2024-04-20 01:09:12, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001161440 3401 bp mRNA linear PRI 11-MAY-2013 DEFINITION Homo sapiens protein tyrosine phosphatase, receptor type, H (PTPRH), transcript variant 2, mRNA. ACCESSION NM_001161440 VERSION NM_001161440.1 GI:241896925 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3401) AUTHORS Pasquali,C., Curchod,M.L., Walchli,S., Espanel,X., Guerrier,M., Arigoni,F., Strous,G. and Hooft van Huijsduijnen,R. TITLE Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor JOURNAL Mol. Endocrinol. 17 (11), 2228-2239 (2003) PUBMED 12907755 REFERENCE 2 (bases 1 to 3401) AUTHORS Nagano,H., Noguchi,T., Inagaki,K., Yoon,S., Matozaki,T., Itoh,H., Kasuga,M. and Hayashi,Y. TITLE Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma JOURNAL Oncogene 22 (30), 4656-4663 (2003) PUBMED 12879010 REMARK GeneRIF: SAP-1 expression is downregulated during the dedifferentiation of human hepatocellular carcinoma, which may play a causal role in disease progression REFERENCE 3 (bases 1 to 3401) AUTHORS Takada,T., Noguchi,T., Inagaki,K., Hosooka,T., Fukunaga,K., Yamao,T., Ogawa,W., Matozaki,T. and Kasuga,M. TITLE Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1 JOURNAL J. Biol. Chem. 277 (37), 34359-34366 (2002) PUBMED 12101188 REMARK GeneRIF: SAP-1 induces apoptotic cell death by inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. REFERENCE 4 (bases 1 to 3401) AUTHORS Noguchi,T., Tsuda,M., Takeda,H., Takada,T., Inagaki,K., Yamao,T., Fukunaga,K., Matozaki,T. and Kasuga,M. TITLE Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas JOURNAL J. Biol. Chem. 276 (18), 15216-15224 (2001) PUBMED 11278335 REFERENCE 5 (bases 1 to 3401) AUTHORS Marneros,A.G., Mehenni,H., Reichenberger,E., Antonarakis,S.E., Krieg,T. and Olsen,B.R. TITLE Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome JOURNAL Cytogenet. Cell Genet. 92 (3-4), 213-216 (2001) PUBMED 11435690 REFERENCE 6 (bases 1 to 3401) AUTHORS Matozaki,T., Suzuki,T., Uchida,T., Inazawa,J., Ariyama,T., Matsuda,K., Horita,K., Noguchi,H., Mizuno,H., Sakamoto,C. et al. TITLE Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers JOURNAL J. Biol. Chem. 269 (3), 2075-2081 (1994) PUBMED 8294459 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK097257.1, BC111715.1, AC010327.8 and AA573849.1. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]. Transcript Variant: This variant (2) lacks two in-frame exons in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: BC111715.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-50 AK097257.1 1-50 51-404 BC111715.1 1-354 405-417 AC010327.8 100143-100155 c 418-1456 BC111715.1 368-1406 1457-1457 AC010327.8 90635-90635 c 1458-2005 BC111715.1 1408-1955 2006-2006 AC010327.8 81532-81532 c 2007-2124 BC111715.1 1957-2074 2125-2125 AC010327.8 79967-79967 c 2126-2390 BC111715.1 2076-2340 2391-2391 AC010327.8 79357-79357 c 2392-2863 BC111715.1 2342-2813 2864-3401 AA573849.1 1-538 c FEATURES Location/Qualifiers source 1..3401 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="19" /map="19q13.4" gene 1..3401 /gene="PTPRH" /gene_synonym="SAP1" /note="protein tyrosine phosphatase, receptor type, H" /db_xref="GeneID:5794" /db_xref="HGNC:9672" /db_xref="MIM:602510" exon 1..124 /gene="PTPRH" /gene_synonym="SAP1" /inference="alignment:Splign:1.39.8" misc_feature 11..13 /gene="PTPRH" /gene_synonym="SAP1" /note="upstream in-frame stop codon" CDS 74..2887 /gene="PTPRH" /gene_synonym="SAP1" /EC_number="3.1.3.48" /note="isoform 2 precursor is encoded by transcript variant 2; transmembrane-type protein-tyrosine phosphatase type H; stomach cancer-associated protein tyrosine phosphatase 1; receptor-type tyrosine-protein phosphatase H; R-PTP-H" /codon_start=1 /product="receptor-type tyrosine-protein phosphatase H isoform 2 precursor" /protein_id="NP_001154912.1" /db_xref="GI:241896926" /db_xref="CCDS:CCDS54321.1" /db_xref="GeneID:5794" /db_xref="HGNC:9672" /db_xref="MIM:602510" /translation="
MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDVENLIYENVAAIQAHKLEV
" sig_peptide 74..154 /gene="PTPRH" /gene_synonym="SAP1" /inference="COORDINATES: ab initio prediction:SignalP:4.0" misc_feature 161..427 /gene="PTPRH" /gene_synonym="SAP1" /note="Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063" /db_xref="CDD:28945" misc_feature order(161..163,344..346,389..391) /gene="PTPRH" /gene_synonym="SAP1" /note="Interdomain contacts; other site" /db_xref="CDD:28945" misc_feature order(392..397,401..406) /gene="PTPRH" /gene_synonym="SAP1" /note="Cytokine receptor motif; other site" /db_xref="CDD:28945" misc_feature 428..691 /gene="PTPRH" /gene_synonym="SAP1" /note="Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063" /db_xref="CDD:28945" misc_feature order(428..430,611..613,653..655) /gene="PTPRH" /gene_synonym="SAP1" /note="Interdomain contacts; other site" /db_xref="CDD:28945" misc_feature order(656..661,665..670) /gene="PTPRH" /gene_synonym="SAP1" /note="Cytokine receptor motif; other site" /db_xref="CDD:28945" misc_feature 695..931 /gene="PTPRH" /gene_synonym="SAP1" /note="Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063" /db_xref="CDD:28945" misc_feature order(695..697,878..880,923..925) /gene="PTPRH" /gene_synonym="SAP1" /note="Interdomain contacts; other site" /db_xref="CDD:28945" misc_feature 926..931 /gene="PTPRH" /gene_synonym="SAP1" /note="Cytokine receptor motif; other site" /db_xref="CDD:28945" misc_feature 962..1231 /gene="PTPRH" /gene_synonym="SAP1" /note="Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063" /db_xref="CDD:28945" misc_feature order(962..964,1148..1150,1193..1195) /gene="PTPRH" /gene_synonym="SAP1" /note="Interdomain contacts; other site" /db_xref="CDD:28945" misc_feature order(1196..1201,1205..1210) /gene="PTPRH" /gene_synonym="SAP1" /note="Cytokine receptor motif; other site" /db_xref="CDD:28945" misc_feature 1232..1501 /gene="PTPRH" /gene_synonym="SAP1" /note="Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063" /db_xref="CDD:28945" misc_feature order(1232..1234,1448..1450,1493..1495) /gene="PTPRH" /gene_synonym="SAP1" /note="Interdomain contacts; other site" /db_xref="CDD:28945" misc_feature 1496..1501 /gene="PTPRH" /gene_synonym="SAP1" /note="Cytokine receptor motif; other site" /db_xref="CDD:28945" misc_feature 1994..2773 /gene="PTPRH" /gene_synonym="SAP1" /note="Protein tyrosine phosphatase, catalytic domain; Region: PTPc; smart00194" /db_xref="CDD:197567" misc_feature 2078..2770 /gene="PTPRH" /gene_synonym="SAP1" /note="Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047" /db_xref="CDD:28929" misc_feature order(2495..2497,2594..2599,2606..2608,2615..2620) /gene="PTPRH" /gene_synonym="SAP1" /note="active site" /db_xref="CDD:28929" exon 125..158 /gene="PTPRH" /gene_synonym="SAP1" /inference="alignment:Splign:1.39.8" exon 159..425 /gene="PTPRH" /gene_synonym="SAP1" /inference="alignment:Splign:1.39.8" exon 426..692 /gene="PTPRH" /gene_synonym="SAP1" /inference="alignment:Splign:1.39.8" variation 581 /gene="PTPRH" /gene_synonym="SAP1" /replace="c" /replace="t" /db_xref="dbSNP:2288515" exon 693..959 /gene="PTPRH" /gene_synonym="SAP1" /inference="alignment:Splign:1.39.8" exon 960..1229 /gene="PTPRH" /gene_synonym="SAP1" /inference="alignment:Splign:1.39.8" variation 1219 /gene="PTPRH" /gene_synonym="SAP1" /replace="c" /replace="t" /db_xref="dbSNP:2288518" exon 1230..1529 /gene="PTPRH" /gene_synonym="SAP1" /inference="alignment:Splign:1.39.8" variation 1441 /gene="PTPRH" /gene_synonym="SAP1" /replace="c" /replace="t" /db_xref="dbSNP:2288520" variation 1457 /gene="PTPRH" /gene_synonym="SAP1" /replace="c" /replace="t" /db_xref="dbSNP:2288521" exon 1530..1796 /gene="PTPRH" /gene_synonym="SAP1" /inference="alignment:Splign:1.39.8" exon 1797..1875 /gene="PTPRH" /gene_synonym="SAP1" /inference="alignment:Splign:1.39.8" exon 1876..1923 /gene="PTPRH" /gene_synonym="SAP1" /inference="alignment:Splign:1.39.8" variation 1882 /gene="PTPRH" /gene_synonym="SAP1" /replace="g" /replace="t" /db_xref="dbSNP:2288523" exon 1924..2014 /gene="PTPRH" /gene_synonym="SAP1" /inference="alignment:Splign:1.39.8" variation 2006 /gene="PTPRH" /gene_synonym="SAP1" /replace="a" /replace="g" /db_xref="dbSNP:890870" exon 2015..2105 /gene="PTPRH" /gene_synonym="SAP1" /inference="alignment:Splign:1.39.8" exon 2106..2182 /gene="PTPRH" /gene_synonym="SAP1" /inference="alignment:Splign:1.39.8" variation 2125 /gene="PTPRH" /gene_synonym="SAP1" /replace="c" /replace="t" /db_xref="dbSNP:1136578" exon 2183..2317 /gene="PTPRH" /gene_synonym="SAP1" /inference="alignment:Splign:1.39.8" exon 2318..2440 /gene="PTPRH" /gene_synonym="SAP1" /inference="alignment:Splign:1.39.8" exon 2441..2601 /gene="PTPRH" /gene_synonym="SAP1" /inference="alignment:Splign:1.39.8" exon 2602..2737 /gene="PTPRH" /gene_synonym="SAP1" /inference="alignment:Splign:1.39.8" exon 2738..3394 /gene="PTPRH" /gene_synonym="SAP1" /inference="alignment:Splign:1.39.8" variation 2765 /gene="PTPRH" /gene_synonym="SAP1" /replace="a" /replace="g" /db_xref="dbSNP:2288419" variation 2886 /gene="PTPRH" /gene_synonym="SAP1" /replace="a" /replace="g" /db_xref="dbSNP:2288420" STS 2927..3070 /gene="PTPRH" /gene_synonym="SAP1" /standard_name="STS-D15049" /db_xref="UniSTS:50041" STS 2950..3093 /gene="PTPRH" /gene_synonym="SAP1" /standard_name="D19S1081" /db_xref="UniSTS:12607" variation 2994 /gene="PTPRH" /gene_synonym="SAP1" /replace="a" /replace="g" /db_xref="dbSNP:17458" ORIGIN
ttcttgagtgtaaagtccagcaggtggaaggactaggcctgggactcctgggtccccggcagtgtctggaggcatggctggggctggcgggggcctcggggtctgggggaacctggtgctgctgggcctgtgcagctggacaggggccagggcgcctgcccccaacccagggaggaacctgacagtggagactcagaccaccagctccatctccctgagctgggaggtccccgatggcctagactcacagaactccaactactgggttcagtgtactggagacggcggcacaacagagactcgaaacacaacagccaccaacgtcaccgtggatggccttggacccgggtcattgtatacgtgttctgtgtgggtggagaaagacggagtaaatagctctgtggggactgtcactactgccacagctcccaacccagtgagaaacctgacagtggaggctcagaccaacagctccatcgccctgacctgggaggtccccgatggcccagacccacagaactccacctacggggttgagtacactggagatggtggcagagcagggactcgaagcacagcacacaccaacatcaccgtggatagacttgaacccgggtgtttgtatgtgttttccgtgtgggtggggaagaatggaatcaacagctcccgggagactcgaaatgccaccacagcccccaacccagtgagaaacctccatatggagactcagaccaacagctccatcgccctatgctgggaagtccccgatggcccataccctcaggactacacctactgggtagagtacactggagacggtggtggcacagagacccgaaacacaacaaataccagtgtgacagctgagagacttgagcccggaaccttgtacacattctctgtatgggcagaaaaaaatggagcacgtggctccaggcagaatgtcagcatctccacagtccccaacgcagtgacaagcctcagcaagcaggactggaccaacagcaccattgctttgcgctggacagctccccagggcccaggccagtcttcctacagctactgggtctcatgggtcagggaaggcatgactgaccccaggacccaaagcacctcaggtactgacatcaccctaaaggaactggaagctggcagcctgtaccacctcaccgtctgggccgagaggaatgaggtcagaggctataacagcaccctcactgcagccactgctcccaatgaggtcacagatctccagaatgaaactcagactaagaactcagtcatgctgtggtggaaggcccctggagacccccactctcagttgtacgtatactgggtccagtgggccagcaagggacatccccggagggggcaagatccccaagcgaattgggtcaaccagaccagcaggaccaatgagacgtggtacaaagtggaggccctggaacccgggacgttgtacaatttcaccgtgtgggcagagaggaatgacgtagccagttccacgcagagcctctgtgcgtccacatacccagacacagtcaccatcacttcctgtgtcagcacctcagcgggctatggagtcaacttgatctggtcctgcccccagggaggctacgaggcctttgagttggaggtgggaggacagcggggctcccaggacagatcttcatgtggggaggctgtgtctgtgttgggtctcgggccggctcggtcctacccagccaccatcacgaccatctgggacggaatgaaggtcgtgtctcactctgtggtctgccacaccgagagtgcaggggtcattgccggagcctttgtgggcatcctcctgtttctcatcctcgtgggcctgctgattttcttcctgaagaggaggaataagaagaagcagcagaaaccagaactcagggatctggtctttagctccccaggggacatcccagctgaagacttcgctgaccacgtcaggaagaatgagagggacagcaactgtggttttgcagacaagtaccagcaactctccctggtgggccacagccagtctcagatggtggcttcggcttcagagaacaacgccaagaaccgctacagaaatgtgctgccctatgactggtcccgggtgcccctgaagcccatccatgaggagccaggctctgactacatcaatgccagcttcatgcccggtctctggagcccccaggagttcattgcaacccagggtcccctgccacagacagtgggtgacttctggcgcctggtgtgggaacagcagagccacaccctggtcatgctgaccaactgcatggaggccggccgggtgaagtgtgagcattactggcctctggactcgcagccctgcacccatgggcacctgcgggtaaccctggtaggtgaggaagtgatggagaactggacggtgcgggaactgctgctcctccaggtggaggagcagaagacactgtctgtgcgccaattccactaccaggcctggccggatcacggcgttccctcctccccagacaccttgctggctttctggaggatgcttcggcagtggctggatcagaccatggagggaggcccacccattgtgcactgcagtgctggcgtgggtcgcacaggaaccctcattgccctggacgtcctgctccggcagctgcagtccgagggtctccttgggcccttcagctttgtaaggaagatgagagagagtcggccgttgatggtgcagactgaggctcagtacgtattcctgcatcagtgcatcctgcggttcctccaacagtcagcccaggccccagccgagaaggaagtcccgtatgaggatgtcgaaaacctcatctacgagaacgtggccgccatccaggcccacaagttggaggtctaagtgacgagggggctgggtcggcagcccaggcatcctcaagctctggacacccacttgagcccagattcctggaagagcagagggctgggctcccagactcctgggtgctgtgggaggagggggctggtatcccaaactctggtttccccaggagagagtggtctggtgggcttcagatgagtcctatgggagctggggatctggattcctggttccctgaaggaggagagggatgatagcttggattccctaggtctttccaggatgcagaaagaaacaggctggggcctggattctgaggcaggaaggaatttgggtctggagttctggctacttgaggaccaaaggcaggaaggatcctgccttgattttacttcagaaaccaaatcagtcttctataatctggggtcggagggagtccctgtgcccaaggtctctctgcaccccaccatccacatgtatttttccttctatcccataatttattaaatcactgttctccccagaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:5794 -> Molecular function: GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] evidence: TAS GeneID:5794 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:5794 -> Biological process: GO:0006470 [protein dephosphorylation] evidence: TAS GeneID:5794 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:5794 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:5794 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA GeneID:5794 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:5794 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA GeneID:5794 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001154912 -> EC 3.1.3.48
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