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2024-04-26 03:50:49, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001146288 2439 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens apoptosis-inducing factor, mitochondrion-associated, 3
(AIFM3), transcript variant 3, mRNA.
ACCESSION NM_001146288
VERSION NM_001146288.1 GI:226437567
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2439)
AUTHORS Yang,W., Sun,T., Cao,J., Liu,F., Tian,Y. and Zhu,W.
TITLE Downregulation of miR-210 expression inhibits proliferation,
induces apoptosis and enhances radiosensitivity in hypoxic human
hepatoma cells in vitro
JOURNAL Exp. Cell Res. 318 (8), 944-954 (2012)
PUBMED 22387901
REMARK GeneRIF: AIFM3 is a direct target of miR-210 in human hepatoma
cells.
REFERENCE 2 (bases 1 to 2439)
AUTHORS Lin'kova,N.S., Katanugina,A.S. and Khavinson,V.Kh.
TITLE [Expression of AIF and CGRP markers in pineal gland and thymus
during aging]
JOURNAL Adv Gerontol 24 (4), 601-605 (2011)
PUBMED 22550867
REMARK GeneRIF: The expression of apoptosis-inducing factor was identified
in pineal gland and thymus, but it did not change with age.
REFERENCE 3 (bases 1 to 2439)
AUTHORS Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
TITLE Genetic variants in nuclear-encoded mitochondrial genes influence
AIDS progression
JOURNAL PLoS ONE 5 (9), E12862 (2010)
PUBMED 20877624
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 2439)
AUTHORS Satoh,J., Obayashi,S., Misawa,T., Sumiyoshi,K., Oosumi,K. and
Tabunoki,H.
TITLE Protein microarray analysis identifies human cellular prion protein
interactors
JOURNAL Neuropathol. Appl. Neurobiol. 35 (1), 16-35 (2009)
PUBMED 18482256
REFERENCE 5 (bases 1 to 2439)
AUTHORS Ashktorab,H., Dashwood,R.H., Dashwood,M.M., Zaidi,S.I.,
Hewitt,S.M., Green,W.R., Lee,E.L., Daremipouran,M., Nouraie,M.,
Malekzadeh,R. and Smoot,D.T.
TITLE H. pylori-induced apoptosis in human gastric cancer cells mediated
via the release of apoptosis-inducing factor from mitochondria
JOURNAL Helicobacter 13 (6), 506-517 (2008)
PUBMED 19166416
REMARK GeneRIF: H. pylori triggers apoptosis in AGS cells via interaction
with death receptors in the plasma membrane, leading to the
cleavage of procaspase-8, release of cytochrome c and AIF from
mitochondria, and activation of subsequent downstream apoptotic
events
REFERENCE 6 (bases 1 to 2439)
AUTHORS Urbano,A., Lakshmanan,U., Choo,P.H., Kwan,J.C., Ng,P.Y., Guo,K.,
Dhakshinamoorthy,S. and Porter,A.
TITLE AIF suppresses chemical stress-induced apoptosis and maintains the
transformed state of tumor cells
JOURNAL EMBO J. 24 (15), 2815-2826 (2005)
PUBMED 16001080
REMARK GeneRIF: AIF maintains the transformed state of colon cancer cells
through its NADH oxidase activity, by mechanisms that involve
complex I function.
REFERENCE 7 (bases 1 to 2439)
AUTHORS Xie,Q., Lin,T., Zhang,Y., Zheng,J. and Bonanno,J.A.
TITLE Molecular cloning and characterization of a human AIF-like gene
with ability to induce apoptosis
JOURNAL J. Biol. Chem. 280 (20), 19673-19681 (2005)
PUBMED 15764604
REMARK GeneRIF: AIFL has 598 amino acids, with a characteristic Rieske
domain and a pyridine nucleotide-disulfide oxidoreductase domain
(Pyr_redox). AIFL shares 35% homology with AIF, mainly in the
Pyr_redox domain.
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DB172173.1, AK094844.1, AK295581.1 and BQ028401.1.
Transcript Variant: This variant (3) differs in the 5' UTR and has
multiple coding region differences compared to variant 1. The
encoded isoform (3) is shorter than isoform 1.
##Evidence-Data-START##
Transcript exon combination :: AK094844.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025082, ERS025090 [ECO:0000350]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: PMID: 15764604; reported by
MitoCarta
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-96 DB172173.1 1-96
97-796 AK094844.1 1-700
797-1281 AK295581.1 572-1056
1282-2428 AK094844.1 1186-2332
2429-2439 BQ028401.1 9-19 c
FEATURES Location/Qualifiers
source 1..2439
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="22"
/map="22q11.21"
gene 1..2439
/gene="AIFM3"
/gene_synonym="AIFL"
/note="apoptosis-inducing factor,
mitochondrion-associated, 3"
/db_xref="GeneID:150209"
/db_xref="HGNC:26398"
exon 1..145
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 37
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="g"
/replace="t"
/db_xref="dbSNP:112472055"
variation 45
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:141871613"
variation 72
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:369454650"
variation 133
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:183159029"
variation 144
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="c"
/db_xref="dbSNP:373183163"
exon 146..316
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 172
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:375049491"
misc_feature 187..189
/gene="AIFM3"
/gene_synonym="AIFL"
/note="upstream in-frame stop codon"
variation 261
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:372042715"
variation 264
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:201078355"
variation 283
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:371215112"
CDS 286..2100
/gene="AIFM3"
/gene_synonym="AIFL"
/note="isoform 3 is encoded by transcript variant 3;
apoptosis-inducing factor like; apoptosis-inducing factor
3"
/codon_start=1
/product="apoptosis-inducing factor 3 isoform 3"
/protein_id="NP_001139760.1"
/db_xref="GI:226437568"
/db_xref="CCDS:CCDS54503.1"
/db_xref="GeneID:150209"
/db_xref="HGNC:26398"
/translation="
MGGCFSKPKPGAALPTVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEERLSTPHPYPSPQDCVEAAVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGVLSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVYVRASKQALQLQRRTKVMAKCISPSAGYSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRPKLSKSLDTQPEQLALRPKEFFRAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSSPKTLSCKGKEVENVFTIRTPEDANRVVRLARGRNVVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQEGKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNVPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEMSTVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDLEELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVETGDMSWLTGKGS
"
misc_feature 511..795
/gene="AIFM3"
/gene_synonym="AIFL"
/note="AIFL (apoptosis-inducing factor like) family,
N-terminal Rieske domain; members of this family show
similarity to human AIFL, containing an N-terminal Rieske
domain and a C-terminal pyridine nucleotide-disulfide
oxidoreductase domain (Pyr_redox). The...; Region:
Rieske_AIFL_N; cd03478"
/db_xref="CDD:58548"
misc_feature order(628..630,634..639,685..687,694..696,700..702)
/gene="AIFM3"
/gene_synonym="AIFL"
/note="[2Fe-2S] cluster binding site [ion binding]; other
site"
/db_xref="CDD:58548"
misc_feature 889..1722
/gene="AIFM3"
/gene_synonym="AIFL"
/note="Pyridine nucleotide-disulphide oxidoreductase;
Region: Pyr_redox_2; pfam07992"
/db_xref="CDD:203833"
misc_feature 898..>993
/gene="AIFM3"
/gene_synonym="AIFL"
/note="NAD(P)-binding Rossmann-like domain; Region:
NAD_binding_8; pfam13450"
/db_xref="CDD:205628"
misc_feature 1327..1515
/gene="AIFM3"
/gene_synonym="AIFL"
/note="Pyridine nucleotide-disulphide oxidoreductase;
Region: Pyr_redox; pfam00070"
/db_xref="CDD:200974"
variation 291
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:148333657"
variation 296
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:146335337"
variation 297
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:374136982"
exon 317..548
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 319
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:375316928"
variation 328
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:178264"
variation 381
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:114399555"
variation 392
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:373088207"
variation 415
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:376327467"
variation 420
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="c"
/db_xref="dbSNP:59876863"
variation 428
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:370994357"
variation 455
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:373462664"
variation 463
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:142848384"
variation 498
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:71312796"
variation 516
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="t"
/db_xref="dbSNP:142254599"
variation 526
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:150622444"
variation 531
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:139684602"
variation 537
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:183325820"
exon 549..658
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 553
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="c"
/db_xref="dbSNP:377274696"
variation 578..579
/gene="AIFM3"
/gene_synonym="AIFL"
/replace=""
/replace="a"
/db_xref="dbSNP:34371345"
variation 579
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:149749799"
variation 613
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:367600638"
variation 614
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:371361440"
variation 616
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:375928890"
variation 633
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:151248970"
variation 639
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:148456772"
exon 659..768
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 670
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:370362252"
variation 683
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:374048838"
variation 696
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:368820001"
variation 742
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:201450835"
exon 769..813
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 783
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:200048332"
variation 795
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:201969997"
variation 796
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:56179977"
variation 800
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:147613113"
exon 814..910
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 829
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:142117053"
variation 838
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:144287643"
variation 876
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:201015871"
variation 899
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:144284647"
variation 903
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="g"
/replace="t"
/db_xref="dbSNP:200165374"
variation 910
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:151146728"
exon 911..1023
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 921
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:178266"
variation 931
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:140062749"
variation 943
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:150271585"
variation 953
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="g"
/replace="t"
/db_xref="dbSNP:145844241"
variation 964
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:370089581"
variation 970
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:202122018"
variation 981
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:373816290"
variation 988
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:140711648"
variation 999
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:145844603"
variation 1002
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:138399322"
variation 1009
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:201527012"
exon 1024..1110
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1038
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:78729788"
variation 1041
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:142889178"
variation 1044
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:143272206"
variation 1062
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:200227096"
variation 1075
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:148304997"
exon 1111..1202
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1114
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:199698549"
variation 1126
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:371705249"
variation 1128
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:376361841"
variation 1143
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:141390776"
variation 1144
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:201100852"
exon 1203..1333
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1213
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:5752353"
variation 1252
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="c"
/db_xref="dbSNP:377284602"
variation 1256
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:150801089"
variation 1259
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:139810844"
variation 1284
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:149430218"
variation 1293
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:7285694"
variation 1294
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:201655926"
variation 1295
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:181636008"
variation 1301
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:147200843"
variation 1305
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:369535222"
variation 1306
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:185338332"
variation 1310
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:372650074"
variation 1312
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:200032972"
variation 1324
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:140466618"
variation 1326
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:369724765"
exon 1334..1449
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1358
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:145487001"
variation 1359
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:369219792"
variation 1379
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:45606234"
variation 1400
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:373473269"
variation 1401
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:186357127"
variation 1406
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="g"
/replace="t"
/db_xref="dbSNP:371098629"
variation 1426
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:139501949"
variation 1428
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:142530985"
variation 1437
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="t"
/db_xref="dbSNP:178269"
exon 1450..1521
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1465
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:140732562"
variation 1467
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:373121171"
variation 1473
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:201592533"
variation 1481
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="g"
/replace="t"
/db_xref="dbSNP:145883640"
variation 1488
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:186295000"
exon 1522..1585
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1525
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:146611400"
variation 1531
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:141335687"
variation 1554
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:370782854"
variation 1555
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:374823610"
variation 1569
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:146322967"
variation 1573
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:376592022"
exon 1586..1662
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1621
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:138766186"
variation 1627
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:201028984"
variation 1649
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="t"
/db_xref="dbSNP:150983915"
exon 1663..1780
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1673
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:140853714"
variation 1704
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:202070098"
variation 1738
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:143682848"
variation 1749
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:73392570"
exon 1781..1879
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1783
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:373787248"
variation 1826
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:61356271"
variation 1838
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:147210962"
variation 1842
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:140507708"
variation 1849
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:367937547"
exon 1880..1955
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1884
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:141235166"
variation 1885
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:377494972"
variation 1886
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="g"
/replace="t"
/db_xref="dbSNP:371219265"
variation 1891
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:374162437"
variation 1918
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="g"
/replace="t"
/db_xref="dbSNP:367787216"
exon 1956..2060
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 1974
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:150768856"
variation 1988
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="t"
/db_xref="dbSNP:368864004"
variation 1999
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:371794358"
variation 2015
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="c"
/db_xref="dbSNP:9620700"
variation 2036
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:116635261"
exon 2061..2429
/gene="AIFM3"
/gene_synonym="AIFL"
/inference="alignment:Splign:1.39.8"
variation 2064
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="t"
/db_xref="dbSNP:200537959"
variation 2067
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:375943087"
variation 2084
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:370473954"
variation 2101
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:149904114"
variation 2109
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:199601611"
variation 2112
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:368429589"
variation 2118
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:372669531"
variation 2124
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:374539558"
variation 2156
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:142727436"
variation 2190
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:190042788"
variation 2271
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="c"
/db_xref="dbSNP:6005114"
variation 2339
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:7292968"
variation 2340
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:115986263"
variation 2345
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="c"
/db_xref="dbSNP:181674065"
variation 2373
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="g"
/db_xref="dbSNP:146061792"
variation 2386
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="c"
/replace="t"
/db_xref="dbSNP:389183"
variation 2391
/gene="AIFM3"
/gene_synonym="AIFL"
/replace="a"
/replace="g"
/db_xref="dbSNP:367851"
ORIGIN
ctcctggccacagcttgagctgggaggagggtggaggctgggccgcctcctggacccctgccctccctgcccggccttccaaggcccggcagcctcagtccactgctgggcctggaacacggagcagtggctgccctgcgaggaggtcctagagcagctccagcaggatggcggctccagcgtctctaaggcctgcagggggtccagccccatggggggcgccctaggcctccgacagctccccatctgtgctcctgcctgccggccatcctcaggccactcgccatgggcggctgcttctccaaacccaaaccaggcgctgccttgcccacagtggagctcaagatcgaggtggtgctgcctgagaaggagcgaggcaaggaggagctgtcggccagtgggaagggcagcccccgggcctaccagggcaatggcacggcccgccacttccacacggaggagcgcctgtccacccctcacccctaccccagccctcaggattgcgtggaggctgctgtctgccacgtcaaggacctcgagaatggccagatgcgggaagtggagctgggctgggggaaggtgttgctggtgaaggacaatggggagttccacgccctgggccataagtgtccgcactacggcgcacccctggtgaaaggcgttctgtcccgtggtcgggtgcgctgcccctggcacggcgcctgcttcaacatcagcactggggacctggaggacttccctggcctggacagtctacacaagttccaggtgaagattgagaaggagaaggtgtacgtccgggccagcaagcaggccctacagctgcagcgaaggaccaaggtgatggccaagtgtatctctccaagtgctgggtacagcagtagcaccaatgtgctcattgtgggtgcaggtgcagctggcctggtgtgtgcagagacactgcggcaggagggcttctccgaccggatcgtcctgtgcacgctagaccggcaccttccctacgaccgtcccaagctcagcaagtccctggacacacagcctgagcagctggccctgaggcccaaggagtttttccgagcctatggcatcgaggtgctcaccgaggctcaggtggtcacagtggacgtgagaactaagaaggtcgtgttcaaggatggcttcaagctggagtacagcaagctgctgctggcaccagggagcagccccaagactctgagctgcaaaggcaaagaagtggagaacgtgttcactatccggacgccagaggatgccaatcgcgtggtgaggctggcccgaggccgcaacgtggtcgtcgtgggagccggcttcctggggatggaggtggccgcttacctgacggagaaggcccactctgtgtctgtggtggagctggaggagacgcccttcaggaggttcctgggggagcgcgtgggtcgtgccctcatgaagatgtttgagaacaaccgggtgaagttctacatgcagacggaggtgtctgagctgcggggccaggagggaaagctgaaggaggttgtgctgaagagcagcaaggtcgtgcgggctgacgtctgcgtggtgggcattggtgcagtgcccgccacaggcttcctgaggcaaagcggcatcggtttggattcccgaggcttcatccctgtcaacaagatgatgcagaccaatgtcccaggcgtgtttgcagctggcgatgctgtcaccttcccccttgcctggaggaacaaccgcaaagtgaacattccacattggcagatggctcatgctcaggggcgcgtggcagcccagaacatgttggcgcaggaggcggagatgagcactgtgccctacctctggaccgccatgtttggcaagagcctgcgctacgcgggctacggagaaggcttcgacgacgtcatcatccagggggatctggaggagctgaagtttgtggctttttacactaaaggcgacgaggtgatcgccgtggccagcatgaactacgatcccattgtgtccaaggtcgctgaggtgctggcctcaggccgtgccatccggaagcgggaggtggagactggcgacatgtcctggcttacggggaaaggatcctgagctcacatgcagtagacttgggcaggcaaagggggcaccaagggcacaggccaagccttgggggcaggtgccaatctccagtcccaggatcccccagggcagaacctgagccctcccagtgcttgccttcagccacctggctcccctcctgggaggcctctgctggatccagaagatgctcaaccctcaaggcctctgctgccactgacagctggcactggaggcaggacaagccctgcctcttctccctctattgggactggtcccctgaagaaccctgcaacatgttagacattaccgtaaaattaaaacgcacaaatttgcagatcaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:150209 -> Molecular function: GO:0016491 [oxidoreductase activity] evidence: IEA
GeneID:150209 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:150209 -> Molecular function: GO:0050660 [flavin adenine dinucleotide binding] evidence: IEA
GeneID:150209 -> Molecular function: GO:0051537 [2 iron, 2 sulfur cluster binding] evidence: IEA
GeneID:150209 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:150209 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IDA
GeneID:150209 -> Biological process: GO:0022900 [electron transport chain] evidence: IEA
GeneID:150209 -> Biological process: GO:0045454 [cell redox homeostasis] evidence: IEA
GeneID:150209 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:150209 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:150209 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
GeneID:150209 -> Cellular component: GO:0005743 [mitochondrial inner membrane] evidence: IDA
GeneID:150209 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001139760 -> EC 1.-.-.-
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.