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2019-03-25 14:30:29, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001164407            5901 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens TLC domain containing 2 (TLCD2), mRNA.
ACCESSION   NM_001164407 XM_001126126
VERSION     NM_001164407.1  GI:256542292
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5901)
  AUTHORS   Pewzner-Jung,Y., Ben-Dor,S. and Futerman,A.H.
  TITLE     When do Lasses (longevity assurance genes) become CerS (ceramide
            synthases)?: Insights into the regulation of ceramide synthesis
  JOURNAL   J. Biol. Chem. 281 (35), 25001-25005 (2006)
   PUBMED   16793762
  REMARK    Review article
REFERENCE   2  (bases 1 to 5901)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130343.7.
            On Aug 25, 2009 this sequence version replaced gi:239745669.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD580337.2, DV111297.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               AC130343.7         159581-159882       c
            303-385             AC130343.7         159318-159400       c
            386-468             AC130343.7         159013-159095       c
            469-5901            AC130343.7         152304-157736       c
FEATURES             Location/Qualifiers
     source          1..5901
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..5901
                     /gene="TLCD2"
                     /note="TLC domain containing 2"
                     /db_xref="GeneID:727910"
                     /db_xref="HGNC:33522"
     exon            1..302
                     /gene="TLCD2"
                     /inference="alignment:Splign:1.39.8"
     CDS             127..921
                     /gene="TLCD2"
                     /codon_start=1
                     /product="TLC domain-containing protein 2"
                     /protein_id="NP_001157879.1"
                     /db_xref="GI:256542293"
                     /db_xref="CCDS:CCDS45567.1"
                     /db_xref="GeneID:727910"
                     /db_xref="HGNC:33522"
                     /translation="
MAPTGLLVAGASFLAFRGLHWGLRRLPTPESAARDRWQWWNLCVSLAHSLLSGTGALLGLSLYPQMAADPIHGHPRWALVLVAVSVGYFLADGADLLWNQTLGKTWDLLCHHLVVVSCLSTAVLSGHYVGFSMVSLLLELNSACLHLRKLLLLSRQAPSLAFSVTSWASLATLALFRLVPLGWMSLWLFRQHHQVPLALVTLGGIGLVTVGIMSIILGIRILVNDVLQSRPHPPSPGHEKTRGTRTRRDNGPVTSNSSTLSLKD
"
     misc_feature    133..195
                     /gene="TLCD2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
                     transmembrane region"
     misc_feature    250..312
                     /gene="TLCD2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
                     transmembrane region"
     misc_feature    313..717
                     /gene="TLCD2"
                     /note="TLC domain; Region: TRAM_LAG1_CLN8; cl02759"
                     /db_xref="CDD:207718"
     misc_feature    355..417
                     /gene="TLCD2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
                     transmembrane region"
     misc_feature    466..528
                     /gene="TLCD2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
                     transmembrane region"
     misc_feature    631..693
                     /gene="TLCD2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
                     transmembrane region"
     misc_feature    721..783
                     /gene="TLCD2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
                     transmembrane region"
     exon            303..385
                     /gene="TLCD2"
                     /inference="alignment:Splign:1.39.8"
     exon            386..468
                     /gene="TLCD2"
                     /inference="alignment:Splign:1.39.8"
     exon            469..5901
                     /gene="TLCD2"
                     /inference="alignment:Splign:1.39.8"
     STS             1579..2048
                     /gene="TLCD2"
                     /standard_name="D1S1423"
                     /db_xref="UniSTS:149619"
     STS             1963..2052
                     /gene="TLCD2"
                     /standard_name="L18426"
                     /db_xref="UniSTS:34648"
     STS             1972..2048
                     /gene="TLCD2"
                     /standard_name="D1S1423"
                     /db_xref="UniSTS:149619"
     STS             2165..3732
                     /gene="TLCD2"
                     /standard_name="GDB:631813"
                     /db_xref="UniSTS:158430"
     STS             2165..2460
                     /gene="TLCD2"
                     /standard_name="GDB:631813"
                     /db_xref="UniSTS:158430"
     STS             2487..2600
                     /gene="TLCD2"
                     /standard_name="D10S16"
                     /db_xref="UniSTS:155756"
     STS             2526..3882
                     /gene="TLCD2"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     STS             2526..2613
                     /gene="TLCD2"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     STS             2653..4345
                     /gene="TLCD2"
                     /standard_name="D3S1673"
                     /db_xref="UniSTS:148450"
     STS             3748..5235
                     /gene="TLCD2"
                     /standard_name="sY3084"
                     /db_xref="UniSTS:515126"
     STS             3793..5172
                     /gene="TLCD2"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     STS             3793..3882
                     /gene="TLCD2"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     STS             3862..4337
                     /gene="TLCD2"
                     /standard_name="GDB:434012"
                     /db_xref="UniSTS:157204"
     STS             4360..5208
                     /gene="TLCD2"
                     /standard_name="G35510"
                     /db_xref="UniSTS:44150"
     STS             5130..5212
                     /gene="TLCD2"
                     /standard_name="L18426"
                     /db_xref="UniSTS:34648"
     STS             5132..5234
                     /gene="TLCD2"
                     /standard_name="D11S2921"
                     /db_xref="UniSTS:152074"
     variation       5726
                     /gene="TLCD2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3208963"
     variation       5743
                     /gene="TLCD2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3208964"
     variation       5773
                     /gene="TLCD2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3208965"
ORIGIN      
aaaggcgcggcggggaggggagccggggccccagccctgccgggaaacgggttcccagtcccggccgagagcgcgggcgccgaggggaccgacccggactccccgcaaccccccaaccgccaggccatggcgcccacggggctcctggtggccggcgcctccttcctcgcgttccgggggctgcactgggggttgcggcggctgcccacgccggaatcggccgctcgggaccgctggcagtggtggaacctctgcgtctccctggcgcacagcctgctctcggggaccggggcgctgctcggcctgtcactgtaccctcagatggccgccgaccccatccatggccacccgcgctgggctctggtgctggtggctgtgtctgtgggttacttcctggcagacggagctgacctgctgtggaaccagaccttgggcaagacctgggatcttctctgtcatcatttggtggtggtgagctgcctcagcaccgctgttctgtctggccactacgtgggcttctccatggtgtctctgctcctggaactgaactctgcctgcttgcacctgcggaagctgctgttgctttctcgccaggccccatccctggccttcagcgtgaccagctgggcctccttggccaccttggccctcttccgcctggtcccgctggggtggatgagtctgtggctgttccggcagcaccaccaggttcctcttgctctggtcaccctgggtggaattgggctggtcactgtgggcatcatgagcatcatattggggatccgtattctggtcaatgatgtcctacagtctcgaccccatccacccagccctggccatgagaaaaccagggggaccaggacacgtcgtgacaatggacctgtcaccagcaacagttcgactctcagcctgaaagactagagagaagccatgggcccctcgctgggggaggtggggccaggacaaggagatgagggtcttccatgcacagtcccccatcagggtgagggccagacttgctcatcagaatctcagtttctcttccagctaactcacatcccttccccttcctcggatctaagaagaaatgctgatgttggatgggtgggaacctgggtttctgttcactgaaatccgtcatcagatgagcatcctttccagcaaataaactcaagaggtacagctagagctatcagtaaagggtggcaggaggcatgcagctggaagaaactgccagtggagacagaagctctttgctttaacccagggacagatgggggaaggtgaagtcccactaggatcagagagatctggtatggggcgggtggggacagagagaaaagagatctcacctataaccaaattctggcagtgggaggaaggtagaggaggtgctatctgtagcagcagagatggacgtgatagttgccaagagacagaacctgggccacagcaattgctgctgatgtttctggttctcaaagccacactcctgtttttctttttctttttctttttttttatgagacggaatcttactctgtcacccaggctggagtgtagtggcacgatttcggctcactgcaacctcagcctcctgggttcaagtgattgtcctgccttagcctcccgagtagctgtgacttcaggcatgcaccaccaagcccagctaatttttgtattttttggtggagaggaggtttcaccatgttgcccaggctggtctcgaactcctgacctcaagtaatccacctgcctcggcctcccagagtgctgggattacagacgtgagaacaggcgcacactcctgtttttctccttaaccctggtcctgctgtgtctagccttttatttttatttttatttttagtatcttttgacttttcttttttcttttctttttttttttttttttttgagacaagttcttgctctgttgcccaggatggagtgcagtggcttgatcttggctcactgcaatctctgcctcccaggctcaagcaattctcctgcctcccacctcagcctcccaagtagctgggactacaggtgcacgccactgcaccaggctaatttttgtatttttttgtagagaccaggttttgccatgttgcccaggctggtctcaaacttttgcactcaagtgatccacccacctcagcctcccaaagtgctgggattacagacgtgagccaccgtacccgaccccttttgacttttcaaagacaattcggattcttagaggaatgaacacagggctggtttgtcttcttaggacggcactgaagtctagaattacagaaggaaaggtgcccagtacagagttttcccaggcccaggctttcatggaagaacaagggcagaggtagactgtgtgagagaaggctgcaggaggataaaggaatagctggccctctggctgggcgcagcagctcacgcctgtaatcccagcactttgggaggccgaggcgggaggatcacctgaggtcaggagttcaagaccagcctggtcaacatggtgaaaccctgtctctactaaaaatacaaaattagccgggcatggtggtgcatgcctgtaatcccagctactcaggaggctgaggcaggagaatcgcttgaacccaggaggcagaggttgcagtgagccgaggtcgtgccactgcactccagcctgggcaaacagagtgagactcttgtctctaaagaaaaaaaaaaaaggaagagctgggacttttctgagatacattcataaagtcttcttcctccctgctgcttctgctgcgtttttttctgttgaacaagaccccttccttcccagaacatcgaggtgacgggaagtgcccagcagattaagtctgctgttccactaaacaatggactgagagaggcaacccttagccatccacagaaaagctacatgagcaaaagcaagagacaggaagattgtcttcaaaaaaaaacaaaacaaaacaaaaaccttgctaagaagcggaggtacagaaagatacgaagaatgacagagacagacatacatagattgagtgatagatagaaagagagaaggattattcacatagaggtgacagaggcaaagaaggatggagggcaaaagagacaggccctagcagaaatatggagaaaggctgtcatagatcctgagagacaccaaagtcacagaactgataaaagggttataaacaaaaaggaccagaaaaatagaaatgaaggccgacaagaagagaccccaaggctgaaaggcacagagagtctagacagtgaaatagagtgagtgacaaggagaaacacccaggctcaggagtgatggaggaaatactggcagatagagagatcagaagagcaagaggagaggtgggaacagagaagagcggggacgagtccggggagctgagaagcagaaggcggaggaggcagtcagtgggaagattcactgacagaagagaccaggagatatggggacttggaggcaggcagaaagacaaaggacaaacagctgcagcgcaaaccctaaagacaggctgacagtaaccggtcggcagagactggtaggaagataaggacaagtcagaatcaggggtgtcaactgagatgcaaatataggcaaaggagctgacaaagagaatcacagagagaaaaaaaaggaggagagcacagaacaatttaaatatccaggctgggcatggtgggtcacgcctgtaatcccagcattttgggaggccgaggcaggcggatcacgaggtcaggagatgaccatcctggctaacatggtgaaacaccatctctactaaaaatacaaaaaattggccgggcgtggtggcaggcgcccgtaatcccggctactgaggaggctgaggcaggagaatcgtttgaacctgggaggccgaggttgttataatgagccgagatagtgccactgcagtccagcaggggtgacagagtgagactccgtctcaaaaaaaaaaattgaatatccaaagaacaaagaagaggcaggaacccagaaatgaaaagaggaggaaaaatacaggtgtgaaaaaaaaatgagagggattgtgagaagtctccatcatagagtcataaaaacaggcgcaaaggatgaaaatacatcgagactgaggaaaacacagttggaaggagctaaacacaagcagaaaataagagcagagcatttaaatgtaattagataaaaacccaagaggcaaaggtatagatagtgagctagagaaacaatgcagaattttgtcagagtctgtacttctagaagtcatgtttgctggctgggcatggtggctcacgcctgtaatcccagcactttgggaggccgaggtaggaggagtggttgagctcaggagttcaagaccagtctgggcaacatattgagacctcctctctacaaaaaaaaaaaattttcttttttctttcttttcttctttttttttttttttttttgagacagtttcattcttgctgcccaggctggaatgcagtggcacaatcttggctcactgcaacctccacctcctggactcaagtgattctcctgcctcagcctccctagtagctgggattacaggtacccaccaccacactcggctaatttttgtgtttttagtagagacaggatttcaccatattggccaggctggtctcaaactcctgacctcaggtgatccgcccaccttgggctcccaaactactgggattatatgcgtgagccaacacacccggccaaaaaaaaatttttaattaaaaaaaaaagtcatatctgcaaaactcaatttgccatcttaactgaatgccttgattaacaaaaatgttgtctgccttgagtttttaaagaaaaagaaatatgacaaactcatgtgaggaatctattccttaaatatctgttgaggttgatatgaattgattctaagtcatacaccttttctttggccactggtatacattcatgatggtttgagtgagtgtcccttttggtaatacttgatagtgtctatgaggccgggcgtggtggctcacgcctgtaatcccagcactttgggggaccgaggcaggtgaaatcccatctctactaaaaataaaaaaaattagccgggcgtggtggcgggcgcctgtagtcccagctactcaggaggctgaggcaggagaatggcatgaacccgggaggcggagcttgcagtgagccaagatcgtgccactgcactccagcctgggtgacagagcaagactccgtcttaaaaaataaataaataaataaatagacagatagatagatagatagtgtctatgaaggctgcccaagaacttgaccattagggaaacatggctgtttctgtggattaactagtcaagcccatacaggaagagtgaggtcagctcccaggtggggcaggatgtagtggacgcttggaagaatttgggaccacacacgaattgctaccatggtgagccagtgaaacttgaggaaggcaggactggattgtgattacaactgagtaagtaggcagagaattggagtgtgggcaacataaagatgatgtgaatcaaagaagaatggtcaattaagaccctaaaaaaaggacgttcaaaaatgcagaggttaaaaaaaaaaaaagcagagattgccagatgctccatttggtaggagtctgcttagcacagtggtgcttcgccagactttaccgtggcccagggaaatggtcctcaagacggactccatgtctaccaagctacttgctaatgatttctttgtcctccaggacagggaaggggcttttctggatgggatacattgatattttatggccttgaaacactatcctgattataaattaataaattgctatgcaaataattgcattagttgcatcaatctcttat
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:727910 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA

by @meso_cacase at DBCLS
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