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2024-03-29 07:28:24, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001145847            4257 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens prominin 1 (PROM1), transcript variant 2, mRNA.
ACCESSION   NM_001145847
VERSION     NM_001145847.1  GI:224994188
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4257)
  AUTHORS   Zeng,Z., Shaffer,J.R., Wang,X., Feingold,E., Weeks,D.E., Lee,M.,
            Cuenco,K.T., Wendell,S.K., Weyant,R.J., Crout,R., McNeil,D.W. and
            Marazita,M.L.
  TITLE     Genome-wide association studies of pit-and-fissure- and
            smooth-surface caries in permanent dentition
  JOURNAL   J. Dent. Res. 92 (5), 432-437 (2013)
   PUBMED   23470693
REFERENCE   2  (bases 1 to 4257)
  AUTHORS   Wei,Y., Jiang,Y., Zou,F., Liu,Y., Wang,S., Xu,N., Xu,W., Cui,C.,
            Xing,Y., Liu,Y., Cao,B., Liu,C., Wu,G., Ao,H., Zhang,X. and
            Jiang,J.
  TITLE     Activation of PI3K/Akt pathway by CD133-p85 interaction promotes
            tumorigenic capacity of glioma stem cells
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 110 (17), 6829-6834 (2013)
   PUBMED   23569237
  REMARK    GeneRIF: Activation of PI3K/Akt pathway by CD133-p85 interaction
            promotes tumorigenic capacity of glioma stem cells.
REFERENCE   3  (bases 1 to 4257)
  AUTHORS   Rappa,G., Mercapide,J., Anzanello,F., Le,T.T., Johlfs,M.G.,
            Fiscus,R.R., Wilsch-Brauninger,M., Corbeil,D. and Lorico,A.
  TITLE     Wnt interaction and extracellular release of prominin-1/CD133 in
            human malignant melanoma cells
  JOURNAL   Exp. Cell Res. 319 (6), 810-819 (2013)
   PUBMED   23318676
  REMARK    GeneRIF: Down-regulation of CD133 in malignant melanoma cells
            impaired substrate and inter-cellular adhesion, cell motility and
            invasion. Prominin-1 also mediates Wnt activation.
REFERENCE   4  (bases 1 to 4257)
  AUTHORS   Koyama-Nasu,R., Takahashi,R., Yanagida,S., Nasu-Nishimura,Y.,
            Oyama,M., Kozuka-Hata,H., Haruta,R., Manabe,E., Hoshino-Okubo,A.,
            Omi,H., Yanaihara,N., Okamoto,A., Tanaka,T. and Akiyama,T.
  TITLE     The cancer stem cell marker CD133 interacts with plakoglobin and
            controls desmoglein-2 protein levels
  JOURNAL   PLoS ONE 8 (1), E53710 (2013)
   PUBMED   23326490
  REMARK    GeneRIF: CD133 interacts with plakoglobin and knockdown of CD133 by
            RNA interference (RNAi) results in the downregulation of
            desmoglein-2.
REFERENCE   5  (bases 1 to 4257)
  AUTHORS   Canis,M., Lechner,A., Mack,B., Zengel,P., Laubender,R.P.,
            Koehler,U., Heissmeyer,V. and Gires,O.
  TITLE     CD133 is a predictor of poor survival in head and neck squamous
            cell carcinomas
  JOURNAL   Cancer Biomark 12 (2), 97-105 (2012)
   PUBMED   23396254
  REMARK    GeneRIF: A gradual and inversely proportional correlation between
            CD133 expression in head and neck tumours and decreased overall
            survival was observed, along with a positive correlation with the
            presence of lymph node metastases.
REFERENCE   6  (bases 1 to 4257)
  AUTHORS   Maw,M.A., Corbeil,D., Koch,J., Hellwig,A., Wilson-Wheeler,J.C.,
            Bridges,R.J., Kumaramanickavel,G., John,S., Nancarrow,D., Roper,K.,
            Weigmann,A., Huttner,W.B. and Denton,M.J.
  TITLE     A frameshift mutation in prominin (mouse)-like 1 causes human
            retinal degeneration
  JOURNAL   Hum. Mol. Genet. 9 (1), 27-34 (2000)
   PUBMED   10587575
REFERENCE   7  (bases 1 to 4257)
  AUTHORS   Kniazeva,M., Chiang,M.F., Morgan,B., Anduze,A.L., Zack,D.J., Han,M.
            and Zhang,K.
  TITLE     A new locus for autosomal dominant stargardt-like disease maps to
            chromosome 4
  JOURNAL   Am. J. Hum. Genet. 64 (5), 1394-1399 (1999)
   PUBMED   10205271
REFERENCE   8  (bases 1 to 4257)
  AUTHORS   Horn,P.A., Tesch,H., Staib,P., Kube,D., Diehl,V. and Voliotis,D.
  TITLE     Expression of AC133, a novel hematopoietic precursor antigen, on
            acute myeloid leukemia cells
  JOURNAL   Blood 93 (4), 1435-1437 (1999)
   PUBMED   10075457
REFERENCE   9  (bases 1 to 4257)
  AUTHORS   Miraglia,S., Godfrey,W., Yin,A.H., Atkins,K., Warnke,R.,
            Holden,J.T., Bray,R.A., Waller,E.K. and Buck,D.W.
  TITLE     A novel five-transmembrane hematopoietic stem cell antigen:
            isolation, characterization, and molecular cloning
  JOURNAL   Blood 90 (12), 5013-5021 (1997)
   PUBMED   9389721
REFERENCE   10 (bases 1 to 4257)
  AUTHORS   Yin,A.H., Miraglia,S., Zanjani,E.D., Almeida-Porada,G., Ogawa,M.,
            Leary,A.G., Olweus,J., Kearney,J. and Buck,D.W.
  TITLE     AC133, a novel marker for human hematopoietic stem and progenitor
            cells
  JOURNAL   Blood 90 (12), 5002-5012 (1997)
   PUBMED   9389720
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108063.3, AF117225.1,
            BC012089.1, DB326234.1 and AA622198.1.
            
            Summary: This gene encodes a pentaspan transmembrane glycoprotein.
            The protein localizes to membrane protrusions and is often
            expressed on adult stem cells, where it is thought to function in
            maintaining stem cell properties by suppressing differentiation.
            Mutations in this gene have been shown to result in retinitis
            pigmentosa and Stargardt disease. Expression of this gene is also
            associated with several types of cancer. This gene is expressed
            from at least five alternative promoters that are expressed in a
            tissue-dependent manner. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Mar 2009].
            
            Transcript Variant: This variant (2) represents one of several
            alternative promoters and 5' UTRs, and lacks an alternative
            in-frame exon in the 5' coding region, compared to variant 1. The
            resulting isoform (2), also known as s1, lacks a 9 aa segment near
            the N-terminus, compared to isoform 1. Both variants 2 and 3 encode
            the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF117225.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025082, ERS025083 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC108063.3         56453-56691         c
            240-1277            AF117225.1         1-1038
            1278-1278           BC012089.1         994-994
            1279-3711           AF117225.1         1040-3472
            3712-4118           DB326234.1         138-544             c
            4119-4254           DB326234.1         1-136               c
            4255-4257           AA622198.1         6-8                 c
FEATURES             Location/Qualifiers
     source          1..4257
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.32"
     gene            1..4257
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /note="prominin 1"
                     /db_xref="GeneID:8842"
                     /db_xref="HGNC:9454"
                     /db_xref="MIM:604365"
     exon            1..307
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            308..739
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    469..471
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /note="upstream in-frame stop codon"
     CDS             520..3090
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; hProminin; hematopoietic stem cell antigen;
                     antigen AC133; prominin-like protein 1"
                     /codon_start=1
                     /product="prominin-1 isoform 2 precursor"
                     /protein_id="NP_001139319.1"
                     /db_xref="GI:224994189"
                     /db_xref="CCDS:CCDS54746.1"
                     /db_xref="GeneID:8842"
                     /db_xref="HGNC:9454"
                     /db_xref="MIM:604365"
                     /translation="
MALVLGSLLLLGLCGNSFSGGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKIVYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFAISLLVICIIISIGIFYGFVANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQLPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSAFSVYVNNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCGVCGYDRHATPTTRGCVSNTGGVFLMVGVGLSFLFCWILMIIVVLTFVFGANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTSSVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLNLFWFGIGKATVFLLPALIFAVKLAKYYRRMDSEDVYDDVETIPMKNMENGNNGYHKDHVYGIHNPVMTSPSQH
"
     sig_peptide     520..576
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    583..2982
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /note="Prominin; Region: Prominin; pfam05478"
                     /db_xref="CDD:203254"
     exon            740..795
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            796..1001
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            1002..1122
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            1123..1186
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            1187..1276
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            1277..1494
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     variation       1278
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2286455"
     exon            1495..1569
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            1570..1633
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            1634..1793
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            1794..1946
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            1947..2070
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2071..2174
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2175..2259
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2260..2403
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2404..2475
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2476..2568
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2569..2622
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2623..2703
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2704..2772
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2773..2865
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2866..2981
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            2982..3005
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            3006..3074
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            3075..3114
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     exon            3115..4257
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:1.39.8"
     variation       3328
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2240687"
     variation       3757
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2240688"
     STS             3978..4225
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /standard_name="WI-22012"
                     /db_xref="UniSTS:18249"
     STS             4046..4190
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /standard_name="RH121881"
                     /db_xref="UniSTS:137735"
     variation       4209
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1053767"
     polyA_signal    4233..4238
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
     polyA_site      4257
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
ORIGIN      
atgtttaaggaatcctttccattacggcggccccatacctaggtccccgtccgggacagaggaagccgcaacgggtccccccgggcacccgggcctttctcctgcctcccgccacgtccgagggtccggccgcagcgccgcctgagcccctccgcggccggcagtgggaggcgggctctccgaaagccgtcgcggtggtcccagaagccgggtcataaataattcacgagccagggtctggcgagctaagggaagggcggcggcagcggtgactagggcgggagcaggagcgggagccgggtgcacgggatggtgccttgagtgaatgacccccttggagaacattcttccgcatccctcgcctcaagccagcctcagacagaaaactgaagattcagcagatccagtgcttcctgctcctcttctgcccaggaacacgcttgccttccccaaggcttccagaagctctgaggcaggaggcaccaagttctacctcatgtttggaggatcttgctagctatggccctcgtactcggctccctgttgctgctggggctgtgcgggaactccttttcaggagggcagccttcatccacagatgctcctaaggcttggaattatgaattgcctgcaacaaattatgagacccaagactcccataaagctggacccattggcattctctttgaactagtgcatatctttctctatgtggtacagccgcgtgatttcccagaagatactttgagaaaattcttacagaaggcatatgaatccaaaattgattatgacaagattgtctactatgaagcagggattattctatgctgtgtcctggggctgctgtttattattctgatgcctctggtggggtatttcttttgtatgtgtcgttgctgtaacaaatgtggtggagaaatgcaccagcgacagaaggaaaatgggcccttcctgaggaaatgctttgcaatctccctgttggtgatttgtataataataagcattggcatcttctatggttttgtggcaaatcaccaggtaagaacccggatcaaaaggagtcggaaactggcagatagcaatttcaaggacttgcgaactctcttgaatgaaactccagagcaaatcaaatatatattggcccagtacaacactaccaaggacaaggcgttcacagatctgaacagtatcaattcagtgctaggaggcggaattcttgaccgactgagacccaacatcatccctgttcttgatgagattaagtccatggcaacagcgatcaaggagaccaaagaggcgttggagaacatgaacagcaccttgaagagcttgcaccaacaaagtacacagcttagcagcagtctgaccagcgtgaaaactagcctgcggtcatctctcaatgaccctctgtgcttggtgcatccatcaagtgaaacctgcaacagcatcagattgtctctaagccagctgaatagcaaccctgaactgaggcagcttccacccgtggatgcagaacttgacaacgttaataacgttcttaggacagatttggatggcctggtccaacagggctatcaatcccttaatgatatacctgacagagtacaacgccaaaccacgactgtcgtagcaggtatcaaaagggtcttgaattccattggttcagatatcgacaatgtaactcagcgtcttcctattcaggatatactctcagcattctctgtttatgttaataacactgaaagttacatccacagaaatttacctacattggaagagtatgattcatactggtggctgggtggcctggtcatctgctctctgctgaccctcatcgtgattttttactacctgggcttactgtgtggcgtgtgcggctatgacaggcatgccaccccgaccacccgaggctgtgtctccaacaccggaggcgtcttcctcatggttggagttggattaagtttcctcttttgctggatattgatgatcattgtggttcttacctttgtctttggtgcaaatgtggaaaaactgatctgtgaaccttacacgagcaaggaattattccgggttttggatacaccctacttactaaatgaagactgggaatactatctctctgggaagctatttaataaatcaaaaatgaagctcacttttgaacaagtttacagtgactgcaaaaaaaatagaggcacttacggcactcttcacctgcagaacagcttcaatatcagtgaacatctcaacattaatgagcatactggaagcataagcagtgaattggaaagtctgaaggtaaatcttaatatctttctgttgggtgcagcaggaagaaaaaaccttcaggattttgctgcttgtggaatagacagaatgaattatgacagctacttggctcagactggtaaatcccccgcaggagtgaatcttttatcatttgcatatgatctagaagcaaaagcaaacagtttgcccccaggaaatttgaggaactccctgaaaagagatgcacaaactattaaaacaattcaccagcaacgagtccttcctatagaacaatcactgagcactctataccaaagcgtcaagatacttcaacgcacagggaatggattgttggagagagtaactaggattctagcttctctggattttgctcagaacttcatcacaaacaatacttcctctgttattattgaggaaactaagaagtatgggagaacaataataggatattttgaacattatctgcagtggatcgagttctctatcagtgagaaagtggcatcgtgcaaacctgtggccaccgctctagatactgctgttgatgtctttctgtgtagctacattatcgaccccttgaatttgttttggtttggcataggaaaagctactgtatttttacttccggctctaatttttgcggtaaaactggctaagtactatcgtcgaatggattcggaggacgtgtacgatgatgttgaaactatacccatgaaaaatatggaaaatggtaataatggttatcataaagatcatgtatatggtattcacaatcctgttatgacaagcccatcacaacattgatagctgatgttgaaactgcttgagcatcaggatactcaaagtggaaaggatcacagatttttggtagtttctgggtctacaaggactttccaaatccaggagcaacgccagtggcaacgtagtgactcaggcgggcaccaaggcaacggcaccattggtctctgggtagtgctttaagaatgaacacaatcacgttatagtccatggtccatcactattcaaggatgactccctcccttcctgtctatttttgttttttacttttttacactgagtttctatttagacactacaacatatggggtgtttgttcccattggatgcatttctatcaaaactctatcaaatgtgatggctagattctaacatattgccatgtgtggagtgtgctgaacacacaccagtttacaggaaagatgcattttgtgtacagtaaacggtgtatataccttttgttaccacagagttttttaaacaaatgagtattataggactttcttctaaatgagctaaataagtcaccattgacttcttggtgctgttgaaaataatccattttcactaaaagtgtgtgaaacctacagcatattcttcacgcagagattttcatctattatactttatcaaagattggccatgttccacttggaaatggcatgcaaaagcaatcatagagaaacctgcgtaactccatctgacaaattcaaaagagagagagagatcttgagagagaaatgctgttcgttcaaaagtggagttgttttaacagatgccaattacggtgtacagtttaacagagttttctgttgcattaggataaacattaattggagtgcagctaacatgagtatcatcagactagtatcaagtgttctaaaatgaaatatgagaagatcctgtcacaattcttagatctggtgtccagcatggatgaaacctttgagtttggtccctaaatttgcatgaaagcacaaggtaaatattcatttgcttcaggagtttcatgttggatctgtcattatcaaaagtgatcagcaatgaagaactggtcggacaaaatttaacgttgatgtaatgaaattccagatgtaggcattccccccaggtcttttcatgtgcagattgcagttctgattcatttgaataaaaaggaacttggaaaacatg
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:8842 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:8842 -> Molecular function: GO:0042805 [actinin binding] evidence: IDA
            GeneID:8842 -> Molecular function: GO:0045296 [cadherin binding] evidence: IPI
            GeneID:8842 -> Biological process: GO:0010842 [retina layer formation] evidence: ISS
            GeneID:8842 -> Biological process: GO:0045494 [photoreceptor cell maintenance] evidence: IMP
            GeneID:8842 -> Biological process: GO:0060042 [retina morphogenesis in camera-type eye] evidence: IMP
            GeneID:8842 -> Biological process: GO:0060219 [camera-type eye photoreceptor cell differentiation] evidence: IMP
            GeneID:8842 -> Biological process: GO:0060219 [camera-type eye photoreceptor cell differentiation] evidence: ISS
            GeneID:8842 -> Biological process: GO:0072112 [glomerular visceral epithelial cell differentiation] evidence: IMP
            GeneID:8842 -> Biological process: GO:0072139 [glomerular parietal epithelial cell differentiation] evidence: IMP
            GeneID:8842 -> Biological process: GO:2000768 [positive regulation of nephron tubule epithelial cell differentiation] evidence: IMP
            GeneID:8842 -> Cellular component: GO:0001750 [photoreceptor outer segment] evidence: ISS
            GeneID:8842 -> Cellular component: GO:0005615 [extracellular space] evidence: IEA
            GeneID:8842 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:8842 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: IEA
            GeneID:8842 -> Cellular component: GO:0005903 [brush border] evidence: IEA
            GeneID:8842 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
            GeneID:8842 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IEA
            GeneID:8842 -> Cellular component: GO:0031528 [microvillus membrane] evidence: IEA
            GeneID:8842 -> Cellular component: GO:0032420 [stereocilium] evidence: IEA
            GeneID:8842 -> Cellular component: GO:0042622 [photoreceptor outer segment membrane] evidence: IDA

by @meso_cacase at DBCLS
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