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2024-04-24 12:45:00, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001145358 6795 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens SIN3 transcription regulator homolog A (yeast)
(SIN3A), transcript variant 1, mRNA.
ACCESSION NM_001145358
VERSION NM_001145358.1 GI:223941784
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6795)
AUTHORS Icardi,L., Mori,R., Gesellchen,V., Eyckerman,S., De Cauwer,L.,
Verhelst,J., Vercauteren,K., Saelens,X., Meuleman,P.,
Leroux-Roels,G., De Bosscher,K., Boutros,M. and Tavernier,J.
TITLE The Sin3a repressor complex is a master regulator of STAT
transcriptional activity
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (30), 12058-12063 (2012)
PUBMED 22783022
REMARK GeneRIF: The Sin3a complex acts as a context-dependent ISGF3/STAT3
transcriptional switch.
REFERENCE 2 (bases 1 to 6795)
AUTHORS Bartholomew,C.R., Suzuki,T., Du,Z., Backues,S.K., Jin,M.,
Lynch-Day,M.A., Umekawa,M., Kamath,A., Zhao,M., Xie,Z., Inoki,K.
and Klionsky,D.J.
TITLE Ume6 transcription factor is part of a signaling cascade that
regulates autophagy
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (28), 11206-11210 (2012)
PUBMED 22733735
REMARK GeneRIF: Ume6 is a negative regulator of ATG8 transcription, which
acts along with a histone deacetylase complex including Sin3 and
Rpd3 to regulate Atg8 levels
REFERENCE 3 (bases 1 to 6795)
AUTHORS Lu,P., Hankel,I.L., Hostager,B.S., Swartzendruber,J.A.,
Friedman,A.D., Brenton,J.L., Rothman,P.B. and Colgan,J.D.
TITLE The developmental regulator protein Gon4l associates with protein
YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates
transcriptional repression
JOURNAL J. Biol. Chem. 286 (20), 18311-18319 (2011)
PUBMED 21454521
REMARK GeneRIF: Sin3a, HDAC1, and YY1 are co-factors for Gon4l and that
Gon4l may function as a platform for the assembly of complexes that
regulate gene expression.
REFERENCE 4 (bases 1 to 6795)
AUTHORS Cheng,P.Y., Lin,Y.P., Chen,Y.L., Lee,Y.C., Tai,C.C., Wang,Y.T.,
Chen,Y.J., Kao,C.F. and Yu,J.
TITLE Interplay between SIN3A and STAT3 mediates chromatin conformational
changes and GFAP expression during cellular differentiation
JOURNAL PLoS ONE 6 (7), E22018 (2011)
PUBMED 21779366
REMARK GeneRIF: Interplay between SIN3A and STAT3 mediates chromatin
conformational changes and GFAP expression during cellular
differentiation.(
REFERENCE 5 (bases 1 to 6795)
AUTHORS Aouizerat,B.E., Vittinghoff,E., Musone,S.L., Pawlikowska,L.,
Kwok,P.Y., Olgin,J.E. and Tseng,Z.H.
TITLE GWAS for discovery and replication of genetic loci associated with
sudden cardiac arrest in patients with coronary artery disease
JOURNAL BMC Cardiovasc Disord 11, 29 (2011)
PUBMED 21658281
REMARK Publication Status: Online-Only
REFERENCE 6 (bases 1 to 6795)
AUTHORS Laherty,C.D., Yang,W.M., Sun,J.M., Davie,J.R., Seto,E. and
Eisenman,R.N.
TITLE Histone deacetylases associated with the mSin3 corepressor mediate
mad transcriptional repression
JOURNAL Cell 89 (3), 349-356 (1997)
PUBMED 9150134
REMARK GeneRIF: mSin3A interacts with HDAC2 via the HDAC-interacting
domain (HID) of mSin3A.
GeneRIF: The transcriptional repressor mSin3A associates with
histone deacetylase 1 forming a co-repressor complex. See also PMID
(PubMed identifier) 9150133.
REFERENCE 7 (bases 1 to 6795)
AUTHORS Hassig,C.A., Fleischer,T.C., Billin,A.N., Schreiber,S.L. and
Ayer,D.E.
TITLE Histone deacetylase activity is required for full transcriptional
repression by mSin3A
JOURNAL Cell 89 (3), 341-347 (1997)
PUBMED 9150133
REFERENCE 8 (bases 1 to 6795)
AUTHORS Hurlin,P.J., Queva,C., Koskinen,P.J., Steingrimsson,E., Ayer,D.E.,
Copeland,N.G., Jenkins,N.A. and Eisenman,R.N.
TITLE Mad3 and Mad4: novel Max-interacting transcriptional repressors
that suppress c-myc dependent transformation and are expressed
during neural and epidermal differentiation
JOURNAL EMBO J. 14 (22), 5646-5659 (1995)
PUBMED 8521822
REMARK Erratum:[EMBO J. 1996 Apr 15;15(8):2030. PMID: 8617250]
REFERENCE 9 (bases 1 to 6795)
AUTHORS Halleck,M.S., Pownall,S., Harder,K.W., Duncan,A.M., Jirik,F.R. and
Schlegel,R.A.
TITLE A widely distributed putative mammalian transcriptional regulator
containing multiple paired amphipathic helices, with similarity to
yeast SIN3
JOURNAL Genomics 26 (2), 403-406 (1995)
PUBMED 7601471
REFERENCE 10 (bases 1 to 6795)
AUTHORS Ayer,D.E., Lawrence,Q.A. and Eisenman,R.N.
TITLE Mad-Max transcriptional repression is mediated by ternary complex
formation with mammalian homologs of yeast repressor Sin3
JOURNAL Cell 80 (5), 767-776 (1995)
PUBMED 7889570
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB074084.1, AK096477.1,
AF418569.1, AC068338.14 and BM676304.1.
Summary: The protein encoded by this gene is a transcriptional
regulatory protein. It contains paired amphipathic helix (PAH)
domains, which are important for protein-protein interactions and
may mediate repression by the Mad-Max complex. [provided by RefSeq,
Jul 2008].
Transcript Variant: This variant (1) represents the longest
transcript. Variants 1, 2 and 3 encode the same protein.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BX649162.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-49 DB074084.1 1-49
50-1003 AK096477.1 1-954
1004-4096 AF418569.1 906-3998
4097-6315 AC068338.14 3683-5901
6316-6795 BM676304.1 1-480 c
FEATURES Location/Qualifiers
source 1..6795
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q24.2"
gene 1..6795
/gene="SIN3A"
/note="SIN3 transcription regulator homolog A (yeast)"
/db_xref="GeneID:25942"
/db_xref="HGNC:19353"
/db_xref="MIM:607776"
exon 1..324
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 325..546
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
misc_feature 331..333
/gene="SIN3A"
/note="upstream in-frame stop codon"
CDS 358..4179
/gene="SIN3A"
/note="transcriptional co-repressor Sin3A; histone
deacetylase complex subunit Sin3a; transcriptional
corepressor Sin3a; transcriptional regulator, SIN3A; SIN3
homolog A, transcription regulator"
/codon_start=1
/product="paired amphipathic helix protein Sin3a"
/protein_id="NP_001138830.1"
/db_xref="GI:223941785"
/db_xref="CCDS:CCDS10279.1"
/db_xref="GeneID:25942"
/db_xref="HGNC:19353"
/db_xref="MIM:607776"
/translation="
MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTPSYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQRLKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIMGFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQPAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYAQVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRPSQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAYENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATEGIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSSKKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGTSEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQNEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLAYEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEEEMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYPAFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQVTDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIELLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGREQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHERVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSINKYRVKYGTVFKAP
"
misc_feature 379..>2823
/gene="SIN3A"
/note="Histone deacetylase complex, SIN3 component
[Chromatin structure and dynamics]; Region: SIN3; COG5602"
/db_xref="CDD:35161"
misc_feature 385..387
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96ST3.2); phosphorylation site"
misc_feature 712..945
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96ST3.2);
Region: Interaction with HCFC1"
misc_feature 778..918
/gene="SIN3A"
/note="Paired amphipathic helix repeat; Region: PAH;
pfam02671"
/db_xref="CDD:202341"
misc_feature 970..1797
/gene="SIN3A"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96ST3.2);
Region: Interaction with REST (By similarity)"
misc_feature 1186..1188
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96ST3.2); phosphorylation site"
misc_feature 1321..1500
/gene="SIN3A"
/note="Paired amphipathic helix repeat; Region: PAH;
pfam02671"
/db_xref="CDD:202341"
misc_feature 1729..1932
/gene="SIN3A"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96ST3.2);
Region: Interaction with SAP30 (By similarity)"
misc_feature 1762..1764
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q96ST3.2); acetylation site"
misc_feature 1789..1926
/gene="SIN3A"
/note="Paired amphipathic helix repeat; Region: PAH;
pfam02671"
/db_xref="CDD:202341"
misc_feature 1924..2907
/gene="SIN3A"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96ST3.2);
Region: Interaction with NCOR1 (By similarity)"
misc_feature 1927..2334
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96ST3.2);
Region: Interaction with SUDS3 and SAP130"
misc_feature 2005..2307
/gene="SIN3A"
/note="Sin3 family co-repressor; Region: Sin3_corepress;
pfam08295"
/db_xref="CDD:191990"
misc_feature 2416..2844
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96ST3.2);
Region: Interaction with HDAC1 and ARID4B"
misc_feature 2851..2853
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96ST3.2); phosphorylation site"
misc_feature 2935..2937
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96ST3.2); phosphorylation site"
misc_feature 3019..3258
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96ST3.2);
Region: Interaction with OGT"
misc_feature 3175..3177
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96ST3.2); phosphorylation site"
misc_feature 3691..3693
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96ST3.2); phosphorylation site"
exon 547..723
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 724..830
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 831..1113
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
variation 1004
/gene="SIN3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:199949593"
exon 1114..1365
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 1366..1518
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 1519..1674
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 1675..1764
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 1765..1883
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 1884..2094
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 2095..2211
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 2212..2450
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 2451..2634
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 2635..3208
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 3209..3378
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 3379..3552
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 3553..3645
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 3646..3740
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 3741..3948
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 3949..6779
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
STS 4237..4428
/gene="SIN3A"
/standard_name="D15S735E"
/db_xref="UniSTS:151629"
STS 4309..4461
/gene="SIN3A"
/standard_name="RH101985"
/db_xref="UniSTS:96319"
STS 4349..5241
/gene="SIN3A"
/standard_name="SIN3A_8019"
/db_xref="UniSTS:471761"
variation 5058
/gene="SIN3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551123"
polyA_signal 5198..5203
/gene="SIN3A"
polyA_signal 5202..5207
/gene="SIN3A"
polyA_site 5228
/gene="SIN3A"
variation 5485
/gene="SIN3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551122"
polyA_signal 6761..6766
/gene="SIN3A"
variation 6770
/gene="SIN3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:16967090"
polyA_site 6779
/gene="SIN3A"
ORIGIN
agctgagtcttccctctgcggggcggggtcgggggagtgggcgggatttcccgggtaacagagaagcggccgcggcggtagaggcggcggagacggtttctccatcttcccccctccccttcccccctcggagtttccctccctccctccctccctccttcccagtctgggcaccggagcctgtgaccgcttcgttagtggagaggtagctggcagtccgcttcggcgggcctgtgccccgcgccgttctcggggcctccctgctgagctcgcggctcacgctgagagggacacgcagtgacgagcggccgaagcagctttgcggttttgtagtgcatccctgagcatgagcacagaatgaagcggcgtttggatgaccaggagtcaccggtgtatgcagcccagcagcgtcggatccctggcagcacagaggcttttcctcaccagcaccgggtgcttgcccctgcccctcctgtgtatgaagcagtgtctgagaccatgcagtcagctacgggaattcagtactctgtaacacccagctaccaggtttcagccatgccacagagctccggcagtcatgggcccgctatagcagcagttcatagcagccatcatcacccaacagcggtgcagccccacggaggccaggtggtccagagtcatgctcatccagccccaccagttgcaccagtgcagggacagcagcaatttcagaggctgaaggtggaggatgcgctatcttatcttgaccaggtgaagctgcagtttggtagtcagcctcaggtctacaatgatttccttgacatcatgaaggaatttaaatctcagagcatcgacaccccaggagtgattagtcgtgtgtcccagctattcaaaggccaccccgatctgataatgggattcaacaccttcttgccccctggctacaaaattgaggtgcaaaccaatgacatggtgaatgtgacaactcctggccaggttcatcagattcccacccatggcatccagccacagcctcaaccaccaccccaacatccttcccagccttcagcccagtcagccccagctcctgcccagccagctcctcagcccccacctgccaaagtcagcaagccctcccaactgcaagcacatactccggccagtcagcagactcccccacttccaccgtatgcatccccacgttctccgccggtccagcctcacacaccagtgacaatctcgttgggaacggccccatccttgcagaacaatcaacctgtggagtttaatcatgccatcaactatgttaataagatcaagaacagatttcagggccaaccagacatctacaaagcattcctggagattttgcacacatatcagaaagagcagagaaatgccaaggaagctggaggaaactacactccagcattgacagagcaggaggtgtatgcccaggttgctcgtctctttaaaaaccaggaagatttgttgtcagagtttggacaattcctaccagatgccaacagctccgtgcttttaagcaaaacaactgctgagaaggttgattctgtgagaaatgatcatggaggcactgtcaagaagccccaactgaacaacaagccgcagaggcccagccagaatggctgccagatccgcagacatcctacaggaaccacccctccagttaagaagaaacccaaactgctcaatctgaaggattcttctatggcagatgccagcaaacatggtggtggaacagaatcgttattttttgataaggtccgaaaggctcttcggagtgcagaagcctacgaaaatttcctacgctgtcttgttatttttaaccaggaggtgatctctcgtgctgagcttgtgcaactagtctctcctttcctggggaaattccctgagttgtttaattggtttaaaaactttctgggctataaggagtctgtacatctggaaacttatccaaaggagcgagccacagagggcattgctatggagatagattatgcttcttgtaaacgattgggctccagctatcgagccttaccaaagagttaccagcagcccaagtgtacaggacggactcctctctgtaaagaggttttaaatgatacctgggtttccttcccttcgtggtctgaggactctacctttgtgagttccaagaagactcaatatgaagaacatatttatcgttgtgaagatgaacgctttgagcttgatgtagttttagagaccaatctggcaacaatccgggttctggaagcaatacagaagaagctttcccgcttgtctgctgaagaacaagccaaatttcgcttggacaacacccttgggggcacatcagaagtcatccatagaaaagcactccagaggatatatgctgataaagcagctgacatcattgatggtctgagaaagaatccctccattgctgttccaattgtccttaaaaggttgaagatgaaagaggaagaatggcgagaagctcagagaggctttaacaaagtatggcgagaacaaaatgagaaatactacttgaagtctctggaccaccaggggatcaactttaaacagaatgacaccaaggtcctgaggtctaagagcttactcaatgagattgagagtatctatgatgagaggcaagagcaggctacggaggagaatgctggtgtacctgttggcccacacctctcacttgcgtatgaagacaaacaaatactggaagatgctgctgctctgattatccaccatgtgaagaggcagacaggcattcagaaggaggacaaatataagataaaacaaatcatgcatcattttattccagatttgctctttgcccaaagaggtgatctctcagatgtggaggaagaggaagaagaagagatggatgtagatgaagccacaggggcagttaagaagcacaatggtgttgggggcagtccccctaagtccaagttactgtttagtaacacagcagctcaaaaattaagaggaatggatgaagtatacaacctcttctatgtcaacaacaactggtatatttttatgcgactgcaccagattctctgcctgaggctgctacggatttgttcccaagccgaacggcaaattgaagaagaaaaccgagagagagaatgggaacgggaagtgctgggcataaagcgagacaagagtgacagccctgccattcagctacgtctcaaagaacctatggatgttgatgtagaagattattacccagctttcctggacatggtgcggagcctgctggatggcaacatagactcatcacagtatgaagattcactgagagagatgttcaccattcatgcctacattgcctttaccatggacaaactgatccagagcattgtcagacagctgcagcatatcgtgagtgatgagatctgtgtgcaggtgactgacctttacctggcagaaaataataatggggccaccggaggccagctgaacacacagaactcaaggagcctcctggagtcaacgtatcagcggaaagctgagcagctaatgtcagatgagaattgctttaagcttatgtttattcagagccaaggccaggtccagctgactattgagcttctggacacagaagaggagaattcggatgaccctgtggaagcagagcgctggtcagactacgtggagcgatacatgaattcagatactacctcgcctgagcttcgtgaacatctagcacagaaaccagtatttctccccaggaatctacggcggatccggaagtgtcaacgtggtcgagagcagcaggaaaaggaagggaaggaaggaaacagcaagaagaccatggagaatgtggatagtctggataagctggagtgtagattcaagctgaattcctacaagatggtgtatgtgatcaaatcagaggactatatgtatcggaggaccgccctgctccgggctcatcagtcccatgagcgtgtaagcaagcgtctacatcagagattccaggcctgggtagataaatggaccaaggagcatgtgccccgtgaaatggcagcagagaccagcaagtggctcatgggtgaggggctggagggcctggtgccctgtaccaccacctgtgatacagagaccctgcattttgtgagcattaacaagtatcgtgtcaaatacggcacagtattcaaagccccttaactgcaaagccagagcagataacttggggtgtgtgtggggatgtgtgtgtgggcctatgcactcacacactgaagaaacaaggaagatgcctttcaagcctcactgggcctctctgggacatggccacctgacctgtgtgtggctggtgcagcctggcaccaagtgggctacctgttaggaacatgaataccttacaaagctgaagctggaacttttcccaaagggttttgggtatagcctgccctggaggggaaggaagtccatgcaagcaaagacatgcagtttgcttgcacacaccagcagagctaagactggagtctcctgtggcctaactttcaatgagggaaccggatgctgttcacactttgactggatggagatgcatttacaaaacagactggagaaggacttaatactcagatggattggaactatcatggtcactgctcctctcccctccccacaaaaggaaaaaaaagctggatttgattttttttttctggtcactcgagcacatctaagatcacccattaggttttatctgggacctgcagtttggctttgggattgatcatcttgtggattttattcctgacgattcccttgctgcctacccttttctctcctctggttctcaacctcaacgagttcaaatcagttgtcctttttagctcccgtggaactgttttgtatctgcctctttactagtctaccttagtgccatccaccagctttactctctgacacacacacgcacacacacacacaattttaacttgtttttttgtacataatgtacatactgtcaattttttattaaaagaaatatgctttgatgtgctagcataactgctctagcttcttgtgtaccatagtactgtggcttcagatttagtacctatgaacagatgtacaagacatttattacactttttaccaaagggagttaccattgtagtacttttgtgtaaaacttgtcttcccctttgcccccaacttttttttttttttttttgtaaataaataaagcttggttcttacttaaggaataaactctcaacccacgtcccttgtcctcaccagaaaatactgtgaagcagggattttgacttcagttccttatccagggtagaaacaggattttgcttaaaatacttgttacttgtcccaaatcaaaatattccaaaatcttagaatacttaagtcttttagtacgtgtttttttcccttgttcaaataatctgaaaatattttatatttgggtaagttgtcaagctatgtagtttgtatttctatatattttttcttattcacattggtgatggatgggggtgagcaacttaaataccaaaccagtgtttgaaaaaaaagtgtgcataaggcatgtggtataccttataaatggagttgggagggagagaatttgaaatgggatacctatttttttaattacataaatttaaactagcagacatttaaacatgaatgattaggatttttctatgtggttaacctggactttctgaacaaagaccaactgagcccctcccagtactctggtggatttttcttcagcaaccattacgcaagtcttagttgtaaccagcaatgttctgtgtgttttatgtttgctttttagttaaaaatcaccaccaccaccaaaaagaaaaacaaaattttttggctcctggattttcaaaacacatggtagacctctctgattttaggcttttattgtttaaagacagtgtctcgctttatgacccacactggagtgcagtgccacgatcatagctcactgcaggcttgacctcccaggctcaagcagtcctcccacctcggcctcctgagtagctgcatgccaccacgcccagctaattttttaactttttgtagagacagggtcttgctatgctgcccaggttggtctcaaactcctggcctcaagctgtcctcccacctcggcctcgcaaagtgctgagattacaggtgtgagccaccctggcctgattttaggctttttttgtactggggagaagagactgtgagccaaagtgtagggtgccaaaaagagctttgtgggatgagattttagggcaaagctggggcagtgtctgacttggcggtggtcatgtgtactgatttaggggaaagatcttgaggttttctcaaataattcacctatccccgtgttccctcaagaaaggtcatgttgacctggaaccataggggaaattggtggggtgtgatcagggtcagccccagctgttgctgcccctgcagtgttttgtccagagcacttgcctgcaggtcaggataggatttcaaggccagttcaggagaaagtcccaacccaccagtgcaaccaacaaaagagtaagttttacctacagcctgggttttcacaagtagcatttttattcctcctgctgtctgacatctgagctccaagctctaaacccaacctgtattatatgcagcagcaggttatctttgttttaaatcacatttgttattctgtacttagtcacctttccgtgtgatctgcatttgaaatgttgtaaacttggtcagtatttccattaaaatatcagggctaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:25942 -> Molecular function: GO:0001102 [RNA polymerase II activating transcription factor binding] evidence: IPI
GeneID:25942 -> Molecular function: GO:0001103 [RNA polymerase II repressing transcription factor binding] evidence: IEA
GeneID:25942 -> Molecular function: GO:0001106 [RNA polymerase II transcription corepressor activity] evidence: IEA
GeneID:25942 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:25942 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
GeneID:25942 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:25942 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: RCA
GeneID:25942 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:25942 -> Molecular function: GO:0032403 [protein complex binding] evidence: IEA
GeneID:25942 -> Molecular function: GO:0033558 [protein deacetylase activity] evidence: IMP
GeneID:25942 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:25942 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
GeneID:25942 -> Biological process: GO:0002218 [activation of innate immune response] evidence: IMP
GeneID:25942 -> Biological process: GO:0002230 [positive regulation of defense response to virus by host] evidence: IMP
GeneID:25942 -> Biological process: GO:0006260 [DNA replication] evidence: IEA
GeneID:25942 -> Biological process: GO:0006476 [protein deacetylation] evidence: IMP
GeneID:25942 -> Biological process: GO:0007568 [aging] evidence: IEA
GeneID:25942 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:25942 -> Biological process: GO:0010243 [response to organonitrogen compound] evidence: IEA
GeneID:25942 -> Biological process: GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle] evidence: IEA
GeneID:25942 -> Biological process: GO:0031937 [positive regulation of chromatin silencing] evidence: IMP
GeneID:25942 -> Biological process: GO:0034613 [cellular protein localization] evidence: IEA
GeneID:25942 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
GeneID:25942 -> Biological process: GO:0043619 [regulation of transcription from RNA polymerase II promoter in response to oxidative stress] evidence: IEA
GeneID:25942 -> Biological process: GO:0044255 [cellular lipid metabolic process] evidence: TAS
GeneID:25942 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:25942 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: ISS
GeneID:25942 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:25942 -> Biological process: GO:0051595 [response to methylglyoxal] evidence: IEA
GeneID:25942 -> Biological process: GO:0071333 [cellular response to glucose stimulus] evidence: IEA
GeneID:25942 -> Biological process: GO:1900181 [negative regulation of protein localization to nucleus] evidence: IMP
GeneID:25942 -> Biological process: GO:1901675 [negative regulation of histone H3-K27 acetylation] evidence: IMP
GeneID:25942 -> Biological process: GO:2000678 [negative regulation of transcription regulatory region DNA binding] evidence: IMP
GeneID:25942 -> Cellular component: GO:0000776 [kinetochore] evidence: IEA
GeneID:25942 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:25942 -> Cellular component: GO:0005634 [nucleus] evidence: ISS
GeneID:25942 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:25942 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
GeneID:25942 -> Cellular component: GO:0005730 [nucleolus] evidence: IEA
GeneID:25942 -> Cellular component: GO:0016580 [Sin3 complex] evidence: IDA
GeneID:25942 -> Cellular component: GO:0016580 [Sin3 complex] evidence: NAS
GeneID:25942 -> Cellular component: GO:0017053 [transcriptional repressor complex] evidence: IEA
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