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2024-03-28 17:40:50, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001165923            2773 bp    mRNA    linear   PRI 14-JUL-2013
DEFINITION  Homo sapiens HNF1 homeobox B (HNF1B), transcript variant 2, mRNA.
ACCESSION   NM_001165923
VERSION     NM_001165923.1  GI:260064064
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2773)
  AUTHORS   Pharoah PD, Tsai YY, Ramus SJ, Phelan CM, Goode EL, Lawrenson K,
            Buckley M, Fridley BL, Tyrer JP, Shen H, Weber R, Karevan R, Larson
            MC, Song H, Tessier DC, Bacot F, Vincent D, Cunningham JM, Dennis
            J, Dicks E, Aben KK, Anton-Culver H, Antonenkova N, Armasu SM,
            Baglietto L, Bandera EV, Beckmann MW, Birrer MJ, Bloom G, Bogdanova
            N, Brenton JD, Brinton LA, Brooks-Wilson A, Brown R, Butzow R,
            Campbell I, Carney ME, Carvalho RS, Chang-Claude J, Chen YA, Chen
            Z, Chow WH, Cicek MS, Coetzee G, Cook LS, Cramer DW, Cybulski C,
            Dansonka-Mieszkowska A, Despierre E, Doherty JA, Dork T, du Bois A,
            Durst M, Eccles D, Edwards R, Ekici AB, Fasching PA, Fenstermacher
            D, Flanagan J, Gao YT, Garcia-Closas M, Gentry-Maharaj A, Giles G,
            Gjyshi A, Gore M, Gronwald J, Guo Q, Halle MK, Harter P, Hein A,
            Heitz F, Hillemanns P, Hoatlin M, Hogdall E, Hogdall CK, Hosono S,
            Jakubowska A, Jensen A, Kalli KR, Karlan BY, Kelemen LE, Kiemeney
            LA, Kjaer SK, Konecny GE, Krakstad C, Kupryjanczyk J, Lambrechts D,
            Lambrechts S, Le ND, Lee N, Lee J, Leminen A, Lim BK, Lissowska J,
            Lubinski J, Lundvall L, Lurie G, Massuger LF, Matsuo K, McGuire V,
            McLaughlin JR, Menon U, Modugno F, Moysich KB, Nakanishi T, Narod
            SA, Ness RB, Nevanlinna H, Nickels S, Noushmehr H, Odunsi K, Olson
            S, Orlow I, Paul J, Pejovic T, Pelttari LM, Permuth-Wey J, Pike MC,
            Poole EM, Qu X, Risch HA, Rodriguez-Rodriguez L, Rossing MA,
            Rudolph A, Runnebaum I, Rzepecka IK, Salvesen HB, Schwaab I, Severi
            G, Shen H, Shridhar V, Shu XO, Sieh W, Southey MC, Spellman P,
            Tajima K, Teo SH, Terry KL, Thompson PJ, Timorek A, Tworoger SS,
            van Altena AM, van den Berg D, Vergote I, Vierkant RA, Vitonis AF,
            Wang-Gohrke S, Wentzensen N, Whittemore AS, Wik E, Winterhoff B,
            Woo YL, Wu AH, Yang HP, Zheng W, Ziogas A, Zulkifli F, Goodman MT,
            Hall P, Easton DF, Pearce CL, Berchuck A, Chenevix-Trench G,
            Iversen E, Monteiro AN, Gayther SA, Schildkraut JM and Sellers TA.
  CONSRTM   Australian Cancer Study; Australian Ovarian Cancer Study Group
  TITLE     GWAS meta-analysis and replication identifies three new
            susceptibility loci for ovarian cancer
  JOURNAL   Nat. Genet. 45 (4), 362-370 (2013)
   PUBMED   23535730
REFERENCE   2  (bases 1 to 2773)
  AUTHORS   Li H, Gan W, Lu L, Dong X, Han X, Hu C, Yang Z, Sun L, Bao W, Li P,
            He M, Sun L, Wang Y, Zhu J, Ning Q, Tang Y, Zhang R, Wen J, Wang D,
            Zhu X, Guo K, Zuo X, Guo X, Yang H, Zhou X, Zhang X, Qi L, Loos RJ,
            Hu FB, Wu T, Liu Y, Liu L, Yang Z, Hu R, Jia W, Ji L, Li Y and Lin
            X.
  CONSRTM   DIAGRAM Consortium; AGEN-T2D Consortium
  TITLE     A genome-wide association study identifies GRK5 and RASGRP1 as type
            2 diabetes loci in Chinese Hans
  JOURNAL   Diabetes 62 (1), 291-298 (2013)
   PUBMED   22961080
REFERENCE   3  (bases 1 to 2773)
  AUTHORS   Machiela,M.J., Lindstrom,S., Allen,N.E., Haiman,C.A., Albanes,D.,
            Barricarte,A., Berndt,S.I., Bueno-de-Mesquita,H.B., Chanock,S.,
            Gaziano,J.M., Gapstur,S.M., Giovannucci,E., Henderson,B.E.,
            Jacobs,E.J., Kolonel,L.N., Krogh,V., Ma,J., Stampfer,M.J.,
            Stevens,V.L., Stram,D.O., Tjonneland,A., Travis,R., Willett,W.C.,
            Hunter,D.J., Le Marchand,L. and Kraft,P.
  TITLE     Association of type 2 diabetes susceptibility variants with
            advanced prostate cancer risk in the Breast and Prostate Cancer
            Cohort Consortium
  JOURNAL   Am. J. Epidemiol. 176 (12), 1121-1129 (2012)
   PUBMED   23193118
  REMARK    GeneRIF: No evidence that diabetes mediates the association of the
            HNF1B locus with prostate cancer risk from a mediation analysis of
            9,065 prostate cancer cases and 9,526 controls.
REFERENCE   4  (bases 1 to 2773)
  AUTHORS   Zhang,X., Qiao,H., Zhao,Y., Wang,X., Sun,H., Liu,A., Xu,L., Sun,D.,
            Jin,Y., Yu,Y., Meng,X., Bai,J., Chen,F. and Fu,S.
  TITLE     Association of single nucleotide polymorphisms in TCF2 with type 2
            diabetes susceptibility in a Han Chinese population
  JOURNAL   PLoS ONE 7 (12), E52938 (2012)
   PUBMED   23300827
  REMARK    GeneRIF: Our findings suggested that TCF2 variants may be involved
            in type 2 diabetes risk in a Han population of northeastern China.
REFERENCE   5  (bases 1 to 2773)
  AUTHORS   Maestro,M.A., Cardalda,C., Boj,S.F., Luco,R.F., Servitja,J.M. and
            Ferrer,J.
  TITLE     Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating
            pancreas development, beta-cell function and growth
  JOURNAL   Endocr Dev 12, 33-45 (2007)
   PUBMED   17923767
  REMARK    GeneRIF: Findings implicate HNF1beta as a regulator of pancreas
            organogenesis and differentiation. [REVIEW]
            Review article
REFERENCE   6  (bases 1 to 2773)
  AUTHORS   Senkel,S., Lucas,B., Klein-Hitpass,L. and Ryffel,G.U.
  TITLE     Identification of target genes of the transcription factor HNF1beta
            and HNF1alpha in a human embryonic kidney cell line
  JOURNAL   Biochim. Biophys. Acta 1731 (3), 179-190 (2005)
   PUBMED   16297991
  REMARK    GeneRIF: we propose that HNF1beta overexpression in the ovarian
            cancer participates in the altered expression pattern
REFERENCE   7  (bases 1 to 2773)
  AUTHORS   Horikawa,Y., Iwasaki,N., Hara,M., Furuta,H., Hinokio,Y.,
            Cockburn,B.N., Lindner,T., Yamagata,K., Ogata,M., Tomonaga,O.,
            Kuroki,H., Kasahara,T., Iwamoto,Y. and Bell,G.I.
  TITLE     Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated
            with MODY
  JOURNAL   Nat. Genet. 17 (4), 384-385 (1997)
   PUBMED   9398836
REFERENCE   8  (bases 1 to 2773)
  AUTHORS   Bach,I., Mattei,M.G., Cereghini,S. and Yaniv,M.
  TITLE     Two members of an HNF1 homeoprotein family are expressed in human
            liver
  JOURNAL   Nucleic Acids Res. 19 (13), 3553-3559 (1991)
   PUBMED   1677179
REFERENCE   9  (bases 1 to 2773)
  AUTHORS   Mendel,D.B., Hansen,L.P., Graves,M.K., Conley,P.B. and
            Crabtree,G.R.
  TITLE     HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo
            domains, but not activation domains, and form heterodimers in vitro
  JOURNAL   Genes Dev. 5 (6), 1042-1056 (1991)
   PUBMED   2044952
REFERENCE   10 (bases 1 to 2773)
  AUTHORS   Abbott,C., Piaggio,G., Ammendola,R., Solomon,E., Povey,S.,
            Gounari,F., De Simone,V. and Cortese,R.
  TITLE     Mapping of the gene TCF2 coding for the transcription factor LFB3
            to human chromosome 17 by polymerase chain reaction
  JOURNAL   Genomics 8 (1), 165-167 (1990)
   PUBMED   2081590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC340648.1, AK296633.1,
            AC091199.6 and BC017714.1.
            
            Summary: This gene encodes a member of the homeodomain-containing
            superfamily of transcription factors. The protein binds to DNA as
            either a homodimer, or a heterodimer with the related protein
            hepatocyte nuclear factor 1-alpha. The gene has been shown to
            function in nephron development, and regulates development of the
            embryonic pancreas. Mutations in this gene result in renal cysts
            and diabetes syndrome and noninsulin-dependent diabetes mellitus,
            and expression of this gene is altered in some types of cancer.
            Multiple transcript variants encoding different isoforms have been
            found for this gene.[provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1.
            The resulting isoform (2) lacks an internal segment, compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK296633.1, HM116553.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                DC340648.1         1-46
            47-2017             AK296633.1         1-1971
            2018-2261           AC091199.6         29629-29872
            2262-2773           BC017714.1         2307-2818
FEATURES             Location/Qualifiers
     source          1..2773
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..2773
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /note="HNF1 homeobox B"
                     /db_xref="GeneID:6928"
                     /db_xref="HGNC:11630"
                     /db_xref="MIM:189907"
     exon            1..565
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    150..152
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /note="upstream in-frame stop codon"
     CDS             222..1817
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     hepatocyte nuclear factor 1-beta; transcription factor 2,
                     hepatic; HNF1 beta A; HNF-1-beta; homeoprotein LFB3"
                     /codon_start=1
                     /product="hepatocyte nuclear factor 1-beta isoform 2"
                     /protein_id="NP_001159395.1"
                     /db_xref="GI:260064065"
                     /db_xref="CCDS:CCDS58538.1"
                     /db_xref="GeneID:6928"
                     /db_xref="HGNC:11630"
                     /db_xref="MIM:189907"
                     /translation="
MVSKLTSLQQELLSALLSSGVTKEVLVQALEELLPSPNFGVKLETLPLSPGSGAEPDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPPILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREILRQFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSGVRYSQQGNNEITSSSTISHHGNSAMVTSQSVLQQVSPASLDPGHNLLSPDGKMISVSGGGLPPVSTLTNIHSLSHHNPQQSQNLIMTPLSGVMAIAQSLNTSQAQSVPVINSVAGSLAALQPVQFSQQLHSPHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEPPQYSHTSRFPSAMVVTDTSSISTLTNMSSSKQCPLQAW
"
     misc_feature    222..767
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /note="Hepatocyte nuclear factor 1 (HNF-1), N terminus;
                     Region: HNF-1_N; pfam04814"
                     /db_xref="CDD:147128"
     misc_feature    837..1055
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cl00084"
                     /db_xref="CDD:206827"
     misc_feature    1083..1751
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /note="Hepatocyte nuclear factor 1 (HNF-1), beta isoform C
                     terminus; Region: HNF-1B_C; pfam04812"
                     /db_xref="CDD:191099"
     STS             481..1200
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /standard_name="Hnf1b"
                     /db_xref="UniSTS:506980"
     exon            566..765
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /inference="alignment:Splign:1.39.8"
     STS             742..942
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /standard_name="Hnf1b"
                     /db_xref="UniSTS:545949"
     exon            766..952
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /inference="alignment:Splign:1.39.8"
     exon            953..1188
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /inference="alignment:Splign:1.39.8"
     exon            1189..1349
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /inference="alignment:Splign:1.39.8"
     exon            1350..1482
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /inference="alignment:Splign:1.39.8"
     exon            1483..1677
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /inference="alignment:Splign:1.39.8"
     exon            1678..1796
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /inference="alignment:Splign:1.39.8"
     exon            1797..2758
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /inference="alignment:Splign:1.39.8"
     variation       1916
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2229295"
     variation       1917
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1800929"
     STS             2027..2351
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /standard_name="WI-7310"
                     /db_xref="UniSTS:29648"
     STS             2046..2350
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /standard_name="G60393"
                     /db_xref="UniSTS:137499"
     STS             2080..2273
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /standard_name="TCF2"
                     /db_xref="UniSTS:480211"
     variation       2091
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:2689"
     variation       2201
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1058166"
     variation       2261
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2688"
     polyA_signal    2734..2739
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
     variation       2741
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:10962"
     polyA_site      2758
                     /gene="HNF1B"
                     /gene_synonym="FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3;
                     LFB3; MODY5; TCF-2; TCF2; VHNF1"
ORIGIN      
aatttgcatatcttatatggcctaatggtggcgatcatggcaagttagaagttttctgactcctttcggaggagcctccgggaccccggggagtaacaggtgtctggaggctgaagggtggaggggttcctggatttggggtttgcttgtgaaactcccctccaccctcctctctcgcacccacccaccccctcacccccttctttttccgtccttggaaaatggtgtccaagctcacgtcgctccagcaagaactcctgagcgccctgctgagctccggggtcaccaaggaggtgctggttcaggccttggaggagttgctgccatccccgaacttcggggtgaagctggagacgctgcccctgtcccctggcagcggggccgagcccgacaccaagccggtcttccatactctcaccaacggccacgccaagggccgcttgtccggcgacgagggctccgaggacggcgacgactatgacacacctcccatcctcaaggagctgcaggcgctcaacaccgaggaggcggcggagcagcgggcggaggtggaccggatgctcagtgaggacccttggagggctgctaaaatgatcaagggttacatgcagcaacacaacatcccccagagggaggtggtcgatgtcaccggcctgaaccagtcgcacctctcccagcatctcaacaagggcacccctatgaagacccagaagcgtgccgctctgtacacctggtacgtcagaaagcaacgagagatcctccgacagttcagtcaacagagccatgggcctgggcagtccgatgatgcctgctctgagcccaccaacaagaagatgcgccgcaaccggttcaaatgggggcccgcgtcccagcaaatcttgtaccaggcctacgatcggcaaaagaaccccagcaaggaagagagagaggccttagtggaggaatgcaacagggcagaatgtttgcagcgaggggtgtccccctccaaagcccacggcctgggctccaacttggtcactgaggtccgtgtctacaactggtttgcaaaccgcaggaaggaggaggcattccggcaaaagctggccatggacgcctatagctccaaccagactcacagcctgaaccctctgctctcccacggctccccccaccaccagcccagctcctctcctccaaacaagctgtcaggagtgcgctacagccagcagggaaacaatgagatcacttcctcctcaacaatcagtcaccatggcaacagcgccatggtgaccagccagtcggttttacagcaagtctccccagccagcctggacccaggccacaatctcctctcacctgatggtaaaatgatctcagtctcaggaggaggtttgcccccagtcagcaccttgacgaatatccacagcctctcccaccataatccccagcaatctcaaaacctcatcatgacacccctctctggagtcatggcaattgcacaaagcctcaacacctcccaagcacagagtgtccctgtcatcaacagtgtggccggcagcctggcagccctgcagcccgtccagttctcccagcagctgcacagccctcaccagcagcccctcatgcagcagagcccaggcagccacatggcccagcagcccttcatggcagctgtgactcagctgcagaactcacacatgtacgcacacaagcaggaacccccccagtattcccacacctcccggtttccatctgcaatggtggtcacagataccagcagcatcagtacactcaccaacatgtcttcaagtaaacagtgtcctctacaagcctggtgatgcccacacaccacttacttcgtgcgcaacaacaaggaccctgttttccacaccatcaccctctgggcagctgtcatggaaaagcccagtgacctgaccggcacctgcgagaggtccctgcttacctgacggacgtcctgctggcacctcagacaatccactctcaggaggcgcagcccgaagcccagtttcccttctatgcagtattgccacaatgcctctcccacgatgtcaaggactcctgtctgtcctggaggtgggagacaaggaaccaccgaagaggaagcaagaaagccgtactgtctatgttgtgatccttcatcgaacaaactgatgcgaaaacttgaatctgttactgaaatgaggagagaaggacatgtgctattgaactgagccaaacacactgtaaatatccacagactccctcccctgcccccatcccacatgatcttgagatttcttttaaagaagtaaatttgtccaatggctgtaaactataaactactgtaattaagtgcaatttcccctctgtgtcctctcccctctgccctgtatataatactaaagtgtctattagttttctttgtaaaggtcagagtcaaaatttcaaaagtgatctgtcccctctcccctcatggagaaacatcctaagtgggaagtgaagccccttgtcctctcccgcgggcctggacacttatggggacagcataccttggactgactaccagctaactccagtctcctgacattaagacacacctctggatccctggaggggctgaatgtagtgtgtcagagtaacatgccagcttcctgtgggccaggagctcagccgtgcactccctaagaaaccccagggcagggaaactggctgtttgatagcagaagaaaaagttgcagtctcagaaagccttccattaaaacaatttattttatcactaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:6928 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA
            GeneID:6928 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:6928 -> Molecular function: GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:6928 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:6928 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IEA
            GeneID:6928 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IPI
            GeneID:6928 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:6928 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: IEA
            GeneID:6928 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA
            GeneID:6928 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IEA
            GeneID:6928 -> Biological process: GO:0001714 [endodermal cell fate specification] evidence: IEA
            GeneID:6928 -> Biological process: GO:0001822 [kidney development] evidence: IDA
            GeneID:6928 -> Biological process: GO:0001822 [kidney development] evidence: IMP
            GeneID:6928 -> Biological process: GO:0001826 [inner cell mass cell differentiation] evidence: IEA
            GeneID:6928 -> Biological process: GO:0009749 [response to glucose stimulus] evidence: IEA
            GeneID:6928 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: IEA
            GeneID:6928 -> Biological process: GO:0030073 [insulin secretion] evidence: IEA
            GeneID:6928 -> Biological process: GO:0030111 [regulation of Wnt receptor signaling pathway] evidence: IEA
            GeneID:6928 -> Biological process: GO:0030902 [hindbrain development] evidence: IEA
            GeneID:6928 -> Biological process: GO:0031018 [endocrine pancreas development] evidence: IMP
            GeneID:6928 -> Biological process: GO:0031018 [endocrine pancreas development] evidence: TAS
            GeneID:6928 -> Biological process: GO:0035565 [regulation of pronephros size] evidence: IMP
            GeneID:6928 -> Biological process: GO:0039020 [pronephric nephron tubule development] evidence: IGI
            GeneID:6928 -> Biological process: GO:0042663 [regulation of endodermal cell fate specification] evidence: IEA
            GeneID:6928 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
            GeneID:6928 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:6928 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
            GeneID:6928 -> Biological process: GO:0048557 [embryonic digestive tract morphogenesis] evidence: IEA
            GeneID:6928 -> Biological process: GO:0048754 [branching morphogenesis of an epithelial tube] evidence: IEA
            GeneID:6928 -> Biological process: GO:0048793 [pronephros development] evidence: IMP
            GeneID:6928 -> Biological process: GO:0048806 [genitalia development] evidence: IMP
            GeneID:6928 -> Biological process: GO:0050673 [epithelial cell proliferation] evidence: IEA
            GeneID:6928 -> Biological process: GO:0060261 [positive regulation of transcription initiation from RNA polymerase II promoter] evidence: IDA
            GeneID:6928 -> Biological process: GO:0060677 [ureteric bud elongation] evidence: IEA
            GeneID:6928 -> Biological process: GO:0061017 [hepatoblast differentiation] evidence: IEA
            GeneID:6928 -> Biological process: GO:0072095 [regulation of branch elongation involved in ureteric bud branching] evidence: IEA
            GeneID:6928 -> Biological process: GO:0072181 [mesonephric duct formation] evidence: IEA
            GeneID:6928 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:6928 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
            GeneID:6928 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA

by @meso_cacase at DBCLS
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