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2024-04-23 16:44:27, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001146069 1767 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens major facilitator superfamily domain containing 10
(MFSD10), transcript variant 2, mRNA.
ACCESSION NM_001146069
VERSION NM_001146069.1 GI:225703103
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1767)
AUTHORS Ushijima,H., Hiasa,M., Namba,T., Hwang,H.J., Hoshino,T., Mima,S.,
Tsuchiya,T., Moriyama,Y. and Mizushima,T.
TITLE Expression and function of TETRAN, a new type of membrane
transporter
JOURNAL Biochem. Biophys. Res. Commun. 374 (2), 325-330 (2008)
PUBMED 18638446
REMARK GeneRIF: TETRAN is a novel human organic anion transporter, and
that it serves as a transporter for some NSAIDs and various other
organic anions at the final excretion step.
REFERENCE 2 (bases 1 to 1767)
AUTHORS Mima,S., Ushijima,H., Hwang,H.J., Tsutsumi,S., Makise,M.,
Yamaguchi,Y., Tsuchiya,T., Mizushima,H. and Mizushima,T.
TITLE Identification of the TPO1 gene in yeast, and its human orthologue
TETRAN, which cause resistance to NSAIDs
JOURNAL FEBS Lett. 581 (7), 1457-1463 (2007)
PUBMED 17362938
REMARK GeneRIF: A BLAST search identified the possible human orthologue of
Tpo1p, tetracycline transporter-like protein (TETRAN), whose
overexpression in cultured human cells caused resistance to some
NSAIDs, suggesting that TETRAN is an efflux pump for some NSAIDs.
REFERENCE 3 (bases 1 to 1767)
AUTHORS Duyao,M.P., Taylor,S.A., Buckler,A.J., Ambrose,C.M., Lin,C.,
Groot,N., Church,D., Barnes,G., Wasmuth,J.J., Housman,D.E. et al.
TITLE A gene from chromosome 4p16.3 with similarity to a superfamily of
transporter proteins
JOURNAL Hum. Mol. Genet. 2 (6), 673-676 (1993)
PUBMED 8353488
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BX359190.2, CN422014.1,
BC001502.2 and BC023537.2.
Summary: This gene encodes a member of the major facilitator
superfamily of transporter proteins. The encoded protein likely
functions in efflux of organic anions, including the non-steroidal
anti-inflammatory drugs indomethacin and diclofenac. Alternatively
spliced transcript variants have been described. [provided by
RefSeq, Mar 2009].
Transcript Variant: This variant (2) differs in the 5' UTR compared
to variant 1. Both variants 1 and 2 encode the same protein.
##Evidence-Data-START##
Transcript exon combination :: BC014979.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-17 BX359190.2 1-17
18-74 CN422014.1 6-62
75-1751 BC001502.2 1-1677
1752-1767 BC023537.2 1541-1556
FEATURES Location/Qualifiers
source 1..1767
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4p16.3"
gene 1..1767
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/note="major facilitator superfamily domain containing 10"
/db_xref="GeneID:10227"
/db_xref="HGNC:16894"
/db_xref="MIM:610977"
exon 1..91
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 92..283
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
CDS 113..1480
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/note="tetracycline transporter-like protein"
/codon_start=1
/product="major facilitator superfamily domain-containing
protein 10"
/protein_id="NP_001139541.1"
/db_xref="GI:225703104"
/db_xref="CCDS:CCDS3365.1"
/db_xref="GeneID:10227"
/db_xref="HGNC:16894"
/db_xref="MIM:610977"
/translation="
MGWGGGGGCTPRPPIHQQPPERRVVTVVFLGLLLDLLAFTLLLPLLPGLLESHGRAHDPLYGSWQGGVDWFATAIGMPVEKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAASDLLFIFCFLPETLPLEKRAPSIALGFRDAADLLSPLALLRFSAVARGQDPPSGDRLSSLRRLGLVYFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTMATIQGAYARRIHPGGEVAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVMGTLRSLGALARAAGPLVAASVYWLAGAQACFTTWSGLFLLPFFLLQKLSYPAQTLKAE
"
misc_feature 191..253
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 323..>706
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/note="The Major Facilitator Superfamily (MFS) is a large
and diverse group of secondary transporters that includes
uniporters, symporters, and antiporters. MFS proteins
facilitate the transport across cytoplasmic or internal
membranes of a variety of...; Region: MFS; cd06174"
/db_xref="CDD:119392"
misc_feature 365..>706
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/note="Major Facilitator Superfamily; Region: MFS_1;
pfam07690"
/db_xref="CDD:191813"
misc_feature 368..430
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 449..517
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 554..616
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 638..700
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 716..778
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 935..997
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 1040..1093
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 1118..1180
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 1187..1249
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 1373..1435
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
exon 284..380
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 381..484
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
variation 397
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/replace="a"
/replace="c"
/db_xref="dbSNP:34745961"
exon 485..643
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 644..805
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 806..914
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 915..1026
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 1027..1135
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 1136..1226
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 1227..1274
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 1275..1364
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 1365..1757
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
variation 1456
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/replace="a"
/replace="g"
/db_xref="dbSNP:1034400"
polyA_signal 1730..1735
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
polyA_site 1757
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
ORIGIN
gccgggcgtggccgtcccgcccctggcggcgtgcctggtgccctgttccgcgtctgtgcgaccgtccgtcccgagcgcgcagccgcggcaggccaggtcagagcagcccaccatgggatggggagggggtggaggctgcaccccgcgcccacccatccaccagcagccgccggagcgccgcgtggtcaccgttgtctttctcggcctcctgctggacctcctggccttcacgctgctgctgcccctgctgcccgggctgttggagagccacggccgtgcccacgaccccctctatggctcctggcagggcggggtggactggtttgccaccgccatcgggatgccagtggagaagaggtacaacagtgtcctgttcggaggtctcattggctcggcattctctgtcctgcagtttctgtgtgcgccactcactggggccacctctgactgcttggggaggcgcccggtgatgctgctgtgcctgatgggtgtggccacctcatatgcagtctgggccacctctcggagctttgcggccttcctggcctccaggctgattgggggcatcagcaaagggaacgtcagcctctccacggccatcgttgctgacctgggctcgcctctggcccgcagtcaaggcatggcggtcattggggtggccttctcactgggcttcaccctgggccctatgctcggagcctccctgcccctggaaatggcaccctggtttgccctgctcttcgcagcctccgacctgctgttcatcttctgcttcctgccagagacgctgcccctggagaaacgggcgccctctatcgccctggggttccgtgatgcggctgatctgctcagccccctggccctgctgcgcttctcggctgtcgctcgtggccaggacccaccctctggagacaggctcagcagcctgcgccgcctgggcctagtctacttcctctacctcttcctgttctcgggcctggagtacacgctgagcttcctcacacaccagcgcttccagttcagtagcctacagcaggggaagatgtttttcctcatcggcctcaccatggccaccatccagggtgcctatgcccggcggatccaccctggcggggaagttgctgccgtgaagcgggccctcctgctgctggtgcccgccttcctcctcatcggctggggacgttctctgcccgtgctgggcctggggctgctgctctactcctttgccgccgccgttgtggtgccctgcctgtcctccgtggtcgctggctatggctcaccagggcagaagggcacggtcatgggtacactgcgcagcctaggtgctctggccagggccgcggggcccctggtggccgcttcagtgtactggctggccggggcccaggcctgcttcaccacgtggtccgggctctttttgctccccttcttcctcctgcagaagctgagttacccggcacagacgctcaaggctgagtagctgagccactgtgcccaggctgtgggcaccaggcagagtgggagcctaggtcaggcccctgcccactgcctgacccccaccccccgccagtccagggagaccctgtgggtgggggccggcccctaagcaggaagctcaggcagctcctccagacttacttactccttcagtgactccgagctgcagcactccaaggctgtcagggcttctgtttgttttttaaactatgcaccaggtttctgatgatgaaataaagcacctgtttgttttataccaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10227 -> Molecular function: GO:0008493 [tetracycline transporter activity] evidence: TAS
GeneID:10227 -> Biological process: GO:0006810 [transport] evidence: TAS
GeneID:10227 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:10227 -> Biological process: GO:0015904 [tetracycline transport] evidence: TAS
GeneID:10227 -> Biological process: GO:0055085 [transmembrane transport] evidence: IEA
GeneID:10227 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
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