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2019-03-23 03:49:57, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001161780            4247 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1
            (PDP1), transcript variant 3, mRNA.
ACCESSION   NM_001161780
VERSION     NM_001161780.1  GI:239985425
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4247)
  AUTHORS   Kiilerich,K., Ringholm,S., Bienso,R.S., Fisher,J.P., Iversen,N.,
            van Hall,G., Wojtaszewski,J.F., Saltin,B., Lundby,C., Calbet,J.A.
            and Pilegaard,H.
  TITLE     Exercise-induced pyruvate dehydrogenase activation is not affected
            by 7 days of bed rest
  JOURNAL   J. Appl. Physiol. 111 (3), 751-757 (2011)
   PUBMED   21680880
  REMARK    GeneRIF: Although 7 days of bed rest induced whole body glucose
            intolerance, exercise-induced PDH regulation in skeletal muscle was
            not changed, suggesting that exercise-induced PDH regulation in
            skeletal muscle is maintained in glucose-intolerant individuals.
REFERENCE   2  (bases 1 to 4247)
  AUTHORS   Kato,J. and Kato,M.
  TITLE     Crystallization and preliminary crystallographic studies of the
            catalytic subunits of human pyruvate dehydrogenase phosphatase
            isoforms 1 and 2
  JOURNAL   Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (PT 3),
            342-345 (2010)
   PUBMED   20208177
  REMARK    GeneRIF: catalytic subunit of PDP1 crystals belonged to space group
            P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 65.1, c
            = 216.1 A.
REFERENCE   3  (bases 1 to 4247)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS ONE 5 (9), E12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4247)
  AUTHORS   Cameron,J.M., Maj,M., Levandovskiy,V., Barnett,C.P., Blaser,S.,
            Mackay,N., Raiman,J., Feigenbaum,A., Schulze,A. and Robinson,B.H.
  TITLE     Pyruvate dehydrogenase phosphatase 1 (PDP1) null mutation produces
            a lethal infantile phenotype
  JOURNAL   Hum. Genet. 125 (3), 319-326 (2009)
   PUBMED   19184109
REFERENCE   5  (bases 1 to 4247)
  AUTHORS   Stellingwerff,T., Spriet,L.L., Watt,M.J., Kimber,N.E.,
            Hargreaves,M., Hawley,J.A. and Burke,L.M.
  TITLE     Decreased PDH activation and glycogenolysis during exercise
            following fat adaptation with carbohydrate restoration
  JOURNAL   Am. J. Physiol. Endocrinol. Metab. 290 (2), E380-E388 (2006)
   PUBMED   16188909
  REMARK    GeneRIF: Lower accumulation of free ADP and AMP after the FAT-adapt
            trial may be responsible for the decreased glycogenolysis and PDH
            activation during sprinting.
REFERENCE   6  (bases 1 to 4247)
  AUTHORS   Huang,B., Gudi,R., Wu,P., Harris,R.A., Hamilton,J. and Popov,K.M.
  TITLE     Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino
            acid sequences, expression, and regulation
  JOURNAL   J. Biol. Chem. 273 (28), 17680-17688 (1998)
   PUBMED   9651365
  REMARK    GeneRIF: Functional characterization of the rat counterpart.
REFERENCE   7  (bases 1 to 4247)
  AUTHORS   Korotchkina,L.G. and Patel,M.S.
  TITLE     Mutagenesis studies of the phosphorylation sites of recombinant
            human pyruvate dehydrogenase. Site-specific regulation
  JOURNAL   J. Biol. Chem. 270 (24), 14297-14304 (1995)
   PUBMED   7782287
REFERENCE   8  (bases 1 to 4247)
  AUTHORS   Lawson,J.E., Niu,X.D., Browning,K.S., Trong,H.L., Yan,J. and
            Reed,L.J.
  TITLE     Molecular cloning and expression of the catalytic subunit of bovine
            pyruvate dehydrogenase phosphatase and sequence similarity with
            protein phosphatase 2C
  JOURNAL   Biochemistry 32 (35), 8987-8993 (1993)
   PUBMED   8396421
  REMARK    GeneRIF: Functional characterization of the bovine counterpart.
REFERENCE   9  (bases 1 to 4247)
  AUTHORS   Ito,M., Kobashi,H., Naito,E., Saijo,T., Takeda,E., Huq,A.H. and
            Kuroda,Y.
  TITLE     Decrease of pyruvate dehydrogenase phosphatase activity in patients
            with congenital lactic acidemia
  JOURNAL   Clin. Chim. Acta 209 (1-2), 1-7 (1992)
   PUBMED   1327585
  REMARK    GeneRIF: In cultured skin fibroblasts from three patients with
            congenital lactic acidemia due to a defect in activation of the
            pyruvate dehydrogenase complex, the PDP-activity was significantly
            reduced to 50.7%, 64.6% and 63.1% of that of control fibroblasts.
REFERENCE   10 (bases 1 to 4247)
  AUTHORS   Robinson,B.H. and Sherwood,W.G.
  TITLE     Pyruvate dehydrogenase phosphatase deficiency: a cause of
            congenital chronic lactic acidosis in infancy
  JOURNAL   Pediatr. Res. 9 (12), 935-939 (1975)
   PUBMED   172850
  REMARK    GeneRIF: In postmortem tissue samples, from male child with
            metabolic acidosis, PDK normally reduced PDH-activity in
            ATP-presence. Addition of Ca++ and Mg++ did not restored
            PDH-activity. The defect was attributed to a markedly reduced
            PDP-activity.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA507397.1, BC064978.1,
            AK126862.1 and BX099681.1.
            
            Summary: Pyruvate dehydrogenase (E1) is one of the three components
            (E1, E2, and E3) of the large pyruvate dehydrogenase complex.
            Pyruvate dehydrogenase kinases catalyze phosphorylation of serine
            residues of E1 to inactivate the E1 component and inhibit the
            complex. Pyruvate dehydrogenase phosphatases catalyze the
            dephosphorylation and activation of the E1 component to reverse the
            effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase
            phosphatase is a heterodimer consisting of catalytic and regulatory
            subunits. Two catalytic subunits have been reported; one is
            predominantly expressed in skeletal muscle and another one is is
            much more abundant in the liver. The catalytic subunit, encoded by
            this gene, is the former, and belongs to the protein phosphatase 2C
            (PP2C) superfamily. Along with the pyruvate dehydrogenase complex
            and pyruvate dehydrogenase kinases, this enzyme is located in the
            mitochondrial matrix. Mutation in this gene causes pyruvate
            dehydrogenase phosphatase deficiency. Multiple alternatively
            spliced transcript variants encoding different isoforms have been
            identified.[provided by RefSeq, Jun 2009].
            
            Transcript Variant: This variant (3) lacks an internal segment in
            the 5' UTR, compared to variant 2. Variants 2 and 3 encode the same
            isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA775855.1, BC064978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DA507397.1         1-16
            17-2542             BC064978.1         1-2526
            2543-4232           AK126862.1         2964-4653
            4233-4247           BX099681.1         512-526
FEATURES             Location/Qualifiers
     source          1..4247
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..4247
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /note="pyruvate dehyrogenase phosphatase catalytic subunit
                     1"
                     /db_xref="GeneID:54704"
                     /db_xref="HGNC:9279"
                     /db_xref="MIM:605993"
     exon            1..146
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /inference="alignment:Splign:1.39.8"
     variation       55
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202016823"
     variation       124
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:372548037"
     exon            147..181
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /inference="alignment:Splign:1.39.8"
     CDS             151..1839
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /EC_number="3.1.3.43"
                     /note="isoform 2 is encoded by transcript variant 3;
                     pyruvate dehydrogenase (Lipoamide)
                     phosphatase-phosphatase; [Pyruvate dehydrogenase
                     [acetyl-transferring]]-phosphatase 1, mitochondrial;
                     protein phosphatase 2C, magnesium-dependent, catalytic
                     subunit; PDP 1; PDPC 1; pyruvate dehydrogenase phosphatase
                     catalytic subunit 1"
                     /codon_start=1
                     /product="pyruvate dehyrogenase phosphatase catalytic
                     subunit 1 isoform 2"
                     /protein_id="NP_001155252.1"
                     /db_xref="GI:239985426"
                     /db_xref="CCDS:CCDS55262.1"
                     /db_xref="GeneID:54704"
                     /db_xref="HGNC:9279"
                     /db_xref="MIM:605993"
                     /translation="
MCVCPGPRRIGIPVRSSSLPLFSDAMPAPTQLFFPLIRNCELSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
"
     misc_feature    550..1545
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; Region: PP2Cc; cd00143"
                     /db_xref="CDD:29062"
     misc_feature    order(583..585,595..600,655..663,1477..1479)
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /note="active site"
                     /db_xref="CDD:29062"
     exon            182..4234
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /inference="alignment:Splign:1.39.8"
     variation       184
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368896704"
     variation       199
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76597597"
     variation       213
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373914341"
     variation       239
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376864107"
     variation       250
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371323550"
     variation       316
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201452113"
     variation       353
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201081450"
     variation       379
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140713866"
     variation       420
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375147234"
     variation       427
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374758737"
     variation       464
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79439881"
     variation       486
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144544236"
     variation       502
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:267606938"
     variation       509
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368756677"
     variation       592
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144604949"
     variation       602
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147845975"
     variation       630
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376531662"
     variation       631
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201131767"
     variation       643
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141399719"
     variation       646
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151019488"
     variation       648
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368265235"
     variation       735
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200661557"
     variation       771
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202034256"
     variation       866
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200145429"
     variation       882
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374859758"
     variation       894
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138512618"
     variation       896
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140780685"
     variation       903
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199977411"
     variation       906
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369055053"
     variation       914
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201467137"
     variation       942
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150112501"
     variation       978
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138553326"
     variation       1005
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140224111"
     variation       1007
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145915456"
     variation       1080
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201021364"
     variation       1117
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373016029"
     variation       1131
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138488258"
     variation       1134
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146222349"
     variation       1138
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149633208"
     variation       1192
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370143029"
     variation       1204
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373354872"
     variation       1218
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200054483"
     variation       1246
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144339806"
     variation       1438
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377342640"
     variation       1453
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369447724"
     variation       1458
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374326474"
     variation       1467
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148348306"
     variation       1499
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200222464"
     variation       1506
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141493326"
     variation       1588
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373946288"
     variation       1627
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377553463"
     variation       1642
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201132164"
     variation       1656
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147477305"
     variation       1659
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117294206"
     variation       1671
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:137975172"
     variation       1672
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370390664"
     variation       1680
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374262682"
     variation       1721
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376060350"
     variation       1745
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:145358369"
     variation       1759
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202225648"
     variation       1783
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202145000"
     variation       1795
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:147237491"
     variation       1839
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:139199750"
     variation       1864
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:41272415"
     variation       1875
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4735258"
     variation       1888
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:192535454"
     variation       1890
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149521176"
     variation       1904
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144036151"
     variation       1910
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148691545"
     variation       1932
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144473673"
     variation       2212
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185126352"
     STS             2266..2517
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /standard_name="D8S1599"
                     /db_xref="UniSTS:1082"
     variation       2330
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:41272417"
     variation       2348
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199846257"
     STS             2389..2504
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /standard_name="SHGC-24323"
                     /db_xref="UniSTS:92277"
     variation       2405
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78884124"
     variation       2449
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190420045"
     variation       2468
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192629673"
     variation       2470
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:911"
     variation       2478
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147461233"
     variation       2494
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185015320"
     variation       2505
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:139623857"
     variation       2646
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:188727327"
     variation       2749
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:7461396"
     variation       2769
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:180752222"
     variation       2796
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75265995"
     variation       2841..2842
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35866235"
     variation       2846
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185360919"
     variation       3042..3043
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35793146"
     variation       3258
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201779185"
     variation       3326
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:189435075"
     variation       3403
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:111728711"
     variation       3448
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186669527"
     variation       3487
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:145384326"
     variation       3488
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377214447"
     variation       3489
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:192025344"
     variation       3497
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:60316663"
     variation       3575
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:116788695"
     variation       3646
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:77734416"
     variation       3761
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:139839619"
     variation       3914
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:368109978"
     variation       3934
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115434133"
     STS             4086..4207
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /standard_name="STS-N47861"
                     /db_xref="UniSTS:64541"
     variation       4094
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183503324"
     variation       4096
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:367694582"
     variation       4102
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145337691"
     variation       4139..4140
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:371346130"
     variation       4175
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:186410170"
     variation       4192
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:190113849"
     polyA_signal    4208..4213
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
     polyA_site      4234
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
ORIGIN      
acggtaggggagcagagtgggcaggccgggggtgagggctcgcgctccgggagctgcacggggctgcgtggaaagagcgccgagcggtggcgtcgttgtcgccccctcctcgtcgggaagaatcgtttggtctcctgccgtgcccggagaatgtgtgtgtgtcccgggcccagacgaattggaatcccagtcagaagttccagcctgccactgttctctgatgccatgccagcaccaactcaactgttttttcctctcatccgtaactgtgaactgagcaggatctatggcactgcatgttactgccaccacaaacatctctgttgttcctcatcgtacattcctcagagtcgactgagatacacacctcatccagcatatgctaccttttgcaggccaaaggagaactggtggcagtacacccaaggaaggagatatgcttccacaccacagaaattttacctcacacctccacaagtcaatagcatccttaaagctaatgaatacagtttcaaagtgccagaatttgacggcaaaaatgtcagttctatccttggatttgacagcaatcagctgcctgcaaatgcacccattgaggaccggagaagtgcagcaacctgcttgcagaccagagggatgcttttgggggtttttgatggccatgcaggttgtgcttgttcccaggcagtcagtgaaagactcttttattatattgctgtctctttgttaccccatgagactttgctagagattgaaaatgcagtggagagcggccgggcactgctacccattctccagtggcacaagcaccccaatgattactttagtaaggaggcatccaaattgtactttaacagcttgaggacttactggcaagagcttatagacctcaacactggtgagtcgactgatattgatgttaaggaggctctaattaatgccttcaagaggcttgataatgacatctccttggaggcgcaagttggtgatcctaattcttttctcaactacctggtgcttcgagtggcattttctggagccactgcttgtgtggcccatgtggatggtgttgaccttcatgtggccaatactggcgatagcagagccatgctgggtgtgcaggaagaggacggctcatggtcagcagtcacgctgtctaatgaccacaatgctcaaaatgaaagagaactagaacggctgaaattggaacatccaaagagtgaggccaagagtgtcgtgaaacaggatcggctgcttggcttgctgatgccatttagggcatttggagatgtaaagttcaaatggagcattgaccttcaaaagagagtgatagaatctggcccagaccagttgaatgacaatgaatataccaagtttattcctcctaattatcacacacctccttatctcactgctgagccagaggtaacttaccaccgattaaggccacaggataagtttctggtgttggctactgatgggttgtgggagactatgcataggcaggatgtggttaggattgtgggtgagtacctaactggcatgcatcaccaacagccaatagctgttggtggctacaaggtgactctgggacagatgcatggccttttaacagaaaggagaaccaaaatgtcctcggtatttgaggatcagaacgcagcaacccatctcattcgccacgctgtgggcaacaacgagtttgggactgttgatcatgagcgcctctctaaaatgcttagtcttcctgaagagcttgctcgaatgtacagagatgacattacaatcattgtagttcagttcaattctcatgttgtaggggcgtatcaaaaccaagaatagtgagtggctctttcactggcaattctcaaatgatatacatttaaagggcagattttttaaaaagatactactataataaacatttccagttggtcattctaagcatttacccttttgatactctagctagtcaggtactccaaattgactttgcagcagggtggcagggtcaggagagtctggtcctgcctagctcagatttcatggcacctgcacttgaagcaagtcacttctttatcacaggtgtcttgaaacattagcttcttttaccaacctgagaaaattaggatgacctggcaaataagatcttgaataggccaaaagcaagtatcttgctgtgtgtagtctcttggttaaagtgaagaaacagtactgttcacacctttcttcactgagattccagtgtacatgagaacatatatttattgcatgattttctagatacacagtctatgcattattcatatacatttattttagcctaaagtggttttcaaatccagttcttcaagccataaatgaccaagatccaagcaatctgaatttgtttttgtgattatttgactggaatgcttcttaagtggaataactatactccgttatccacccgatttcctaatgtaattgaaagattttctattttgccacacacttggagacaataagggtttttagttttatctactcttctattgaagttaaagaaagaaaaaaagatttttttatttgtattaatgaaaagctttagtttaaaataaggagatccagaataaaaagaagagactgatctcttcaattattgtcatctgtagccaccagcacatcactcttatgtaatccccaaaggcttggcatgccgtaagtgtgtggtgggtagactgctgccggggaatcgtacttcttatttagtaatgataagacttttcattatttttggaattttaaagatgacataaataagtttaaatatcaatttggggagtaaggtttaatattgccatcgggtattgagacaggaggaagtttctgtttttctccatttagacataggtcaattaaaatatttgggtttaaaatgactaaatgctttaaacatattgtagcttaagatatatgtgttaagatatatacatgagaaactttaaaaggtaactactgtgcatgcctgatgcttaatagaatacttagtggcatcaaatgtttgcagcagtctccataattatattcagtcccttctaatactgtatcaatgtaaatgaaataaatatattcaaattggctttttgatatgcatcaagtggcattttgttcctgtgtttaatagtgatctgtatacagctgtgcacatattgtcatcacttattctagcatcactgttaaggctgtgattatgtttgatattcacctggattttaatacaagccaatatcagcttcccattgtgtaataacttgggtgtttaggagtcttttcacattttttggggatatgaactagatgttcaagaactccttctggactgtggatactgaatcagtgtactattggctgcagaatttgtttcaattgaaaatagactcaggaagattgctgctcagaatatcatataatgtttattttttgaggtgtttttgtttttatttgtgtgtttttttttttttaagtcagcttggaacttttttcctgggtagtatttgggagagggaaaggctgtactatatatttatttctaaatgttttgactgggcatttttcttttaatgaaatatgtggactgctctagcaaaccctattttcagctactatttgaatattcttgaacaccaccactgaagagtttcatatacaccaaataatgtctcatctctatagtacagggaatataaaattggtttcctgtggtcatgatcaagatagtagtattattacacaagaaacttggtctgcagtctggaagcttgtctgctctatagaaatgaaaatgcagcatgaagttgacattgtggaaatgaaagtaattgggtattagaaatctgaaagtactgtcatctaaaagcaattgtgattttattgtaattggttgtcactgttgtacggtgtctagaattaaagaatacatgtaaactttcatggtatttagcctttcttaaatttttttaaaatttaaactttctaacctatgtattcaacttctgtatttatatttaatcagtggttcatgttatataatacacccttaactagttaaatggaatgttggtatggtacagagtaccatattgctaagaaaactgtcttataaaagatgtatatgtgtgaagacatgaaagtttaatgtacagaatggttggagaaatgcctatggtgaattaaagcttcatatctgctttctgaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:54704 -> Molecular function: GO:0004722 [protein serine/threonine phosphatase activity] evidence: IDA
            GeneID:54704 -> Molecular function: GO:0004741 [[pyruvate dehydrogenase (lipoamide)] phosphatase activity] evidence: IEA
            GeneID:54704 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:54704 -> Biological process: GO:0006090 [pyruvate metabolic process] evidence: TAS
            GeneID:54704 -> Biological process: GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate] evidence: TAS
            GeneID:54704 -> Biological process: GO:0035970 [peptidyl-threonine dephosphorylation] evidence: IDA
            GeneID:54704 -> Biological process: GO:0044237 [cellular metabolic process] evidence: TAS
            GeneID:54704 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:54704 -> Cellular component: GO:0005759 [mitochondrial matrix] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001155252 -> EC 3.1.3.43

by @meso_cacase at DBCLS
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