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2019-03-25 08:32:59, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001161779            4373 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1
            (PDP1), transcript variant 2, mRNA.
ACCESSION   NM_001161779
VERSION     NM_001161779.1  GI:239985421
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4373)
  AUTHORS   Kiilerich,K., Ringholm,S., Bienso,R.S., Fisher,J.P., Iversen,N.,
            van Hall,G., Wojtaszewski,J.F., Saltin,B., Lundby,C., Calbet,J.A.
            and Pilegaard,H.
  TITLE     Exercise-induced pyruvate dehydrogenase activation is not affected
            by 7 days of bed rest
  JOURNAL   J. Appl. Physiol. 111 (3), 751-757 (2011)
   PUBMED   21680880
  REMARK    GeneRIF: Although 7 days of bed rest induced whole body glucose
            intolerance, exercise-induced PDH regulation in skeletal muscle was
            not changed, suggesting that exercise-induced PDH regulation in
            skeletal muscle is maintained in glucose-intolerant individuals.
REFERENCE   2  (bases 1 to 4373)
  AUTHORS   Kato,J. and Kato,M.
  TITLE     Crystallization and preliminary crystallographic studies of the
            catalytic subunits of human pyruvate dehydrogenase phosphatase
            isoforms 1 and 2
  JOURNAL   Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (PT 3),
            342-345 (2010)
   PUBMED   20208177
  REMARK    GeneRIF: catalytic subunit of PDP1 crystals belonged to space group
            P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 65.1, c
            = 216.1 A.
REFERENCE   3  (bases 1 to 4373)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS ONE 5 (9), E12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4373)
  AUTHORS   Cameron,J.M., Maj,M., Levandovskiy,V., Barnett,C.P., Blaser,S.,
            Mackay,N., Raiman,J., Feigenbaum,A., Schulze,A. and Robinson,B.H.
  TITLE     Pyruvate dehydrogenase phosphatase 1 (PDP1) null mutation produces
            a lethal infantile phenotype
  JOURNAL   Hum. Genet. 125 (3), 319-326 (2009)
   PUBMED   19184109
REFERENCE   5  (bases 1 to 4373)
  AUTHORS   Stellingwerff,T., Spriet,L.L., Watt,M.J., Kimber,N.E.,
            Hargreaves,M., Hawley,J.A. and Burke,L.M.
  TITLE     Decreased PDH activation and glycogenolysis during exercise
            following fat adaptation with carbohydrate restoration
  JOURNAL   Am. J. Physiol. Endocrinol. Metab. 290 (2), E380-E388 (2006)
   PUBMED   16188909
  REMARK    GeneRIF: Lower accumulation of free ADP and AMP after the FAT-adapt
            trial may be responsible for the decreased glycogenolysis and PDH
            activation during sprinting.
REFERENCE   6  (bases 1 to 4373)
  AUTHORS   Huang,B., Gudi,R., Wu,P., Harris,R.A., Hamilton,J. and Popov,K.M.
  TITLE     Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino
            acid sequences, expression, and regulation
  JOURNAL   J. Biol. Chem. 273 (28), 17680-17688 (1998)
   PUBMED   9651365
  REMARK    GeneRIF: Functional characterization of the rat counterpart.
REFERENCE   7  (bases 1 to 4373)
  AUTHORS   Korotchkina,L.G. and Patel,M.S.
  TITLE     Mutagenesis studies of the phosphorylation sites of recombinant
            human pyruvate dehydrogenase. Site-specific regulation
  JOURNAL   J. Biol. Chem. 270 (24), 14297-14304 (1995)
   PUBMED   7782287
REFERENCE   8  (bases 1 to 4373)
  AUTHORS   Lawson,J.E., Niu,X.D., Browning,K.S., Trong,H.L., Yan,J. and
            Reed,L.J.
  TITLE     Molecular cloning and expression of the catalytic subunit of bovine
            pyruvate dehydrogenase phosphatase and sequence similarity with
            protein phosphatase 2C
  JOURNAL   Biochemistry 32 (35), 8987-8993 (1993)
   PUBMED   8396421
  REMARK    GeneRIF: Functional characterization of the bovine counterpart.
REFERENCE   9  (bases 1 to 4373)
  AUTHORS   Ito,M., Kobashi,H., Naito,E., Saijo,T., Takeda,E., Huq,A.H. and
            Kuroda,Y.
  TITLE     Decrease of pyruvate dehydrogenase phosphatase activity in patients
            with congenital lactic acidemia
  JOURNAL   Clin. Chim. Acta 209 (1-2), 1-7 (1992)
   PUBMED   1327585
  REMARK    GeneRIF: In cultured skin fibroblasts from three patients with
            congenital lactic acidemia due to a defect in activation of the
            pyruvate dehydrogenase complex, the PDP-activity was significantly
            reduced to 50.7%, 64.6% and 63.1% of that of control fibroblasts.
REFERENCE   10 (bases 1 to 4373)
  AUTHORS   Robinson,B.H. and Sherwood,W.G.
  TITLE     Pyruvate dehydrogenase phosphatase deficiency: a cause of
            congenital chronic lactic acidosis in infancy
  JOURNAL   Pediatr. Res. 9 (12), 935-939 (1975)
   PUBMED   172850
  REMARK    GeneRIF: In postmortem tissue samples, from male child with
            metabolic acidosis, PDK normally reduced PDH-activity in
            ATP-presence. Addition of Ca++ and Mg++ did not restored
            PDH-activity. The defect was attributed to a markedly reduced
            PDP-activity.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA769567.1, BC098343.1,
            AK126862.1 and BX099681.1.
            
            Summary: Pyruvate dehydrogenase (E1) is one of the three components
            (E1, E2, and E3) of the large pyruvate dehydrogenase complex.
            Pyruvate dehydrogenase kinases catalyze phosphorylation of serine
            residues of E1 to inactivate the E1 component and inhibit the
            complex. Pyruvate dehydrogenase phosphatases catalyze the
            dephosphorylation and activation of the E1 component to reverse the
            effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase
            phosphatase is a heterodimer consisting of catalytic and regulatory
            subunits. Two catalytic subunits have been reported; one is
            predominantly expressed in skeletal muscle and another one is is
            much more abundant in the liver. The catalytic subunit, encoded by
            this gene, is the former, and belongs to the protein phosphatase 2C
            (PP2C) superfamily. Along with the pyruvate dehydrogenase complex
            and pyruvate dehydrogenase kinases, this enzyme is located in the
            mitochondrial matrix. Mutation in this gene causes pyruvate
            dehydrogenase phosphatase deficiency. Multiple alternatively
            spliced transcript variants encoding different isoforms have been
            identified.[provided by RefSeq, Jun 2009].
            
            Transcript Variant: This variant (2) is the longest transcript.
            This variant and variant 3 encode the same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA769567.1, DA233418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025091 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-581               DA769567.1         1-581
            582-2000            BC098343.1         254-1672
            2001-4358           AK126862.1         2296-4653
            4359-4373           BX099681.1         512-526
FEATURES             Location/Qualifiers
     source          1..4373
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..4373
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /note="pyruvate dehyrogenase phosphatase catalytic subunit
                     1"
                     /db_xref="GeneID:54704"
                     /db_xref="HGNC:9279"
                     /db_xref="MIM:605993"
     exon            1..272
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /inference="alignment:Splign:1.39.8"
     variation       42
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202016823"
     variation       111
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:372548037"
     variation       228
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186315844"
     exon            273..307
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /inference="alignment:Splign:1.39.8"
     CDS             277..1965
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /EC_number="3.1.3.43"
                     /note="isoform 2 is encoded by transcript variant 2;
                     pyruvate dehydrogenase (Lipoamide)
                     phosphatase-phosphatase; [Pyruvate dehydrogenase
                     [acetyl-transferring]]-phosphatase 1, mitochondrial;
                     protein phosphatase 2C, magnesium-dependent, catalytic
                     subunit; PDP 1; PDPC 1; pyruvate dehydrogenase phosphatase
                     catalytic subunit 1"
                     /codon_start=1
                     /product="pyruvate dehyrogenase phosphatase catalytic
                     subunit 1 isoform 2"
                     /protein_id="NP_001155251.1"
                     /db_xref="GI:239985422"
                     /db_xref="CCDS:CCDS55262.1"
                     /db_xref="GeneID:54704"
                     /db_xref="HGNC:9279"
                     /db_xref="MIM:605993"
                     /translation="
MCVCPGPRRIGIPVRSSSLPLFSDAMPAPTQLFFPLIRNCELSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
"
     misc_feature    676..1671
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; Region: PP2Cc; cd00143"
                     /db_xref="CDD:29062"
     misc_feature    order(709..711,721..726,781..789,1603..1605)
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /note="active site"
                     /db_xref="CDD:29062"
     exon            308..4360
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /inference="alignment:Splign:1.39.8"
     variation       310
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368896704"
     variation       325
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76597597"
     variation       339
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373914341"
     variation       365
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376864107"
     variation       376
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371323550"
     variation       442
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201452113"
     variation       479
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201081450"
     variation       505
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140713866"
     variation       546
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375147234"
     variation       553
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374758737"
     variation       590
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79439881"
     variation       612
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144544236"
     variation       628
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:267606938"
     variation       635
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368756677"
     variation       718
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144604949"
     variation       728
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147845975"
     variation       756
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376531662"
     variation       757
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201131767"
     variation       769
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141399719"
     variation       772
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151019488"
     variation       774
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368265235"
     variation       861
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200661557"
     variation       897
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202034256"
     variation       992
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200145429"
     variation       1008
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374859758"
     variation       1020
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138512618"
     variation       1022
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140780685"
     variation       1029
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199977411"
     variation       1032
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369055053"
     variation       1040
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201467137"
     variation       1068
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150112501"
     variation       1104
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138553326"
     variation       1131
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140224111"
     variation       1133
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145915456"
     variation       1206
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201021364"
     variation       1243
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373016029"
     variation       1257
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138488258"
     variation       1260
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146222349"
     variation       1264
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149633208"
     variation       1318
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370143029"
     variation       1330
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373354872"
     variation       1344
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200054483"
     variation       1372
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144339806"
     variation       1564
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377342640"
     variation       1579
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369447724"
     variation       1584
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374326474"
     variation       1593
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148348306"
     variation       1625
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200222464"
     variation       1632
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141493326"
     variation       1714
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373946288"
     variation       1753
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377553463"
     variation       1768
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201132164"
     variation       1782
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147477305"
     variation       1785
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117294206"
     variation       1797
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:137975172"
     variation       1798
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370390664"
     variation       1806
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374262682"
     variation       1847
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376060350"
     variation       1871
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:145358369"
     variation       1885
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202225648"
     variation       1909
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202145000"
     variation       1921
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:147237491"
     variation       1965
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:139199750"
     variation       1990
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:41272415"
     variation       2001
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4735258"
     variation       2014
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:192535454"
     variation       2016
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149521176"
     variation       2030
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144036151"
     variation       2036
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148691545"
     variation       2058
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144473673"
     variation       2338
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185126352"
     STS             2392..2643
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /standard_name="D8S1599"
                     /db_xref="UniSTS:1082"
     variation       2456
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:41272417"
     variation       2474
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199846257"
     STS             2515..2630
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /standard_name="SHGC-24323"
                     /db_xref="UniSTS:92277"
     variation       2531
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78884124"
     variation       2575
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190420045"
     variation       2594
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192629673"
     variation       2596
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:911"
     variation       2604
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147461233"
     variation       2620
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185015320"
     variation       2631
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:139623857"
     variation       2772
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:188727327"
     variation       2875
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:7461396"
     variation       2895
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:180752222"
     variation       2922
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75265995"
     variation       2967..2968
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35866235"
     variation       2972
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185360919"
     variation       3168..3169
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35793146"
     variation       3384
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201779185"
     variation       3452
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:189435075"
     variation       3529
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:111728711"
     variation       3574
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186669527"
     variation       3613
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:145384326"
     variation       3614
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377214447"
     variation       3615
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:192025344"
     variation       3623
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:60316663"
     variation       3701
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:116788695"
     variation       3772
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:77734416"
     variation       3887
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:139839619"
     variation       4040
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:368109978"
     variation       4060
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115434133"
     STS             4212..4333
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /standard_name="STS-N47861"
                     /db_xref="UniSTS:64541"
     variation       4220
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183503324"
     variation       4222
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:367694582"
     variation       4228
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145337691"
     variation       4265..4266
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:371346130"
     variation       4301
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:186410170"
     variation       4318
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:190113849"
     polyA_signal    4334..4339
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
     polyA_site      4360
                     /gene="PDP1"
                     /gene_synonym="PDH; PDP; PDPC; PPM2C"
ORIGIN      
agagtgggcaggccgggggtgagggctcgcgctccgggagctgcacggggctgcgtggaaagagcgccgagcggtggcgtcgttgtcgccccctcctcgtcgggaagaatcgtttggtctcctgccgtgcccggttcgtattccctactccctgccacgagccgccccgtccgggatcctccacccgtccaaagttgtgagggggcgccgggcgtgctcgcggatcggcggccgcgggcgtgcggagggctggacgagccctggagcgccaggagaatgtgtgtgtgtcccgggcccagacgaattggaatcccagtcagaagttccagcctgccactgttctctgatgccatgccagcaccaactcaactgttttttcctctcatccgtaactgtgaactgagcaggatctatggcactgcatgttactgccaccacaaacatctctgttgttcctcatcgtacattcctcagagtcgactgagatacacacctcatccagcatatgctaccttttgcaggccaaaggagaactggtggcagtacacccaaggaaggagatatgcttccacaccacagaaattttacctcacacctccacaagtcaatagcatccttaaagctaatgaatacagtttcaaagtgccagaatttgacggcaaaaatgtcagttctatccttggatttgacagcaatcagctgcctgcaaatgcacccattgaggaccggagaagtgcagcaacctgcttgcagaccagagggatgcttttgggggtttttgatggccatgcaggttgtgcttgttcccaggcagtcagtgaaagactcttttattatattgctgtctctttgttaccccatgagactttgctagagattgaaaatgcagtggagagcggccgggcactgctacccattctccagtggcacaagcaccccaatgattactttagtaaggaggcatccaaattgtactttaacagcttgaggacttactggcaagagcttatagacctcaacactggtgagtcgactgatattgatgttaaggaggctctaattaatgccttcaagaggcttgataatgacatctccttggaggcgcaagttggtgatcctaattcttttctcaactacctggtgcttcgagtggcattttctggagccactgcttgtgtggcccatgtggatggtgttgaccttcatgtggccaatactggcgatagcagagccatgctgggtgtgcaggaagaggacggctcatggtcagcagtcacgctgtctaatgaccacaatgctcaaaatgaaagagaactagaacggctgaaattggaacatccaaagagtgaggccaagagtgtcgtgaaacaggatcggctgcttggcttgctgatgccatttagggcatttggagatgtaaagttcaaatggagcattgaccttcaaaagagagtgatagaatctggcccagaccagttgaatgacaatgaatataccaagtttattcctcctaattatcacacacctccttatctcactgctgagccagaggtaacttaccaccgattaaggccacaggataagtttctggtgttggctactgatgggttgtgggagactatgcataggcaggatgtggttaggattgtgggtgagtacctaactggcatgcatcaccaacagccaatagctgttggtggctacaaggtgactctgggacagatgcatggccttttaacagaaaggagaaccaaaatgtcctcggtatttgaggatcagaacgcagcaacccatctcattcgccacgctgtgggcaacaacgagtttgggactgttgatcatgagcgcctctctaaaatgcttagtcttcctgaagagcttgctcgaatgtacagagatgacattacaatcattgtagttcagttcaattctcatgttgtaggggcgtatcaaaaccaagaatagtgagtggctctttcactggcaattctcaaatgatatacatttaaagggcagattttttaaaaagatactactataataaacatttccagttggtcattctaagcatttacccttttgatactctagctagtcaggtactccaaattgactttgcagcagggtggcagggtcaggagagtctggtcctgcctagctcagatttcatggcacctgcacttgaagcaagtcacttctttatcacaggtgtcttgaaacattagcttcttttaccaacctgagaaaattaggatgacctggcaaataagatcttgaataggccaaaagcaagtatcttgctgtgtgtagtctcttggttaaagtgaagaaacagtactgttcacacctttcttcactgagattccagtgtacatgagaacatatatttattgcatgattttctagatacacagtctatgcattattcatatacatttattttagcctaaagtggttttcaaatccagttcttcaagccataaatgaccaagatccaagcaatctgaatttgtttttgtgattatttgactggaatgcttcttaagtggaataactatactccgttatccacccgatttcctaatgtaattgaaagattttctattttgccacacacttggagacaataagggtttttagttttatctactcttctattgaagttaaagaaagaaaaaaagatttttttatttgtattaatgaaaagctttagtttaaaataaggagatccagaataaaaagaagagactgatctcttcaattattgtcatctgtagccaccagcacatcactcttatgtaatccccaaaggcttggcatgccgtaagtgtgtggtgggtagactgctgccggggaatcgtacttcttatttagtaatgataagacttttcattatttttggaattttaaagatgacataaataagtttaaatatcaatttggggagtaaggtttaatattgccatcgggtattgagacaggaggaagtttctgtttttctccatttagacataggtcaattaaaatatttgggtttaaaatgactaaatgctttaaacatattgtagcttaagatatatgtgttaagatatatacatgagaaactttaaaaggtaactactgtgcatgcctgatgcttaatagaatacttagtggcatcaaatgtttgcagcagtctccataattatattcagtcccttctaatactgtatcaatgtaaatgaaataaatatattcaaattggctttttgatatgcatcaagtggcattttgttcctgtgtttaatagtgatctgtatacagctgtgcacatattgtcatcacttattctagcatcactgttaaggctgtgattatgtttgatattcacctggattttaatacaagccaatatcagcttcccattgtgtaataacttgggtgtttaggagtcttttcacattttttggggatatgaactagatgttcaagaactccttctggactgtggatactgaatcagtgtactattggctgcagaatttgtttcaattgaaaatagactcaggaagattgctgctcagaatatcatataatgtttattttttgaggtgtttttgtttttatttgtgtgtttttttttttttaagtcagcttggaacttttttcctgggtagtatttgggagagggaaaggctgtactatatatttatttctaaatgttttgactgggcatttttcttttaatgaaatatgtggactgctctagcaaaccctattttcagctactatttgaatattcttgaacaccaccactgaagagtttcatatacaccaaataatgtctcatctctatagtacagggaatataaaattggtttcctgtggtcatgatcaagatagtagtattattacacaagaaacttggtctgcagtctggaagcttgtctgctctatagaaatgaaaatgcagcatgaagttgacattgtggaaatgaaagtaattgggtattagaaatctgaaagtactgtcatctaaaagcaattgtgattttattgtaattggttgtcactgttgtacggtgtctagaattaaagaatacatgtaaactttcatggtatttagcctttcttaaatttttttaaaatttaaactttctaacctatgtattcaacttctgtatttatatttaatcagtggttcatgttatataatacacccttaactagttaaatggaatgttggtatggtacagagtaccatattgctaagaaaactgtcttataaaagatgtatatgtgtgaagacatgaaagtttaatgtacagaatggttggagaaatgcctatggtgaattaaagcttcatatctgctttctgaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:54704 -> Molecular function: GO:0004722 [protein serine/threonine phosphatase activity] evidence: IDA
            GeneID:54704 -> Molecular function: GO:0004741 [[pyruvate dehydrogenase (lipoamide)] phosphatase activity] evidence: IEA
            GeneID:54704 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:54704 -> Biological process: GO:0006090 [pyruvate metabolic process] evidence: TAS
            GeneID:54704 -> Biological process: GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate] evidence: TAS
            GeneID:54704 -> Biological process: GO:0035970 [peptidyl-threonine dephosphorylation] evidence: IDA
            GeneID:54704 -> Biological process: GO:0044237 [cellular metabolic process] evidence: TAS
            GeneID:54704 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:54704 -> Cellular component: GO:0005759 [mitochondrial matrix] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001155251 -> EC 3.1.3.43

by @meso_cacase at DBCLS
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