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2024-03-30 08:47:17, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001145852            3857 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens prominin 1 (PROM1), transcript variant 4, mRNA.
ACCESSION   NM_001145852
VERSION     NM_001145852.1  GI:224994198
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3857)
  AUTHORS   Zeng,Z., Shaffer,J.R., Wang,X., Feingold,E., Weeks,D.E., Lee,M.,
            Cuenco,K.T., Wendell,S.K., Weyant,R.J., Crout,R., McNeil,D.W. and
            Marazita,M.L.
  TITLE     Genome-wide association studies of pit-and-fissure- and
            smooth-surface caries in permanent dentition
  JOURNAL   J. Dent. Res. 92 (5), 432-437 (2013)
   PUBMED   23470693
REFERENCE   2  (bases 1 to 3857)
  AUTHORS   Wei,Y., Jiang,Y., Zou,F., Liu,Y., Wang,S., Xu,N., Xu,W., Cui,C.,
            Xing,Y., Liu,Y., Cao,B., Liu,C., Wu,G., Ao,H., Zhang,X. and
            Jiang,J.
  TITLE     Activation of PI3K/Akt pathway by CD133-p85 interaction promotes
            tumorigenic capacity of glioma stem cells
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 110 (17), 6829-6834 (2013)
   PUBMED   23569237
  REMARK    GeneRIF: Activation of PI3K/Akt pathway by CD133-p85 interaction
            promotes tumorigenic capacity of glioma stem cells.
REFERENCE   3  (bases 1 to 3857)
  AUTHORS   Rappa,G., Mercapide,J., Anzanello,F., Le,T.T., Johlfs,M.G.,
            Fiscus,R.R., Wilsch-Brauninger,M., Corbeil,D. and Lorico,A.
  TITLE     Wnt interaction and extracellular release of prominin-1/CD133 in
            human malignant melanoma cells
  JOURNAL   Exp. Cell Res. 319 (6), 810-819 (2013)
   PUBMED   23318676
  REMARK    GeneRIF: Down-regulation of CD133 in malignant melanoma cells
            impaired substrate and inter-cellular adhesion, cell motility and
            invasion. Prominin-1 also mediates Wnt activation.
REFERENCE   4  (bases 1 to 3857)
  AUTHORS   Koyama-Nasu,R., Takahashi,R., Yanagida,S., Nasu-Nishimura,Y.,
            Oyama,M., Kozuka-Hata,H., Haruta,R., Manabe,E., Hoshino-Okubo,A.,
            Omi,H., Yanaihara,N., Okamoto,A., Tanaka,T. and Akiyama,T.
  TITLE     The cancer stem cell marker CD133 interacts with plakoglobin and
            controls desmoglein-2 protein levels
  JOURNAL   PLoS ONE 8 (1), E53710 (2013)
   PUBMED   23326490
  REMARK    GeneRIF: CD133 interacts with plakoglobin and knockdown of CD133 by
            RNA interference (RNAi) results in the downregulation of
            desmoglein-2.
REFERENCE   5  (bases 1 to 3857)
  AUTHORS   Canis,M., Lechner,A., Mack,B., Zengel,P., Laubender,R.P.,
            Koehler,U., Heissmeyer,V. and Gires,O.
  TITLE     CD133 is a predictor of poor survival in head and neck squamous
            cell carcinomas
  JOURNAL   Cancer Biomark 12 (2), 97-105 (2012)
   PUBMED   23396254
  REMARK    GeneRIF: A gradual and inversely proportional correlation between
            CD133 expression in head and neck tumours and decreased overall
            survival was observed, along with a positive correlation with the
            presence of lymph node metastases.
REFERENCE   6  (bases 1 to 3857)
  AUTHORS   Maw,M.A., Corbeil,D., Koch,J., Hellwig,A., Wilson-Wheeler,J.C.,
            Bridges,R.J., Kumaramanickavel,G., John,S., Nancarrow,D., Roper,K.,
            Weigmann,A., Huttner,W.B. and Denton,M.J.
  TITLE     A frameshift mutation in prominin (mouse)-like 1 causes human
            retinal degeneration
  JOURNAL   Hum. Mol. Genet. 9 (1), 27-34 (2000)
   PUBMED   10587575
REFERENCE   7  (bases 1 to 3857)
  AUTHORS   Kniazeva,M., Chiang,M.F., Morgan,B., Anduze,A.L., Zack,D.J., Han,M.
            and Zhang,K.
  TITLE     A new locus for autosomal dominant stargardt-like disease maps to
            chromosome 4
  JOURNAL   Am. J. Hum. Genet. 64 (5), 1394-1399 (1999)
   PUBMED   10205271
REFERENCE   8  (bases 1 to 3857)
  AUTHORS   Horn,P.A., Tesch,H., Staib,P., Kube,D., Diehl,V. and Voliotis,D.
  TITLE     Expression of AC133, a novel hematopoietic precursor antigen, on
            acute myeloid leukemia cells
  JOURNAL   Blood 93 (4), 1435-1437 (1999)
   PUBMED   10075457
REFERENCE   9  (bases 1 to 3857)
  AUTHORS   Miraglia,S., Godfrey,W., Yin,A.H., Atkins,K., Warnke,R.,
            Holden,J.T., Bray,R.A., Waller,E.K. and Buck,D.W.
  TITLE     A novel five-transmembrane hematopoietic stem cell antigen:
            isolation, characterization, and molecular cloning
  JOURNAL   Blood 90 (12), 5013-5021 (1997)
   PUBMED   9389721
REFERENCE   10 (bases 1 to 3857)
  AUTHORS   Yin,A.H., Miraglia,S., Zanjani,E.D., Almeida-Porada,G., Ogawa,M.,
            Leary,A.G., Olweus,J., Kearney,J. and Buck,D.W.
  TITLE     AC133, a novel marker for human hematopoietic stem and progenitor
            cells
  JOURNAL   Blood 90 (12), 5002-5012 (1997)
   PUBMED   9389720
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC012089.1, AY449690.1,
            DB326234.1 and AA622198.1.
            
            Summary: This gene encodes a pentaspan transmembrane glycoprotein.
            The protein localizes to membrane protrusions and is often
            expressed on adult stem cells, where it is thought to function in
            maintaining stem cell properties by suppressing differentiation.
            Mutations in this gene have been shown to result in retinitis
            pigmentosa and Stargardt disease. Expression of this gene is also
            associated with several types of cancer. This gene is expressed
            from at least five alternative promoters that are expressed in a
            tissue-dependent manner. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Mar 2009].
            
            Transcript Variant: This variant (4) lacks an alternate in-frame
            exon in the 5' coding region and two in-frame exons in the 3'
            coding region, compared to variant 1. The resulting isoform (4),
            also known as s7, lacks an internal segment near the N-terminus and
            a second internal segment near the C-terminus, compared to isoform
            1. The full structure of the 5' UTR for this variant has not been
            determined.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY449690.1 [ECO:0000331]
            RNAseq introns       :: mixed/partial sample support ERS025082,
                                    ERS025083 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               BC012089.1         24-235
            213-2690            AY449690.1         1-2478
            2691-3311           BC012089.1         2807-3427
            3312-3718           DB326234.1         138-544             c
            3719-3854           DB326234.1         1-136               c
            3855-3857           AA622198.1         6-8                 c
FEATURES             Location/Qualifiers
     source          1..3857
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.32"
     gene            1..3857
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /note="prominin 1"
                     /db_xref="GeneID:8842"
                     /db_xref="HGNC:9454"
                     /db_xref="MIM:604365"
     exon            1..432
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    162..164
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /note="upstream in-frame stop codon"
     CDS             213..2690
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; hProminin; hematopoietic stem cell antigen;
                     antigen AC133; prominin-like protein 1"
                     /codon_start=1
                     /product="prominin-1 isoform 4 precursor"
                     /protein_id="NP_001139324.1"
                     /db_xref="GI:224994199"
                     /db_xref="GeneID:8842"
                     /db_xref="HGNC:9454"
                     /db_xref="MIM:604365"
                     /translation="
MALVLGSLLLLGLCGNSFSGGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKIVYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFAISLLVICIIISIGIFYGFVANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQLPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSAFSVYVNNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCGVCGYDRHATPTTRGCVSNTGGVFLMVGVGLSFLFCWILMIIVVLTFVFGANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTSSVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLNLFWFGIGKATVFLLPALIFAVKLAKYYRRMDSEDVYDDPSQH
"
     sig_peptide     213..269
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    276..2675
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /note="Prominin; Region: Prominin; pfam05478"
                     /db_xref="CDD:203254"
     exon            433..488
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            489..694
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            695..815
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            816..879
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            880..969
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            970..1187
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     variation       971
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2286455"
     exon            1188..1262
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            1263..1326
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            1327..1486
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            1487..1639
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            1640..1763
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            1764..1867
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            1868..1952
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            1953..2096
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2097..2168
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2169..2261
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2262..2315
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2316..2396
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2397..2465
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2466..2558
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2559..2674
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2675..2714
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2715..3857
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     variation       2928
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2240687"
     variation       3357
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2240688"
     STS             3578..3825
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /standard_name="WI-22012"
                     /db_xref="UniSTS:18249"
     STS             3646..3790
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /standard_name="RH121881"
                     /db_xref="UniSTS:137735"
     variation       3809
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1053767"
     polyA_signal    3833..3838
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
     polyA_site      3857
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
ORIGIN      
ggatggtgccttgagtgaatgacccccttggagaacattcttccgcatccctcgcctcaagccagcctcagacagaaaactgaagattcagcagatccagtgcttcctgctcctcttctgcccaggaacacgcttgccttccccaaggcttccagaagctctgaggcaggaggcaccaagttctacctcatgtttggaggatcttgctagctatggccctcgtactcggctccctgttgctgctggggctgtgcgggaactccttttcaggagggcagccttcatccacagatgctcctaaggcttggaattatgaattgcctgcaacaaattatgagacccaagactcccataaagctggacccattggcattctctttgaactagtgcatatctttctctatgtggtacagccgcgtgatttcccagaagatactttgagaaaattcttacagaaggcatatgaatccaaaattgattatgacaagattgtctactatgaagcagggattattctatgctgtgtcctggggctgctgtttattattctgatgcctctggtggggtatttcttttgtatgtgtcgttgctgtaacaaatgtggtggagaaatgcaccagcgacagaaggaaaatgggcccttcctgaggaaatgctttgcaatctccctgttggtgatttgtataataataagcattggcatcttctatggttttgtggcaaatcaccaggtaagaacccggatcaaaaggagtcggaaactggcagatagcaatttcaaggacttgcgaactctcttgaatgaaactccagagcaaatcaaatatatattggcccagtacaacactaccaaggacaaggcgttcacagatctgaacagtatcaattcagtgctaggaggcggaattcttgaccgactgagacccaacatcatccctgttcttgatgagattaagtccatggcaacagcgatcaaggagaccaaagaggcgttggagaacatgaacagcaccttgaagagcttgcaccaacaaagtacacagcttagcagcagtctgaccagcgtgaaaactagcctgcggtcatctctcaatgaccctctgtgcttggtgcatccatcaagtgaaacctgcaacagcatcagattgtctctaagccagctgaatagcaaccctgaactgaggcagcttccacccgtggatgcagaacttgacaacgttaataacgttcttaggacagatttggatggcctggtccaacagggctatcaatcccttaatgatatacctgacagagtacaacgccaaaccacgactgtcgtagcaggtatcaaaagggtcttgaattccattggttcagatatcgacaatgtaactcagcgtcttcctattcaggatatactctcagcattctctgtttatgttaataacactgaaagttacatccacagaaatttacctacattggaagagtatgattcatactggtggctgggtggcctggtcatctgctctctgctgaccctcatcgtgattttttactacctgggcttactgtgtggcgtgtgcggctatgacaggcatgccaccccgaccacccgaggctgtgtctccaacaccggaggcgtcttcctcatggttggagttggattaagtttcctcttttgctggatattgatgatcattgtggttcttacctttgtctttggtgcaaatgtggaaaaactgatctgtgaaccttacacgagcaaggaattattccgggttttggatacaccctacttactaaatgaagactgggaatactatctctctgggaagctatttaataaatcaaaaatgaagctcacttttgaacaagtttacagtgactgcaaaaaaaatagaggcacttacggcactcttcacctgcagaacagcttcaatatcagtgaacatctcaacattaatgagcatactggaagcataagcagtgaattggaaagtctgaaggtaaatcttaatatctttctgttgggtgcagcaggaagaaaaaaccttcaggattttgctgcttgtggaatagacagaatgaattatgacagctacttggctcagactggtaaatcccccgcaggagtgaatcttttatcatttgcatatgatctagaagcaaaagcaaacagtttgcccccaggaaatttgaggaactccctgaaaagagatgcacaaactattaaaacaattcaccagcaacgagtccttcctatagaacaatcactgagcactctataccaaagcgtcaagatacttcaacgcacagggaatggattgttggagagagtaactaggattctagcttctctggattttgctcagaacttcatcacaaacaatacttcctctgttattattgaggaaactaagaagtatgggagaacaataataggatattttgaacattatctgcagtggatcgagttctctatcagtgagaaagtggcatcgtgcaaacctgtggccaccgctctagatactgctgttgatgtctttctgtgtagctacattatcgaccccttgaatttgttttggtttggcataggaaaagctactgtatttttacttccggctctaatttttgcggtaaaactggctaagtactatcgtcgaatggattcggaggacgtgtacgatgacccatcacaacattgatagctgatgttgaaactgcttgagcatcaggatactcaaagtggaaaggatcacagatttttggtagtttctgggtctacaaggactttccaaatccaggagcaacgccagtggcaacgtagtgactcaggcgggcaccaaggcaacggcaccattggtctctgggtagtgctttaagaatgaacacaatcacgttatagtccatggtccatcactattcaaggatgactccctcccttcctgtctatttttgttttttacttttttacactgagtttctatttagacactacaacatatggggtgtttgttcccattggatgcatttctatcaaaactctatcaaatgtgatggctagattctaacatattgccatgtgtggagtgtgctgaacacacaccagtttacaggaaagatgcattttgtgtacagtaaacggtgtatataccttttgttaccacagagttttttaaacaaatgagtattataggactttcttctaaatgagctaaataagtcaccattgacttcttggtgctgttgaaaataatccattttcactaaaagtgtgtgaaacctacagcatattcttcacgcagagattttcatctattatactttatcaaagattggccatgttccacttggaaatggcatgcaaaagcaatcatagagaaacctgcgtaactccatctgacaaattcaaaagagagagagagatcttgagagagaaatgctgttcgttcaaaagtggagttgttttaacagatgccaattacggtgtacagtttaacagagttttctgttgcattaggataaacattaattggagtgcagctaacatgagtatcatcagactagtatcaagtgttctaaaatgaaatatgagaagatcctgtcacaattcttagatctggtgtccagcatggatgaaacctttgagtttggtccctaaatttgcatgaaagcacaaggtaaatattcatttgcttcaggagtttcatgttggatctgtcattatcaaaagtgatcagcaatgaagaactggtcggacaaaatttaacgttgatgtaatgaaattccagatgtaggcattccccccaggtcttttcatgtgcagattgcagttctgattcatttgaataaaaaggaacttggaaaacatg
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:8842 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:8842 -> Molecular function: GO:0042805 [actinin binding] evidence: IDA
            GeneID:8842 -> Molecular function: GO:0045296 [cadherin binding] evidence: IPI
            GeneID:8842 -> Biological process: GO:0010842 [retina layer formation] evidence: ISS
            GeneID:8842 -> Biological process: GO:0045494 [photoreceptor cell maintenance] evidence: IMP
            GeneID:8842 -> Biological process: GO:0060042 [retina morphogenesis in camera-type eye] evidence: IMP
            GeneID:8842 -> Biological process: GO:0060219 [camera-type eye photoreceptor cell differentiation] evidence: IMP
            GeneID:8842 -> Biological process: GO:0060219 [camera-type eye photoreceptor cell differentiation] evidence: ISS
            GeneID:8842 -> Biological process: GO:0072112 [glomerular visceral epithelial cell differentiation] evidence: IMP
            GeneID:8842 -> Biological process: GO:0072139 [glomerular parietal epithelial cell differentiation] evidence: IMP
            GeneID:8842 -> Biological process: GO:2000768 [positive regulation of nephron tubule epithelial cell differentiation] evidence: IMP
            GeneID:8842 -> Cellular component: GO:0001750 [photoreceptor outer segment] evidence: ISS
            GeneID:8842 -> Cellular component: GO:0005615 [extracellular space] evidence: IEA
            GeneID:8842 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:8842 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: IEA
            GeneID:8842 -> Cellular component: GO:0005903 [brush border] evidence: IEA
            GeneID:8842 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
            GeneID:8842 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IEA
            GeneID:8842 -> Cellular component: GO:0031528 [microvillus membrane] evidence: IEA
            GeneID:8842 -> Cellular component: GO:0032420 [stereocilium] evidence: IEA
            GeneID:8842 -> Cellular component: GO:0042622 [photoreceptor outer segment membrane] evidence: IDA

by @meso_cacase at DBCLS
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