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2020-10-24 06:31:07, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001145418           11795 bp    mRNA    linear   PRI 12-MAY-2013
DEFINITION  Homo sapiens tetratricopeptide repeat domain 28 (TTC28), mRNA.
ACCESSION   NM_001145418 XM_929318
VERSION     NM_001145418.1  GI:224028288
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11795)
  AUTHORS   Izumiyama,T., Minoshima,S., Yoshida,T. and Shimizu,N.
  TITLE     A novel big protein TPRBK possessing 25 units of TPR motif is
            essential for the progress of mitosis and cytokinesis
  JOURNAL   Gene 511 (2), 202-217 (2012)
   PUBMED   23036704
  REMARK    GeneRIF: observations indicated that a novel big protein TPRBK is
            essential for the formation and integrity of the midbody, hence we
            postulated that TPRBK plays a critical role in the progress of
            mitosis and cytokinesis during mammalian cell cycle
REFERENCE   2  (bases 1 to 11795)
  AUTHORS   Wang,K., Li,W.D., Zhang,C.K., Wang,Z., Glessner,J.T., Grant,S.F.,
            Zhao,H., Hakonarson,H. and Price,R.A.
  TITLE     A genome-wide association study on obesity and obesity-related
            traits
  JOURNAL   PLoS ONE 6 (4), E18939 (2011)
   PUBMED   21552555
  REMARK    Erratum:[PLoS One. 2012;7(2). doi:
            10.1371/annotation/a34ee94e-3e6a-48bd-a19e-398a4bb88580]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11795)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121825.19, AL023281.1, AL035397.4, AL050313.6, AL035453.4 and
            AL033538.1.
            On Feb 25, 2009 this sequence version replaced gi:169215555.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB665284.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               AL121825.19        88018-88261         c
            245-523             AL121825.19        37948-38226         c
            524-671             AL023281.1         96000-96147         c
            672-944             AL023281.1         87084-87356         c
            945-1075            AL023281.1         85702-85832         c
            1076-1583           AL035397.4         30093-30600         c
            1584-2626           AL050313.6         101-1143            c
            2627-2925           AL035453.4         31606-31904         c
            2926-3449           AL035453.4         29823-30346         c
            3450-3559           AL035453.4         25715-25824         c
            3560-3689           AL035453.4         23459-23588         c
            3690-3908           AL035453.4         20734-20952         c
            3909-4074           AL035453.4         18624-18789         c
            4075-4215           AL033538.1         69270-69410         c
            4216-4360           AL033538.1         53292-53436         c
            4361-4540           AL033538.1         40418-40597         c
            4541-5261           AL033538.1         37584-38304         c
            5262-5386           AL033538.1         35179-35303         c
            5387-5618           AL033538.1         32331-32562         c
            5619-5695           AL033538.1         31631-31707         c
            5696-5719           AL033538.1         29833-29856         c
            5720-5849           AL033538.1         28922-29051         c
            5850-5957           AL033538.1         24293-24400         c
            5958-11795          AL033538.1         17058-22895         c
FEATURES             Location/Qualifiers
     source          1..11795
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.1"
     gene            1..11795
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="tetratricopeptide repeat domain 28"
                     /db_xref="GeneID:23331"
                     /db_xref="HGNC:29179"
                     /db_xref="MIM:615098"
     exon            1..244
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    92..94
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="upstream in-frame stop codon"
     CDS             143..7588
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="TPR repeat protein 28; TPR-containing big gene
                     cloned at Keio; TPR repeat-containing big gene cloned at
                     Keio"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 28"
                     /protein_id="NP_001138890.1"
                     /db_xref="GI:224028289"
                     /db_xref="CCDS:CCDS46678.1"
                     /db_xref="GeneID:23331"
                     /db_xref="HGNC:29179"
                     /db_xref="MIM:615098"
                     /translation="
MEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHDEALAVAERGRTRAFADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSLAAGYLYSWLLAPGAGIVKFHEHYLGENTVENSSDFQASSSVTLPTATGSALEQHIASVREALGVESHYSRACASSETESEAGDIMDQQFEEMNNKLNSVTDPTGFLRMVRRNNLFNRSCQSMTSLFSNTVSPTQDGTSSLPRRQSSFAKPPLRALYDLLIAPMEGGLMHSSGPVGRHRQLILVLEGELYLIPFALLKGSSSNEYLYERFGLLAVPSIRSLSVQSKSHLRKNPPTYSSSTSMAAVIGNPKLPSAVMDRWLWGPMPSAEEEAYMVSELLGCQPLVGSVATKERVMSALTQAECVHFATHISWKLSALVLTPSMDGNPASSKSSFGHPYTIPESLRVQDDASDGESISDCPPLQELLLTAADVLDLQLPVKLVVLGSSQESNSKVTADGVIALTRAFLAAGAQCVLVSLWPVPVAASKMFIHAFYSSLLNGLKASAALGEAMKVVQSSKAFSHPSNWAGFMLIGSDVKLNSPSSLIGQALTEILQHPERARDALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENKVGGIPGWQALLTAVGFRLDPPTSGLPAAVFFPTSDPGDRLQQCSSTLQSLLGLPNPALQALCKLITASETGEQLISRAVKNMVGMLHQVLVQLQAGEKEQDLASAPIQVSISVQLWRLPGCHEFLAALGFDLCEVGQEEVILKTGKQANRRTVHFALQSLLSLFDSTELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPTGADSIASDAISVYSLSSIASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSKGSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQELAQKILEETQSHLIAVERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVLSHQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQLDQPLFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAPDIDKLKMAAIDEKVQAVHNLKMFWQSTPQHSTGPMKIFRGAPGTMTSKRDVLSLLNLSPRHNKKEEGVDKLELKELSLQQHDGAPPKAPPNGHWRTETTSLGSLPLPAGPPATAPARPLRLPSGNGYKFLSPGRFFPSSKC
"
     misc_feature    224..226
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q96AY4.4); phosphorylation site"
     misc_feature    314..415
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 1"
     misc_feature    356..568
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat domain; typically contains
                     34 amino acids
                     [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-
                     X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in
                     a variety of organisms including bacteria, cyanobacteria,
                     yeast, fungi; Region: TPR; cd00189"
                     /db_xref="CDD:238112"
     misc_feature    order(371..373,383..385,392..394,437..439,473..475,
                     485..487,494..496,539..541)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="TPR motif; other site"
                     /db_xref="CDD:238112"
     misc_feature    419..517
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 2"
     misc_feature    order(428..433,437..442,449..454,530..535,542..547,
                     554..559)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="binding surface"
                     /db_xref="CDD:238112"
     misc_feature    518..619
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 3"
     misc_feature    728..829
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 4"
     misc_feature    842..943
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 5"
     misc_feature    845..1039
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:205602"
     misc_feature    962..1063
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 6"
     misc_feature    965..1165
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:205602"
     misc_feature    977..1300
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat domain; typically contains
                     34 amino acids
                     [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-
                     X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in
                     a variety of organisms including bacteria, cyanobacteria,
                     yeast, fungi; Region: TPR; cd00189"
                     /db_xref="CDD:238112"
     misc_feature    order(977..979,986..991,1094..1099,1103..1108,1115..1120,
                     1214..1219,1226..1231,1238..1243)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="binding surface"
                     /db_xref="CDD:238112"
     misc_feature    order(983..985,1019..1021,1031..1033,1052..1054,
                     1103..1105,1139..1141,1151..1153,1160..1162,1223..1225,
                     1259..1261,1271..1273,1280..1282)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="TPR motif; other site"
                     /db_xref="CDD:238112"
     misc_feature    1082..1183
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 7"
     misc_feature    1163..2119
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="FOG: TPR repeat [General function prediction only];
                     Region: NrfG; COG0457"
                     /db_xref="CDD:223533"
     misc_feature    1202..1303
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 8"
     misc_feature    1208..1525
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat domain; typically contains
                     34 amino acids
                     [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-
                     X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in
                     a variety of organisms including bacteria, cyanobacteria,
                     yeast, fungi; Region: TPR; cd00189"
                     /db_xref="CDD:238112"
     misc_feature    order(1208..1210,1214..1219,1226..1231,1334..1339,
                     1343..1348,1355..1360,1454..1459,1466..1471,1478..1483)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="binding surface"
                     /db_xref="CDD:238112"
     misc_feature    order(1223..1225,1259..1261,1271..1273,1280..1282,
                     1343..1345,1379..1381,1424..1426,1433..1435,1463..1465,
                     1499..1501,1511..1513,1520..1522)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="TPR motif; other site"
                     /db_xref="CDD:238112"
     misc_feature    1322..1423
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 9"
     misc_feature    1442..1543
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 10"
     misc_feature    1448..1759
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat domain; typically contains
                     34 amino acids
                     [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-
                     X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in
                     a variety of organisms including bacteria, cyanobacteria,
                     yeast, fungi; Region: TPR; cd00189"
                     /db_xref="CDD:238112"
     misc_feature    order(1448..1450,1454..1459,1466..1471,1574..1579,
                     1583..1588,1595..1600,1673..1678,1685..1690,1697..1702)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="binding surface"
                     /db_xref="CDD:238112"
     misc_feature    order(1463..1465,1499..1501,1511..1513,1532..1534,
                     1583..1585,1619..1621,1631..1633,1640..1642,1682..1684,
                     1718..1720,1730..1732,1739..1741)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="TPR motif; other site"
                     /db_xref="CDD:238112"
     misc_feature    1562..1663
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 11"
     misc_feature    1682..1783
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 12"
     misc_feature    1688..2020
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat domain; typically contains
                     34 amino acids
                     [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-
                     X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in
                     a variety of organisms including bacteria, cyanobacteria,
                     yeast, fungi; Region: TPR; cd00189"
                     /db_xref="CDD:238112"
     misc_feature    order(1688..1690,1694..1699,1706..1711,1814..1819,
                     1823..1828,1835..1840,1934..1939,1946..1951,1958..1963)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="binding surface"
                     /db_xref="CDD:238112"
     misc_feature    order(1703..1705,1739..1741,1751..1753,1760..1762,
                     1823..1825,1859..1861,1871..1873,1880..1882,1943..1945,
                     1979..1981,1991..1993,2000..2002)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="TPR motif; other site"
                     /db_xref="CDD:238112"
     misc_feature    1802..1903
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 13"
     misc_feature    1922..2023
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 14"
     misc_feature    1928..2230
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat domain; typically contains
                     34 amino acids
                     [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-
                     X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in
                     a variety of organisms including bacteria, cyanobacteria,
                     yeast, fungi; Region: TPR; cd00189"
                     /db_xref="CDD:238112"
     misc_feature    order(1928..1930,1934..1939,1946..1951,2054..2059,
                     2063..2068,2075..2080,2174..2179,2186..2191,2198..2203)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="binding surface"
                     /db_xref="CDD:238112"
     misc_feature    order(1943..1945,1979..1981,1991..1993,2000..2002,
                     2063..2065,2099..2101,2111..2113,2120..2122,2183..2185,
                     2219..2221)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="TPR motif; other site"
                     /db_xref="CDD:238112"
     misc_feature    2042..2143
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 15"
     misc_feature    2054..2230
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="TPR repeat; Region: TPR_11; pfam13414"
                     /db_xref="CDD:222112"
     misc_feature    2162..2263
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 16"
     misc_feature    2282..2383
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 17"
     misc_feature    2285..2500
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:205602"
     misc_feature    2288..2611
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat domain; typically contains
                     34 amino acids
                     [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-
                     X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in
                     a variety of organisms including bacteria, cyanobacteria,
                     yeast, fungi; Region: TPR; cd00189"
                     /db_xref="CDD:238112"
     misc_feature    order(2288..2290,2294..2299,2306..2311,2414..2419,
                     2423..2428,2435..2440,2534..2539,2546..2551,2558..2563)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="binding surface"
                     /db_xref="CDD:238112"
     misc_feature    order(2303..2305,2339..2341,2351..2353,2360..2362,
                     2423..2425,2459..2461,2492..2494,2501..2503,2543..2545,
                     2579..2581,2591..2593,2600..2602)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="TPR motif; other site"
                     /db_xref="CDD:238112"
     misc_feature    2402..2620
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:205602"
     misc_feature    2402..2503
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 18"
     misc_feature    2522..2623
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 19"
     misc_feature    2540..2860
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat domain; typically contains
                     34 amino acids
                     [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-
                     X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in
                     a variety of organisms including bacteria, cyanobacteria,
                     yeast, fungi; Region: TPR; cd00189"
                     /db_xref="CDD:238112"
     misc_feature    order(2543..2545,2579..2581,2591..2593,2600..2602,
                     2663..2665,2699..2701,2711..2713,2720..2722,2792..2794,
                     2828..2830,2840..2842,2849..2851)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="TPR motif; other site"
                     /db_xref="CDD:238112"
     misc_feature    order(2546..2551,2654..2659,2663..2668,2675..2680,
                     2783..2788,2795..2800,2807..2812)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="binding surface"
                     /db_xref="CDD:238112"
     misc_feature    2642..2869
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:205602"
     misc_feature    2642..2743
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 20"
     misc_feature    2771..2872
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 21"
     misc_feature    2882..3109
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:205602"
     misc_feature    2891..2992
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 22"
     misc_feature    2894..3229
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat domain; typically contains
                     34 amino acids
                     [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-
                     X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in
                     a variety of organisms including bacteria, cyanobacteria,
                     yeast, fungi; Region: TPR; cd00189"
                     /db_xref="CDD:238112"
     misc_feature    order(2894..2899,2903..2908,2915..2920,3023..3028,
                     3032..3037,3044..3049,3143..3148,3155..3160,3167..3172)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="binding surface"
                     /db_xref="CDD:238112"
     misc_feature    order(2912..2914,2948..2950,2960..2962,2981..2983,
                     3032..3034,3068..3070,3080..3082,3089..3091,3152..3154,
                     3188..3190,3200..3202,3209..3211)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="TPR motif; other site"
                     /db_xref="CDD:238112"
     misc_feature    3011..3229
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:205602"
     misc_feature    3011..3112
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 23"
     misc_feature    3131..3232
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 24"
     misc_feature    3134..3469
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat domain; typically contains
                     34 amino acids
                     [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-
                     X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in
                     a variety of organisms including bacteria, cyanobacteria,
                     yeast, fungi; Region: TPR; cd00189"
                     /db_xref="CDD:238112"
     misc_feature    order(3134..3139,3143..3148,3155..3160,3263..3268,
                     3272..3277,3284..3289,3383..3388,3395..3400,3407..3412)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="binding surface"
                     /db_xref="CDD:238112"
     misc_feature    order(3152..3154,3188..3190,3200..3202,3209..3211,
                     3272..3274,3308..3310,3320..3322,3329..3331,3392..3394,
                     3428..3430,3440..3442,3449..3451)
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="TPR motif; other site"
                     /db_xref="CDD:238112"
     misc_feature    3251..3352
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 25"
     misc_feature    3254..3469
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:205602"
     misc_feature    3371..3472
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 26"
     misc_feature    3377..3586
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:205602"
     misc_feature    3491..3592
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 27"
     misc_feature    3647..3748
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AY4.4);
                     Region: TPR 28"
     misc_feature    4310..5281
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /note="CHAT domain; Region: CHAT; pfam12770"
                     /db_xref="CDD:221764"
     misc_feature    6452..6454
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q96AY4.4); phosphorylation site"
     misc_feature    7319..7321
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q96AY4.4); phosphorylation site"
     misc_feature    7334..7336
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q96AY4.4); phosphorylation site"
     exon            245..523
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            524..671
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            672..944
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            945..1075
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            1076..1583
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            1584..2925
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            2926..3449
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            3450..3559
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            3560..3689
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            3690..3908
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            3909..4074
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            4075..4215
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            4216..4360
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            4361..4540
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            4541..5261
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            5262..5386
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            5387..5618
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            5619..5695
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            5696..5719
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            5720..5849
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            5850..5957
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     exon            5958..11795
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /inference="alignment:Splign:1.39.8"
     variation       5998
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11550448"
     STS             8600..8872
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /standard_name="G65733"
                     /db_xref="UniSTS:167000"
     variation       9997
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200082161"
     STS             10072..10230
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /standard_name="RH69365"
                     /db_xref="UniSTS:54853"
     STS             10326..10470
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /standard_name="D18S21"
                     /db_xref="UniSTS:148514"
     STS             11573..11786
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /standard_name="D22S1262"
                     /db_xref="UniSTS:44774"
     STS             11575..11740
                     /gene="TTC28"
                     /gene_synonym="TPRBK"
                     /standard_name="D22S986E"
                     /db_xref="UniSTS:48289"
ORIGIN      
gggggcgcgcgcgcggtttgggggcagtgaggggcgccgcggcggcgcgcagcacggcgggaacatggcgcgcggaaccggcgcgcgcgcctagctggcgggaccgttagctcgaggcggacgcggcccgggccccgtggggatggagcagtcgccgccgccggcgcccgagccgacccaagggccgacccccgcaaggagccgaaggcggcgggagccagagtcgccgccggcgtcggcgccgattcctctctttggtgctgacactattggccagagaagtcctgatggaccggtactgagcaaagctgaatttgttgagaaagttcgtcagagtaatcaggcctgtcatgatggagatttccacacagctattgttctgtataatgaagccctggctgttgaccctcagaactgcatcttatacagcaatagatctgcagcctacatgaaaatccagcagtatgacaaggcactggatgatgcaatcaaagctcgacttctcaatcccaagtggccaaaggcatacttccgacagggtgttgccctccagtaccttggacgtcatgccgatgccctggcagcctttgcatctggactggctcaagaccccaagagtctccagcttctggtggggatggtggaagccgccatgaaatctcccatgagagactccctcgagcccacttatcagcagcttcagaaaatgaaactggacaagagtccctttgtggtcgtgtctgtggttgggcaggaactcctgacagctggccatcatggggcctctgtggttgtcttagaagccgcactgaagattggcacctgcagcctcaaactgagaggttctgttttctctgccctgagcagtgcttactggtctcttggaaatacagagaagagcaccggatatatgcagcaggacttggatgtagccaagaccttaggtgaccagacaggagaatgccgagctcatgggaatctgggctctgcattcttctccaaaggaaattaccgggaggctctcactaaccacaggcatcagttggtactcgccatgaaactcaaagatcgagaggcagcttcatcagccttgagcagtctgggccacgtgtacacagccattggagactaccccaatgcactggccagtcacaaacagtgtgttcttcttgccaagcaatccaaagatgaactttctgaagcccgagaacttggcaacatgggagctgtgtatattgccatgggtgactttgagaatgctgtgcagtgccatgagcagcatctgaagatagccaaggacctggggaacaagcgagaagaggcccgggcttatagcaacctgggcagtgcctatcactaccggaggaactttgacaaggccatgtcttaccataactatgtcctggagctggcacaggagttgatggagaaggctattgagatgcgggcctatgctggactaggccatgctgccaggtgcatgcaggatttggagagagctaaacaataccatgagcagcagctgggcattgctgaggatctcaaggaccgggctgcagaggggcgagcatcctccaatctaggaatcatacaccagatgaaaggtgattatgacactgcactgaaactccacaagacccacctgtgcattgcccaggagctgagtgattatgctgcccagggccgtgcctatgggaatatgggcaatgcctacaatgccctgggcatgtacgaccaggcggtcaaataccatcggcaggagctgcagatctccatggaagtgaatgaccgcgcctcacaggcctccacacatgggaaccttgccgtggcctaccaggccctgggtgcccatgaccgggccctgcaacactatcagaaccacttgaacatcgcccgggagctacgagacatccagagcgaggcccgggccctcagcaacctgggcaatttccactgctctcggggagagtatgtccaggctgccccctattatgaacagtacctccggcttgctcccgaccttcaagacatggaaggagaagggaaggtctgccacaatcttggctatgcccattactgccttggaaactatcaggaggcagtgaagtactacgaacaggatctggcactggctaaagaccttcacgacaagttgagccaagcaaaagcctactgcaacttgggcctagcattcaaggctctgctgaatttcagtaaagctgaagagtgtcagaagtacctactgtccctagcccagtctctgaataattcccaggctaaatttcgagccctaggaaacctgggcgatatattcatctgtaaaaaagatataaatggtgcaataaaattctatgagcagcaactgggcttagctcaccaggtaaaggacagaagattagaagccagtgcatatgcagccctgggcactgcataccgaatgatccagaagtatgacaaggccctgggttatcacacacaggaactggaggtatatcaggagctgagtgacttgccaggggagtgcagagctcatgggcacctggctgctgtctacatggcccttgggaaatacacaatggcattcaagtgttatgaagagcaactggatctagggcaaaagctgaaggatccgagtctggaagcccaggtctatggcaacatgggcatcacaaagatgaacatgaatgtgatggaagaagccattggctactttgagcagcaattggccatgctgcagcagctaagtggaaatgagtctgtgctcgacaggggccgggcctatggcaacctgggggattgctacgaagccctgggtgactatgaggaagctatcaaatactatgaacaatatttatctgtcgcgcagagtctgaatcgcatgcaagaccaagccaaggcttaccggggcctgggaaatggacacagggcaatggggagcttgcagcaagcccttgtgtgctttgaaaagaggctcgtggttgctcatgaacttggagaggccttcaataaagcccaggcctatggagagctgggaagtctgcacagccaattagggaattacgaacaagccatttcctgccttgaacgccagctgaacattgctagagatatgaaagaccgagccctggagagtgacgcagcctgtggcctggggggcgtttaccagcagatgggggagtatgacacagccctgcagtaccaccagcttgatctacagatagcagaggaaaccaacaaccccacgtgccagggccgagcctatgggaacctgggcctgacttatgaatccctgggcaccttcgagagggctgtggtctatcaagaacagcacttgagcattgctgcacagatgaatgacttggcggccaagacggtgtcatatagtagccttggaaggacccatcatgccttgcagaactattcccaagcagtcatgtacttacaggaaggtttaaggttagctgagcaactgggccgaagagaagatgaggcaaaaattcgccatggccttggcctctccctttgggctagtggaaacttggaggaggcccaacaccagctttatagggcatcagccttgtttgaaacaatccgacatgaggcacagctgagcacggactacaaactctccctctttgacctgcagacatcatcctaccaggccttgcagcgggtgctcgtcagcctaggccatcatgatgaagccctggctgtggcagaaaggggacggacaagggcatttgctgatcttctggtggaacgacaaacaggacaacaagactccgacccctactccccagtcactattgatcagatcttagagatggtaaatggccagaggggactagtgctttactattccctggctgcaggctatctgtatagctggctgctggctcctggggcaggaattgtgaagtttcatgaacactacctgggtgagaacacagtggaaaactcaagtgacttccaggccagcagcagtgtaacccttccaacagcaaccggctcagccctggagcagcacattgccagtgtccgggaggccctgggggtggagtctcactactcaagggcctgtgccagcagtgagacagagagtgaagcgggagacatcatggaccagcaatttgaagagatgaacaacaaactcaactcggtcactgaccccactggctttctgcggatggttcgccgcaataacctgtttaacaggagctgccagagcatgacgagcctgttcagtaacactgtgtcaccgacccaggacgggacctcctctcttcccaggaggcagagctcgtttgccaagcccccgctccgtgccctgtatgacctgctcatcgcgcccatggaagggggcctgatgcactccagcggccccgtgggccggcaccggcagctcatcctggttctggagggggagctctacctcattcctttcgccctcctgaagggaagctcctccaatgagtacctctacgagcgcttcggcctccttgctgtcccttccatccgctccctcagcgtgcagtccaagtctcacttacggaagaacccgcccacatactccagctccacatccatggcggctgtcatcggcaaccccaagctaccatcggccgtgatggacaggtggctgtgggggcccatgccatcggccgaggaagaggcctacatggtgtccgagctgctgggctgccagcccctagtgggcagtgtggccaccaaggagagggtcatgagtgccctgacccaggctgaatgcgtccactttgccacccacatctcctggaagctgtcggccttggtcctcacgcccagcatggacggcaaccctgccagcagcaagagctccttcggccacccctacacgatccctgagtccttgcgggtgcaggacgatgccagtgatggggagagcatctcggactgcccgcccctgcaggagctgctgcttactgccgccgacgtcctggacctgcagctgcctgtgaagc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//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:23331 -> Biological process: GO:0007067 [mitosis] evidence: IEA
            GeneID:23331 -> Biological process: GO:0051301 [cell division] evidence: IEA
            GeneID:23331 -> Cellular component: GO:0000922 [spindle pole] evidence: IEA
            GeneID:23331 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
            GeneID:23331 -> Cellular component: GO:0005815 [microtubule organizing center] evidence: IEA
            GeneID:23331 -> Cellular component: GO:0030496 [midbody] evidence: IEA

by @meso_cacase at DBCLS
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