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2024-04-17 04:05:36, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001145369 8783 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens protein tyrosine phosphatase, non-receptor type 3
(PTPN3), transcript variant 3, mRNA.
ACCESSION NM_001145369
VERSION NM_001145369.1 GI:223941881
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8783)
AUTHORS Hou,S., Suresh,P.S., Qi,X., Lepp,A., Mirza,S.P. and Chen,G.
TITLE p38gamma Mitogen-activated protein kinase signals through
phosphorylating its phosphatase PTPH1 in regulating ras protein
oncogenesis and stress response
JOURNAL J. Biol. Chem. 287 (33), 27895-27905 (2012)
PUBMED 22730326
REMARK GeneRIF: p38gamma Mitogen-activated protein kinase signals through
phosphorylating its phosphatase PTPH1 in regulating ras protein
oncogenesis and stress response.
REFERENCE 2 (bases 1 to 8783)
AUTHORS Jung,Y., Kim,P., Jung,Y., Keum,J., Kim,S.N., Choi,Y.S., Do,I.G.,
Lee,J., Choi,S.J., Kim,S., Lee,J.E., Kim,J., Lee,S. and Kim,J.
TITLE Discovery of ALK-PTPN3 gene fusion from human non-small cell lung
carcinoma cell line using next generation RNA sequencing
JOURNAL Genes Chromosomes Cancer 51 (6), 590-597 (2012)
PUBMED 22334442
REMARK GeneRIF: The fusion transcript of ALK and PTPN3 identified resulted
from translocation of a part of ALK gene into the third intron of
PTPN3. Analysis of the transcript sequence indicates that no
protein with any enzymatic activity is produced.
REFERENCE 3 (bases 1 to 8783)
AUTHORS Zhi,H.Y., Hou,S.W., Li,R.S., Basir,Z., Xiang,Q., Szabo,A. and
Chen,G.
TITLE PTPH1 cooperates with vitamin D receptor to stimulate breast cancer
growth through their mutual stabilization
JOURNAL Oncogene 30 (14), 1706-1715 (2011)
PUBMED 21119599
REMARK GeneRIF: PTPH1 stimulated breast cancer growth through regulating
vitamin D receptor expression. PTPH1 was overexpressed in primary
breast cancer and levels of its protein expression positively
correlated with clinical metastasis.
REFERENCE 4 (bases 1 to 8783)
AUTHORS Hou,S.W., Zhi,H.Y., Pohl,N., Loesch,M., Qi,X.M., Li,R.S., Basir,Z.
and Chen,G.
TITLE PTPH1 dephosphorylates and cooperates with p38gamma MAPK to
increase ras oncogenesis through PDZ-mediated interaction
JOURNAL Cancer Res. 70 (7), 2901-2910 (2010)
PUBMED 20332238
REMARK GeneRIF: PTPH1 plays a role in Ras-dependent malignant growth by a
mechanism depending on its p38gamma-binding activity. Ras increases
p38gamma and PTPH1 expression and there is a coupling of increased
p38gamma and PTPH1 protein expression in colon cancer.
REFERENCE 5 (bases 1 to 8783)
AUTHORS Barr,A.J., Ugochukwu,E., Lee,W.H., King,O.N., Filippakopoulos,P.,
Alfano,I., Savitsky,P., Burgess-Brown,N.A., Muller,S. and Knapp,S.
TITLE Large-scale structural analysis of the classical human protein
tyrosine phosphatome
JOURNAL Cell 136 (2), 352-363 (2009)
PUBMED 19167335
REFERENCE 6 (bases 1 to 8783)
AUTHORS Zhang,S.H., Kobayashi,R., Graves,P.R., Piwnica-Worms,H. and
Tonks,N.K.
TITLE Serine phosphorylation-dependent association of the band
4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta
protein
JOURNAL J. Biol. Chem. 272 (43), 27281-27287 (1997)
PUBMED 9341175
REFERENCE 7 (bases 1 to 8783)
AUTHORS Ikuta,S., Itoh,F., Hinoda,Y., Toyota,M., Makiguchi,Y., Imai,K. and
Yachi,A.
TITLE Expression of cytoskeletal-associated protein tyrosine phosphatase
PTPH1 mRNA in human hepatocellular carcinoma
JOURNAL J. Gastroenterol. 29 (6), 727-732 (1994)
PUBMED 7874267
REFERENCE 8 (bases 1 to 8783)
AUTHORS Itoh,F., Ikuta,S., Hinoda,Y., Arimura,Y., Ohe,M., Adachi,M.,
Ariyama,T., Inazawa,J., Imai,K. and Yachi,A.
TITLE Expression and chromosomal assignment of PTPH1 gene encoding a
cytosolic protein tyrosine phosphatase homologous to
cytoskeletal-associated proteins
JOURNAL Int. J. Cancer 55 (6), 947-951 (1993)
PUBMED 8253532
REFERENCE 9 (bases 1 to 8783)
AUTHORS Arimura,Y., Hinoda,Y., Itoh,F., Takekawa,M., Tsujisaki,M.,
Adachi,M., Imai,K. and Yachi,A.
TITLE cDNA cloning of new protein tyrosine phosphatases in the human
colon
JOURNAL Tumour Biol. 13 (3), 180-186 (1992)
PUBMED 1626183
REFERENCE 10 (bases 1 to 8783)
AUTHORS Yang,Q. and Tonks,N.K.
TITLE Isolation of a cDNA clone encoding a human protein-tyrosine
phosphatase with homology to the cytoskeletal-associated proteins
band 4.1, ezrin, and talin
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (14), 5949-5953 (1991)
PUBMED 1648725
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB306298.1, BX648253.1,
AL162733.9, BX648735.1, DB173093.1, AK096975.1, AL359963.29 and
BU624870.1.
Summary: The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. This protein contains a C-terminal PTP
domain and an N-terminal domain homologous to the band 4.1
superfamily of cytoskeletal-associated proteins. P97, a cell cycle
regulator involved in a variety of membrane related functions, has
been shown to be a substrate of this PTP. This PTP was also found
to interact with, and be regulated by adaptor protein 14-3-3 beta.
Several alternatively spliced transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq, Feb 2009].
Transcript Variant: This variant (3) differs in the 5' UTR, and
initiates translation from an in-frame downstream AUG, resulting in
an isoform (3) with a shorter N-terminus compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BX648735.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-301 DB306298.1 26-326 c
302-1380 BX648253.1 302-1380
1381-1381 AL162733.9 26875-26875 c
1382-2482 BX648253.1 1382-2482
2483-6220 BX648735.1 918-4655
6221-6561 DB173093.1 250-590
6562-7045 AK096975.1 196-679
7046-7085 AL359963.29 93827-93866 c
7086-8760 AK096975.1 702-2376
8761-8783 BU624870.1 1-23 c
FEATURES Location/Qualifiers
source 1..8783
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q31"
gene 1..8783
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/note="protein tyrosine phosphatase, non-receptor type 3"
/db_xref="GeneID:5774"
/db_xref="HGNC:9655"
/db_xref="MIM:176877"
exon 1..2574
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
polyA_signal 355..360
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
variation 2481..2482
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace=""
/replace="t"
/db_xref="dbSNP:71372568"
misc_feature 2510..2512
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/note="upstream in-frame stop codon"
CDS 2555..4903
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/EC_number="3.1.3.48"
/note="isoform 3 is encoded by transcript variant 3;
cytoskeletal-associated protein tyrosine phosphatase;
tyrosine-protein phosphatase non-receptor type 3;
protein-tyrosine phosphatase H1"
/codon_start=1
/product="tyrosine-protein phosphatase non-receptor type 3
isoform 3"
/protein_id="NP_001138841.1"
/db_xref="GI:223941882"
/db_xref="CCDS:CCDS48001.1"
/db_xref="GeneID:5774"
/db_xref="HGNC:9655"
/db_xref="MIM:176877"
/translation="
MDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS
"
misc_feature <2558..2827
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/note="Band 4.1 homologues; Region: B41; smart00295"
/db_xref="CDD:197635"
misc_feature 2558..2827
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/note="FERM central domain; Region: FERM_M; pfam00373"
/db_xref="CDD:201187"
misc_feature 2807..3085
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/note="FERM_C domain; Region: FERM_C; cd00836"
/db_xref="CDD:176273"
misc_feature order(2819..2842,2849..2872,2876..2896,2924..2929,
2936..2947,2960..2980,3008..3022,3047..3073)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/note="PH/PTB-like core; other site"
/db_xref="CDD:176273"
misc_feature order(2933..2935,2939..2944,2948..2956,2978..2980,
3053..3055,3065..3067,3074..3076)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/note="peptide binding site [polypeptide binding]; other
site"
/db_xref="CDD:176273"
misc_feature 3044..3046
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/note="lipid binding site [chemical binding];
lipid-binding site"
/db_xref="CDD:176273"
misc_feature 3683..3946
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/note="PDZ domain found in a variety of Eumetazoan
signaling molecules, often in tandem arrangements. May be
responsible for specific protein-protein interactions, as
most PDZ domains bind C-terminal polypeptides, and binding
to internal (non-C-terminal)...; Region: PDZ_signaling;
cd00992"
/db_xref="CDD:29049"
misc_feature order(3719..3730,3734..3736,3884..3889,3896..3901)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/note="protein binding site [polypeptide binding]; other
site"
/db_xref="CDD:29049"
misc_feature 4106..4861
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/note="Protein tyrosine phosphatase, catalytic domain;
Region: PTPc; smart00194"
/db_xref="CDD:197567"
misc_feature 4175..4858
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/note="Protein tyrosine phosphatases (PTP) catalyze the
dephosphorylation of phosphotyrosine peptides; they
regulate phosphotyrosine levels in signal transduction
pathways. The depth of the active site cleft renders the
enzyme specific for phosphorylated Tyr; Region: PTPc;
cd00047"
/db_xref="CDD:28929"
misc_feature order(4592..4594,4682..4687,4694..4696,4703..4708)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/note="active site"
/db_xref="CDD:28929"
exon 2575..2627
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 2628..2748
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 2749..2836
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 2837..2925
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 2926..2989
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 2990..3162
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 3163..3297
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 3298..3474
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 3475..3661
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 3662..3739
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 3740..3796
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 3797..3953
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 3954..4114
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 4115..4205
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 4206..4267
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 4268..4414
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 4415..4543
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 4544..4689
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 4690..4825
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
exon 4826..8765
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
STS 5495..6191
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/standard_name="PTPN3_2445"
/db_xref="UniSTS:280941"
STS 5916..6055
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/standard_name="RH78381"
/db_xref="UniSTS:38153"
STS 6005..6186
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/standard_name="STS-W15441"
/db_xref="UniSTS:82348"
polyA_signal 6202..6207
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
polyA_site 6223
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
STS 6958..7090
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/standard_name="D9S58"
/db_xref="UniSTS:33358"
STS 8538..8660
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/standard_name="D9S1760"
/db_xref="UniSTS:12586"
STS 8541..8719
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/standard_name="D9S1693"
/db_xref="UniSTS:65182"
STS 8541..8713
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/standard_name="RH91146"
/db_xref="UniSTS:88337"
STS 8608..8720
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/standard_name="A009V09"
/db_xref="UniSTS:77964"
STS 8608..8720
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/standard_name="G32870"
/db_xref="UniSTS:117449"
polyA_site 8765
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
ORIGIN
gaagggtggtatcccgttgtggagtagaatgtaactatgaccttctgggatttgggcaccagatttatcttactgcaacaggagccatggtgggagccacccccataactcttatagagctggtgggccaccaggactgccagatatatatatatattttttgaaacagggtcttgctatgttgcccagactggcctcaaactcctggactcaaaggatcctccctcagcctcctgagtagctgggattataggcacataccaccacgactagctgccagatcatcttatcttggaccaggcttctaccattaattcacatgctttaaaaaaattaaaaattaaaaaaatgaaaaataaaaaaacttaaaagattttacctatattcctggaacatagttatcttaccccagctttgtagttcctgtttaaggaaattccctctgaaggaaattttagctctcaagagtcaaagaagatgtatagaggtggtatctgttagtttttgtttgtttgttaaggatctaggcagagaggtcattacatttttctgaagttgaggtcacaggtggggtacccacaagagaggtcattacatttctgaagttaggcatcccaggcatctcttctaaagaactatcctgtattctaattgttaaataaatatcttcttcattgtgagcctccacaactgctgtttctgataaatttagatcattctttgcagaattttatatactggcaatctcaaaactaggctccttcaagattcctaggaagtctcccaagctcgggttgggttccactattctagtttctttgtgtatgatgccatggggttgactcagaaactttgctcaatatatgacaaggcagcatttggtgagtggtgatctccacgtttatcttctcatttatatccctaggaagacatactgattagctgagcttgtcaatgaaagcccgggttcaccattggattatctataactctcctttctctttttttctctcagtagcattgtaggaggagagaacacttaattctggttgaatgtcagcttggataaacatagaaacaaactagaaagaactgatgatgttctcctaggtggaaaagatggagattccaataccaaataggtgtgaatcagcaaatgtatgttatactgtctctcaaggccaggtgttcaatacattgtgggtagttaattataatcaaagtaataatattagagttacgacatggatcctaagctttttagccattaaacatataagaaatttgtagcatagtgagtttttttataacatgatcatccaggttaaaataagacacaattgacctcacatatcctatctgagctccgattttgtcatctgtaaaaatggagatagtggtacctaccttacagagttatgaggctgagataagagggaaagttacaaagtagtaccatgtacaaagcccggaactgtgcaaataggaggttgtaatactgtttgaagcattcccatctcaaaaagccagttccttggcctttataaatttgaaggaataatgaaactgatttgtttcaattgtgaaaattatttctctcctgcccctgtgcacttctgccctgtctatattagatttcaagaggtttcccttttgtcatcttggccagacaatggaatgtctatcccgtttgaatctgggtttaaaaaagcatgggagctagtggccaagtgtcacatgtatgccgcatccctaaatagaagtctccccagggcgcttcctgacctgcgcaatgctgccgaaggcctcctttccccgctccccaggcagaggagcaaagtcacaggctgaggggcctgccacgacttgcccacaaaacaggtctggagtttggaagttacatttgctggttgcccagagatgagtgcagaattcagcttggaggtcctggaaacttctagtttactgatgtttatgcttttgctcatgcacccacagttcctgggacacagaatgctcacctgggggtttgtaccccagccaagaaggtgtcttcacagactcccctccttttagcaacttcatgcagatggagcttgggtggatggatcctggcacagtgttcagaacagtggccctgccagtgtgtgggcgccgcttgtgcagagcccctgtgggttctggtcctcaagggcaggggcgctcactgacagcggaacccatagtaccagcccatctttggtgggctgtttccaccccattcatccctgctcagctcttcataggacagcctgtgctggcagaaaattgcccccaccagtcaagacgtagggcatcaacatgagccatcagtaatgacagggcagctttgcagagcgtaaggtagcacctgataccttggaccaaaaccgtatttttatgtatctttcacatgtacagctcttgtctttgactcatcaaactttcttttttttttttttttgcttatttcagtttgagtatgaattaatgaaaacaattgtttcataggcacttgtatttcttacaactgaagatggatatttgcgaaggaaggttaacctgccctcttaactcagcagtggttctagcgtcctatgccgtacaatctcattttggagactataattcttccatacatcatccaggctatctttccgatagtcactttatacccgatcaaaatgaggactttttaacaaaagtcgaatctctgcatgagcagcacagtgggctaaaacaatcagaagcagaatcctgctatatcaacatagcgcggaccctcgacttctatggagtagaactgcacagtggtagggatctgcacaatttagacctaatgattggaattgcttccgcgggtgttgctgtgtaccgaaaatacatttgcacaagtttctatccttgggtgaacattctcaaaatttctttcaaaaggaaaaagttcttcatacatcagcgacagaaacaggctgaatccagggaacatattgtggccttcaacatgctgaattaccgatcttgcaaaaacttgtggaaatcctgtgttgagcaccatacgttctttcaggcaaagaagctactacctcaggaaaagaatgttctgtctcagtactggactatgggctctcggaacaccaaaaagtcggtaaataaccaatattgcaaaaaggtgattggcgggatggtgtggaacccagccatgcggagatccttatcagtggagcacttagaaaccaagagtctgccttctcgttcccctcccattactcccaactggcgaagtcctcggctccggcacgaaatccgaaagccacgccactcttctgcagataaccttgcaaatgaaatgacctacatcacggaaacggaagatgtattttacacgtacaagggctctctggcccctcaagacagcgattctgaagtttctcagaaccgaagcccgcaccaagagagtttatccgagaacaatccggcacaaagctacctgacccagaagtcatccagttctgtgtctccatcttcaaatgctccaggctcctgctcacctgacggcgttgatcagcagctcttagatgacttccacagggtgaccaaagggggctccaccgaggacgccagccagtactactgtgacaagaatgataatggtgacagctacttagtcttgatccgtatcacaccagatgaagatggaaaatttggatttaatcttaagggaggagtggatcaaaagatgcctcttgtggtatcaaggataaacccagagtcacctgcggacacctgcattcctaagctgaacgaaggggatcaaatcgtgttaatcaatggccgggacatctcagaacacacgcatgaccaagtggtgatgttcatcaaagccagccgggagtcccactcacgggagctggccctggtgatcaggaggagagctgtccgctcatttgctgacttcaagtctgaagatgaactgaaccagcttttccccgaagccattttccccatgtgtccggagggtggggacactttggagggatccatggcacagctaaagaagggcctcgaaagcgggacggtgctgatccagtttgagcaactctacagaaaaaagccaggtttggccatcacgtttgcaaagctgcctcaaaatttggacaaaaaccgatataaagatgtgctgccttatgacaccacccgggtattattgcagggaaatgaagattatattaatgcaagttacgtgaacatggaaattcctgctgctaaccttgtgaacaagtacatcgccactcaggggcccctgccgcatacctgtgcacagttttggcaggttgtctgggatcagaagttgtcactcattgtcatgttgacgactctcacagaacgagggcggaccaaatgtcaccagtactggccagatccccccgacgtcatgaaccacggcggctttcacatccagtgtcagtcagaggactgcaccatcgcctatgtgtcccgagaaatgctggtcacaaacacccagaccggggaagaacacacagtgacacatctccagtacgtcgcatggcctgaccacggtgtgcccgatgactcctccgactttctggaatttgtaaactatgtgaggtctctgagagtggacagcgagcccgtcctagttcactgcagtgctggaataggtcgaaccggtgtgttggtcactatggaaacagccatgtgcctaactgagaggaacctgcccatttacccactggatattgtccgaaaaatgcgagaccagcgcgccatgatggtgcagacatcaagccagtacaagtttgtgtgtgaagcgattcttcgtgtgtatgaagaaggtttagtccaaatgctggatcctagttaagacaactgtgaaaaagttcattcctctttcccaagggcatcctccttgaaagaggaggacagacctctctggaagcagcaagaggaaccagtagctgtgggaaaggaatgggcacctctgaacccaggcactttaaacttctatagaaaagatatcgtgtacataggaactggtgtagataagcatgcaattatggcatcatttaggcctgtatttctatggaaagatacaaaaaggatctcagtttggggcctgtcctaatgccttcttccctaacatcaccacacacacccctgtcggcatcctggagcaattgagaccggacacccacagagctgttgtcctcccagcaacaagatggtgtggttatcttgggtcatttggatgttttgtttgtttctgtgtgtcagactgtaagggctgagctttctgtgcttctaggtggagctggaacaattcagattcacccgccctgatgctaaggaaaccctgacgtatgtactagatggcagggcactgggggtcaggctgaaggctgagcaacacctctctgccctccctccctttgtcccatctcccagcgacttccaatattcatgtttctgagaattgtgtccctcttcaggttccctcttggtgcctaacctggattagtaatgtgcattcaggtgaattttcagctgaggctctgagaactggtactctcagtgtgttctggtcatcttgtggcttagttgtagaagcaggtgtgtctcttgcctctgcttgcctcctactgcacactcagcacccaggactggaatcaccgactactgaatctcctacatgtattgctgctacttcaagctcctccacttgaaaccttatgattttcccaaggggagatgggacagtgtcatctaaatattccgaatgtttggccttctgagaaaagagcttctagtaattgaaccatgggaaacccagcttctggagggttggccgtggggctgtgtacatgtgtgtgcccaggggtgagtgtttctcaggattcctaacgattcaaattaccgttgagtatatataaagaatgagtctctgtatggaagaacaaatgtgtgcattcacccccagtcacaatggtctccattgcatttcaaaggagaggatcagactatctgaatataaacacaatctgatgttaatttattctaagaacaccatcattttgattgtcctaaagaattctgcctttgtgaataccgtgttaaatttttttaaatttgtgacaggattgtagcaaattattatttaaggaaaataaattgtgtaaacatttaatgtggtatttttgaacagcggtttttatgtactcagaagaggaagtaaagccaggttcttaatggtatttatagaaaagatgttttcatattataatgcacataaatgaagccattttgatattcagcaaattcggtgccaattgaatagtttgctggtagcaagacggatgaagacctatatgggagattctttatctctagagctagcatatttacttgcatactttgtttcttttccacatggatattttactgctaaatggcagaggtgggagggagatgtcacacagtaccataaccccatattgaaaacaagaaaccaccagaaagtttgcagctaaggggcaggggattcagttcctacgcccactcagcactaactacttgcgggcctggttgcttagaagctctacctctctttcattatctgtaaaatagaaacaatacttaggactttagttggaacatgaggattgaataagatcacgctattcatgtgactttttatcggctagaacagcaacagacactgctgtgggtgagttacttagaaaagtttagttatcagtgattagcccaaaaacacatcagtcaaaaatagaatccactggatttttgtctctctttttagagacagggtctcactgtcgcccaggctggagtacagtggcatgatcattgttcactgcagcctcaaattcctgggctcaagcaatcctcgcacctcagcctcctgagtagccgggactataggcacatgccacctcacctggcttgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtagagacaggatcttgatgtgttgcctaggctggtctcaaactcctggcctcaagtgatcttcccacctcagcctccaaaactgttgggattataggcgtgagccactgtgcccagcctaactgggtttttatgagaggaaaatagaaaatgctcttctagaagagagagaacaagagcacaaaataatctggactcacaaaaattcagcaagctccaagaaagggggatggagggaacgctggcaaaaatttaaatgccattaggatatttagcaagttattactgtttggtaaaaatgcatcatcaccctgtgtgcaaaatgcttgcaaagtagtctaaatgtctttggagatgggtgttttactgcttttttccaaaaacaaattgtttattatggttgcagaaatgcagccattacggtcacataaatttctaaaaagcctaccaaaggttgcaagcagtcttctgccactgggcaggccagcagttcagacccagcgaggttgccaggaacaaatccaggaaatactgggaagaacaagacaagagaattacctaaaagagcaaacaattcaagtaaatcctgtagctattaccacttaaaatccgtagctcaagattcctgtttcaccaccttatacacttaagcaattatacttaagcctttttttagtcctaagtgaagaactacatcagaatcaggataagtattttgcctgggaaatttggctgcatatgaatggagaagacatttacatcctatgttctggcactttctgaaagatctaattaaacatgttgatgtgccaatttaatcaagatgagagatccctgctggtgtcaccctctagaacctgcacttggtgttttgactttccagaagaaaaaaatgcaactttggttagggggcagtggttggatcacacagttgtctttcgtttcctaccacagtaattcatatttaaatatgcttttagattagtgtggatactattgctgctgtgttgctacctgacctttttctggggggggtacctcagaaatgagcatttgagggcaagcgaaaaagccctcttcatcctccagaggcaacaaagaggcagcagaaatggggaaagattgtgagaggcagggcttgggtctagacctggacttaggcaagatatgttgccctcaaccctgagttttcttatatgtaaaaagggaaggttgggctggactagatgaggtcaagatttgccattctgggaggctgatattccagagaatcaaaattaatcctaaaccaaagctttatggctgctacagagacatgtcacatttctgagacttgtcaccaagagtttgtccctcagactttggcgctgttgaatgcaaagacaaggatggccaccttctggttcttgcctgttgtcctcagctgagagcagtctcggtaaaggtggcaaagattctgtgacctcagaccggggaccaaatgcttgggagtctgatggccgggctgggccaccattctcatagctctcattctgtttggagcaaccaaaggatttgtgtgaagttatttggaaaaggaccttaactgagcagtaatcttttttctgtatatttggaatgtttttcattctgacctgttctgtcagtgattctactgaaaaacaatttaatcaatataaaaatgttcaagctatgcaacactgtaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5774 -> Molecular function: GO:0001784 [phosphotyrosine binding] evidence: IPI
GeneID:5774 -> Molecular function: GO:0004725 [protein tyrosine phosphatase activity] evidence: IDA
GeneID:5774 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5774 -> Molecular function: GO:0008092 [cytoskeletal protein binding] evidence: IEA
GeneID:5774 -> Molecular function: GO:0051117 [ATPase binding] evidence: IPI
GeneID:5774 -> Biological process: GO:0006470 [protein dephosphorylation] evidence: IDA
GeneID:5774 -> Biological process: GO:0035335 [peptidyl-tyrosine dephosphorylation] evidence: IDA
GeneID:5774 -> Biological process: GO:0035335 [peptidyl-tyrosine dephosphorylation] evidence: TAS
GeneID:5774 -> Biological process: GO:0045930 [negative regulation of mitotic cell cycle] evidence: IDA
GeneID:5774 -> Biological process: GO:0051045 [negative regulation of membrane protein ectodomain proteolysis] evidence: IMP
GeneID:5774 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:5774 -> Cellular component: GO:0005856 [cytoskeleton] evidence: IEA
GeneID:5774 -> Cellular component: GO:0009898 [internal side of plasma membrane] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001138841 -> EC 3.1.3.48
by
@meso_cacase at
DBCLS
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