2024-04-20 16:33:10, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001145370 8648 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens protein tyrosine phosphatase, non-receptor type 3 (PTPN3), transcript variant 4, mRNA. ACCESSION NM_001145370 VERSION NM_001145370.1 GI:223941884 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 8648) AUTHORS Hou,S., Suresh,P.S., Qi,X., Lepp,A., Mirza,S.P. and Chen,G. TITLE p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response JOURNAL J. Biol. Chem. 287 (33), 27895-27905 (2012) PUBMED 22730326 REMARK GeneRIF: p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response. REFERENCE 2 (bases 1 to 8648) AUTHORS Jung,Y., Kim,P., Jung,Y., Keum,J., Kim,S.N., Choi,Y.S., Do,I.G., Lee,J., Choi,S.J., Kim,S., Lee,J.E., Kim,J., Lee,S. and Kim,J. TITLE Discovery of ALK-PTPN3 gene fusion from human non-small cell lung carcinoma cell line using next generation RNA sequencing JOURNAL Genes Chromosomes Cancer 51 (6), 590-597 (2012) PUBMED 22334442 REMARK GeneRIF: The fusion transcript of ALK and PTPN3 identified resulted from translocation of a part of ALK gene into the third intron of PTPN3. Analysis of the transcript sequence indicates that no protein with any enzymatic activity is produced. REFERENCE 3 (bases 1 to 8648) AUTHORS Zhi,H.Y., Hou,S.W., Li,R.S., Basir,Z., Xiang,Q., Szabo,A. and Chen,G. TITLE PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization JOURNAL Oncogene 30 (14), 1706-1715 (2011) PUBMED 21119599 REMARK GeneRIF: PTPH1 stimulated breast cancer growth through regulating vitamin D receptor expression. PTPH1 was overexpressed in primary breast cancer and levels of its protein expression positively correlated with clinical metastasis. REFERENCE 4 (bases 1 to 8648) AUTHORS Hou,S.W., Zhi,H.Y., Pohl,N., Loesch,M., Qi,X.M., Li,R.S., Basir,Z. and Chen,G. TITLE PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction JOURNAL Cancer Res. 70 (7), 2901-2910 (2010) PUBMED 20332238 REMARK GeneRIF: PTPH1 plays a role in Ras-dependent malignant growth by a mechanism depending on its p38gamma-binding activity. Ras increases p38gamma and PTPH1 expression and there is a coupling of increased p38gamma and PTPH1 protein expression in colon cancer. REFERENCE 5 (bases 1 to 8648) AUTHORS Barr,A.J., Ugochukwu,E., Lee,W.H., King,O.N., Filippakopoulos,P., Alfano,I., Savitsky,P., Burgess-Brown,N.A., Muller,S. and Knapp,S. TITLE Large-scale structural analysis of the classical human protein tyrosine phosphatome JOURNAL Cell 136 (2), 352-363 (2009) PUBMED 19167335 REFERENCE 6 (bases 1 to 8648) AUTHORS Zhang,S.H., Kobayashi,R., Graves,P.R., Piwnica-Worms,H. and Tonks,N.K. TITLE Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein JOURNAL J. Biol. Chem. 272 (43), 27281-27287 (1997) PUBMED 9341175 REFERENCE 7 (bases 1 to 8648) AUTHORS Ikuta,S., Itoh,F., Hinoda,Y., Toyota,M., Makiguchi,Y., Imai,K. and Yachi,A. TITLE Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma JOURNAL J. Gastroenterol. 29 (6), 727-732 (1994) PUBMED 7874267 REFERENCE 8 (bases 1 to 8648) AUTHORS Itoh,F., Ikuta,S., Hinoda,Y., Arimura,Y., Ohe,M., Adachi,M., Ariyama,T., Inazawa,J., Imai,K. and Yachi,A. TITLE Expression and chromosomal assignment of PTPH1 gene encoding a cytosolic protein tyrosine phosphatase homologous to cytoskeletal-associated proteins JOURNAL Int. J. Cancer 55 (6), 947-951 (1993) PUBMED 8253532 REFERENCE 9 (bases 1 to 8648) AUTHORS Arimura,Y., Hinoda,Y., Itoh,F., Takekawa,M., Tsujisaki,M., Adachi,M., Imai,K. and Yachi,A. TITLE cDNA cloning of new protein tyrosine phosphatases in the human colon JOURNAL Tumour Biol. 13 (3), 180-186 (1992) PUBMED 1626183 REFERENCE 10 (bases 1 to 8648) AUTHORS Yang,Q. and Tonks,N.K. TITLE Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (14), 5949-5953 (1991) PUBMED 1648725 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB306298.1, BX648253.1, AL162733.9, BX648735.1, DB173093.1, AK096975.1, AL359963.29 and BU624870.1. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]. Transcript Variant: This variant (4) differs in the 5' UTR, and is missing an in-frame coding exon compared to transcript variant 1, resulting in an isoform (4) with a shorter N-terminus and lacking an internal protein segment compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX648253.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-301 DB306298.1 26-326 c 302-1380 BX648253.1 302-1380 1381-1381 AL162733.9 26875-26875 c 1382-2482 BX648253.1 1382-2482 2483-3162 BX648735.1 918-1597 3163-6085 BX648253.1 3164-6086 6086-6426 DB173093.1 250-590 6427-6910 AK096975.1 196-679 6911-6950 AL359963.29 93827-93866 c 6951-8625 AK096975.1 702-2376 8626-8648 BU624870.1 1-23 c FEATURES Location/Qualifiers source 1..8648 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="9" /map="9q31" gene 1..8648 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /note="protein tyrosine phosphatase, non-receptor type 3" /db_xref="GeneID:5774" /db_xref="HGNC:9655" /db_xref="MIM:176877" exon 1..2574 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" variation 2481..2482 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="" /replace="t" /db_xref="dbSNP:71372568" misc_feature 2510..2512 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /note="upstream in-frame stop codon" CDS 2555..4768 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /EC_number="3.1.3.48" /note="isoform 4 is encoded by transcript variant 4; cytoskeletal-associated protein tyrosine phosphatase; tyrosine-protein phosphatase non-receptor type 3; protein-tyrosine phosphatase H1" /codon_start=1 /product="tyrosine-protein phosphatase non-receptor type 3 isoform 4" /protein_id="NP_001138842.1" /db_xref="GI:223941885" /db_xref="CCDS:CCDS48000.1" /db_xref="GeneID:5774" /db_xref="HGNC:9655" /db_xref="MIM:176877" /translation="
MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS
" misc_feature <2558..2827 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /note="Band 4.1 homologues; Region: B41; smart00295" /db_xref="CDD:197635" misc_feature 2558..2827 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /note="FERM central domain; Region: FERM_M; pfam00373" /db_xref="CDD:201187" misc_feature 2807..3085 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /note="FERM_C domain; Region: FERM_C; cd00836" /db_xref="CDD:176273" misc_feature order(2819..2842,2849..2872,2876..2896,2924..2929, 2936..2947,2960..2980,3008..3022,3047..3073) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /note="PH/PTB-like core; other site" /db_xref="CDD:176273" misc_feature order(2933..2935,2939..2944,2948..2956,2978..2980, 3053..3055,3065..3067,3074..3076) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /note="peptide binding site [polypeptide binding]; other site" /db_xref="CDD:176273" misc_feature 3044..3046 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /note="lipid binding site [chemical binding]; lipid-binding site" /db_xref="CDD:176273" misc_feature 3548..3811 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /note="PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992" /db_xref="CDD:29049" misc_feature order(3584..3595,3599..3601,3749..3754,3761..3766) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /note="protein binding site [polypeptide binding]; other site" /db_xref="CDD:29049" misc_feature 3971..4726 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /note="Protein tyrosine phosphatase, catalytic domain; Region: PTPc; smart00194" /db_xref="CDD:197567" misc_feature 4040..4723 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /note="Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047" /db_xref="CDD:28929" misc_feature order(4457..4459,4547..4552,4559..4561,4568..4573) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /note="active site" /db_xref="CDD:28929" exon 2575..2627 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" exon 2628..2748 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" exon 2749..2836 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" exon 2837..2925 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" exon 2926..2989 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" exon 2990..3162 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" exon 3163..3339 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" exon 3340..3526 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" exon 3527..3604 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" exon 3605..3661 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" exon 3662..3818 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" exon 3819..3979 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" exon 3980..4070 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" exon 4071..4132 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" exon 4133..4279 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" exon 4280..4408 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" exon 4409..4554 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" exon 4555..4690 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" exon 4691..8630 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" STS 5360..6056 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /standard_name="PTPN3_2445" /db_xref="UniSTS:280941" STS 5781..5920 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /standard_name="RH78381" /db_xref="UniSTS:38153" STS 5870..6051 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /standard_name="STS-W15441" /db_xref="UniSTS:82348" polyA_signal 6067..6072 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" polyA_site 6088 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" STS 6823..6955 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /standard_name="D9S58" /db_xref="UniSTS:33358" STS 8403..8525 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /standard_name="D9S1760" /db_xref="UniSTS:12586" STS 8406..8584 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /standard_name="D9S1693" /db_xref="UniSTS:65182" STS 8406..8578 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /standard_name="RH91146" /db_xref="UniSTS:88337" STS 8473..8585 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /standard_name="A009V09" /db_xref="UniSTS:77964" STS 8473..8585 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /standard_name="G32870" /db_xref="UniSTS:117449" polyA_site 8630 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" ORIGIN
gaagggtggtatcccgttgtggagtagaatgtaactatgaccttctgggatttgggcaccagatttatcttactgcaacaggagccatggtgggagccacccccataactcttatagagctggtgggccaccaggactgccagatatatatatatattttttgaaacagggtcttgctatgttgcccagactggcctcaaactcctggactcaaaggatcctccctcagcctcctgagtagctgggattataggcacataccaccacgactagctgccagatcatcttatcttggaccaggcttctaccattaattcacatgctttaaaaaaattaaaaattaaaaaaatgaaaaataaaaaaacttaaaagattttacctatattcctggaacatagttatcttaccccagctttgtagttcctgtttaaggaaattccctctgaaggaaattttagctctcaagagtcaaagaagatgtatagaggtggtatctgttagtttttgtttgtttgttaaggatctaggcagagaggtcattacatttttctgaagttgaggtcacaggtggggtacccacaagagaggtcattacatttctgaagttaggcatcccaggcatctcttctaaagaactatcctgtattctaattgttaaataaatatcttcttcattgtgagcctccacaactgctgtttctgataaatttagatcattctttgcagaattttatatactggcaatctcaaaactaggctccttcaagattcctaggaagtctcccaagctcgggttgggttccactattctagtttctttgtgtatgatgccatggggttgactcagaaactttgctcaatatatgacaaggcagcatttggtgagtggtgatctccacgtttatcttctcatttatatccctaggaagacatactgattagctgagcttgtcaatgaaagcccgggttcaccattggattatctataactctcctttctctttttttctctcagtagcattgtaggaggagagaacacttaattctggttgaatgtcagcttggataaacatagaaacaaactagaaagaactgatgatgttctcctaggtggaaaagatggagattccaataccaaataggtgtgaatcagcaaatgtatgttatactgtctctcaaggccaggtgttcaatacattgtgggtagttaattataatcaaagtaataatattagagttacgacatggatcctaagctttttagccattaaacatataagaaatttgtagcatagtgagtttttttataacatgatcatccaggttaaaataagacacaattgacctcacatatcctatctgagctccgattttgtcatctgtaaaaatggagatagtggtacctaccttacagagttatgaggctgagataagagggaaagttacaaagtagtaccatgtacaaagcccggaactgtgcaaataggaggttgtaatactgtttgaagcattcccatctcaaaaagccagttccttggcctttataaatttgaaggaataatgaaactgatttgtttcaattgtgaaaattatttctctcctgcccctgtgcacttctgccctgtctatattagatttcaagaggtttcccttttgtcatcttggccagacaatggaatgtctatcccgtttgaatctgggtttaaaaaagcatgggagctagtggccaagtgtcacatgtatgccgcatccctaaatagaagtctccccagggcgcttcctgacctgcgcaatgctgccgaaggcctcctttccccgctccccaggcagaggagcaaagtcacaggctgaggggcctgccacgacttgcccacaaaacaggtctggagtttggaagttacatttgctggttgcccagagatgagtgcagaattcagcttggaggtcctggaaacttctagtttactgatgtttatgcttttgctcatgcacccacagttcctgggacacagaatgctcacctgggggtttgtaccccagccaagaaggtgtcttcacagactcccctccttttagcaacttcatgcagatggagcttgggtggatggatcctggcacagtgttcagaacagtggccctgccagtgtgtgggcgccgcttgtgcagagcccctgtgggttctggtcctcaagggcaggggcgctcactgacagcggaacccatagtaccagcccatctttggtgggctgtttccaccccattcatccctgctcagctcttcataggacagcctgtgctggcagaaaattgcccccaccagtcaagacgtagggcatcaacatgagccatcagtaatgacagggcagctttgcagagcgtaaggtagcacctgataccttggaccaaaaccgtatttttatgtatctttcacatgtacagctcttgtctttgactcatcaaactttcttttttttttttttttgcttatttcagtttgagtatgaattaatgaaaacaattgtttcataggcacttgtatttcttacaactgaagatggatatttgcgaaggaaggttaacctgccctcttaactcagcagtggttctagcgtcctatgccgtacaatctcattttggagactataattcttccatacatcatccaggctatctttccgatagtcactttatacccgatcaaaatgaggactttttaacaaaagtcgaatctctgcatgagcagcacagtgggctaaaacaatcagaagcagaatcctgctatatcaacatagcgcggaccctcgacttctatggagtagaactgcacagtggtagggatctgcacaatttagacctaatgattggaattgcttccgcgggtgttgctgtgtaccgaaaatacatttgcacaagtttctatccttgggtgaacattctcaaaatttctttcaaaaggaaaaagttcttcatacatcagcgacagaaacaggctgaatccagggaacatattgtggccttcaacatgctgaattaccgatcttgcaaaaacttgtggaaatcctgtgttgagcaccatacgttctttcaggcaaagaagctactacctcaggaaaagaatgttctgtctcagtactggactatgggctctcggaacaccaaaaagcgaagtcctcggctccggcacgaaatccgaaagccacgccactcttctgcagataaccttgcaaatgaaatgacctacatcacggaaacggaagatgtattttacacgtacaagggctctctggcccctcaagacagcgattctgaagtttctcagaaccgaagcccgcaccaagagagtttatccgagaacaatccggcacaaagctacctgacccagaagtcatccagttctgtgtctccatcttcaaatgctccaggctcctgctcacctgacggcgttgatcagcagctcttagatgacttccacagggtgaccaaagggggctccaccgaggacgccagccagtactactgtgacaagaatgataatggtgacagctacttagtcttgatccgtatcacaccagatgaagatggaaaatttggatttaatcttaagggaggagtggatcaaaagatgcctcttgtggtatcaaggataaacccagagtcacctgcggacacctgcattcctaagctgaacgaaggggatcaaatcgtgttaatcaatggccgggacatctcagaacacacgcatgaccaagtggtgatgttcatcaaagccagccgggagtcccactcacgggagctggccctggtgatcaggaggagagctgtccgctcatttgctgacttcaagtctgaagatgaactgaaccagcttttccccgaagccattttccccatgtgtccggagggtggggacactttggagggatccatggcacagctaaagaagggcctcgaaagcgggacggtgctgatccagtttgagcaactctacagaaaaaagccaggtttggccatcacgtttgcaaagctgcctcaaaatttggacaaaaaccgatataaagatgtgctgccttatgacaccacccgggtattattgcagggaaatgaagattatattaatgcaagttacgtgaacatggaaattcctgctgctaaccttgtgaacaagtacatcgccactcaggggcccctgccgcatacctgtgcacagttttggcaggttgtctgggatcagaagttgtcactcattgtcatgttgacgactctcacagaacgagggcggaccaaatgtcaccagtactggccagatccccccgacgtcatgaaccacggcggctttcacatccagtgtcagtcagaggactgcaccatcgcctatgtgtcccgagaaatgctggtcacaaacacccagaccggggaagaacacacagtgacacatctccagtacgtcgcatggcctgaccacggtgtgcccgatgactcctccgactttctggaatttgtaaactatgtgaggtctctgagagtggacagcgagcccgtcctagttcactgcagtgctggaataggtcgaaccggtgtgttggtcactatggaaacagccatgtgcctaactgagaggaacctgcccatttacccactggatattgtccgaaaaatgcgagaccagcgcgccatgatggtgcagacatcaagccagtacaagtttgtgtgtgaagcgattcttcgtgtgtatgaagaaggtttagtccaaatgctggatcctagttaagacaactgtgaaaaagttcattcctctttcccaagggcatcctccttgaaagaggaggacagacctctctggaagcagcaagaggaaccagtagctgtgggaaaggaatgggcacctctgaacccaggcactttaaacttctatagaaaagatatcgtgtacataggaactggtgtagataagcatgcaattatggcatcatttaggcctgtatttctatggaaagatacaa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//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:5774 -> Molecular function: GO:0001784 [phosphotyrosine binding] evidence: IPI GeneID:5774 -> Molecular function: GO:0004725 [protein tyrosine phosphatase activity] evidence: IDA GeneID:5774 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:5774 -> Molecular function: GO:0008092 [cytoskeletal protein binding] evidence: IEA GeneID:5774 -> Molecular function: GO:0051117 [ATPase binding] evidence: IPI GeneID:5774 -> Biological process: GO:0006470 [protein dephosphorylation] evidence: IDA GeneID:5774 -> Biological process: GO:0035335 [peptidyl-tyrosine dephosphorylation] evidence: IDA GeneID:5774 -> Biological process: GO:0035335 [peptidyl-tyrosine dephosphorylation] evidence: TAS GeneID:5774 -> Biological process: GO:0045930 [negative regulation of mitotic cell cycle] evidence: IDA GeneID:5774 -> Biological process: GO:0051045 [negative regulation of membrane protein ectodomain proteolysis] evidence: IMP GeneID:5774 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:5774 -> Cellular component: GO:0005856 [cytoskeleton] evidence: IEA GeneID:5774 -> Cellular component: GO:0009898 [internal side of plasma membrane] evidence: IDA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001138842 -> EC 3.1.3.48
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