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2024-04-19 22:21:47, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001145811 8957 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens SRY (sex determining region Y)-box 6 (SOX6),
transcript variant 3, mRNA.
ACCESSION NM_001145811
VERSION NM_001145811.1 GI:224967049
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8957)
AUTHORS O'Donnell,P.H., Stark,A.L., Gamazon,E.R., Wheeler,H.E.,
McIlwee,B.E., Gorsic,L., Im,H.K., Huang,R.S., Cox,N.J. and
Dolan,M.E.
TITLE Identification of novel germline polymorphisms governing
capecitabine sensitivity
JOURNAL Cancer 118 (16), 4063-4073 (2012)
PUBMED 22864933
REFERENCE 2 (bases 1 to 8957)
AUTHORS Yamashita,S., Miyaki,S., Kato,Y., Yokoyama,S., Sato,T.,
Barrionuevo,F., Akiyama,H., Scherer,G., Takada,S. and Asahara,H.
TITLE L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA
expression by strengthening dimeric Sox9 activity
JOURNAL J. Biol. Chem. 287 (26), 22206-22215 (2012)
PUBMED 22547066
REMARK GeneRIF: L-Sox5 and Sox6 proteins enhance chondrogenic miR-140
microRNA expression by strengthening dimeric Sox9 activity
REFERENCE 3 (bases 1 to 8957)
AUTHORS Estrada,K., Styrkarsdottir,U., Evangelou,E., Hsu,Y.H., Duncan,E.L.,
Ntzani,E.E., Oei,L., Albagha,O.M., Amin,N., Kemp,J.P., Koller,D.L.,
Li,G., Liu,C.T., Minster,R.L., Moayyeri,A., Vandenput,L.,
Willner,D., Xiao,S.M., Yerges-Armstrong,L.M., Zheng,H.F.,
Alonso,N., Eriksson,J., Kammerer,C.M., Kaptoge,S.K., Leo,P.J.,
Thorleifsson,G., Wilson,S.G., Wilson,J.F., Aalto,V., Alen,M.,
Aragaki,A.K., Aspelund,T., Center,J.R., Dailiana,Z., Duggan,D.J.,
Garcia,M., Garcia-Giralt,N., Giroux,S., Hallmans,G., Hocking,L.J.,
Husted,L.B., Jameson,K.A., Khusainova,R., Kim,G.S., Kooperberg,C.,
Koromila,T., Kruk,M., Laaksonen,M., Lacroix,A.Z., Lee,S.H.,
Leung,P.C., Lewis,J.R., Masi,L., Mencej-Bedrac,S., Nguyen,T.V.,
Nogues,X., Patel,M.S., Prezelj,J., Rose,L.M., Scollen,S.,
Siggeirsdottir,K., Smith,A.V., Svensson,O., Trompet,S., Trummer,O.,
van Schoor,N.M., Woo,J., Zhu,K., Balcells,S., Brandi,M.L.,
Buckley,B.M., Cheng,S., Christiansen,C., Cooper,C., Dedoussis,G.,
Ford,I., Frost,M., Goltzman,D., Gonzalez-Macias,J., Kahonen,M.,
Karlsson,M., Khusnutdinova,E., Koh,J.M., Kollia,P., Langdahl,B.L.,
Leslie,W.D., Lips,P., Ljunggren,O., Lorenc,R.S., Marc,J.,
Mellstrom,D., Obermayer-Pietsch,B., Olmos,J.M.,
Pettersson-Kymmer,U., Reid,D.M., Riancho,J.A., Ridker,P.M.,
Rousseau,F., Slagboom,P.E., Tang,N.L., Urreizti,R., Van Hul,W.,
Viikari,J., Zarrabeitia,M.T., Aulchenko,Y.S.,
Castano-Betancourt,M., Grundberg,E., Herrera,L., Ingvarsson,T.,
Johannsdottir,H., Kwan,T., Li,R., Luben,R., Medina-Gomez,C.,
Palsson,S.T., Reppe,S., Rotter,J.I., Sigurdsson,G., van Meurs,J.B.,
Verlaan,D., Williams,F.M., Wood,A.R., Zhou,Y., Gautvik,K.M.,
Pastinen,T., Raychaudhuri,S., Cauley,J.A., Chasman,D.I.,
Clark,G.R., Cummings,S.R., Danoy,P., Dennison,E.M., Eastell,R.,
Eisman,J.A., Gudnason,V., Hofman,A., Jackson,R.D., Jones,G.,
Jukema,J.W., Khaw,K.T., Lehtimaki,T., Liu,Y., Lorentzon,M.,
McCloskey,E., Mitchell,B.D., Nandakumar,K., Nicholson,G.C.,
Oostra,B.A., Peacock,M., Pols,H.A., Prince,R.L., Raitakari,O.,
Reid,I.R., Robbins,J., Sambrook,P.N., Sham,P.C., Shuldiner,A.R.,
Tylavsky,F.A., van Duijn,C.M., Wareham,N.J., Cupples,L.A.,
Econs,M.J., Evans,D.M., Harris,T.B., Kung,A.W., Psaty,B.M.,
Reeve,J., Spector,T.D., Streeten,E.A., Zillikens,M.C.,
Thorsteinsdottir,U., Ohlsson,C., Karasik,D., Richards,J.B.,
Brown,M.A., Stefansson,K., Uitterlinden,A.G., Ralston,S.H.,
Ioannidis,J.P., Kiel,D.P. and Rivadeneira,F.
TITLE Genome-wide meta-analysis identifies 56 bone mineral density loci
and reveals 14 loci associated with risk of fracture
JOURNAL Nat. Genet. 44 (5), 491-501 (2012)
PUBMED 22504420
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 8957)
AUTHORS Yang,T.L., Guo,Y., Liu,Y.J., Shen,H., Liu,Y.Z., Lei,S.F., Li,J.,
Tian,Q. and Deng,H.W.
TITLE Genetic variants in the SOX6 gene are associated with bone mineral
density in both Caucasian and Chinese populations
JOURNAL Osteoporos Int 23 (2), 781-787 (2012)
PUBMED 21625884
REMARK GeneRIF: Genetic variants in the SOX6 gene are associated with bone
mineral density in both Caucasian and Chinese populations
REFERENCE 5 (bases 1 to 8957)
AUTHORS Lee,J.S. and Im,G.I.
TITLE SOX trio decrease in the articular cartilage with the advancement
of osteoarthritis
JOURNAL Connect. Tissue Res. 52 (6), 496-502 (2011)
PUBMED 21728837
REMARK GeneRIF: SOX trio gene and protein decreased with advancement of
osteoarthritis in human articular cartilage.
REFERENCE 6 (bases 1 to 8957)
AUTHORS Ueda,R., Iizuka,Y., Yoshida,K., Kawase,T., Kawakami,Y. and Toda,M.
TITLE Identification of a human glioma antigen, SOX6, recognized by
patients' sera
JOURNAL Oncogene 23 (7), 1420-1427 (2004)
PUBMED 14691456
REFERENCE 7 (bases 1 to 8957)
AUTHORS Cohen-Barak,O., Hagiwara,N., Arlt,M.F., Horton,J.P. and
Brilliant,M.H.
TITLE Cloning, characterization and chromosome mapping of the human SOX6
gene
JOURNAL Gene 265 (1-2), 157-164 (2001)
PUBMED 11255018
REFERENCE 8 (bases 1 to 8957)
AUTHORS Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
Wiemann,S.
TITLE Systematic subcellular localization of novel proteins identified by
large-scale cDNA sequencing
JOURNAL EMBO Rep. 1 (3), 287-292 (2000)
PUBMED 11256614
REFERENCE 9 (bases 1 to 8957)
AUTHORS Hagiwara,N., Klewer,S.E., Samson,R.A., Erickson,D.T., Lyon,M.F. and
Brilliant,M.H.
TITLE Sox6 is a candidate gene for p100H myopathy, heart block, and
sudden neonatal death
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (8), 4180-4185 (2000)
PUBMED 10760285
REFERENCE 10 (bases 1 to 8957)
AUTHORS Denny,P., Swift,S., Brand,N., Dabhade,N., Barton,P. and Ashworth,A.
TITLE A conserved family of genes related to the testis determining gene,
SRY
JOURNAL Nucleic Acids Res. 20 (11), 2887 (1992)
PUBMED 1614875
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC027016.4, BC037866.1,
AC103794.2 and AC009869.7.
Summary: This gene encodes a member of the D subfamily of sex
determining region y-related transcription factors that are
characterized by a conserved DNA-binding domain termed the high
mobility group box and by their ability to bind the minor groove of
DNA. The encoded protein is a transcriptional activator that is
required for normal development of the central nervous system,
chondrogenesis and maintenance of cardiac and skeletal muscle
cells. The encoded protein interacts with other family members to
cooperatively activate gene expression. Alternative splicing
results in multiple transcript variants.[provided by RefSeq, Mar
2009].
Transcript Variant: This variant (3) has multiple differences in
the coding region, compared to variant 1. The encoded isoform (3)
is shorter than isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC037866.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-4 AC027016.4 108938-108941 c
5-1024 BC037866.1 7-1026
1025-1025 AC103794.2 130924-130924 c
1026-1623 BC037866.1 1028-1625
1624-1624 AC103794.2 65680-65680 c
1625-2704 BC037866.1 1626-2705
2705-8957 AC009869.7 10403-16655
FEATURES Location/Qualifiers
source 1..8957
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11p15.3"
gene 1..8957
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/note="SRY (sex determining region Y)-box 6"
/db_xref="GeneID:55553"
/db_xref="HGNC:16421"
/db_xref="MIM:607257"
exon 1..187
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/inference="alignment:Splign:1.39.8"
misc_feature 69..71
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/note="upstream in-frame stop codon"
exon 188..428
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/inference="alignment:Splign:1.39.8"
CDS 192..2597
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/note="isoform 3 is encoded by transcript variant 3;
SRY-box containing gene 6; transcription factor SOX-6"
/codon_start=1
/product="transcription factor SOX-6 isoform 3"
/protein_id="NP_001139283.1"
/db_xref="GI:224967050"
/db_xref="CCDS:CCDS53604.1"
/db_xref="GeneID:55553"
/db_xref="HGNC:16421"
/db_xref="MIM:607257"
/translation="
MSSKQATSPFACAADGEDAMTQDLTSREKEEGSDQHVASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSRDREIMTSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQQLYAAQLASMQVSPGAKMPSTPQPPNTAGTVSPTGIKNEKRGTSPVTQVKDEAAAQPLNLSSRPKTAEPVKSPTSPTQNLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLGKWKSQHQEETYELDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQQPHGVDGKLSSINNMGLNSCRNEKERTRFENLGPQLTGKSNEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKTDGGSLAGNEMINGEDEMEMYDDYEDDPKSDYSSENEAPEAVSAN
"
misc_feature 1968..2159
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/note="SOX-TCF_HMG-box, class I member of the HMG-box
superfamily of DNA-binding proteins. These proteins
contain a single HMG box, and bind the minor groove of DNA
in a highly sequence-specific manner. Members include SRY
and its homologs in insects and...; Region:
SOX-TCF_HMG-box; cd01388"
/db_xref="CDD:28966"
misc_feature order(1977..1979,1983..1988,1992..1997,2004..2009,
2016..2018,2028..2030,2052..2054,2067..2069,2076..2078,
2085..2087,2142..2144)
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:28966"
exon 429..636
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/inference="alignment:Splign:1.39.8"
exon 637..726
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/inference="alignment:Splign:1.39.8"
exon 727..899
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/inference="alignment:Splign:1.39.8"
exon 900..968
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/inference="alignment:Splign:1.39.8"
exon 969..1089
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/inference="alignment:Splign:1.39.8"
exon 1090..1169
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/inference="alignment:Splign:1.39.8"
exon 1170..1319
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/inference="alignment:Splign:1.39.8"
variation 1203
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/replace="a"
/replace="g"
/db_xref="dbSNP:36071533"
exon 1320..1545
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/inference="alignment:Splign:1.39.8"
exon 1546..1733
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/inference="alignment:Splign:1.39.8"
exon 1734..1842
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/inference="alignment:Splign:1.39.8"
exon 1843..2076
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/inference="alignment:Splign:1.39.8"
exon 2077..2293
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/inference="alignment:Splign:1.39.8"
variation 2105
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/replace="a"
/replace="g"
/db_xref="dbSNP:34438327"
exon 2294..8957
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/inference="alignment:Splign:1.39.8"
variation 2492
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/replace="c"
/replace="g"
/db_xref="dbSNP:34449532"
STS 2580..2742
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/standard_name="Sox6"
/db_xref="UniSTS:144491"
polyA_signal 2660..2665
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
polyA_site 2696
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
STS 2921..3733
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/standard_name="SOX6_844"
/db_xref="UniSTS:277764"
STS 3632..3715
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/standard_name="RH94315"
/db_xref="UniSTS:85843"
STS 6172..6305
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/standard_name="WI-17844"
/db_xref="UniSTS:52420"
variation 7602
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/replace="c"
/replace="t"
/db_xref="dbSNP:1065024"
variation 7793
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/replace="c"
/replace="t"
/db_xref="dbSNP:1065025"
STS 8026..8155
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
/standard_name="RH65285"
/db_xref="UniSTS:46963"
polyA_signal 8933..8938
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
polyA_site 8957
/gene="SOX6"
/gene_synonym="HSSOX6; SOXD"
ORIGIN
ccttggggttagttttagtcatatttttatctctataaaacatcaggctgggaggtggtgtgtgcctgtagtctcaactgctagggagcctgaggcaggaagactccttgagcacaggagttcaaggccagcctgtgcaacatagtgagaccctatcactctggaaaaaaaaaaaaaatctgcggagaagaatgtcttccaagcaagccacctctccatttgcctgtgcagctgatggagaggatgcaatgacccaggatttaacctcaagggaaaaggaagagggcagtgatcaacatgtggcctcccatctgcctctgcaccccataatgcacaacaaacctcactctgaggagctaccaacacttgtcagtaccattcaacaagatgctgactgggacagcgttctgtcatctcagcaaagaatggaatcagagaataataagttatgttccctatattccttccgaaatacctctacctcaccacataagcctgacgaagggagtcgggaccgtgagataatgaccagtgttacttttggaaccccagagcgccgcaaagggagtcttgccgatgtggtggacacactgaaacagaagaagcttgaggaaatgactcggactgaacaagaggattcctcctgcatggaaaaactactttcaaaagattggaaggaaaaaatggaaagactaaataccagtgaacttcttggagaaattaaaggtacacctgagagcctggcagaaaaagaacggcagctctccaccatgattacccagctgatcagtttacgggagcagctactggcagcgcatgatgaacagaaaaaactggcagcgtcacaaattgagaaacaacggcagcaaatggaccttgctcgccaacagcaagaacagattgcgagacaacagcagcaacttctgcaacagcagcacaaaattaatctcctgcagcaacagatccaggttcagggtcacatgcctccgctcatgatcccaatttttccacatgaccagcggactctggcagcagctgctgctgcccaacagggattcctcttcccccctggaataacatacaaaccaggtgataactaccccgtacagttcattccatcaacaatggcagctgctgctgcttctggactcagccctttacagctccagcagctctatgccgctcagctggccagcatgcaggtgtcacctggagcaaagatgccatcaactccacagccaccaaacacagcagggacggtctcacctactgggataaaaaatgaaaagagagggaccagccctgtaactcaagttaaggatgaagcagcagcacagcctctgaatctctcatcccgacccaagacagcagagcctgtaaagtccccaacgtctcccacccagaacctcttcccagccagcaaaaccagccctgtcaatctgccaaacaaaagcagcatccctagccccattggaggaagcctgggaagaggatcctctttaggtaaatggaaaagtcaacaccaggaagagacttacgaattagatatcctatctagtctcaactcccctgccctttttggggatcaggatacagtgatgaaagccattcaggaggcgcggaagatgcgagagcagatccagcgggagcaacagcagcaacagccacatggtgttgacgggaaactgtcctccataaataatatggggctgaacagctgcaggaatgaaaaggaaagaacgcgctttgagaatttggggccccagttaacgggaaagtcaaatgaagatggaaaactgggcccaggtgtcatcgaccttactcggccagaagatgcagagggaagtaaagcaatgaatggctctgcagctaaactacagcagtattattgttggccaacaggaggtgccactgtggctgaagcacgagtctacagggacgcccgcggccgtgccagcagcgagccacacattaagcgaccaatgaatgcattcatggtttgggcaaaggatgagaggagaaaaatccttcaggccttccccgacatgcataactccaacattagcaaaatcttaggatctcgctggaaatcaatgtccaaccaggagaagcaaccttattatgaagagcaggcccggctaagcaagatccacttagagaagtacccaaactataaatacaaaccccgaccgaaacgcacctgcattgttgatggcaaaaagcttcggattggggagtataagcaactgatgaggtctcggagacaggagatgaggcagttctttactgtggggcaacagcctcagattccaatcaccacaggaacaggtgttgtgtatcctggtgctatcactatggcaactaccacaccatcgcctcagatgacatctgactgctctagcacctcggccagcccggagcccagcctcccggtcatccagagcacttatggtatgaagacagatggcggaagcctagctggaaatgaaatgatcaatggagaggatgaaatggaaatgtatgatgactatgaagatgaccccaaatcagactatagcagtgaaaatgaagccccggaggctgtcagtgccaactgaggagtttttgtttgctgaattaaagtactctgacatttcacccccctccccaacaaagagttattaaagagcccgcatgcatttgtggctccacaattacatcagcagaatggtcttaattgtttcgtaaagtgtgagacagattaagttttccctgatttttcatgaacttgagttttttgttgttattgttattgttgttgttgttgtttttttaatttaggtgaagacatattaaatatgagacaccaggacttgaaacttatctcaacccgtagatgtcttacaagtcttatatttttgtcttactttttttttcttttggatgttgataaaggtttaagttactgttttagatggggttaaacattctcactcaggtatgctgtgccggcctacaggttgtgaatgtgtttttattctgaattattttagaaaacaactgaggatttcatattgtgaaacagaacaagtccacggcgtgtgcagctgcatgtagagcatattcaaaaggcctcggaattccaattttccatttgtagagttaaactttgaatgtgccaaactttttcgtaacttttgaatcttaatattttgaaagtcttaaaggagacactgcaaagtcttagacaatctttggcatcttaaaataaaatagcaaaccaacatttttttttccagaaaatggtaaggtactcaggaatctggagacaagatattgtaaggaatgaacaaggttgccacagtgcatggacccaattgtgtttgcctgttgacgtgccatcagtgcgtgatgtggtatgacatacacacaccagagcaaccgccacaccagatatcgacagagtggtcttctctgcctgagaccacctctcactacatccattatccctttgcctttaaccctgacattcagtcttaacacattttatcttaaataatttattcattccagaatgtcaagggtccacttgctatttattttttttcaattgttggtggcattaatttaataattcttgtttttcaccttccttccccgaagaacttttccgtccttttcacctccttctcctgtgtacatagtgattttatgtccccagaacgcctggaagcatttctgaaaccaagatattattaaaaacctattattgtttttaatcatgagtatgtatctggctgcagggctgtgtattgggatataggtatatagtcttacacttaaacaggtatgcccctgaggttcactgtgacctcaagtcttttgccagaattttcccctaattcagttcacaagtggtagggtctgcatcagtggcatttccccctgaattccattcagcagcaaggttcaacagtggtgactgccaggcaggagagtcctgcggccaaacctgaagcccaaggctcgtgggccatgcaggaatctcagtgaagctgtcatgggctggcacctttacactgagttgccttgtcccagctggcacatctagggagttcattgcaaaatccccaggatgcaaaaagccacatgacagcctcagagcaaagatggtggcaaatagtcatgatacatctagagaatgaaagaaaactgtaagggaggagaaggaggggaatacattccctatatgggatgttcctactgttaactctggggaacagatagctccgggggcagcagatgagttcctctggctgactctatctgtagccacatggggacctgcctacgtgtgaacaaaatgaactgcacttatcacacaaggatttctttgaagacatgctactggggtgggaagcagtgaggttttattccccatctcctaactacagggagctctgccatgtcattttggccttcctgaaactaggacaggttgtctatcggggggcttcccccagagaggtttagtgggagaatgtcagtgaatgggatagttcacctcatgggacaacccagaatctgatcaccaggacataggaatggccccatcagatttcttgagccattttgtcacttggaagaaaatagtgtacctttgtatttatttaagagtgctcaaggcctaatagcaataaacaggtctagccaagaaattacaagctattctgttagctgggagtgctctctataagctgattaaggtactgataggaactctttgttattcatgttggttggggattagaaatttgtttttgtacatttatttcaaatgaggaggaggtcattttttctctcaaaaaatgagtatttattattgtcttactgatttctttgattatatacctctcctcctcagttcactcttgttttttttctttctctttggcttttgcttttgctctctctcacttctttcttattttgttgcattggtagagtgttgtatggctagcattgtattgtatgtaattaattttgcacaaaagcaaacatttagcatagtaggttaattttgtttgtttttatgaccatgccaaaataatattctgggctggtggagaacaaaggactgttctttaggactgaaacttgattttgctcatagtaagtaaaaaaaaacaaaaaacacacacactcacagatgttgtttcgtaagtgttataagcactggatataaatggtattttttatcacttctgactaatgtgaaactgttgtacgaaaactacatgaacaaaagtcatctgtttcgactcgtgtgggcttgcctcacagttgccggatttgagtcatttttatgtcttgttatttcatttatttatgcaaaatacatgtgtgtatgaacactttgttttagctccagctctgcctcagtactggggttcatttacttttagccatgttcttaaaaatgaaaggctattcaggaatgatctgattgtaaacgtctttttcattggatcaaacagtaatgctgtatttgaatctaaattttgtgtataagcagtttatttattagccaagtttggctctaaatatccatggaaattaagaatgacaatcatagggatcaattcattttattttcagtggggcttaaacaaagtttatatgactttaccatctcattttagatttttctaattgtgtaaatataacatagaaatagaatttatttttggttcatgaatacttagtgagatataagttatgtatttcctttttgttctctatccatagatgttggtccaaactgaaagttgatgagtcactgtgcctctcggggtagtgagttatcagctacagtgagagagcagtgtttggcctgcagctgggacagcaaaacgtttcaccagggttctcatgcagttcagaacccactgtccacagatccagacatttcccttttttcttacagaaagttgatgattggacatactaaatttccactacagttaggagacagtcagtttgctttgggagtctacataaatcttctaagatagttctgtgaccatttaatagcaagaagcatgaatgccactacaaaggcaaaaatccacctctgagatcggccgttaataaacgtcccgtcatgtcagtttagattcaagaatgttaagcaactttgtttttgcggtgctccctatttcatagtatcttcaaatcaaaaataaaaattatctccattttgttaaagaacttacagggtcagggttctccttgtcacttagaattgggacactgccaggcaatcctctcccaaaaaaaaaaaaaaaaaaaaatagccatatggaatggaaggaaaaggagaaaagaaggaagaaaggaaaaaagtaggaagggagagagaaaaaaaaggtcgctttgcggatacgagccgctaggctgacaacttttctatttcattggcagatatgaagcagtgtcttttccagtaaggtacggaagctttgttgttttcatgtgtacccagctcagccttttagaagcacctcggtttgcttcattaggtatttgatactctccagccttgtcctcaggcctgatttgatttgccagggtcctgacaccaaagcccaggccaagttctaaattcaggtgtgggctcacagtgctattgagcttgtcgaattctggcctcccctgaacattagccccacgggagcctgagggtgtttgaaaagggcgtgatcactctagggctgaaattaaaggctgctttcttttccttctgaagccaggctgcttcttcggagtacaccctcctgagccaggagcacaagcactagcagaaagcagggattgtttcaggaaagcccatttaccctcagtaggaaggcagcctggtcacttgaacagcacagctgaggctgcttctctcaatttactcattttgcaaagaattgacctctaccaactcattagggagaggaaaaagaatcacttagtaattttaaatcatatgagaagtcctgtaccaagtgccaacaactgcaaagaaatgcagctagaggaatgtattgaaattactactgggtcttcctttttaatgagaaaatgacaaaaatggttgctgtagccctgcctgattttgtacacgtttgtctaagaattgagttggcacttaagctcacttctcaaagtataataatattgtatgacctcatttgtcctttcacaaaagcacttgcatcatttccttaagtcatctgctccctgacatgttttcttccctaataaacaacttctgtctgttattcctgccaatgatgttctgtttctgatgccatatcctattgagcgtgcccctgtactaatatcattgaaaatattgatatgcaaacacatttccttttcatccccattctatctttccctttggggacagattgctttccaaaagctcatgaacaaatatttggaatgctggtacctttggggcagaggtaagggtgggcggggtgggggcagaaaggtaatgcttaatgcagataactcttctaatcagtgtccatggcaatatgaacgcttgaagaaaactcagtgacatatcttgctcagtagtttcttattcctgaagaaccacaagcataaagtgaggcctcagtgctggtgctcttggagtatggggaatgtgcaaatatttaactgttttgtatgctgcacattgcaggtctgctcatgtgcattctccctttgtcttcctttgtcatatgtgtttttgcttttttgaaagtgcagtctttattgtaccctcctccagcttgtagcaaattagaatgcttagcatttatgttcattcattattgtatttgccatgtaaaatttttattaccttagacaagcttataagctgttactacataacttatcttactgtaactcttttatttcccccgacgttgtaatttgtttgtgatgtatattgtgaaattgtattctatgttaatttaatcagcacaattcactgacatgctggactgacatgctggctgctgtttcaaagtgtaaagtttgtgtagggctgttgggacaactgcaactctgttgtcaaggtactgtgctttggttcctatagcaacactgggtgtggcccttgaattgctaagggcatttaatacatcctggagcaaattttaactgcagattttctttgtagaaattctatgtataatgcaggtacctacttggcccatggctggtaactatttgggcaattagaaaaaaagaaaaaaacataaaaactagtgtctattgctgctttgaatatgtttgaaagtctgaaaatgtaaatagtttatcaaaaaaaaatcttgtacagtccagtgtaaagtttttaaatgaccttaagggttgccatcacatctttctcacactctcctcttgataataataataataaaaagtttgctaaggattaaagaaatgggaaaaataaaaaaaatctcttcaaatttacaggaatgaatcattgttcttagctttgttgcatacacaaacttcttggattttgttgtgcagtattgacgtgagataaagctcaacattgaataatctttcagtggtacttttcaaagtcttcccctcctctgcctcataattaagggaaaagacaaaattgaaagacacactgtctttatctatcctggtgtatgttggcaccttagctactttttttttttcctttttgcacaaggtgctttcctgatatgttcaacatgccatctttgggtgataatgtatatgccgtgatggggctcaggccccttaggggagtgtctataagaactgcctatttatgctcatttacctcaagactgtcctctctaccctaatctagttgtcatcactccatcttttgtactgctgttgacacttacaaattaaagataaattttgttttatga
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:55553 -> Molecular function: GO:0003677 [DNA binding] evidence: NAS
GeneID:55553 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: NAS
GeneID:55553 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:55553 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
GeneID:55553 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: IEA
GeneID:55553 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA
GeneID:55553 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:55553 -> Biological process: GO:0000902 [cell morphogenesis] evidence: IEA
GeneID:55553 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
GeneID:55553 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:55553 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: NAS
GeneID:55553 -> Biological process: GO:0007517 [muscle organ development] evidence: NAS
GeneID:55553 -> Biological process: GO:0009791 [post-embryonic development] evidence: IEA
GeneID:55553 -> Biological process: GO:0016458 [gene silencing] evidence: IEA
GeneID:55553 -> Biological process: GO:0021778 [oligodendrocyte cell fate specification] evidence: IEA
GeneID:55553 -> Biological process: GO:0032332 [positive regulation of chondrocyte differentiation] evidence: IDA
GeneID:55553 -> Biological process: GO:0035051 [cardiocyte differentiation] evidence: IEA
GeneID:55553 -> Biological process: GO:0042692 [muscle cell differentiation] evidence: IEA
GeneID:55553 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:55553 -> Biological process: GO:0048821 [erythrocyte development] evidence: IEA
GeneID:55553 -> Biological process: GO:0051216 [cartilage development] evidence: IEA
GeneID:55553 -> Biological process: GO:0061036 [positive regulation of cartilage development] evidence: IDA
GeneID:55553 -> Biological process: GO:0071560 [cellular response to transforming growth factor beta stimulus] evidence: IDA
GeneID:55553 -> Biological process: GO:2000741 [positive regulation of mesenchymal stem cell differentiation] evidence: IDA
GeneID:55553 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:55553 -> Cellular component: GO:0005634 [nucleus] evidence: NAS
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