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2024-04-27 03:56:02, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001160 7042 bp mRNA linear PRI 26-MAY-2013
DEFINITION Homo sapiens apoptotic peptidase activating factor 1 (APAF1),
transcript variant 2, mRNA.
ACCESSION NM_001160
VERSION NM_001160.2 GI:32483364
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7042)
AUTHORS Yuan,S., Topf,M., Reubold,T.F., Eschenburg,S. and Akey,C.W.
TITLE Changes in Apaf-1 conformation that drive apoptosome assembly
JOURNAL Biochemistry 52 (13), 2319-2327 (2013)
PUBMED 23521171
REMARK GeneRIF: Apaf-1 conformational changes during apoptosome assembly.
REFERENCE 2 (bases 1 to 7042)
AUTHORS Li,T., Zeng,L., Gao,W., Cui,M.Z., Fu,X. and Xu,X.
TITLE PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial
apoptotic pathway independent of Bcl-2 family proteins
JOURNAL Biochim. Biophys. Acta 1832 (3), 453-474 (2013)
PUBMED 23207240
REMARK GeneRIF: Data indicate that the formation of cytochrome c-Apaf-1
apoptosome and the presence of Smac are absolutely required for
PSAP-induced apoptosis.
REFERENCE 3 (bases 1 to 7042)
AUTHORS Andreev,D.E., Dmitriev,S.E., Zinovkin,R., Terenin,I.M. and
Shatsky,I.N.
TITLE The 5' untranslated region of Apaf-1 mRNA directs translation under
apoptosis conditions via a 5' end-dependent scanning mechanism
JOURNAL FEBS Lett. 586 (23), 4139-4143 (2012)
PUBMED 23085065
REMARK GeneRIF: The 5' untranslated region of Apaf-1 mRNA directs
translation under apoptosis conditions via a 5' end-dependent
scanning mechanism.
REFERENCE 4 (bases 1 to 7042)
AUTHORS Zang,Y.S., Zhong,Y.F., Fang,Z., Li,B. and An,J.
TITLE MiR-155 inhibits the sensitivity of lung cancer cells to cisplatin
via negative regulation of Apaf-1 expression
JOURNAL Cancer Gene Ther. 19 (11), 773-778 (2012)
PUBMED 22996741
REMARK GeneRIF: Both the silencing of miR-155 and the overexpression
Apaf-1 greatly increased the sensitivity of A549 cells to
cisplatin.
REFERENCE 5 (bases 1 to 7042)
AUTHORS Wang,J., Xiao,X., Zhang,Y., Shi,D., Chen,W., Fu,L., Liu,L., Xie,F.,
Kang,T., Huang,W. and Deng,W.
TITLE Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling
by melatonin to inhibit proliferation and induce apoptosis in
breast cancer cells
JOURNAL J. Pineal Res. 53 (1), 77-90 (2012)
PUBMED 22335196
REMARK GeneRIF: melatonin inhibits cell proliferation and induces
apoptosis in MDA-MB-361 breast cancer cells in vitro by
simultaneously suppressing the COX-2/PGE2, p300/NF-kappaB, and
PI3K/Akt/signaling and activating the Apaf-1/caspase-dependent
apoptotic pathway.
REFERENCE 6 (bases 1 to 7042)
AUTHORS Srinivasula,S.M., Ahmad,M., Fernandes-Alnemri,T. and Alnemri,E.S.
TITLE Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
JOURNAL Mol. Cell 1 (7), 949-957 (1998)
PUBMED 9651578
REFERENCE 7 (bases 1 to 7042)
AUTHORS Hu,Y., Benedict,M.A., Wu,D., Inohara,N. and Nunez,G.
TITLE Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent
caspase-9 activation
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (8), 4386-4391 (1998)
PUBMED 9539746
REFERENCE 8 (bases 1 to 7042)
AUTHORS Pan,G., O'Rourke,K. and Dixit,V.M.
TITLE Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
JOURNAL J. Biol. Chem. 273 (10), 5841-5845 (1998)
PUBMED 9488720
REFERENCE 9 (bases 1 to 7042)
AUTHORS Li,P., Nijhawan,D., Budihardjo,I., Srinivasula,S.M., Ahmad,M.,
Alnemri,E.S. and Wang,X.
TITLE Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9
complex initiates an apoptotic protease cascade
JOURNAL Cell 91 (4), 479-489 (1997)
PUBMED 9390557
REFERENCE 10 (bases 1 to 7042)
AUTHORS Zou,H., Henzel,W.J., Liu,X., Lutschg,A. and Wang,X.
TITLE Apaf-1, a human protein homologous to C. elegans CED-4,
participates in cytochrome c-dependent activation of caspase-3
JOURNAL Cell 90 (3), 405-413 (1997)
PUBMED 9267021
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AF013263.1 and AC011248.8.
On Jul 9, 2003 this sequence version replaced gi:4502122.
Summary: This gene encodes a cytoplasmic protein that initiates
apoptosis. This protein contains several copies of the WD-40
domain, a caspase recruitment domain (CARD), and an ATPase domain
(NB-ARC). Upon binding cytochrome c and dATP, this protein forms an
oligomeric apoptosome. The apoptosome binds and cleaves caspase 9
preproprotein, releasing its mature, activated form. Activated
caspase 9 stimulates the subsequent caspase cascade that commits
the cell to apoptosis. Alternative splicing results in several
transcript variants encoding different isoforms. [provided by
RefSeq, Jul 2008].
Transcript Variant: This variant (2) uses an alternate splice site
and lacks an exon in the coding region but maintains the reading
frame, compared to variant 3. Variant 2 encodes isoform b, which is
shorter than isoform c.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF013263.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-5167 AF013263.1 1-5167
5168-5168 AC011248.8 25332-25332 c
5169-6588 AF013263.1 5169-6588
6589-6589 AC011248.8 23911-23911 c
6590-6609 AF013263.1 6590-6609
6610-6610 AC011248.8 23890-23890 c
6611-7042 AF013263.1 6611-7042
FEATURES Location/Qualifiers
source 1..7042
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q23"
gene 1..7042
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/note="apoptotic peptidase activating factor 1"
/db_xref="GeneID:317"
/db_xref="HGNC:576"
/db_xref="HPRD:03755"
/db_xref="MIM:602233"
exon 1..536
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 20
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:367782321"
variation 38
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:116501350"
variation 68
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:371572763"
variation 69
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="t"
/db_xref="dbSNP:113577911"
variation 90
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:11109556"
variation 94
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:113907867"
variation 106
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:74619561"
variation 134
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:192062352"
variation 249
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="g"
/db_xref="dbSNP:2118851"
variation 293
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="g"
/db_xref="dbSNP:139550753"
variation 390
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="g"
/replace="t"
/db_xref="dbSNP:2118852"
exon 537..715
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 567
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="g"
/replace="t"
/db_xref="dbSNP:111232069"
misc_feature 569..571
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/note="upstream in-frame stop codon"
CDS 578..4162
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/note="isoform b is encoded by transcript variant 2;
apoptotic protease-activating factor 1"
/codon_start=1
/product="apoptotic protease-activating factor 1 isoform
b"
/protein_id="NP_001151.1"
/db_xref="GI:4502123"
/db_xref="CCDS:CCDS55863.1"
/db_xref="GeneID:317"
/db_xref="HGNC:576"
/db_xref="HPRD:03755"
/db_xref="MIM:602233"
/translation="
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
"
misc_feature 596..853
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/note="Caspase activation and recruitment domain similar
to that found in Apoptotic Protease-Activating Factor 1;
Region: CARD_APAF1; cd08323"
/db_xref="CDD:176737"
misc_feature order(644..649,656..661,665..670,686..688,695..697)
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/note="APAF1-Caspase9 interaction site [polypeptide
binding]; other site"
/db_xref="CDD:176737"
misc_feature 920..1279
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/note="AAA ATPase domain; Region: AAA_16; pfam13191"
/db_xref="CDD:205372"
misc_feature 929..1786
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/note="NB-ARC domain; Region: NB-ARC; pfam00931"
/db_xref="CDD:201512"
misc_feature 1154..1156
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1256..1258
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1286..1288
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2363..3154
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/note="WD40 domain, found in a number of eukaryotic
proteins that cover a wide variety of functions including
adaptor/regulatory modules in signal transduction,
pre-mRNA processing and cytoskeleton assembly; typically
contains a GH dipeptide 11-24 residues from...; Region:
WD40; cd00200"
/db_xref="CDD:29257"
misc_feature <2372..3274
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/note="FOG: WD40 repeat [General function prediction
only]; Region: COG2319"
/db_xref="CDD:32473"
misc_feature order(2384..2386,2438..2440,2450..2452,2468..2473,
2507..2512,2564..2566,2576..2578,2594..2599,2633..2638,
2693..2695,2708..2710,2726..2731,2768..2770,2819..2821,
2834..2836,2852..2857,2930..2935,2987..2989,2999..3001,
3014..3019,3053..3058,3107..3109,3122..3124,3140..3145)
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/note="structural tetrad; other site"
/db_xref="CDD:29257"
misc_feature 2873..4144
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/note="FOG: WD40 repeat [General function prediction
only]; Region: COG2319"
/db_xref="CDD:32473"
misc_feature 3296..4117
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/note="WD40 domain, found in a number of eukaryotic
proteins that cover a wide variety of functions including
adaptor/regulatory modules in signal transduction,
pre-mRNA processing and cytoskeleton assembly; typically
contains a GH dipeptide 11-24 residues from...; Region:
WD40; cd00200"
/db_xref="CDD:29257"
misc_feature order(3347..3349,3359..3361,3377..3382,3416..3421,
3473..3475,3485..3487,3503..3508,3539..3544,3593..3595,
3605..3607,3623..3628,3665..3667,3716..3718,3731..3733,
3749..3754,3788..3793,3845..3847,3857..3859,3875..3880,
3914..3916,3941..3943,3992..3994,4019..4024,4058..4063,
4115..4117)
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/note="structural tetrad; other site"
/db_xref="CDD:29257"
variation 615
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:373035647"
variation 635
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:368174559"
variation 648
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:150457288"
variation 686
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:372259373"
variation 711
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:145226502"
variation 713
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:199944569"
exon 716..872
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 757
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:200621810"
variation 784
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="t"
/db_xref="dbSNP:202065446"
variation 793
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:373040331"
variation 804
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:376597105"
variation 848
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="t"
/db_xref="dbSNP:139951279"
variation 851
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:141352935"
variation 864
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:150823984"
exon 873..1070
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 883
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/db_xref="dbSNP:139274870"
variation 909
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:150005477"
variation 927
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:147700706"
variation 975
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/db_xref="dbSNP:200533513"
variation 1002
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:377171914"
variation 1021
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:370625919"
variation 1022
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:76680641"
variation 1043
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:113035658"
variation 1054
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="g"
/replace="t"
/db_xref="dbSNP:144787055"
variation 1059
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:147932236"
exon 1071..1254
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 1092
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:200830441"
variation 1103
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="g"
/replace="t"
/db_xref="dbSNP:370928764"
variation 1117
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:143842243"
variation 1145
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:374500915"
variation 1156
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:151139898"
variation 1195
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:146505676"
variation 1242
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:141157255"
variation 1247
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:368744142"
exon 1255..1367
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 1325
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:145270473"
variation 1349
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:199783677"
variation 1351
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:111885484"
exon 1368..1499
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 1403
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="g"
/db_xref="dbSNP:144728788"
variation 1408
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:138616141"
variation 1442
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/db_xref="dbSNP:201562861"
variation 1454
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:149321598"
variation 1455
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:189237320"
variation 1481
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:192898520"
variation 1491
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="t"
/db_xref="dbSNP:369909924"
exon 1500..1738
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 1516
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:144643655"
variation 1537
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:199648389"
variation 1621
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:57171247"
variation 1639
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="g"
/replace="t"
/db_xref="dbSNP:201932795"
variation 1670
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:141824871"
variation 1677
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:201629052"
exon 1739..1906
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 1744
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:368597507"
variation 1745
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:371118366"
variation 1792
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:147249307"
variation 1803
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:140772800"
variation 1818..1819
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace=""
/replace="c"
/db_xref="dbSNP:34602753"
variation 1840
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:374998401"
variation 1844
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:368429786"
variation 1845
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:201872620"
variation 1871
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:144721573"
variation 1880
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="t"
/db_xref="dbSNP:75622772"
variation 1882
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:376806366"
variation 1894
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="g"
/db_xref="dbSNP:139378273"
variation 1901
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:371633206"
variation 1905
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:150056794"
exon 1907..2038
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 1938
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:76732147"
variation 1953
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:145393515"
variation 1968
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:369544125"
variation 1980
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:373209321"
variation 1981
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="g"
/db_xref="dbSNP:149223130"
variation 2025
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:143963802"
exon 2039..2152
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 2106
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:146424586"
exon 2153..2337
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 2174
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="t"
/db_xref="dbSNP:372400613"
variation 2183
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="t"
/db_xref="dbSNP:376175905"
variation 2219
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/db_xref="dbSNP:202243082"
variation 2283
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/db_xref="dbSNP:11613534"
variation 2298
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:199975148"
variation 2308
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:371417225"
variation 2325
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="t"
/db_xref="dbSNP:61758870"
exon 2338..2464
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 2356
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:144715006"
variation 2378
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:371897242"
variation 2379
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:375182344"
variation 2400
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/db_xref="dbSNP:61758871"
variation 2418
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/db_xref="dbSNP:73142307"
variation 2419
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:369089258"
variation 2463
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:140327382"
exon 2465..2590
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 2539
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:372738633"
exon 2591..2722
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 2591
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:200295459"
variation 2617
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:376958146"
variation 2652
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:375497407"
variation 2674
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:111760682"
exon 2723..2848
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 2732
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:371871697"
variation 2745
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:371385003"
variation 2750
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:150355642"
variation 2760
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:138068283"
variation 2778
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:372234984"
variation 2818
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:200562772"
exon 2849..3010
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 2860
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:368374940"
variation 2873
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:138526583"
variation 2889
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/db_xref="dbSNP:117235991"
variation 2927
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="g"
/db_xref="dbSNP:181546874"
variation 2942
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="t"
/db_xref="dbSNP:139083690"
variation 2944
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:372032284"
variation 2958
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/db_xref="dbSNP:375207439"
variation 2959
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:202216630"
variation 2965
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="g"
/replace="t"
/db_xref="dbSNP:143097832"
variation 3007
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/db_xref="dbSNP:144749677"
exon 3011..3136
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 3027
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:145807191"
variation 3030
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:139940389"
variation 3096
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:61757705"
variation 3107
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="g"
/replace="t"
/db_xref="dbSNP:199525775"
exon 3137..3256
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 3249
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="g"
/replace="t"
/db_xref="dbSNP:146420669"
exon 3257..3373
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 3267
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:201911170"
variation 3276
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="g"
/replace="t"
/db_xref="dbSNP:140836008"
variation 3277
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="g"
/replace="t"
/db_xref="dbSNP:143246247"
variation 3346
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/db_xref="dbSNP:145497334"
variation 3367
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:148854272"
exon 3374..3499
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 3393
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:201541593"
variation 3420
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:201122276"
variation 3422
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:367942061"
variation 3466
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:143528358"
variation 3482
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="g"
/replace="t"
/db_xref="dbSNP:372125027"
variation 3489
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/db_xref="dbSNP:77127123"
exon 3500..3619
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 3514
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:142269091"
variation 3527
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:146238655"
variation 3536
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:139016212"
exon 3620..3745
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 3649
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:143961269"
variation 3700
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:139786967"
exon 3746..3871
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 3762
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:138188210"
variation 3839
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:201678092"
variation 3847
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:149589840"
exon 3872..4015
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 3889
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:144336881"
variation 3893
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:184890158"
variation 3916
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:368589663"
variation 3943
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:140151475"
exon 4016..7029
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/inference="alignment:Splign:1.39.8"
variation 4063
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="t"
/db_xref="dbSNP:201917086"
variation 4088
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:201029707"
variation 4093
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/db_xref="dbSNP:369751053"
variation 4097
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="g"
/db_xref="dbSNP:142230441"
variation 4111
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:372861046"
variation 4138
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:375449857"
variation 4155
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:369724536"
variation 4165
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:118102803"
variation 4166
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:375966404"
variation 4368
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:147973432"
variation 4449
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:17227606"
variation 4497
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="g"
/replace="t"
/db_xref="dbSNP:376693352"
variation 4530
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:370287396"
variation 4588
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="g"
/replace="t"
/db_xref="dbSNP:115805629"
variation 4628
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/db_xref="dbSNP:187945549"
variation 4728
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:116884285"
variation 4729
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/db_xref="dbSNP:368133650"
variation 4755..4756
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace=""
/replace="ag"
/db_xref="dbSNP:376965258"
STS 4772..4874
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/standard_name="D11S2921"
/db_xref="UniSTS:152074"
STS 4779..5166
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/standard_name="PMC156606P1"
/db_xref="UniSTS:271408"
STS 4779..4868
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/standard_name="PMC156606P1"
/db_xref="UniSTS:271408"
variation 4799
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:372020077"
variation 4818
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/db_xref="dbSNP:111382335"
STS 4834..4920
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 4840
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:192421145"
variation 4856
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:185285999"
STS 4861..5234
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/standard_name="GDB:313557"
/db_xref="UniSTS:8230"
variation 4919
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:12307986"
variation 4949
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="g"
/db_xref="dbSNP:187456676"
STS 4983..5288
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/standard_name="GDB:434012"
/db_xref="UniSTS:157204"
STS 4983..5152
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/standard_name="GDB:434012"
/db_xref="UniSTS:157204"
variation 4993
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/db_xref="dbSNP:4450213"
STS 4996..5259
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/standard_name="L17791"
/db_xref="UniSTS:42740"
variation 5048
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="t"
/db_xref="dbSNP:375602833"
variation 5065
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:188204280"
variation 5070
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:140030216"
variation 5143
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:192992501"
variation 5168
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:1131019"
variation 5175
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:143208155"
variation 5249
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="g"
/replace="t"
/db_xref="dbSNP:12829605"
variation 5281
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:184748337"
variation 5334
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:188259081"
variation 5347
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:180779783"
variation 5514
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace=""
/replace="a"
/db_xref="dbSNP:11296996"
variation 5577
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:139964896"
variation 5632
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:145416277"
variation 5650
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:183510672"
variation 5819..5820
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace=""
/replace="at"
/db_xref="dbSNP:374060808"
variation 5819
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="t"
/db_xref="dbSNP:6538881"
variation 5820
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:6538882"
variation 5846
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:187010424"
variation 5876
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:191552272"
variation 5891..5892
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace=""
/replace="g"
/db_xref="dbSNP:35746294"
variation 5920
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:145263832"
variation 6003
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:142293344"
variation 6060
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:151008594"
variation 6084
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="g"
/db_xref="dbSNP:111495253"
variation 6110
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="t"
/db_xref="dbSNP:181602728"
variation 6138
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:140896989"
variation 6175
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:73142318"
variation 6518..6519
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace=""
/replace="tt"
/db_xref="dbSNP:371739358"
variation 6539
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:60760345"
variation 6589
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:1131020"
variation 6610
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:1131021"
variation 6690
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:116928965"
STS 6760..6920
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/standard_name="RH69665"
/db_xref="UniSTS:12332"
variation 6789
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="g"
/replace="t"
/db_xref="dbSNP:186272491"
variation 6807
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="g"
/db_xref="dbSNP:116289685"
variation 6837..6838
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace=""
/replace="t"
/db_xref="dbSNP:201081099"
variation 6840
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="t"
/db_xref="dbSNP:12159"
variation 6844
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace=""
/replace="t"
/db_xref="dbSNP:3834481"
variation 6878
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:113354620"
polyA_signal 6999..7004
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
variation 7015
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
/replace="c"
/replace="t"
/db_xref="dbSNP:140352209"
polyA_site 7029
/gene="APAF1"
/gene_synonym="APAF-1; CED4"
ORIGIN
aagaagaggtagcgagtggacgtgactgctctatcccgggcaaaagggatagaaccagaggtggggagtctgggcagtcggcgacccgcgaagacttgaggtgccgcagcggcatccggagtagcgccgggctccctccggggtgcagccgccgtcgggggaagggcgccacaggccgggaagacctcctccctttgtgtccagtagtggggtccaccggagggcggcccgtgggccgggcctcaccgcggcgctccgggactgtggggtcaggctgcgttgggtggacgcccacctcgccaaccttcggaggtccctgggggtcttcgtgcgccccggggctgcagagatccaggggaggcgcctgtgaggcccggacctgccccggggcgaagggtatgtggcgagacagagccctgcacccctaattcccggtggaaaactcctgttgccgtttccctccaccggcctggagtctcccagtcttgtcccggcagtgccgccctccccactaagacctaggcgcaaaggcttggctcatggttgacagctcagagagagaaagatctgagggaagatggatgcaaaagctcgaaattgtttgcttcaacatagagaagctctggaaaaggacatcaagacatcctacatcatggatcacatgattagtgatggatttttaacaatatcagaagaggaaaaagtaagaaatgagcccactcaacagcaaagagcagctatgctgattaaaatgatacttaaaaaagataatgattcctacgtatcattctacaatgctctactacatgaaggatataaagatcttgctgcccttctccatgatggcattcctgttgtctcttcttccagtgtaaggacagtcctgtgtgaaggtggagtaccacagaggccagttgtttttgtcacaaggaagaagctggtgaatgcaattcagcagaagctctccaaattgaaaggtgaaccaggatgggtcaccatacatggaatggcaggctgtgggaagtctgtattagctgcagaagctgttagagatcattcccttttagaaggttgtttcccagggggagtgcattgggtttcagttgggaaacaagacaaatctgggcttctgatgaaactgcagaatctttgcacacggttggatcaggatgagagtttttcccagaggcttccacttaatattgaagaggctaaagaccgtctccgcattctgatgcttcgcaaacacccaaggtctctcttgatcttggatgatgtttgggactcttgggtgttgaaagcttttgacagtcagtgtcagattcttcttacaaccagagacaagagtgttacagattcagtaatgggtcctaaatatgtagtccctgtggagagttccttaggaaaggaaaaaggacttgaaattttatccctttttgttaatatgaagaaggcagatttgccagaacaagctcatagtattataaaagaatgtaaaggctctccccttgtagtatctttaattggtgcacttttacgtgattttcccaatcgctgggagtactacctcaaacagcttcagaataagcagtttaagagaataaggaaatcttcgtcttatgattatgaggctctagatgaagccatgtctataagtgttgaaatgctcagagaagacatcaaagattattacacagatctttccatccttcagaaggacgttaaggtgcctacaaaggtgttatgtattctctgggacatggaaactgaagaagttgaagacatactgcaggagtttgtaaataagtctcttttattctgtgatcggaatggaaagtcgtttcgttattatttacatgatcttcaagtagattttcttacagagaagaattgcagccagcttcaggatctacataagaagataatcactcagtttcagagatatcaccagccgcatactctttcaccagatcaggaagactgtatgtattggtacaactttctggcctatcacatggccagtgccaagatgcacaaggaactttgtgctttaatgttttccctggattggattaaagcaaaaacagaacttgtaggccctgctcatctgattcatgaatttgtggaatacagacatatactagatgaaaaggattgtgcagtcagtgagaattttcaggagtttttatctttaaatggacaccttcttggacgacagccatttcctaatattgtacaactgggtctctgtgagccggaaacttcagaagtttatcagcaagctaagctgcaggccaagcaggaggtcgataatggaatgctttacctggaatggataaacaaaaaaaacatcacgaatctttcccgcttagttgtccgcccccacacagatgctgtttaccatgcctgcttttctgaggatggtcagagaatagcttcttgtggagctgataaaaccttacaggtgttcaaagctgaaacaggagagaaacttctagaaatcaaggctcatgaggatgaagtgctttgttgtgcattctctacagatgacagatttatagcaacctgctcagtggataaaaaagtgaagatttggaattctatgactggggaactagtacacacctatgatgagcactcagagcaagtcaattgctgccatttcaccaacagtagtcatcatcttctcttagccactgggtcaagtgactgcttcctcaaactttgggatttgaatcaaaaagaatgtcgaaataccatgtttggtcatacaaattcagtcaatcactgcagattttcaccagatgataagcttttggctagttgttcagctgatggaaccttaaagctttgggatgcgacatcagcaaatgagaggaaaagcattaatgtgaaacagttcttcctaaatttggaggaccctcaagaggatatggaagtgatagtgaagtgttgttcgtggtctgctgatggtgcaaggataatggtggcagcaaaaaataaaatctttttgtggaatacagactcacgttcaaaggtggctgattgcagaggacatttaagttgggttcatggtgtgatgttttctcctgatggatcatcatttttgacatcttctgatgaccagacaatcaggctctgggagacaaagaaagtatgtaagaactctgctgtaatgttaaagcaagaagtagatgttgtgtttcaagaaaatgaagtgatggtccttgcagttgaccatataagacgtctgcaactcattaatggaagaacaggtcagattgattatctgactgaagctcaagttagctgctgttgcttaagtccacatcttcagtacattgcatttggagatgaaaatggagccattgagattttagaacttgtaaacaatagaatcttccagtccaggtttcagcacaagaaaactgtatggcacatccagttcacagccgatgagaagactcttatttcaagttctgatgatgctgaaattcaggtatggaattggcaattggacaaatgtatctttctacgaggccatcaggaaacagtgaaagactttagactcttgaaaaattcaagactgctttcttggtcatttgatggaacagtgaaggtatggaatattattactggaaataaagaaaaagactttgtctgtcaccagggtacagtactttcttgtgacatttctcacgatgctaccaagttttcatctacctctgctgacaagactgcaaagatctggagttttgatctccttttgccacttcatgaattgaggggccacaacggctgtgtgcgctgctctgccttctctgtggacagtaccctgctggcaacgggagatgacaatggagaaatcaggatatggaatgtctcaaacggtgagcttcttcatttgtgtgctccgctttcagaagaaggagctgctacccatggaggctgggtgactgacctttgcttttctccagatggcaaaatgcttatctctgctggaggatatattaagtggtggaacgttgtcactggggaatcctcacagaccttctacacaaatggaaccaatcttaagaaaatacacgtgtcccctgacttcaaaacatatgtgactgtggataatcttggtattttatatattttacagactttagaataaaatagttaagcattaatgtagttgaactttttaaatttttgaattggaaaaaaattctaatgaaaccctgatatcaactttttataaagctcttaattgttgtgcagtattgcattcattacaaaagtgtttgtggttggatgaataatattaatgtagctttttcccaaatgaacatacctttaatcttgtttttcatgatcatcattaacagtttgtccttaggatgcaaatgaaaatgtgaatacataccttgttgtactgttggtaaaattctgtcttgatgcattcaaaatggttgacataattaatgagaagaatttggaagaaattggtattttaatactgtctgtatttattactgttatgcaggctgtgcctcagggtagcagtggcctgctttttgaaccacacttaccccaagggggttttgttctcctaaatacaatcttagaggttttttgcactctttaaatttgctttaaaaatattgtgtctgtgtgcatagtctgcagcatttcctttaattgactcaataagtgagtcttggatttagcaggcccccccaccttttttttttgtttttggagacagagtcttgctttgttgccaggctggagtgcagtggcgcgatctcggctcaccacaatcgctgcctcctgggttcaagcaattctcctgcctcagcctcccgagtagctgggactacaggtgtgcgcacatgccaggctaatttttgtatttttagtagagacggggtttcaccatgttggccgggatggtctcgatctcttgacctcatgatctacccgccttggcctcccaaagtgctgagattacaggcgtgagccaccgtgcctggccaggccccttctcttttaatggagacagggtcttgcactatcacccaggctggagtgcagtggcataatcatacctcattgcagcctcagactcctgggttcaagcaatcctcctgcctcagcctcccaagtagctgagactacaggcacgagccaccacacccagctaatttttaagttttcttgtagagacagggtctcactatgttgtctaggctggtcttgaactcttggcctcaagtaatcctcctgcctcagcctcccaaagtgttgggattgcagatatgagccactggcctggccttcagcagttctttttgtgaagtaaaacttgtatgttggaaagagtagattttattggtctacccttttctcactgtagctgctggcagccctgtgccatatctggactctagttgtcagtatctgagttggacactattcctgctccctcttgtttcttacatatcagacttcttacttgaatgaaacctgatctttcctaatcctcacttttttcttttttaaaaagcagtttctccactgctaaatgttagtcattgaggtggggccaattttaatcataagccttaataagatttttctaagaaatgtgaaatagaacaattttcatctaattccatttacttttagatgaatggcattgtgaatgccattcttttaatgaatttcaagagaattctctggttttctgtgtaattccagatgagtcactgtaactctagaagattaaccttccagccaacctattttcctttcccttgtctctctcatcctcttttccttccttctttcctttctcttcttttatctccaaggttaatcaggaaaaatagcttttgacaggggaaaaaactcaataactagctatttttgacctcctgatcaggaactttagttgaagcgtaaatctaaagaaacattttctctgaaatatattattaagggcaatggagataaattaatagtagatgtggttcccagaaaatataatcaaaattcaaagattttttttgtttctgtaactggaactaaatcaaatgattactagtgttaatagtagataacttgtttttattgttggtgcatattagtataactgtggggtaggtcggggagagggtaagggaatagatcactcagatgtattttagataagctatttagcctttgatggaatcataaatacagtgaatacaatcctttgcattgttaaggaggttttttgtttttaaatggtgggtcaaggagctagtttacaggcttactgtgatttaagcaaatgtgaaaagtgaaaccttaattttatcaaaagaaatttctgtaaatggtatgtctccttagaatacccaaatcataattttatttgtacacactgttaggggctcatctcatgtaggcagagtataaagtattaccttttggaattaaaagccactgactgttataaagtataacaacacacatcaggttttaaaaagccttgaatggcccttgtcttaaaaagaaattaggagccaggtgcggtggcacgtgcctgtaatcccagctccttgggaggctaagacaggaggattccttgagccctggagtttgagtccagcctgggtgacatagcaagaccctgtcttaaaagaaaaatgggaagaaagacaaggtaacatgaagaaagaagagatacctagtatgatggagctgcaaatttcatggcagttcatgcagtcggtcaagaggaggattttgttttgtagtttgcagatgagcatttctaaagcattttcccttgctgtatttttttgtattataaattacattggacttcatatatataatttttttttacattatatgtctcttgtatgttttgaaactcttgtatttatgatatagcttatatgatttttttgccttggtatacattttaaaatatgaatttaaaaaatttttgtaaaaataaaattcacaaaattgttttgaaaaacaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:317 -> Molecular function: GO:0000166 [nucleotide binding] evidence: TAS
GeneID:317 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:317 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:317 -> Molecular function: GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] evidence: NAS
GeneID:317 -> Molecular function: GO:0042802 [identical protein binding] evidence: IEA
GeneID:317 -> Molecular function: GO:0043531 [ADP binding] evidence: IEA
GeneID:317 -> Biological process: GO:0001843 [neural tube closure] evidence: IEA
GeneID:317 -> Biological process: GO:0006309 [apoptotic DNA fragmentation] evidence: IEA
GeneID:317 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:317 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: IDA
GeneID:317 -> Biological process: GO:0006952 [defense response] evidence: IEA
GeneID:317 -> Biological process: GO:0007399 [nervous system development] evidence: TAS
GeneID:317 -> Biological process: GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c] evidence: IDA
GeneID:317 -> Biological process: GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c] evidence: TAS
GeneID:317 -> Biological process: GO:0030900 [forebrain development] evidence: IEA
GeneID:317 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:317 -> Biological process: GO:0051402 [neuron apoptotic process] evidence: IEA
GeneID:317 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS
GeneID:317 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:317 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:317 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:317 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
GeneID:317 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:317 -> Cellular component: GO:0043293 [apoptosome] evidence: IDA
GeneID:317 -> Cellular component: GO:0043293 [apoptosome] evidence: TAS
by
@meso_cacase at
DBCLS
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