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2020-10-24 07:33:00, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001162951            4057 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens synaptotagmin-like 2 (SYTL2), transcript variant g,
            mRNA.
ACCESSION   NM_001162951
VERSION     NM_001162951.1  GI:244790012
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4057)
  AUTHORS   Cao,W.F., Zhang,L.Y., Zhang,B., Wang,Y.Q., Liu,Z.H. and Sun,B.C.
  TITLE     [Expression of SLP-2 protein in esophageal squamous cell carcinoma
            is associated with cancer invasion]
  JOURNAL   Zhonghua Zhong Liu Za Zhi 32 (11), 830-833 (2010)
   PUBMED   21223688
  REMARK    GeneRIF: SLP2 may play an important role in tumorigenesis of
            esophageal squamous cell carcinoma.
REFERENCE   2  (bases 1 to 4057)
  AUTHORS   Pang,Z.P., Xu,W., Cao,P. and Sudhof,T.C.
  TITLE     Calmodulin suppresses synaptotagmin-2 transcription in cortical
            neurons
  JOURNAL   J. Biol. Chem. 285 (44), 33930-33939 (2010)
   PUBMED   20729199
  REMARK    GeneRIF: Calmodulin suppresses synaptotagmin-2 transcription in
            cortical neurons
REFERENCE   3  (bases 1 to 4057)
  AUTHORS   Cao,W.F., Zhang,L.Y., Zhang,B., Liu,M.B., Liu,Z.H. and Sun,B.C.
  TITLE     [Relationship between SLP-2 expression and prognosis in laryngeal
            squamous cell carcinoma and mammary invasive carcinoma]
  JOURNAL   Zhonghua Bing Li Xue Za Zhi 39 (5), 332-337 (2010)
   PUBMED   20654157
  REMARK    GeneRIF: A high expression level of SLP-2 may be associating with
            the development of invasion and metastasis in laryngeal squamous
            cell carcinoma and breast cancer.
REFERENCE   4  (bases 1 to 4057)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem. Biol. 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   5  (bases 1 to 4057)
  AUTHORS   Chavas,L.M., Ihara,K., Kawasaki,M., Torii,S., Uejima,T., Kato,R.,
            Izumi,T. and Wakatsuki,S.
  TITLE     Elucidation of Rab27 recruitment by its effectors: structure of
            Rab27a bound to Exophilin4/Slp2-a
  JOURNAL   Structure 16 (10), 1468-1477 (2008)
   PUBMED   18940603
REFERENCE   6  (bases 1 to 4057)
  AUTHORS   Craxton,M.
  TITLE     Genomic analysis of synaptotagmin genes
  JOURNAL   Genomics 77 (1-2), 43-49 (2001)
   PUBMED   11543631
REFERENCE   7  (bases 1 to 4057)
  AUTHORS   Fukuda,M., Saegusa,C. and Mikoshiba,K.
  TITLE     Novel splicing isoforms of synaptotagmin-like proteins 2 and 3:
            identification of the Slp homology domain
  JOURNAL   Biochem. Biophys. Res. Commun. 283 (2), 513-519 (2001)
   PUBMED   11327731
REFERENCE   8  (bases 1 to 4057)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Synaptotagmin-like protein 1-3: a novel family of C-terminal-type
            tandem C2 proteins
  JOURNAL   Biochem. Biophys. Res. Commun. 281 (5), 1226-1233 (2001)
   PUBMED   11243866
REFERENCE   9  (bases 1 to 4057)
  AUTHORS   Duncan,R.R., Shipston,M.J. and Chow,R.H.
  TITLE     Double C2 protein. A review
  JOURNAL   Biochimie 82 (5), 421-426 (2000)
   PUBMED   10865129
  REMARK    Review article
REFERENCE   10 (bases 1 to 4057)
  AUTHORS   Nalefski,E.A. and Falke,J.J.
  TITLE     The C2 domain calcium-binding motif: structural and functional
            diversity
  JOURNAL   Protein Sci. 5 (12), 2375-2390 (1996)
   PUBMED   8976547
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC144114.1, EU035829.1 and
            AK124754.1.
            
            Summary: The protein encoded by this gene is a synaptotagmin-like
            protein (SLP) that belongs to a C2 domain-containing protein
            family. The SLP homology domain (SHD) of this protein has been
            shown to specifically bind the GTP-bound form of Ras-related
            protein Rab-27A (RAB27A). This protein plays a role in
            RAB27A-dependent vesicle trafficking and controls melanosome
            distribution in the cell periphery. Alternative splicing results in
            multiple transcript variants encoding distinct isoforms.[provided
            by RefSeq, Jun 2009].
            
            Transcript Variant: This variant (g) differs in the 5' region
            compared to variant c. The resulting isoform (g) has a distinct and
            shorter N-terminus, as compared to the longest isoform (c).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144115.1, EU035829.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               BC144114.1         1-276
            277-2082            EU035829.1         1-1806
            2083-3561           AK124754.1         2066-3544
            3562-4057           AK124754.1         3546-4041
FEATURES             Location/Qualifiers
     source          1..4057
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14"
     gene            1..4057
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /note="synaptotagmin-like 2"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:15585"
                     /db_xref="MIM:612880"
     exon            1..377
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    211..213
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /note="upstream in-frame stop codon"
     CDS             277..3081
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /note="isoform g is encoded by transcript variant g;
                     chromosome 11 synaptotagmin; breast cancer-associated
                     antigen SGA-72M; exophilin-4; synaptotagmin-like protein
                     2"
                     /codon_start=1
                     /product="synaptotagmin-like protein 2 isoform g"
                     /protein_id="NP_001156423.1"
                     /db_xref="GI:244790013"
                     /db_xref="CCDS:CCDS53688.1"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:15585"
                     /db_xref="MIM:612880"
                     /translation="
MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEPEEDAAPASPSSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLEKSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFEPKSKIVSPGLTIHERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKNGMEDAGDTEEFQSDPKPSQYRKPSLFHQSTSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSHCVEPEPSQVPGGSSRDRQQGSEEEPSPVLKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDVSTVPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDTASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLRMLLIAKISK
"
     misc_feature    2161..2544
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /note="C2 domain first repeat present in
                     Synaptotagmin-like proteins 1 and 2; Region: C2A_SLP-1_2;
                     cd08393"
                     /db_xref="CDD:176039"
     misc_feature    2581..3051
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; Region: C2B_SLP_1-2-3-4;
                     cd04020"
                     /db_xref="CDD:175987"
     exon            378..529
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /inference="alignment:Splign:1.39.8"
     exon            530..665
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /inference="alignment:Splign:1.39.8"
     variation       642
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:647912"
     exon            666..747
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /inference="alignment:Splign:1.39.8"
     exon            748..859
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /inference="alignment:Splign:1.39.8"
     exon            860..1663
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /inference="alignment:Splign:1.39.8"
     exon            1664..1735
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /inference="alignment:Splign:1.39.8"
     exon            1736..1837
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /inference="alignment:Splign:1.39.8"
     exon            1838..1891
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /inference="alignment:Splign:1.39.8"
     exon            1892..1986
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /inference="alignment:Splign:1.39.8"
     exon            1987..2106
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /inference="alignment:Splign:1.39.8"
     exon            2107..2276
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /inference="alignment:Splign:1.39.8"
     exon            2277..2379
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /inference="alignment:Splign:1.39.8"
     exon            2380..2550
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /inference="alignment:Splign:1.39.8"
     exon            2551..2629
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /inference="alignment:Splign:1.39.8"
     exon            2630..2729
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /inference="alignment:Splign:1.39.8"
     variation       2633
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1140983"
     exon            2730..2935
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /inference="alignment:Splign:1.39.8"
     exon            2936..4055
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /inference="alignment:Splign:1.39.8"
     STS             3723..3881
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
                     /standard_name="RH46567"
                     /db_xref="UniSTS:90215"
     polyA_signal    3966..3971
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
     polyA_site      3988
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
     polyA_signal    4023..4028
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
     polyA_site      4055
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; SGA72M; SLP2; SLP2A"
ORIGIN      
aacaagcgacctgtttggcaaggaatacagcatccttctgagagcctcttctcgacactatcccacagaccaggacttcctcatgggaaagagcacttaggatcttgctatcagctgccctaaacttttgctgagccaaaataagactttgatgcagaactgaacaagatatttcatttttgtgtgttttaatcttcctggttgcagtcttagttgttcagccctgagaattttgagccacatttgttgctattatttttgcatgcacttttcaaaatgattgacttaagcttcctgactgaagaggaacaagaggccatcatgaaggttttgcagcgggatgctgctctgaagagggccgaagaagagagagtcagacatttgcctgaaaaaattaaggatgaccagcagctgaagaatatgagtggccaatggttttatgaagccaaggcaaaaaggcacagggacaaaatccatggcgcagatatcatcagagcatctatgagaaagaagaggccccagatagcagctgagcagagtaaagacagagaaaatggggcaaaggaaagctgggtgaataatgtcaacaaagatgctttccttcctccagagctggctggcgttgtagaagagccagaagaagatgcagcaccagcaagcccgagttccagtgtggtaaatccagcttccagtgtgattgatatgtcccaggaaaacacaaggaaaccaaatgtgtctccagagaagaggaagaatccgtttaatagctccaagttgccagaaggtcactcatcacaacaaactaaaaatgaacagtcaaaaaatggaagaactggtttatttcagacttcaaaagaggatgaattgtcagagtcaaaagaaaagtcaactgtcgcagatacttcaatccaaaagttagagaaatcaaagcagactttgccaggcctttcaaatgggtcccaaatcaaggctccaatccccaaagccaggaagatgatctacaaatcaactgatttaaacaaagatgataaccagtcttttcctagacaaaggacagactccctgaaagcgagaggggctccgagagggatcctcaagcgcaactccagttccagtagcacagactcagaaacccttcgttataatcacaactttgaacccaaaagcaaaattgtgtcacctggcctaaccatccatgagagaatttctgagaaggagcattctttagaagacaactcttccccaaactccctggagccattaaagcatgtgagattctctgcagtgaaggatgagcttccacagagtcctgggctaatccatggtcgggaagtaggagaatttagtgttttagaatctgacagattgaaaaatggaatggaagatgcaggggacacagaagagtttcagagtgaccctaagccttctcaatacagaaagccttcgctttttcatcaatcaacctcaagcccatatgtatcaaaaagtgaaacacatcagccaatgacttctggttcttttccaattaatgggctgcattctcattcagaagttttaactgcaagaccacagtctatggagaattcaccaaccatcaatgaacccaaagataaatcatcagaattaacaaggcttgaatctgtattacccagaagccctgctgatgaactgtctcattgtgttgagcctgagccatctcaggtgccaggtggcagttctagagaccgtcagcaaggttcagaagaagaacccagtcctgttttgaaaactttggaaaggagtgccgctaggaaaatgccttccaaaagtctagaagacatttcatcagattcatcaaatcaagcaaaagtagataatcagccagaagaattagtgcgtagtgctgaagatgtttccacagtgcctacacaacctgataatccattttctcaccctgacaaactcaaaaggatgagcaagtctgttccagcatttctccaagatgagagtgatgacagagaaacagatacagcatcagaaagcagttaccagctcagcagacacaagaagagcccgagctctttaaccaatcttagcagctcctctggcatgacgtccttgtcttctgtgagtggcagtgtgatgagtgtttatagtggagactttggcaatctggaagttaaaggaaatattcagtttgcaattgaatatgtggagtcactgaaggagttgcatgtttttgtggcccagtgtaaggacttagcagcagcggatgtaaaaaaacagcgttcagacccatatgtaaaggcctatttgctaccagacaaaggcaaaatgggcaagaagaaaacactcgtagtgaagaaaaccttgaatcctgtgtataacgaaatactgcggtataaaattgaaaaacaaatcttaaagacacagaaattgaacctgtccatttggcatcgggatacatttaagcgcaatagtttcctaggggaggtggaacttgatttggaaacatgggactgggataacaaacagaataaacaattgagatggtaccctctgaagcggaagacagcaccagttgcccttgaagcagaaaacagaggtgaaatgaaactagctctccagtatgtcccagagccagtccctggtaaaaagcttcctacaactggagaagtgcacatctgggtgaaggaatgccttgatctaccactgctaaggggaagtcatctaaattcttttgttaaatgtaccatccttccagatacaagtaggaaaagtcgccagaagacaagagctgtagggaaaaccaccaaccctatcttcaaccacactatggtgtatgatgggttcaggcctgaagatctgatggaagcctgtgtagagcttactgtctgggaccattacaaattaaccaaccaatttttgggaggtcttcgtattggctttggaacaggtaaaagttatgggactgaagtggactggatggactctacttcagaggaagttgctctctgggagaagatggtaaactcccccaatacttggattgaagcaacactgcctctcagaatgcttttgattgccaagatttccaaatgagcccaaattccactggctcctccactgaaaactactaaaccggtggaatctgatcttgaaaatctgagtaggtggacaaatatcctcactttctatctattgcacctaaggaatactacacagcatgtaaaagtcaatctgcatgtgcttctttgattacaaggcccaagggatttaaatataacaaaatgtgtaatttgtgactctaatattaaataagatatttgaacaagctaggaaaattgaatttctgctgctgcttcaaagaaaaagctgccccagagcattaaacatggggtattgttaagaagcaaaatgttcttgtttgccatcatgtgtttcacaccacaattctgtgccacagttaagagggtctggtacccttgcaggacctttgtaggttgtgggaaaaagtcgcagaaagatactcaaagtggagcagggaatggagacagacatcagtgatgataaaaaaaaaaatggaccttaagaaactatttactctgtaatctctaataaaatatggaattccatattagggcaatgagactgaaactactggtgtttttctgccttgagaaaacaaacagttaaaacaagcctcaaatgtattttagtgccacccactggccataggtacaattcagttgttggcttgttttgacttaattctaaaataggtctcaagcctgtatttttatgagtttatttttttaaaaccctgcatatatatgattgtttttcttataactttactatatgaaagcagcataagagtagtcacaaacatgttttgcaacaaagttttaattagaatgtaagttgctcagttatactgttcttcttatgtatgtaaaattttcgtattttgtaaaaacccttagaataaattatcatttgatttaaattgtattagaaaattagcgtgacttctcattttaaataaaatattttaggaattctaaacatctaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:54843 -> Molecular function: GO:0001786 [phosphatidylserine binding] evidence: IMP
            GeneID:54843 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:54843 -> Molecular function: GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] evidence: IMP
            GeneID:54843 -> Molecular function: GO:0017137 [Rab GTPase binding] evidence: IEA
            GeneID:54843 -> Molecular function: GO:0019902 [phosphatase binding] evidence: IDA
            GeneID:54843 -> Molecular function: GO:0042043 [neurexin family protein binding] evidence: ISS
            GeneID:54843 -> Biological process: GO:0006886 [intracellular protein transport] evidence: IEA
            GeneID:54843 -> Biological process: GO:0006887 [exocytosis] evidence: IDA
            GeneID:54843 -> Biological process: GO:0006904 [vesicle docking involved in exocytosis] evidence: IDA
            GeneID:54843 -> Biological process: GO:0010923 [negative regulation of phosphatase activity] evidence: IDA
            GeneID:54843 -> Biological process: GO:0016192 [vesicle-mediated transport] evidence: ISS
            GeneID:54843 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:54843 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:54843 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
            GeneID:54843 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:54843 -> Cellular component: GO:0016020 [membrane] evidence: ISS
            GeneID:54843 -> Cellular component: GO:0019897 [extrinsic to plasma membrane] evidence: ISS
            GeneID:54843 -> Cellular component: GO:0042470 [melanosome] evidence: ISS
            GeneID:54843 -> Cellular component: GO:0070382 [exocytic vesicle] evidence: IDA

by @meso_cacase at DBCLS
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