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2024-04-16 19:25:07, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001159353 1176 bp mRNA linear PRI 12-MAY-2013
DEFINITION Homo sapiens regenerating islet-derived family, member 4 (REG4),
transcript variant 3, mRNA.
ACCESSION NM_001159353
VERSION NM_001159353.1 GI:226823234
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1176)
AUTHORS Ying,L.S., Yu,J.L., Lu,X.X. and Ling,Z.Q.
TITLE Enhanced RegIV expression predicts the intrinsic 5-fluorouracil
(5-FU) resistance in advanced gastric cancer
JOURNAL Dig. Dis. Sci. 58 (2), 414-422 (2013)
PUBMED 23010741
REMARK GeneRIF: RegIV may play an important role in the intrinsic
resistance of gastric cancer cells to 5-FU.
REFERENCE 2 (bases 1 to 1176)
AUTHORS He,X.J., Jiang,X.T., Ma,Y.Y., Xia,Y.J., Wang,H.J., Guan,T.P.,
Shao,Q.S. and Tao,H.Q.
TITLE REG4 contributes to the invasiveness of pancreatic cancer by
upregulating MMP-7 and MMP-9
JOURNAL Cancer Sci. 103 (12), 2082-2091 (2012)
PUBMED 22957785
REMARK GeneRIF: REG4 promotes not only growth but also in vitro
invasiveness of pancreatic cancer cells by upregulating MMP-7 and
MMP-9.
REFERENCE 3 (bases 1 to 1176)
AUTHORS Katsuno,Y., Ehata,S., Yashiro,M., Yanagihara,K., Hirakawa,K. and
Miyazono,K.
TITLE Coordinated expression of REG4 and aldehyde dehydrogenase 1
regulating tumourigenic capacity of diffuse-type gastric
carcinoma-initiating cells is inhibited by TGF-beta
JOURNAL J. Pathol. 228 (3), 391-404 (2012)
PUBMED 22430847
REMARK GeneRIF: TGF-beta signalling reduces the expression of ALDH1 and
REG4, and the size of the ALDH1+ cell population.
REFERENCE 4 (bases 1 to 1176)
AUTHORS Naito,Y., Oue,N., Hinoi,T., Sakamoto,N., Sentani,K., Ohdan,H.,
Yanagihara,K., Sasaki,H. and Yasui,W.
TITLE Reg IV is a direct target of intestinal transcriptional factor CDX2
in gastric cancer
JOURNAL PLoS ONE 7 (11), E47545 (2012)
PUBMED 23133598
REMARK GeneRIF: CDX2 protein directly regulates Reg IV expression in
gastric cancer
REFERENCE 5 (bases 1 to 1176)
AUTHORS Wang,Q., Deng,J., Yuan,J., Wang,L., Zhao,Z., He,S., Zhang,Y. and
Tu,Y.
TITLE Oncogenic reg IV is a novel prognostic marker for glioma patient
survival
JOURNAL Diagn Pathol 7, 69 (2012)
PUBMED 22713481
REMARK GeneRIF: Suggest that Reg IV might accelerate disease progression
and act as a candidate prognostic marker for gliomas.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 1176)
AUTHORS Zhang,Z. and Henzel,W.J.
TITLE Signal peptide prediction based on analysis of experimentally
verified cleavage sites
JOURNAL Protein Sci. 13 (10), 2819-2824 (2004)
PUBMED 15340161
REFERENCE 7 (bases 1 to 1176)
AUTHORS Zhang,Y., Lai,M., Lv,B., Gu,X., Wang,H., Zhu,Y., Zhu,Y., Shao,L.
and Wang,G.
TITLE Overexpression of Reg IV in colorectal adenoma
JOURNAL Cancer Lett. 200 (1), 69-76 (2003)
PUBMED 14550954
REMARK GeneRIF: overexpression of Reg IV may be an early event in
colorectal carcinogenesis.
REFERENCE 8 (bases 1 to 1176)
AUTHORS Kamarainen,M., Heiskala,K., Knuutila,S., Heiskala,M., Winqvist,O.
and Andersson,L.C.
TITLE RELP, a novel human REG-like protein with up-regulated expression
in inflammatory and metaplastic gastrointestinal mucosa
JOURNAL Am. J. Pathol. 163 (1), 11-20 (2003)
PUBMED 12819006
REMARK GeneRIF: Results suggest that RELP might be involved in
inflammatory and metaplastic responses of the gastrointestinal
epithelium.
REFERENCE 9 (bases 1 to 1176)
AUTHORS Violette,S., Festor,E., Pandrea-Vasile,I., Mitchell,V., Adida,C.,
Dussaulx,E., Lacorte,J.M., Chambaz,J., Lacasa,M. and Lesuffleur,T.
TITLE Reg IV, a new member of the regenerating gene family, is
overexpressed in colorectal carcinomas
JOURNAL Int. J. Cancer 103 (2), 185-193 (2003)
PUBMED 12455032
REFERENCE 10 (bases 1 to 1176)
AUTHORS Hartupee,J.C., Zhang,H., Bonaldo,M.F., Soares,M.B. and
Dieckgraefe,B.K.
TITLE Isolation and characterization of a cDNA encoding a novel member of
the human regenerating protein family: Reg IV
JOURNAL Biochim. Biophys. Acta 1518 (3), 287-293 (2001)
PUBMED 11311942
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL359752.11 and AY126672.1.
Transcript Variant: This variant (3) lacks several 3' exons but has
an alternate 3' end, as compared to variant 1. The resulting
isoform (2) has a shorter and different C-terminus, as compared to
isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AY126672.1, DB010408.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025094 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-49 AL359752.11 21061-21109 c
50-472 AY126672.1 50-472
473-1176 AL359752.11 11852-12555 c
FEATURES Location/Qualifiers
source 1..1176
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p13.1-p12"
gene 1..1176
/gene="REG4"
/gene_synonym="GISP; REG-IV; RELP"
/note="regenerating islet-derived family, member 4"
/db_xref="GeneID:83998"
/db_xref="HGNC:22977"
/db_xref="MIM:609846"
exon 1..172
/gene="REG4"
/gene_synonym="GISP; REG-IV; RELP"
/inference="alignment:Splign:1.39.8"
variation 142..147
/gene="REG4"
/gene_synonym="GISP; REG-IV; RELP"
/replace=""
/replace="aggggc"
/db_xref="dbSNP:3216034"
exon 173..333
/gene="REG4"
/gene_synonym="GISP; REG-IV; RELP"
/inference="alignment:Splign:1.39.8"
misc_feature 240..242
/gene="REG4"
/gene_synonym="GISP; REG-IV; RELP"
/note="upstream in-frame stop codon"
CDS 267..671
/gene="REG4"
/gene_synonym="GISP; REG-IV; RELP"
/note="isoform 2 precursor is encoded by transcript
variant 3; regenerating gene type IV; gastrointestinal
secretory protein; regenerating islet-derived protein 4;
REG-4; reg IV; REG-like protein; regenerating
islet-derived protein IV"
/codon_start=1
/product="regenerating islet-derived protein 4 isoform 2
precursor"
/protein_id="NP_001152825.1"
/db_xref="GI:226823235"
/db_xref="CCDS:CCDS53354.1"
/db_xref="GeneID:83998"
/db_xref="HGNC:22977"
/db_xref="MIM:609846"
/translation="
MASRSMRLLLLLSCLAKTGVLGDIIMRPSCAPGWFYHKSNCYGYFRKLRNWSDAEVRNLLPAWPGLSRAKDQPEPQISFDSGSSVLPGHYEEKPLWLVKWREEGCVFNSFNSVSIAEAGAVCQTLDGLQAHTDT
"
sig_peptide 267..332
/gene="REG4"
/gene_synonym="GISP; REG-IV; RELP"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
misc_feature 354..>431
/gene="REG4"
/gene_synonym="GISP; REG-IV; RELP"
/note="C-type lectin (CTL)/C-type lectin-like (CTLD)
domain; Region: CLECT; cl02432"
/db_xref="CDD:207592"
exon 334..1176
/gene="REG4"
/gene_synonym="GISP; REG-IV; RELP"
/inference="alignment:Splign:1.39.8"
variation 473
/gene="REG4"
/gene_synonym="GISP; REG-IV; RELP"
/replace="a"
/replace="g"
/db_xref="dbSNP:3009202"
variation 905
/gene="REG4"
/gene_synonym="GISP; REG-IV; RELP"
/replace="c"
/replace="t"
/db_xref="dbSNP:1772387"
variation 1021
/gene="REG4"
/gene_synonym="GISP; REG-IV; RELP"
/replace="c"
/replace="t"
/db_xref="dbSNP:1660605"
ORIGIN
ataagacttttatggatggattgtttttctcaaataatattatcgctttgtgactaaagtaaagattattaattcctgaggcaagaagatataaaagctccagaaacgttgactgggaccactggagacactgaagaaggcaggggcccttagagtcttggttgccaaacagatttgcagatcaaggagaacccaggagtttcaaagaagcgctagtaaggtctctgagatccttgcactagctacatcctcagggtaggaggaagatggcttccagaagcatgcggctgctcctattgctgagctgcctggccaaaacaggagtcctgggtgatatcatcatgagacccagctgtgctcctggatggttttaccacaagtccaattgctatggttacttcaggaagctgaggaactggtctgatgccgaggtaagaaacttgctgcctgcttggcctggcctttctagagcaaaggaccagccagagccccagatctcatttgattcaggatcaagtgtccttcctgggcactatgaagagaagcccctttggctggtgaaatggagagaagagggttgtgtgttcaactcattcaattctgtaagcattgctgaagcaggtgctgtatgccagaccctagatgggctacaagcacatacggatacataggaaagagcccctaccctcagcaagctcactgtcagtaaaggagacagaaatacatcaatcaaaggaggaagagaagatgaggaattcacagaaaggataatggagtttctgtacaagatttaccagaaagagagtggtgtgtagacatgcctggagcagacaccttggagccgctgacagaaggtgaagcagtccaagaaaatgtggaaacttttccgctgctctacacagtccacaaacctgtccattttatttcgttgaagctttgtctgagagataaccaaatagacagtcaaagtaagttatctcagccacatatggggagtggatgctgctgaattgtgattaattgggggagccatataggtacatttggcatgatctgggcctatgcggtcttacaatccctgtataaaactagacaatgaaaaacagaaaacaaaacaaacaaacaaaaaaacaagaacgaagcacctaccacatgccagctactgaggctatgaag
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:83998 -> Molecular function: GO:0030246 [carbohydrate binding] evidence: IEA
GeneID:83998 -> Cellular component: GO:0005576 [extracellular region] evidence: IEA
by
@meso_cacase at
DBCLS
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