note="3'5'-cyclic nucleotide phosphodiesterase; Region: PDEase_I; pfam00233" /db_xref="CDD:109297" variation 163 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:199827682" exon 195..308 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 199 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:147900601" variation 200 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:374027304" variation 202 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:61733023" variation 205 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:139920915" variation 232 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:376974140" variation 273 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="t" /db_xref="dbSNP:2887906" variation 289 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:200096201" variation 307 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:373781937" exon 309..491 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 323 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:371717266" variation 374 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:142799171" variation 375 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:372746803" variation 421 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:374242340" variation 434 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="t" /db_xref="dbSNP:377170220" variation 483 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:151025806" exon 492..558 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 500 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:376631753" variation 540 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:369117826" variation 551 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:373914778" variation 558 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:140892078" exon 559..675 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 565 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:112699956" variation 596 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="c" /db_xref="dbSNP:11615709" variation 666 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:377445884" exon 676..816 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" STS 706..896 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /standard_name="MARC_21181-21182:1027091922:1" /db_xref="UniSTS:268504" variation 742 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="c" /db_xref="dbSNP:150159795" variation 747 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:146735076" variation 762 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:115951482" variation 776 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:200815928" variation 802 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:145391059" exon 817..917 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 827 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:137936270" variation 828 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:113265707" variation 833 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:373565313" variation 850 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="t" /db_xref="dbSNP:143034173" variation 855 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:376805586" variation 873 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:148185581" variation 885 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:115481291" exon 918..1043 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 932 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="t" /db_xref="dbSNP:375085069" variation 960 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:12812036" variation 962 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="t" /db_xref="dbSNP:12811532" variation 1018 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:201756814" variation 1020 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:150688398" variation 1027 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="c" /replace="t" /db_xref="dbSNP:12811737" exon 1044..1145 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 1104 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="g" /db_xref="dbSNP:139284651" variation 1129 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:200839405" variation 1131 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:199536319" exon 1146..1266 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 1262 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="g" /replace="t" /db_xref="dbSNP:143206355" exon 1267..1348 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" exon 1349..1457 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 1350 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="g" /replace="t" /db_xref="dbSNP:147497085" variation 1357 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:372439210" variation 1408 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="c" /db_xref="dbSNP:376262595" variation 1424 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:147477377" variation 1440 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="g" /db_xref="dbSNP:150000693" variation 1443 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="g" /replace="t" /db_xref="dbSNP:148673155" exon 1458..1588 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 1469 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:148711763" variation 1487 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="g" /replace="t" /db_xref="dbSNP:142239113" variation 1526 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:202001120" variation 1557 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:1249950" variation 1573 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:140368041" variation 1584 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="c" /db_xref="dbSNP:200779298" exon 1589..1709 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" variation 1592 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="t" /db_xref="dbSNP:183676395" variation 1595 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="c" /db_xref="dbSNP:144100250" variation 1599 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:146475493" variation 1625 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="g" /db_xref="dbSNP:371822951" variation 1636 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:140787002" variation 1656 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:150107941" exon 1710..3089 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /inference="alignment:Splign:1.39.8" STS 1710..2548 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /standard_name="PDE1B_3295" /db_xref="UniSTS:462390" variation 1886..1887 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="" /replace="t" /db_xref="dbSNP:35108378" variation 1890 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:372424493" variation 1921..1922 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="" /replace="t" /db_xref="dbSNP:34320482" variation 1940 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:376600771" variation 2051 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:143775746" STS 2061..2347 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /standard_name="SHGC-148605" /db_xref="UniSTS:176493" variation 2260 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:11170978" variation 2275 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="" /replace="g" /db_xref="dbSNP:5798310" variation 2343 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:371896018" variation 2365 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:884510" variation 2592 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:191560225" variation 2631 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:76676851" variation 2665 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:1249499" variation 2673 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:148127859" variation 2688 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="g" /db_xref="dbSNP:183626030" variation 2702 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:1144996" STS 2740..2927 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /standard_name="RH78688" /db_xref="UniSTS:48654" variation 2746 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:111571643" STS 2882..3071 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /standard_name="A007D03" /db_xref="UniSTS:80815" variation 2908 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:144107699" variation 2909 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="g" /db_xref="dbSNP:10783631" variation 2984..2985 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="" /replace="c" /db_xref="dbSNP:71444859" variation 3014 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="c" /replace="t" /db_xref="dbSNP:189001857" variation 3058 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" /replace="a" /replace="c" /replace="t" /db_xref="dbSNP:3825195" polyA_signal 3070..3075 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" polyA_site 3089 /gene="PDE1B" /gene_synonym="PDE1B1; PDES1B" ORIGIN
gttctctctggtcagttgctcagttctactgggacctggaggaggaaggcaggggccaaagaggaagttgtcccctcttgggggccctggggctcctggggtcaggattttgatactctgaagcaggaaactttgattcccatggcaaaccctgttcctgttcagaggagccacctccagggccccattctcaggctgcgctacatggtgaagcagttggagaatggggagataaacattgaggagctgaagaaaaatctggagtacacagcttctctgctggaagccgtctacatagatgagacacggcaaatcttggacacggaggacgagctgcaggagctgcggtcagatgccgtgccttcggaggtgcgggactggctggcctccaccttcacccagcaggcccgggccaaaggccgccgagcagaggagaagcccaagttccgaagcattgtgcacgctgtgcaggctgggatcttcgtggaacggatgttccggagaacatacacctctgtgggccccacttactctactgcggttctcaactgtctcaagaacctggatctctggtgctttgatgtcttttccttgaaccaggcagcagatgaccatgccctgaggaccattgtttttgagttgctgactcggcataacctcatcagccgcttcaagattcccactgtgtttttgatgagtttcctggatgccttggagacaggctatgggaagtacaagaatccttaccacaaccagatccacgcagccgatgttacccagacagtccattgcttcttgctccgcacagggatggtgcactgcctgtcggagattgagctcctggccatcatctttgctgcagctatccatgattatgagcacacgggcactaccaacagcttccacatccagaccaagtcagaatgtgccatcgtgtacaatgatcgttcagtgctggagaatcaccacatcagctctgttttccgattgatgcaggatgatgagatgaacattttcatcaacctcaccaaggatgagtttgtagaactccgagccctggtcattgagatggtgttggccacagacatgtcctgccatttccagcaagtgaagaccatgaagacagccttgcaacagctggagaggattgacaagcccaaggccctgtctctactgctccatgctgctgacatcagccacccaaccaagcagtggttggtccacagccgttggaccaaggccctcatggaggaattcttccgtcagggtgacaaggaggcagagttgggcctgcccttttctccactctgtgaccgcacttccactctagtggcacagtctcagatagggttcatcgacttcattgtggagcccacattctctgtgctgactgacgtggcagagaagagtgttcagcccctggcggatgaggactccaagtctaaaaaccagcccagctttcagtggcgccagccctctctggatgtggaagtgggagaccccaaccctgatgtggtcagctttcgttccacctgggtcaagcgcattcaggagaataagcagaaatggaaggaacgggcagcaagtggcatcaccaaccagatgtccattgacgagctgtccccctgtgaagaagaggcccccccatcccctgccgaagatgaacacaaccagaatgggaatctggattagccctggggctggcccaggtcttcattgagtccaaagtgtttgatgtcatcagcaccatccatcaggactggctcccccatctgctccaagggagcgtggtcgtggaagaaacaacccacctgaaggccaaatgccagagatttggggttggggaaagggcccctccccacctgacacccactggggtgcactttaatgttccggcagcaagactggggaacttcaggctcccagtggtcactgtgcccatccctcagcctctggattctcttcatggccaggtggctgccagggagcggggagcttcctggaggcttcccagggccttggggaagggtcagagatgccagccccctgggacctcccccatcctttttgcctccaagtttctaagcaatacattttgggggttccctcagccccccaccccagatcttagctggcaggtctgggtgccccttttcctcccctgggaagggctggaataggatagaaagctgggggttttcagagccctatgtgtggggaggggagtggattccttcagggcatggtacctttctaggacctgggaatggggtggagaggacatcctcttcaccccagaattgcgctgcttcagccccatctccagcctgatcctctgaatcttccttccctccctttctgatacagtgactggggcaaaaggagccattgtgaccaggggctgcgggaggcctttcctgggaccttccttgggactggtctgggcccctggggcttgtcgcctgccctgagtccggagccctttgcctccttcctctcccctggggctgggaggctccatccgaccaatgtctgtaaagtgctttgaggatctccccagcaaagcaccttcagaatgtatcgacaccagctgggttagggtcaagggtgcctggggagggtgagtaatcctgcattgctaaaagagagggtctgtcccctcctctccacgtcccagaactggcccagctgcaggcactaagaagctcctcccctgagacaagtgaggggtagtcggtgaaaggcagatggacaaggggctcagggctgctgccttcctgtcctctggagagaacccagccaggcgcggtgccccttcctctcctcaggctcctccttgcccccaccttgccccaggaaaggccaaagtccaggtgactgccctccttctttcttgtaaataccaaccatgcatttgtacagtgggccctgttcatgcgaaatccacatccatggtctcctagacctgctaccctggtacttccaccctaccccaccccgagaagggcagagacgcatgtgactcacccctgcccttggtttcccagacccctgctatagccagagaacaataaagaagggagaccaggaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:5153 -> Molecular function: GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] evidence: IEA GeneID:5153 -> Molecular function: GO:0004117 [calmodulin-dependent cyclic-nucleotide phosphodiesterase activity] evidence: TAS GeneID:5153 -> Molecular function: GO:0005516 [calmodulin binding] evidence: IEA GeneID:5153 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA GeneID:5153 -> Molecular function: GO:0048101 [calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity] evidence: IEA GeneID:5153 -> Biological process: GO:0001505 [regulation of neurotransmitter levels] evidence: IEA GeneID:5153 -> Biological process: GO:0001975 [response to amphetamine] evidence: IEA GeneID:5153 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IDA GeneID:5153 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:5153 -> Biological process: GO:0007165 [signal transduction] evidence: TAS GeneID:5153 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS GeneID:5153 -> Biological process: GO:0007202 [activation of phospholipase C activity] evidence: TAS GeneID:5153 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS GeneID:5153 -> Biological process: GO:0007626 [locomotory behavior] evidence: IEA GeneID:5153 -> Biological process: GO:0008542 [visual learning] evidence: IEA GeneID:5153 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS GeneID:5153 -> Biological process: GO:0030224 [monocyte differentiation] evidence: IEP GeneID:5153 -> Biological process: GO:0036006 [cellular response to macrophage colony-stimulating factor stimulus] evidence: IDA GeneID:5153 -> Biological process: GO:0042053 [regulation of dopamine metabolic process] evidence: IEA GeneID:5153 -> Biological process: GO:0042428 [serotonin metabolic process] evidence: IEA GeneID:5153 -> Biological process: GO:0045087 [innate immune response] evidence: TAS GeneID:5153 -> Biological process: GO:0046069 [cGMP catabolic process] evidence: IDA GeneID:5153 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS GeneID:5153 -> Biological process: GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus] evidence: IDA GeneID:5153 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:5153 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA GeneID:5153 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:5153 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:5153 -> Cellular component: GO:0043025 [neuronal cell body] evidence: IEA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001159447 -> EC 3.1.4.17
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