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2024-04-20 16:28:53, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001162953 4060 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens synaptotagmin-like 2 (SYTL2), transcript variant i,
mRNA.
ACCESSION NM_001162953
VERSION NM_001162953.1 GI:244790019
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4060)
AUTHORS Cao,W.F., Zhang,L.Y., Zhang,B., Wang,Y.Q., Liu,Z.H. and Sun,B.C.
TITLE [Expression of SLP-2 protein in esophageal squamous cell carcinoma
is associated with cancer invasion]
JOURNAL Zhonghua Zhong Liu Za Zhi 32 (11), 830-833 (2010)
PUBMED 21223688
REMARK GeneRIF: SLP2 may play an important role in tumorigenesis of
esophageal squamous cell carcinoma.
REFERENCE 2 (bases 1 to 4060)
AUTHORS Pang,Z.P., Xu,W., Cao,P. and Sudhof,T.C.
TITLE Calmodulin suppresses synaptotagmin-2 transcription in cortical
neurons
JOURNAL J. Biol. Chem. 285 (44), 33930-33939 (2010)
PUBMED 20729199
REMARK GeneRIF: Calmodulin suppresses synaptotagmin-2 transcription in
cortical neurons
REFERENCE 3 (bases 1 to 4060)
AUTHORS Cao,W.F., Zhang,L.Y., Zhang,B., Liu,M.B., Liu,Z.H. and Sun,B.C.
TITLE [Relationship between SLP-2 expression and prognosis in laryngeal
squamous cell carcinoma and mammary invasive carcinoma]
JOURNAL Zhonghua Bing Li Xue Za Zhi 39 (5), 332-337 (2010)
PUBMED 20654157
REMARK GeneRIF: A high expression level of SLP-2 may be associating with
the development of invasion and metastasis in laryngeal squamous
cell carcinoma and breast cancer.
REFERENCE 4 (bases 1 to 4060)
AUTHORS Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
Nicolaescu,E., Lesage,B. and Bollen,M.
TITLE Docking motif-guided mapping of the interactome of protein
phosphatase-1
JOURNAL Chem. Biol. 16 (4), 365-371 (2009)
PUBMED 19389623
REFERENCE 5 (bases 1 to 4060)
AUTHORS Chavas,L.M., Ihara,K., Kawasaki,M., Torii,S., Uejima,T., Kato,R.,
Izumi,T. and Wakatsuki,S.
TITLE Elucidation of Rab27 recruitment by its effectors: structure of
Rab27a bound to Exophilin4/Slp2-a
JOURNAL Structure 16 (10), 1468-1477 (2008)
PUBMED 18940603
REFERENCE 6 (bases 1 to 4060)
AUTHORS Craxton,M.
TITLE Genomic analysis of synaptotagmin genes
JOURNAL Genomics 77 (1-2), 43-49 (2001)
PUBMED 11543631
REFERENCE 7 (bases 1 to 4060)
AUTHORS Fukuda,M., Saegusa,C. and Mikoshiba,K.
TITLE Novel splicing isoforms of synaptotagmin-like proteins 2 and 3:
identification of the Slp homology domain
JOURNAL Biochem. Biophys. Res. Commun. 283 (2), 513-519 (2001)
PUBMED 11327731
REFERENCE 8 (bases 1 to 4060)
AUTHORS Fukuda,M. and Mikoshiba,K.
TITLE Synaptotagmin-like protein 1-3: a novel family of C-terminal-type
tandem C2 proteins
JOURNAL Biochem. Biophys. Res. Commun. 281 (5), 1226-1233 (2001)
PUBMED 11243866
REFERENCE 9 (bases 1 to 4060)
AUTHORS Duncan,R.R., Shipston,M.J. and Chow,R.H.
TITLE Double C2 protein. A review
JOURNAL Biochimie 82 (5), 421-426 (2000)
PUBMED 10865129
REMARK Review article
REFERENCE 10 (bases 1 to 4060)
AUTHORS Nalefski,E.A. and Falke,J.J.
TITLE The C2 domain calcium-binding motif: structural and functional
diversity
JOURNAL Protein Sci. 5 (12), 2375-2390 (1996)
PUBMED 8976547
REMARK Review article
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC144114.1, DA449325.1 and
AK124754.1.
Summary: The protein encoded by this gene is a synaptotagmin-like
protein (SLP) that belongs to a C2 domain-containing protein
family. The SLP homology domain (SHD) of this protein has been
shown to specifically bind the GTP-bound form of Ras-related
protein Rab-27A (RAB27A). This protein plays a role in
RAB27A-dependent vesicle trafficking and controls melanosome
distribution in the cell periphery. Alternative splicing results in
multiple transcript variants encoding distinct isoforms.[provided
by RefSeq, Jun 2009].
Transcript Variant: This variant (i) differs in the 5' region
compared to variant c. The resulting isoform (i) has a distinct and
shorter N-terminus, as compared to the longest isoform (c).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC136450.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-641 BC144114.1 1-641
642-795 DA449325.1 247-400
796-3538 BC144114.1 796-3538
3539-3564 AK124754.1 3519-3544
3565-4060 AK124754.1 3546-4041
FEATURES Location/Qualifiers
source 1..4060
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q14"
gene 1..4060
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/note="synaptotagmin-like 2"
/db_xref="GeneID:54843"
/db_xref="HGNC:15585"
/db_xref="MIM:612880"
exon 1..377
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/inference="alignment:Splign:1.39.8"
misc_feature 211..213
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/note="upstream in-frame stop codon"
CDS 277..3084
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/note="isoform i is encoded by transcript variant i;
chromosome 11 synaptotagmin; breast cancer-associated
antigen SGA-72M; exophilin-4; synaptotagmin-like protein
2"
/codon_start=1
/product="synaptotagmin-like protein 2 isoform i"
/protein_id="NP_001156425.1"
/db_xref="GI:244790020"
/db_xref="CCDS:CCDS53689.1"
/db_xref="GeneID:54843"
/db_xref="HGNC:15585"
/db_xref="MIM:612880"
/translation="
MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEPEEDAAPASPSSSVVNPASSVIDMSQENTRKPNVSPEKQRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLEKSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFEPKSKIVSPGLTIHERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKNGMEDAGDTEEFQSDPKPSQYRKPSLFHQSTSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSHCVEPEPSQVPGGSSRDRQQGSEEEPSPVLKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDVSTVPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDTASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLRMLLIAKISK
"
misc_feature 2164..2547
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/note="C2 domain first repeat present in
Synaptotagmin-like proteins 1 and 2; Region: C2A_SLP-1_2;
cd08393"
/db_xref="CDD:176039"
misc_feature 2584..3054
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/note="C2 domain second repeat present in
Synaptotagmin-like proteins 1-4; Region: C2B_SLP_1-2-3-4;
cd04020"
/db_xref="CDD:175987"
exon 378..529
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/inference="alignment:Splign:1.39.8"
exon 530..665
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/inference="alignment:Splign:1.39.8"
variation 642
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:647912"
exon 666..747
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/inference="alignment:Splign:1.39.8"
exon 748..862
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/inference="alignment:Splign:1.39.8"
exon 863..1666
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/inference="alignment:Splign:1.39.8"
exon 1667..1738
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/inference="alignment:Splign:1.39.8"
exon 1739..1840
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/inference="alignment:Splign:1.39.8"
exon 1841..1894
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/inference="alignment:Splign:1.39.8"
exon 1895..1989
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/inference="alignment:Splign:1.39.8"
exon 1990..2109
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/inference="alignment:Splign:1.39.8"
exon 2110..2279
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/inference="alignment:Splign:1.39.8"
exon 2280..2382
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/inference="alignment:Splign:1.39.8"
exon 2383..2553
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/inference="alignment:Splign:1.39.8"
exon 2554..2632
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/inference="alignment:Splign:1.39.8"
exon 2633..2732
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/inference="alignment:Splign:1.39.8"
variation 2636
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:1140983"
exon 2733..2938
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/inference="alignment:Splign:1.39.8"
exon 2939..4058
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/inference="alignment:Splign:1.39.8"
STS 3726..3884
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
/standard_name="RH46567"
/db_xref="UniSTS:90215"
polyA_signal 3969..3974
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
polyA_site 3991
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
polyA_signal 4026..4031
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
polyA_site 4058
/gene="SYTL2"
/gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
ORIGIN
aacaagcgacctgtttggcaaggaatacagcatccttctgagagcctcttctcgacactatcccacagaccaggacttcctcatgggaaagagcacttaggatcttgctatcagctgccctaaacttttgctgagccaaaataagactttgatgcagaactgaacaagatatttcatttttgtgtgttttaatcttcctggttgcagtcttagttgttcagccctgagaattttgagccacatttgttgctattatttttgcatgcacttttcaaaatgattgacttaagcttcctgactgaagaggaacaagaggccatcatgaaggttttgcagcgggatgctgctctgaagagggccgaagaagagagagtcagacatttgcctgaaaaaattaaggatgaccagcagctgaagaatatgagtggccaatggttttatgaagccaaggcaaaaaggcacagggacaaaatccatggcgcagatatcatcagagcatctatgagaaagaagaggccccagatagcagctgagcagagtaaagacagagaaaatggggcaaaggaaagctgggtgaataatgtcaacaaagatgctttccttcctccagagctggctggcgttgtagaagagccagaagaagatgcagcaccagcaagcccgagttccagtgtggtaaatccagcttccagtgtgattgatatgtcccaggaaaacacaaggaaaccaaatgtgtctccagagaagcagaggaagaatccgtttaatagctccaagttgccagaaggtcactcatcacaacaaactaaaaatgaacagtcaaaaaatggaagaactggtttatttcagacttcaaaagaggatgaattgtcagagtcaaaagaaaagtcaactgtcgcagatacttcaatccaaaagttagagaaatcaaagcagactttgccaggcctttcaaatgggtcccaaatcaaggctccaatccccaaagccaggaagatgatctacaaatcaactgatttaaacaaagatgataaccagtcttttcctagacaaaggacagactccctgaaagcgagaggggctccgagagggatcctcaagcgcaactccagttccagtagcacagactcagaaacccttcgttataatcacaactttgaacccaaaagcaaaattgtgtcacctggcctaaccatccatgagagaatttctgagaaggagcattctttagaagacaactcttccccaaactccctggagccattaaagcatgtgagattctctgcagtgaaggatgagcttccacagagtcctgggctaatccatggtcgggaagtaggagaatttagtgttttagaatctgacagattgaaaaatggaatggaagatgcaggggacacagaagagtttcagagtgaccctaagccttctcaatacagaaagccttcgctttttcatcaatcaacctcaagcccatatgtatcaaaaagtgaaacacatcagccaatgacttctggttcttttccaattaatgggctgcattctcattcagaagttttaactgcaagaccacagtctatggagaattcaccaaccatcaatgaacccaaagataaatcatcagaattaacaaggcttgaatctgtattacccagaagccctgctgatgaactgtctcattgtgttgagcctgagccatctcaggtgccaggtggcagttctagagaccgtcagcaaggttcagaagaagaacccagtcctgttttgaaaactttggaaaggagtgccgctaggaaaatgccttccaaaagtctagaagacatttcatcagattcatcaaatcaagcaaaagtagataatcagccagaagaattagtgcgtagtgctgaagatgtttccacagtgcctacacaacctgataatccattttctcaccctgacaaactcaaaaggatgagcaagtctgttccagcatttctccaagatgagagtgatgacagagaaacagatacagcatcagaaagcagttaccagctcagcagacacaagaagagcccgagctctttaaccaatcttagcagctcctctggcatgacgtccttgtcttctgtgagtggcagtgtgatgagtgtttatagtggagactttggcaatctggaagttaaaggaaatattcagtttgcaattgaatatgtggagtcactgaaggagttgcatgtttttgtggcccagtgtaaggacttagcagcagcggatgtaaaaaaacagcgttcagacccatatgtaaaggcctatttgctaccagacaaaggcaaaatgggcaagaagaaaacactcgtagtgaagaaaaccttgaatcctgtgtataacgaaatactgcggtataaaattgaaaaacaaatcttaaagacacagaaattgaacctgtccatttggcatcgggatacatttaagcgcaatagtttcctaggggaggtggaacttgatttggaaacatgggactgggataacaaacagaataaacaattgagatggtaccctctgaagcggaagacagcaccagttgcccttgaagcagaaaacagaggtgaaatgaaactagctctccagtatgtcccagagccagtccctggtaaaaagcttcctacaactggagaagtgcacatctgggtgaaggaatgccttgatctaccactgctaaggggaagtcatctaaattcttttgttaaatgtaccatccttccagatacaagtaggaaaagtcgccagaagacaagagctgtagggaaaaccaccaaccctatcttcaaccacactatggtgtatgatgggttcaggcctgaagatctgatggaagcctgtgtagagcttactgtctgggaccattacaaattaaccaaccaatttttgggaggtcttcgtattggctttggaacaggtaaaagttatgggactgaagtggactggatggactctacttcagaggaagttgctctctgggagaagatggtaaactcccccaatacttggattgaagcaacactgcctctcagaatgcttttgattgccaagatttccaaatgagcccaaattccactggctcctccactgaaaactactaaaccggtggaatctgatcttgaaaatctgagtaggtggacaaatatcctcactttctatctattgcacctaaggaatactacacagcatgtaaaagtcaatctgcatgtgcttctttgattacaaggcccaagggatttaaatataacaaaatgtgtaatttgtgactctaatattaaataagatatttgaacaagctaggaaaattgaatttctgctgctgcttcaaagaaaaagctgccccagagcattaaacatggggtattgttaagaagcaaaatgttcttgtttgccatcatgtgtttcacaccacaattctgtgccacagttaagagggtctggtacccttgcaggacctttgtaggttgtgggaaaaagtcgcagaaagatactcaaagtggagcagggaatggagacagacatcagtgatgataaaaaaaaaaatggaccttaagaaactatttactctgtaatctctaataaaatatggaattccatattagggcaatgagactgaaactactggtgtttttctgccttgagaaaacaaacagttaaaacaagcctcaaatgtattttagtgccacccactggccataggtacaattcagttgttggcttgttttgacttaattctaaaataggtctcaagcctgtatttttatgagtttatttttttaaaaccctgcatatatatgattgtttttcttataactttactatatgaaagcagcataagagtagtcacaaacatgttttgcaacaaagttttaattagaatgtaagttgctcagttatactgttcttcttatgtatgtaaaattttcgtattttgtaaaaacccttagaataaattatcatttgatttaaattgtattagaaaattagcgtgacttctcattttaaataaaatattttaggaattctaaacatctaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:54843 -> Molecular function: GO:0001786 [phosphatidylserine binding] evidence: IMP
GeneID:54843 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:54843 -> Molecular function: GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] evidence: IMP
GeneID:54843 -> Molecular function: GO:0017137 [Rab GTPase binding] evidence: IEA
GeneID:54843 -> Molecular function: GO:0019902 [phosphatase binding] evidence: IDA
GeneID:54843 -> Molecular function: GO:0042043 [neurexin family protein binding] evidence: ISS
GeneID:54843 -> Biological process: GO:0006886 [intracellular protein transport] evidence: IEA
GeneID:54843 -> Biological process: GO:0006887 [exocytosis] evidence: IDA
GeneID:54843 -> Biological process: GO:0006904 [vesicle docking involved in exocytosis] evidence: IDA
GeneID:54843 -> Biological process: GO:0010923 [negative regulation of phosphatase activity] evidence: IDA
GeneID:54843 -> Biological process: GO:0016192 [vesicle-mediated transport] evidence: ISS
GeneID:54843 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:54843 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:54843 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
GeneID:54843 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:54843 -> Cellular component: GO:0016020 [membrane] evidence: ISS
GeneID:54843 -> Cellular component: GO:0019897 [extrinsic to plasma membrane] evidence: ISS
GeneID:54843 -> Cellular component: GO:0042470 [melanosome] evidence: ISS
GeneID:54843 -> Cellular component: GO:0070382 [exocytic vesicle] evidence: IDA
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