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2024-04-16 19:11:57, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001165 6932 bp mRNA linear PRI 16-JUN-2013
DEFINITION Homo sapiens baculoviral IAP repeat containing 3 (BIRC3),
transcript variant 1, mRNA.
ACCESSION NM_001165
VERSION NM_001165.4 GI:342307084
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6932)
AUTHORS Rossi,D., Rasi,S., Spina,V., Bruscaggin,A., Monti,S., Ciardullo,C.,
Deambrogi,C., Khiabanian,H., Serra,R., Bertoni,F., Forconi,F.,
Laurenti,L., Marasca,R., Dal-Bo,M., Rossi,F.M., Bulian,P.,
Nomdedeu,J., Del Poeta,G., Gattei,V., Pasqualucci,L., Rabadan,R.,
Foa,R., Dalla-Favera,R. and Gaidano,G.
TITLE Integrated mutational and cytogenetic analysis identifies new
prognostic subgroups in chronic lymphocytic leukemia
JOURNAL Blood 121 (8), 1403-1412 (2013)
PUBMED 23243274
REMARK GeneRIF: Clonal evolution from lower to higher risk implicated the
emergence of NOTCH1, SF3B1, and BIRC3 abnormalities in addition to
TP53 and 11q22-q23 lesions in chronic lymphocytic leukemia.
REFERENCE 2 (bases 1 to 6932)
AUTHORS Lau,R., Niu,M.Y. and Pratt,M.A.
TITLE cIAP2 represses IKKalpha/beta-mediated activation of MDM2 to
prevent p53 degradation
JOURNAL Cell Cycle 11 (21), 4009-4019 (2012)
PUBMED 23032264
REMARK GeneRIF: A novel role for cIAP2 in maintaining wild-type p53 levels
by preventing both an NFkappaB-mediated increase and
IKKalpha/-beta-dependent transcriptional and post-translational
modifications of MDM2.
REFERENCE 3 (bases 1 to 6932)
AUTHORS Bi,M., Yang,D., Li,X., Zhong,K., Liu,Y., Li,G., Liao,X. and Liu,X.
TITLE [Association of cellular inhibitor of apoptosis protein-2
expression with clinical outcomes of hepatocellular carcinoma]
JOURNAL Nan Fang Yi Ke Da Xue Xue Bao 32 (7), 1020-1025 (2012)
PUBMED 22820591
REMARK GeneRIF: The expression of C-IAP2 in hepatocellular carcinoma is
associated with tumor recurrence and metastasis.
REFERENCE 4 (bases 1 to 6932)
AUTHORS Busca,A., Saxena,M. and Kumar,A.
TITLE Critical role for antiapoptotic Bcl-xL and Mcl-1 in human
macrophage survival and cellular IAP1/2 (cIAP1/2) in resistance to
HIV-Vpr-induced apoptosis
JOURNAL J. Biol. Chem. 287 (18), 15118-15133 (2012)
PUBMED 22403404
REMARK GeneRIF: resistance to Vpr-induced apoptosis is specifically
mediated by cIAP1/2 genes independent of Bcl-xL and Mcl-1, which
play a key role in maintaining cell viability.
REFERENCE 5 (bases 1 to 6932)
AUTHORS Varfolomeev,E., Goncharov,T., Maecker,H., Zobel,K., Komuves,L.G.,
Deshayes,K. and Vucic,D.
TITLE Cellular inhibitors of apoptosis are global regulators of NF-kappaB
and MAPK activation by members of the TNF family of receptors
JOURNAL Sci Signal 5 (216), RA22 (2012)
PUBMED 22434933
REMARK GeneRIF: c-IAP1 and c-IAP2 were required for canonical activation
of NF-B and MAPK by members of the TNFR family.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 6932)
AUTHORS Roy,N., Deveraux,Q.L., Takahashi,R., Salvesen,G.S. and Reed,J.C.
TITLE The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific
caspases
JOURNAL EMBO J. 16 (23), 6914-6925 (1997)
PUBMED 9384571
REFERENCE 7 (bases 1 to 6932)
AUTHORS Rajcan-Separovic,E., Liston,P., Lefebvre,C. and Korneluk,R.G.
TITLE Assignment of human inhibitor of apoptosis protein (IAP) genes
xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by
fluorescence in situ hybridization
JOURNAL Genomics 37 (3), 404-406 (1996)
PUBMED 8938457
REFERENCE 8 (bases 1 to 6932)
AUTHORS Uren,A.G., Pakusch,M., Hawkins,C.J., Puls,K.L. and Vaux,D.L.
TITLE Cloning and expression of apoptosis inhibitory protein homologs
that function to inhibit apoptosis and/or bind tumor necrosis
factor receptor-associated factors
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (10), 4974-4978 (1996)
PUBMED 8643514
REFERENCE 9 (bases 1 to 6932)
AUTHORS Liston,P., Roy,N., Tamai,K., Lefebvre,C., Baird,S.,
Cherton-Horvat,G., Farahani,R., McLean,M., Ikeda,J.E., MacKenzie,A.
and Korneluk,R.G.
TITLE Suppression of apoptosis in mammalian cells by NAIP and a related
family of IAP genes
JOURNAL Nature 379 (6563), 349-353 (1996)
PUBMED 8552191
REFERENCE 10 (bases 1 to 6932)
AUTHORS Rothe,M., Pan,M.G., Henzel,W.J., Ayres,T.M. and Goeddel,D.V.
TITLE The TNFR2-TRAF signaling complex contains two novel proteins
related to baculoviral inhibitor of apoptosis proteins
JOURNAL Cell 83 (7), 1243-1252 (1995)
PUBMED 8548810
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BG569841.1, AF070674.1,
BU428906.1, BX475964.1, U37546.1, BC037420.1, U45878.1, AI880555.1,
BE907592.1, BX415415.2, AA805622.1 and AA873008.1.
On Aug 2, 2011 this sequence version replaced gi:33946283.
Summary: This gene encodes a member of the IAP family of proteins
that inhibit apoptosis by binding to tumor necrosis factor
receptor-associated factors TRAF1 and TRAF2, probably by
interfering with activation of ICE-like proteases. The encoded
protein inhibits apoptosis induced by serum deprivation but does
not affect apoptosis resulting from exposure to menadione, a potent
inducer of free radicals. It contains 3 baculovirus IAP repeats and
a ring finger domain. Transcript variants encoding the same isoform
have been identified. [provided by RefSeq, Aug 2011].
Transcript Variant: This variant (1) represents the longer
transcript. Variants 1 and 2 encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF070674.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025083, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-45 BG569841.1 55-99
46-1089 AF070674.1 1-1044
1090-1357 AF070674.1 1046-1313
1358-1698 BU428906.1 20-360
1699-2125 BX475964.1 105-531
2126-3994 U37546.1 55-1923
3995-4627 BC037420.1 1336-1968
4628-4857 U45878.1 2281-2510
4858-5236 BC037420.1 2199-2577
5237-5640 AI880555.1 1-404 c
5641-5956 BE907592.1 250-565
5957-6689 BX415415.2 115-847 c
6690-6830 AA805622.1 11-151 c
6831-6932 AA873008.1 1-102 c
FEATURES Location/Qualifiers
source 1..6932
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q22"
gene 1..6932
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/note="baculoviral IAP repeat containing 3"
/db_xref="GeneID:330"
/db_xref="HGNC:591"
/db_xref="HPRD:03426"
/db_xref="MIM:601721"
exon 1..122
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/inference="alignment:Splign:1.39.8"
exon 123..3648
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/inference="alignment:Splign:1.39.8"
variation 129
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="c"
/db_xref="dbSNP:17878442"
variation 201
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:11558755"
variation 296
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:377068531"
variation 299
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:17880156"
variation 320
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:17885474"
variation 385
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:144117251"
variation 484
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:375905102"
variation 644
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:17882531"
variation 719
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:17884964"
variation 763
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="c"
/db_xref="dbSNP:192973907"
variation 764
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:184753031"
variation 821
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:145238414"
variation 882
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:369139094"
variation 922
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:188075699"
variation 966
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:191250382"
variation 1004
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:693746"
variation 1032
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="g"
/db_xref="dbSNP:17097648"
variation 1064
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace=""
/replace="a"
/replace="aa"
/db_xref="dbSNP:5794162"
variation 1089
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace=""
/replace="aa"
/replace="aaa"
/db_xref="dbSNP:56399203"
variation 1132
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:17879998"
variation 1135
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:11225208"
variation 1193
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="t"
/db_xref="dbSNP:17879707"
variation 1221..1222
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace=""
/replace="t"
/db_xref="dbSNP:17879484"
variation 1229
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace=""
/replace="t"
/db_xref="dbSNP:3834449"
variation 1234
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="g"
/replace="t"
/db_xref="dbSNP:78786418"
variation 1353
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:148750626"
variation 1408
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:183839272"
variation 1425
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="c"
/db_xref="dbSNP:17881122"
variation 1458
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:188457392"
variation 1461
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:181843916"
variation 1694..1695
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace=""
/replace="c"
/db_xref="dbSNP:35864208"
variation 1765
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="g"
/replace="t"
/db_xref="dbSNP:185682340"
variation 1772
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:190101178"
variation 2002
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="t"
/db_xref="dbSNP:373111989"
variation 2247
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:17885946"
variation 2251
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="g"
/replace="t"
/db_xref="dbSNP:77049382"
variation 2293
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="t"
/db_xref="dbSNP:142361708"
variation 2416
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:17885312"
variation 2488
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:376038375"
variation 2494
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:371507673"
STS 2499..2648
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/standard_name="SHGC-31347"
/db_xref="UniSTS:22678"
variation 2539..2540
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace=""
/replace="t"
/db_xref="dbSNP:373862803"
variation 2594
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:151238797"
variation 2639
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:1802410"
variation 2679
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:17882391"
variation 2685
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="t"
/db_xref="dbSNP:181803711"
variation 2703
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:141553919"
misc_feature 2766..2768
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/note="upstream in-frame stop codon"
variation 2768
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:377518449"
variation 2792
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="c"
/db_xref="dbSNP:373107755"
CDS 2796..4610
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/note="apoptosis inhibitor 2; baculoviral IAP
repeat-containing 3; TNFR2-TRAF signaling complex protein;
mammalian IAP homolog C; inhibitor of apoptosis protein 1;
IAP-1; RING finger protein 49; TNFR2-TRAF-signaling
complex protein 1"
/codon_start=1
/product="baculoviral IAP repeat-containing protein 3"
/protein_id="NP_001156.1"
/db_xref="GI:4502139"
/db_xref="CCDS:CCDS8315.1"
/db_xref="GeneID:330"
/db_xref="HGNC:591"
/db_xref="HPRD:03426"
/db_xref="MIM:601721"
/translation="
MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS
"
misc_feature 2880..3083
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q13489.2);
Region: BIR 1"
misc_feature 2889..3089
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/note="Baculoviral inhibition of apoptosis protein repeat
domain; Found in inhibitors of apoptosis proteins (IAPs)
and other proteins. In higher eukaryotes, BIR domains
inhibit apoptosis by acting as direct inhibitors of the
caspase family of protease enzymes; Region: BIR; cd00022"
/db_xref="CDD:28906"
misc_feature order(2967..2969,2982..2984,2988..2990,3009..3017,
3021..3023,3033..3035,3048..3050,3060..3065)
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/note="peptide binding groove; other site"
/db_xref="CDD:28906"
misc_feature order(2991..2993,3000..3002,3051..3053,3072..3074)
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/note="Zn2+ binding site [ion binding]; other site"
/db_xref="CDD:28906"
misc_feature 3300..3500
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q13489.2);
Region: BIR 2"
misc_feature 3306..3506
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/note="Baculoviral inhibition of apoptosis protein repeat
domain; Found in inhibitors of apoptosis proteins (IAPs)
and other proteins. In higher eukaryotes, BIR domains
inhibit apoptosis by acting as direct inhibitors of the
caspase family of protease enzymes; Region: BIR; cd00022"
/db_xref="CDD:28906"
misc_feature order(3384..3386,3399..3401,3405..3407,3426..3434,
3438..3440,3450..3452,3465..3467,3477..3482)
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/note="peptide binding groove; other site"
/db_xref="CDD:28906"
misc_feature order(3408..3410,3417..3419,3468..3470,3489..3491)
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/note="Zn2+ binding site [ion binding]; other site"
/db_xref="CDD:28906"
misc_feature 3558..3761
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q13489.2);
Region: BIR 3"
misc_feature 3561..3761
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/note="Baculoviral inhibition of apoptosis protein repeat
domain; Found in inhibitors of apoptosis proteins (IAPs)
and other proteins. In higher eukaryotes, BIR domains
inhibit apoptosis by acting as direct inhibitors of the
caspase family of protease enzymes; Region: BIR; cd00022"
/db_xref="CDD:28906"
misc_feature order(3645..3647,3660..3662,3666..3668,3687..3695,
3699..3701,3711..3713,3726..3728,3738..3743)
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/note="peptide binding groove; other site"
/db_xref="CDD:28906"
misc_feature order(3669..3671,3678..3680,3729..3731,3750..3752)
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/note="Zn2+ binding site [ion binding]; other site"
/db_xref="CDD:28906"
misc_feature 4116..4385
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/note="Caspase activation and recruitment domain found in
Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1)
and BIRC3 (c-IAP2); Region: CARD_BIRC2_BIRC3; cd08329"
/db_xref="CDD:176742"
misc_feature 4119..4124
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/experiment="experimental evidence, no additional details
recorded"
/note="Breakpoint for translocation to form BIRC3-MALT1;
propagated from UniProtKB/Swiss-Prot (Q13489.2); other
site"
misc_feature 4461..4580
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/note="RING-finger (Really Interesting New Gene) domain, a
specialized type of Zn-finger of 40 to 60 residues that
binds two atoms of zinc; defined by the 'cross-brace'
motif C-X2-C-X(9-39)-C-X(1-3)-
H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved
in...; Region: RING; cd00162"
/db_xref="CDD:29102"
misc_feature 4461..4574
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/note="Zinc finger, C3HC4 type (RING finger); Region:
zf-C3HC4_2; pfam13923"
/db_xref="CDD:206094"
misc_feature order(4464..4466,4473..4475,4509..4511,4515..4517,
4527..4529,4536..4538,4557..4559,4566..4568)
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/note="cross-brace motif; other site"
/db_xref="CDD:29102"
variation 2805
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="g"
/db_xref="dbSNP:376445512"
variation 2826
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:142523935"
variation 2844
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:186307109"
variation 2849
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:144852435"
variation 2868
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="g"
/replace="t"
/db_xref="dbSNP:370738985"
variation 2873
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="g"
/replace="t"
/db_xref="dbSNP:375640711"
variation 2900
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="g"
/db_xref="dbSNP:190140643"
variation 2924
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:1055078"
variation 2951
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:1055079"
variation 2969
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:377679122"
variation 2973
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:370995428"
variation 2989
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:147902919"
variation 2993
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:376004906"
variation 3011
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="g"
/db_xref="dbSNP:140520103"
variation 3035
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="c"
/db_xref="dbSNP:150392143"
variation 3056
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:7930386"
variation 3098
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="g"
/db_xref="dbSNP:374571638"
variation 3129
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:149102827"
variation 3178
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:368897232"
variation 3184
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="c"
/db_xref="dbSNP:147101958"
variation 3198
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:200590873"
variation 3200
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:199804199"
STS 3218..3411
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/standard_name="PMC166414P2"
/db_xref="UniSTS:271591"
variation 3230
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:372538367"
variation 3254
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:138773847"
variation 3267
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:141741107"
variation 3281
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:146254676"
variation 3357
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="g"
/db_xref="dbSNP:147996132"
variation 3414
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="g"
/replace="t"
/db_xref="dbSNP:76109257"
variation 3477
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="c"
/db_xref="dbSNP:369162016"
variation 3507
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="g"
/db_xref="dbSNP:141682743"
variation 3517
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:150502736"
STS 3528..3654
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/standard_name="SGC33804"
/db_xref="UniSTS:68768"
variation 3538
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="g"
/db_xref="dbSNP:373514370"
variation 3539
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:147757750"
variation 3574
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:2276113"
variation 3591
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:377560709"
variation 3592
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="g"
/db_xref="dbSNP:201026275"
variation 3593
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:181325614"
variation 3609
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:370712639"
variation 3612
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="c"
/db_xref="dbSNP:201739570"
exon 3649..3748
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/inference="alignment:Splign:1.39.8"
variation 3653
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:199818066"
variation 3682
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:200850963"
variation 3692
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="g"
/db_xref="dbSNP:150254499"
exon 3749..3827
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/inference="alignment:Splign:1.39.8"
variation 3759
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="g"
/replace="t"
/db_xref="dbSNP:373892386"
variation 3765
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="c"
/db_xref="dbSNP:144238776"
variation 3776
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="t"
/db_xref="dbSNP:199868222"
variation 3778
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:147320536"
variation 3789
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:200082566"
variation 3795
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:141069802"
exon 3828..3876
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/inference="alignment:Splign:1.39.8"
variation 3839
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:200328626"
variation 3844
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:372905086"
variation 3850..3851
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace=""
/replace="c"
/db_xref="dbSNP:60576372"
variation 3876
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:377252240"
exon 3877..4119
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/inference="alignment:Splign:1.39.8"
variation 3886
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:144815282"
variation 3915
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:373338711"
variation 3946
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:145818257"
variation 3950
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:375831197"
variation 3951
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:12222256"
variation 3995
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:17878663"
variation 3997
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:17881197"
variation 4027
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:201361356"
variation 4060
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:369562282"
variation 4094
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="t"
/db_xref="dbSNP:151072309"
exon 4120..4374
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/inference="alignment:Splign:1.39.8"
variation 4175
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:140923351"
variation 4195
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="g"
/db_xref="dbSNP:377413987"
variation 4209
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:145025961"
variation 4225
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:200653824"
variation 4227
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="g"
/db_xref="dbSNP:200833305"
variation 4236
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:202087665"
STS 4245..4594
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/standard_name="PMC229255P1"
/db_xref="UniSTS:272168"
variation 4258
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:200008391"
variation 4275
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:199509362"
variation 4285
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:373311655"
variation 4288
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:138752976"
variation 4311
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="g"
/db_xref="dbSNP:77165340"
variation 4330
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="c"
/db_xref="dbSNP:370069893"
variation 4355
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:140413133"
exon 4375..4416
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/inference="alignment:Splign:1.39.8"
exon 4417..6911
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/inference="alignment:Splign:1.39.8"
variation 4440
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:145399165"
variation 4441
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:373651361"
variation 4458
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="c"
/db_xref="dbSNP:57261191"
variation 4462
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:149475723"
variation 4487
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:200499457"
variation 4502
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="t"
/db_xref="dbSNP:200093408"
variation 4576
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:202122377"
variation 4619
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="c"
/db_xref="dbSNP:368682383"
variation 4625
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:370911167"
variation 4628
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:1055088"
variation 4645
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:367703544"
variation 4670
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="c"
/db_xref="dbSNP:183114032"
variation 4676
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:1055093"
variation 4698
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="c"
/db_xref="dbSNP:191120561"
variation 4774
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:183381992"
variation 4817
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:17878891"
variation 4831
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:11225216"
variation 4885
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:187585104"
STS 4950..5082
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/standard_name="RH79205"
/db_xref="UniSTS:39572"
variation 4962
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:192795034"
STS 5000..5140
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/standard_name="A007H38"
/db_xref="UniSTS:56564"
variation 5061
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="c"
/db_xref="dbSNP:369605039"
variation 5083
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:141442196"
STS 5100..5200
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/standard_name="G43312"
/db_xref="UniSTS:94933"
STS 5100..5199
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/standard_name="G60088"
/db_xref="UniSTS:137217"
variation 5157
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:183091195"
variation 5167
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="g"
/db_xref="dbSNP:3460"
variation 5177
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:368324256"
variation 5192
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:3740932"
polyA_signal 5218..5223
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
polyA_site 5242
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
variation 5287
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace=""
/replace="c"
/db_xref="dbSNP:17885412"
variation 5385
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:375211458"
variation 5413
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="g"
/replace="t"
/db_xref="dbSNP:11225217"
variation 5495
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:187762878"
variation 5514
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:375818758"
variation 5521
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="g"
/replace="t"
/db_xref="dbSNP:191963415"
variation 5688
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:184383338"
variation 5693
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:150899790"
variation 5863
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="c"
/db_xref="dbSNP:190364614"
variation 5914
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:113594316"
variation 5949
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="g"
/db_xref="dbSNP:3903273"
variation 5952
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:192625169"
variation 6124
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:115064569"
variation 6136
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:372672561"
variation 6217
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:17883781"
variation 6273
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="g"
/db_xref="dbSNP:185058581"
variation 6362
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:189021228"
variation 6514
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="c"
/db_xref="dbSNP:13711"
variation 6544
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="g"
/db_xref="dbSNP:200999395"
variation 6545
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace=""
/replace="t"
/db_xref="dbSNP:11305884"
variation 6630
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="c"
/replace="t"
/db_xref="dbSNP:180920499"
variation 6639
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:139423991"
variation 6718..6719
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace=""
/replace="t"
/replace="tt"
/db_xref="dbSNP:11403428"
variation 6718
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="g"
/replace="t"
/db_xref="dbSNP:77617947"
variation 6732
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:202063614"
variation 6790
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="a"
/replace="g"
/db_xref="dbSNP:17880337"
variation 6808
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
/replace="g"
/replace="t"
/db_xref="dbSNP:75825022"
polyA_signal 6809..6814
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
polyA_site 6830
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
polyA_signal 6890..6895
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
polyA_site 6911
/gene="BIRC3"
/gene_synonym="AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1;
MALT2; MIHC; RNF49"
ORIGIN
gcatttaaaagacagcgtgagactcgcgccctccggcacggaaaaggccaggcgacaggtgtcgcttgaaaagactgggcttgtccttgctggtgcatgcgtcgtcggcctctgggcagcaggtttacaaaggaggaaaacgacttcttctagatttttttttcagtttcttctataaatcaaaacatctcaaaatggagacctaaaatccttaaagggacttagtctaatctcgggaggtagttttgtgcatgggtaaacaaattaagtattaactggtgttttactatccaaagaatgctaattttataaacatgatcgagttatataaggtataccataatgagtttgattttgaatttgatttgtggaaataaaggaaaagtgattctagctggggcatattgttaaagcatttttttcagagttggccaggcagtctcctactggcacattctcccattatgtagaatagaaatagtacctgtgtttgggaaagattttaaaatgagtgacagttatttggaacaaagagctaataatcaatccactgcaaattaaagaaacatgcagatgaaagttttgacacattaaaatacttctacagtgacaaagaaaaatcaagaacaaagctttttgatatgtgcaacaaatttagaggaagtaaaaagataaatgtgatgattggtcaagaaattatccagttatttacaaggccactgatattttaaacgtccaaaagtttgtttaaatgggctgttaccgctgagaatgatgaggatgagaatgatggttgaaggttacattttaggaaatgaagaaacttagaaaattaatataaagacagtgatgaatacaaagaagatttttataacaatgtgtaaaatttttggccagggaaaggaatattgaagttagatacaattacttacctttgagggaaataattgttggtaatgagatgtgatgtttctcctgccacctggaaacaaagcattgaagtctgcagttgaaaagcccaacgtctgtgagatccaggaaaccatgcttgcaaaccactggtaaaaaaaaaaaaaaaaaaaaaaaaaagccacagtgacttgcttattggtcattgctagtattatcgactcagaacctctttactaatggctagtaaatcataattgagaaattctgaattttgacaaggtctctgctgttgaaatggtaaatttattattttttttgtcatgataaattctggttcaaggtatgctatccatgaaataatttctgaccaaaactaaattgatgcaatttgattatccatcttagcctacagatggcatctggtaacttttgactgttttaaaaaataaatccactatcagagtagatttgatgttggcttcagaaacatttagaaaaacaaaagttcaaaaatgttttcaggaggtgataagttgaataactctacaatgttagttctttgagggggacaaaaaatttaaaatctttgaaaggtcttattttacagccatatctaaattatcttaagaaaatttttaacaaagggaatgaaatatatatcatgattctgtttttccaaaagtaacctgaatatagcaatgaagttcagttttgttattggtagtttgggcagagtctctttttgcagcacctgttgtctaccataattacagaggacatttccatgttctagccaagtatactattagaataaaaaaacttaacattgagttgcttcaacagcatgaaactgagtccaaaagaccaaatgaacaaacacattaatctctgattatttattttaaatagaatatttaattgtgtaagatctaatagtatcattatacttaagcaatcatattcctgatgatctatgggaaataactattatttaattaatattgaaaccaggttttaagatgtgttagccagtcctgttactagtaaatctctttatttggagagaaattttagattgttttgttctccttattagaaggattgtagaaagaaaaaaatgactaattggagaaaaattggggatatatcatatttcactgaattcaaaatgtcttcagttgtaaatcttaccattattttacgtacctctaagaaataaaagtgcttctaattaaaatatgatgtcattaattatgaaatacttcttgataacagaagttttaaaatagccatcttagaatcagtgaaatatggtaatgtattattttcctcctttgagttaggtcttgtgcttttttttcctggccactaaatttcacaatttccaaaaagcaaaataaacatattctgaatatttttgctgtgaaacacttgacagcagagctttccaccatgaaaagaagcttcatgagtcacacattacatctttgggttgattgaatgccactgaaacattctagtagcctggagaagttgacctacctgtggagatgcctgccattaaatggcatcctgatggcttaatacacatcactcttctgtgaagggttttaattttcaacacagcttactctgtagcatcatgtttacattgtatgtataaagattatacaaaggtgcaattgtgtatttcttccttaaaatgtatcagtataggatttagaatctccatgttgaaactctaaatgcatagaaataaaaataataaaaaatttttcattttggcttttcagcctagtattaaaactgataaaagcaaagccatgcacaaaactacctccctagagaaaggctagtcccttttcttccccattcatttcattatgaacatagtagaaaacagcatattcttatcaaatttgatgaaaagcgccaacacgtttgaactgaaatacgacttgtcatgtgaactgtaccgaatgtctacgtattccacttttcctgctggggttcctgtctcagaaaggagtcttgctcgtgctggtttctattacactggtgtgaatgacaaggtcaaatgcttctgttgtggcctgatgctggataactggaaaagaggagacagtcctactgaaaagcataaaaagttgtatcctagctgcagattcgttcagagtctaaattccgttaacaacttggaagctacctctcagcctacttttccttcttcagtaacaaattccacacactcattacttccgggtacagaaaacagtggatatttccgtggctcttattcaaactctccatcaaatcctgtaaactccagagcaaatcaagatttttctgccttgatgagaagttcctaccactgtgcaatgaataacgaaaatgccagattacttacttttcagacatggccattgacttttctgtcgccaacagatctggcaaaagcaggcttttactacataggacctggagacagagtggcttgctttgcctgtggtggaaaattgagcaattgggaaccgaaggataatgctatgtcagaacacctgagacattttcccaaatgcccatttatagaaaatcagcttcaagacacttcaagatacacagtttctaatctgagcatgcagacacatgcagcccgctttaaaacattctttaactggccctctagtgttctagttaatcctgagcagcttgcaagtgcgggtttttattatgtgggtaacagtgatgatgtcaaatgcttttgctgtgatggtggactcaggtgttgggaatctggagatgatccatgggttcaacatgccaagtggtttccaaggtgtgagtacttgataagaattaaaggacaggagttcatccgtcaagttcaagccagttaccctcatctacttgaacagctgctatccacatcagacagcccaggagatgaaaatgcagagtcatcaattatccattttgaacctggagaagaccattcagaagatgcaatcatgatgaatactcctgtgattaatgctgccgtggaaatgggctttagtagaagcctggtaaaacagacagttcagagaaaaatcctagcaactggagagaattatagactagtcaatgatcttgtgttagacttactcaatgcagaagatgaaataagggaagaggagagagaaagagcaactgaggaaaaagaatcaaatgatttattattaatccggaagaatagaatggcactttttcaacatttgacttgtgtaattccaatcctggatagtctactaactgccggaattattaatgaacaagaacatgatgttattaaacagaagacacagacgtctttacaagcaagagaactgattgatacgattttagtaaaaggaaatattgcagccactgtattcagaaactctctgcaagaagctgaagctgtgttatatgagcatttatttgtgcaacaggacataaaatatattcccacagaagatgtttcagatctaccagtggaagaacaattgcggagactacaagaagaaagaacatgtaaagtgtgtatggacaaagaagtgtccatagtgtttattccttgtggtcatctagtagtatgcaaagattgtgctccttctttaagaaagtgtcctatttgtaggagtacaatcaagggtacagttcgtacatttctttcatgaagaagaaccaaaacatcgtctaaactttagaattaatttattaaatgtattataactttaacttttatcctaatttggtttccttaaaatttttatttatttacaactcaaaaaacattgttttgtgtaacatatttatatatgtatctaaaccatatgaacatatattttttagaaactaagagaatgataggcttttgttcttatgaacgaaaaagaggtagcactacaaacacaatattcaatcaaaatttcagcattattgaaattgtaagtgaagtaaaacttaagatatttgagttaacctttaagaattttaaatattttggcattgtactaataccgggaacatgaagccaggtgtggtggtatgtgcctgtagtcccaggctgaggcaagagaattacttgagcccaggagtttgaatccatcctgggcagcatactgagaccctgcctttaaaaacaaacagaacaaaaacaaaacaccagggacacatttctctgtcttttttgatcagtgtcctatacatcgaaggtgtgcatatatgttgaatgacattttagggacatggtgtttttataaagaattctgtgagaaaaaatttaataaagcaacaaaaattactcttattcttcattgctttatttcaatgacattggatagtttagtcactcccagactctttccataccttcttaaagcctctcaaatattgaactacagtttatactccttcccataagatgcttcttcattgacacttgtagaacacggggtcaacacatcataaaatctattatggaatgcctgagacaagaatcaaacagtccctttagtaagtttgtttattcacttctctattgattcattcaagaagtctcatgccagccccacctattggaagaaggtctgagttttattcttatctctttggtattaattctgaaacttagaaagtacactggttagcaatgcttgggaccaacaggttgttctggtaaataaatctgtttcatattgtcagtgcaacaaaatgtccccctctgcattatgttattggtactcaacacgtccgagtcataactctgtcctttgcttcttatagaggtattaggtcttcaagagcagaagtaagactgtaatagggaatactcaggggaaggcaggcaaaggctagtcatctaaaccagttctagatgtctgtataggggcagatggctctgtaagggcagaagggaaagaccccttcataagggtcacagctgacaatcctataacaaaagacaggttaacaagagaaaaacttaacaaatttatttaatcacagatttacatcaccggggagccttcgtaatgaagatccaaaattacaggggaaactgtgcatttttatgcttaggtttgataatgaatggacagccctgaagaatagtgattggaaaaaaaggatatgatctaatgggaatagacacaggttggggacccagcaaggcctgtctgttcagattattcttggtctctgtgcagcattccttcctcctggatatagggcagggcctgtatgggatggggatattataacctgctatcaagcaaggtaggtcagagaatttatttatggccagctcttacatagttaggtgaggaaagattagagtactatctttaagatgtaagtctggcattgtggaaagatggttccagtttctatgacctaccttggggaagaggaattcaagtttctgtggcttgccttcagggagaatgaggctgagacaggagggcaggataacatcagagaaaaactttgcttctgaggccttcactttgggttttctgagccccaacatctgctagtgttgtaaagagaacaattagggaccaagtgaggggaggaaagaatccatctctgcattctgatgctgggagacttatttccttgaaatgcaattgattttgcctctgctaagaggctctgctggctacccatgtactagccagtgtcctgcatgggtgctaggctgaattatttgtaattgtgcttaggtgatttgtaactcaggtatagggtatttaaatagtaggcaccctttttgcaccatgtgtttttttttttatctagttcttgtatactacagataatatttgaactttgtcatctcactgtaaaacttttgttcatttctcattatggtaataaatagctattataaccaacccatttattcaaatatgttatttccctaagtgttattttgacattttgttttggaaaaaataaatcaccatagataataaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:330 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IDA
GeneID:330 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:330 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:330 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
GeneID:330 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
GeneID:330 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:330 -> Biological process: GO:0007166 [cell surface receptor signaling pathway] evidence: TAS
GeneID:330 -> Biological process: GO:0034121 [regulation of toll-like receptor signaling pathway] evidence: TAS
GeneID:330 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
GeneID:330 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
GeneID:330 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:330 -> Biological process: GO:0038061 [NIK/NF-kappaB cascade] evidence: TAS
GeneID:330 -> Biological process: GO:0039535 [regulation of RIG-I signaling pathway] evidence: TAS
GeneID:330 -> Biological process: GO:0042326 [negative regulation of phosphorylation] evidence: IEA
GeneID:330 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:330 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: TAS
GeneID:330 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:330 -> Biological process: GO:0045088 [regulation of innate immune response] evidence: TAS
GeneID:330 -> Biological process: GO:0050727 [regulation of inflammatory response] evidence: TAS
GeneID:330 -> Biological process: GO:0060546 [negative regulation of necroptosis] evidence: IEA
GeneID:330 -> Biological process: GO:0070266 [necroptosis] evidence: IEA
GeneID:330 -> Biological process: GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway] evidence: TAS
GeneID:330 -> Biological process: GO:2000116 [regulation of cysteine-type endopeptidase activity] evidence: TAS
GeneID:330 -> Biological process: GO:2000378 [negative regulation of reactive oxygen species metabolic process] evidence: IEA
GeneID:330 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:330 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:330 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
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