2024-03-29 10:47:30, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001145001 2810 bp mRNA linear PRI 18-APR-2013 DEFINITION Homo sapiens NIMA-related kinase 6 (NEK6), transcript variant 1, mRNA. ACCESSION NM_001145001 VERSION NM_001145001.2 GI:261244918 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2810) AUTHORS Cao,X., Xia,Y., Yang,J., Jiang,J., Chen,L., Ni,R., Li,L. and Gu,Z. TITLE Clinical and biological significance of never in mitosis gene A-related kinase 6 (NEK6) expression in hepatic cell cancer JOURNAL Pathol. Oncol. Res. 18 (2), 201-207 (2012) PUBMED 21725899 REMARK GeneRIF: High Nek6 is associated with hepatic cell cancer. REFERENCE 2 (bases 1 to 2810) AUTHORS Bertran,M.T., Sdelci,S., Regue,L., Avruch,J., Caelles,C. and Roig,J. TITLE Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5 JOURNAL EMBO J. 30 (13), 2634-2647 (2011) PUBMED 21642957 REMARK GeneRIF: Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. Publication Status: Online-Only REFERENCE 3 (bases 1 to 2810) AUTHORS Jee,H.J., Kim,H.J., Kim,A.J., Song,N., Kim,M. and Yun,J. TITLE Nek6 suppresses the premature senescence of human cancer cells induced by camptothecin and doxorubicin treatment JOURNAL Biochem. Biophys. Res. Commun. 408 (4), 669-673 (2011) PUBMED 21539811 REMARK GeneRIF: These results suggest that the increased expression of Nek6 renders cancer cells resistant to premature senescence, and targeting Nek6 could be an efficient strategy for cancer treatment. REFERENCE 4 (bases 1 to 2810) AUTHORS Regue,L., Sdelci,S., Bertran,M.T., Caelles,C., Reverter,D. and Roig,J. TITLE DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9 JOURNAL J. Biol. Chem. 286 (20), 18118-18129 (2011) PUBMED 21454704 REMARK GeneRIF: DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9. REFERENCE 5 (bases 1 to 2810) AUTHORS Meirelles,G.V., Silva,J.C., Mendonca Yde,A., Ramos,C.H., Torriani,I.L. and Kobarg,J. TITLE Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain JOURNAL BMC Struct. Biol. 11, 12 (2011) PUBMED 21320329 REMARK GeneRIF: the first low resolution 3D structure of hNek6 protein in solution Publication Status: Online-Only REFERENCE 6 (bases 1 to 2810) AUTHORS Belham,C., Comb,M.J. and Avruch,J. TITLE Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase JOURNAL Curr. Biol. 11 (15), 1155-1167 (2001) PUBMED 11516946 REFERENCE 7 (bases 1 to 2810) AUTHORS Kimura,M. and Okano,Y. TITLE Identification and assignment of the human NIMA-related protein kinase 7 gene (NEK7) to human chromosome 1q31.3 JOURNAL Cytogenet. Cell Genet. 94 (1-2), 33-38 (2001) PUBMED 11701951 REMARK GeneRIF: Also includes phylogenetic analysis and tissue-specific RT-PCR of human NEK6 and NEK7. REFERENCE 8 (bases 1 to 2810) AUTHORS Kandli,M., Feige,E., Chen,A., Kilfin,G. and Motro,B. TITLE Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA JOURNAL Genomics 68 (2), 187-196 (2000) PUBMED 10964517 REFERENCE 9 (bases 1 to 2810) AUTHORS Kobayashi,T. and Cohen,P. TITLE Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2 JOURNAL Biochem. J. 339 (PT 2), 319-328 (1999) PUBMED 10191262 REFERENCE 10 (bases 1 to 2810) AUTHORS Li,M.Z., Yu,L., Liu,Q., Chu,J.Y. and Zhao,S.Y. TITLE Assignment of NEK6, a NIMA-related gene, to human chromosome 9q33. 3-->q34.11 by radiation hybrid mapping JOURNAL Cytogenet. Cell Genet. 87 (3-4), 271-272 (1999) PUBMED 10702691 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CF994196.1, BC004174.2, AL137846.24, AF087909.1 and BC012761.2. On Oct 10, 2009 this sequence version replaced gi:222418621. Summary: The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 7 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC004174.2 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-100 CF994196.1 28-127 101-1059 BC004174.2 54-1012 1060-1060 AL137846.24 13825-13825 1061-1738 BC004174.2 1014-1691 1739-1739 AF087909.1 1510-1510 1740-2810 BC012761.2 1522-2592 FEATURES Location/Qualifiers source 1..2810 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="9" /map="9q33.3-q34.11" gene 1..2810 /gene="NEK6" /gene_synonym="SID6-1512" /note="NIMA-related kinase 6" /db_xref="GeneID:10783" /db_xref="HGNC:7749" /db_xref="MIM:604884" exon 1..169 /gene="NEK6" /gene_synonym="SID6-1512" /inference="alignment:Splign:1.39.8" variation 100 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="g" /db_xref="dbSNP:11556891" variation 169 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:112601072" exon 170..334 /gene="NEK6" /gene_synonym="SID6-1512" /inference="alignment:Splign:1.39.8" variation 223 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:200229612" misc_feature 235..237 /gene="NEK6" /gene_synonym="SID6-1512" /note="upstream in-frame stop codon" variation 256 /gene="NEK6" /gene_synonym="SID6-1512" /replace="g" /replace="t" /db_xref="dbSNP:199720840" CDS 262..1305 /gene="NEK6" /gene_synonym="SID6-1512" /EC_number="2.7.11.1" /note="isoform 1 is encoded by transcript variant 1; putative serine-threonine protein kinase; serine/threonine-protein kinase Nek6; protein kinase SID6-1512; nimA-related protein kinase 6; never in mitosis A-related kinase 6; NIMA (never in mitosis gene a)-related kinase 6" /codon_start=1 /product="serine/threonine-protein kinase Nek6 isoform 1" /protein_id="NP_001138473.1" /db_xref="GI:222418622" /db_xref="CCDS:CCDS48015.1" /db_xref="GeneID:10783" /db_xref="HGNC:7749" /db_xref="MIM:604884" /translation="
MPRREVCWEAAHFRQEEQSLPRPRVRALVRLACRMAGQPGHMPHGGSSNNLCHTLGPVHPPDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRPDIGYVHQVAKQMHIWMSST
" misc_feature 487..1284 /gene="NEK6" /gene_synonym="SID6-1512" /note="Catalytic domain of the Protein Serine/Threonine Kinases, Never In Mitosis gene A-related kinase 6 and 7; Region: STKc_Nek6_Nek7; cd08224" /db_xref="CDD:173764" misc_feature 496..1293 /gene="NEK6" /gene_synonym="SID6-1512" /note="Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220" /db_xref="CDD:197582" misc_feature order(514..528,538..540,577..579,583..585,679..681, 727..738,748..750,754..756,877..879,883..885,889..894, 898..900,931..933,940..942,946..948,988..999) /gene="NEK6" /gene_synonym="SID6-1512" /note="active site" /db_xref="CDD:173764" misc_feature order(514..519,523..528,538..540,577..579,583..585, 679..681,730..738,748..750,892..894,898..900,946..948) /gene="NEK6" /gene_synonym="SID6-1512" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:173764" misc_feature order(526..528,748..750,754..756,877..879,883..885, 889..891,940..942,988..999) /gene="NEK6" /gene_synonym="SID6-1512" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:173764" misc_feature 928..999 /gene="NEK6" /gene_synonym="SID6-1512" /note="activation loop (A-loop); other site" /db_xref="CDD:173764" exon 335..453 /gene="NEK6" /gene_synonym="SID6-1512" /inference="alignment:Splign:1.39.8" variation 345 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:373043424" variation 350 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:79304695" variation 392 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:377403028" variation 411 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="c" /db_xref="dbSNP:145488745" variation 420 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:35882196" variation 439 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:140978005" exon 454..594 /gene="NEK6" /gene_synonym="SID6-1512" /inference="alignment:Splign:1.39.8" variation 468 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:116276253" variation 491 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:183673274" variation 505 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:148262318" exon 595..657 /gene="NEK6" /gene_synonym="SID6-1512" /inference="alignment:Splign:1.39.8" variation 612 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:141841414" variation 624 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:200803888" variation 633 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:150614386" variation 638 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:183711992" exon 658..768 /gene="NEK6" /gene_synonym="SID6-1512" /inference="alignment:Splign:1.39.8" variation 660 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:138847171" variation 672 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:199829118" variation 696 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:186179243" variation 704 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:370008827" variation 712 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:143094065" variation 714 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:115563387" exon 769..877 /gene="NEK6" /gene_synonym="SID6-1512" /inference="alignment:Splign:1.39.8" variation 796 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="g" /db_xref="dbSNP:11556892" variation 797 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:368466543" variation 798 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:372516510" variation 810 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:375715210" variation 836 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:200565078" variation 846 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:201692889" variation 859 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:369950028" exon 878..985 /gene="NEK6" /gene_synonym="SID6-1512" /inference="alignment:Splign:1.39.8" variation 915 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:147517890" variation 940 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:140109985" variation 948 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:144636007" variation 950 /gene="NEK6" /gene_synonym="SID6-1512" /replace="g" /replace="t" /db_xref="dbSNP:200086787" variation 954 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="c" /db_xref="dbSNP:201207004" variation 969 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:145520134" exon 986..1080 /gene="NEK6" /gene_synonym="SID6-1512" /inference="alignment:Splign:1.39.8" variation 1047 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:144397688" variation 1053 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="g" /db_xref="dbSNP:201833354" variation 1060 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:10760354" variation 1077 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:200895433" exon 1081..1194 /gene="NEK6" /gene_synonym="SID6-1512" /inference="alignment:Splign:1.39.8" variation 1104 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:142081750" variation 1119 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="g" /db_xref="dbSNP:151138282" variation 1143 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:191153129" variation 1173 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:201681080" variation 1188 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:140302963" variation 1189 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:144052872" exon 1195..2800 /gene="NEK6" /gene_synonym="SID6-1512" /inference="alignment:Splign:1.39.8" variation 1199 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:200398623" variation 1214 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:201113183" variation 1234 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="g" /db_xref="dbSNP:146443565" variation 1257 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:375270617" variation 1258 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:200235098" variation 1264 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="c" /db_xref="dbSNP:376476122" variation 1269 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:141017419" variation 1278 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:200021823" variation 1307 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:370917966" variation 1318 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:375568776" STS 1319..1469 /gene="NEK6" /gene_synonym="SID6-1512" /standard_name="RH11482" /db_xref="UniSTS:58088" variation 1319 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:201649447" variation 1422..1423 /gene="NEK6" /gene_synonym="SID6-1512" /replace="" /replace="c" /db_xref="dbSNP:36107117" variation 1508 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="g" /db_xref="dbSNP:138529813" STS 1530..1790 /gene="NEK6" /gene_synonym="SID6-1512" /standard_name="RH12239" /db_xref="UniSTS:63110" variation 1644 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:187874166" STS 1649..1798 /gene="NEK6" /gene_synonym="SID6-1512" /standard_name="SGC33089" /db_xref="UniSTS:78220" variation 1680 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:190024004" variation 1681 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:142713923" variation 1693 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:58099088" variation 1739 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:2416" variation 1748..1749 /gene="NEK6" /gene_synonym="SID6-1512" /replace="" /replace="tcaa" /db_xref="dbSNP:374990567" variation 1807 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:146937021" variation 1809 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:77933598" variation 1811 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:12555646" variation 1868 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:182662225" variation 1880 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:147972018" variation 1902 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:186630550" variation 1989 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:191474528" variation 2009 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:185386620" variation 2049 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:141687734" variation 2119 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:28687204" variation 2170 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="c" /db_xref="dbSNP:11556890" variation 2206 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="c" /db_xref="dbSNP:189086459" STS 2278..2411 /gene="NEK6" /gene_synonym="SID6-1512" /standard_name="RH77983" /db_xref="UniSTS:226" variation 2347 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="c" /db_xref="dbSNP:192831011" variation 2388 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="c" /db_xref="dbSNP:150524435" variation 2397 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="t" /db_xref="dbSNP:139595461" variation 2402 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="g" /db_xref="dbSNP:76125733" STS 2496..2733 /gene="NEK6" /gene_synonym="SID6-1512" /standard_name="RH11599" /db_xref="UniSTS:61308" STS 2519..2792 /gene="NEK6" /gene_synonym="SID6-1512" /standard_name="A006A17" /db_xref="UniSTS:68860" STS 2519..2792 /gene="NEK6" /gene_synonym="SID6-1512" /standard_name="G20648" /db_xref="UniSTS:68859" variation 2548 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:371394348" variation 2562 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:146280734" variation 2568 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:13467" variation 2570 /gene="NEK6" /gene_synonym="SID6-1512" /replace="c" /replace="t" /db_xref="dbSNP:185361860" variation 2650 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="c" /db_xref="dbSNP:377058344" variation 2701 /gene="NEK6" /gene_synonym="SID6-1512" /replace="a" /replace="g" /db_xref="dbSNP:189170661" polyA_signal 2751..2756 /gene="NEK6" /gene_synonym="SID6-1512" polyA_site 2800 /gene="NEK6" /gene_synonym="SID6-1512" ORIGIN
gggcgggcgcgcgggcgcgcgggcccgcgcaggcggtggcggcggcggcggaaccgagctgacgggcgtgcggccgctgcgccgcaaactcgtgtgggacgcaccgctccagccgcccgcgggccagcgcaccggtcccccagcggcagccgagcccgcccgcgcgccggagaagaagacacatgaattagagacagcacgggggagcaggctgtggagctgggagtgacggggtgagtccaggaaggctgcctggaggagatgcccaggagagaagtttgctgggaggcagctcatttccggcaggaggagcagagcctgccaaggcctcgagttcgtgccctcgtgaggctggcatgcaggatggcaggacagcccggccacatgccccatggagggagttccaacaacctctgccacaccctggggcctgtgcatcctcctgacccacagaggcatcccaacacgctgtcttttcgctgctcgctggcggacttccagatcgaaaagaagataggccgaggacagttcagcgaggtgtacaaggccacctgcctgctggacaggaagacagtggctctgaagaaggtgcagatctttgagatgatggacgccaaggcgaggcaggactgtgtcaaggagatcggcctcttgaagcaactgaaccacccaaatatcatcaagtatttggactcgtttatcgaagacaacgagctgaacattgtgctggagttggctgacgcaggggacctctcgcagatgatcaagtactttaagaagcagaagcggctcatcccggagaggacagtatggaagtactttgtgcagctgtgcagcgccgtggagcacatgcattcacgccgggtgatgcaccgagacatcaagcctgccaacgtgttcatcacagccacgggcgtcgtgaagctcggtgaccttggtctgggccgcttcttcagctctgagaccaccgcagcccactccctagtggggacgccctactacatgtcaccggagaggatccatgagaacggctacaacttcaagtccgacatctggtccctgggctgtctgctgtacgagatggcagccctccagagccccttctatggagataagatgaatctcttctccctgtgccagaagatcgagcagtgtgactaccccccactccccggggagcactactccgagaagttacgagaactggtcagcatgtgcatctgccctgacccccaccagagacctgacatcggatacgtgcaccaggtggccaagcagatgcacatctggatgtccagcacctgagcgtggatgcaccgtgccttatcaaagccagcaccactttgccttacttgagtcgtcttctcttcgagtggccacctggtagcctagaacagctaagaccacagggttcagcaggttccccaaaaggctgcccagccttacagcagatgctgaaggcagagcagctgagggaggggcgctggccacatgtcactgatggtcagattccaaagtcctttctttatactgttgtggacaatctcagctgggtcaataagggcaggtggttcagcgagccacggcagccccctgtatctggattgtaatgtgaatctttagggtaattcctccagtgacctgtcaaggcttatgctaacaggagacttgcaggagaccgtgtgatttgtgtagtgagcctttgaaaatggttagtaccgggttcagtttagttcttagtatcttttcaatcaagctgtgtgcttaatttactctgttgtaaagggataaagtggaaatcatttttttccgtggagtggtgattctgctaacatttttatctacgttttataacttggtgagtgacgatgagagccctgcacctggccagagtgtcacaggcaaaaggcatcgggaagcaggagcatcttcttggcagccaggctgggccatcttctcctggacacctgctgtgtaccaggaacttcgtcacctccttgaatgctggcggttcatttcatgatcagtgttaagcattttcctccatgggaaggaagcatgggatatagaaaagcgaagggctgtcctttacaaattctggttctgcaacttcctagcgtgactttgggcttgggcaagtttcttagccgttctgagccttcatttcctcatctgtacaatgagattaatagtacctatcatctaccttcaggattgctgacagacagaatttgaaataaaatatgcaagttagctaatacaaaaagtagatgatccaaaaatggtagccactcacccttcacaaactgaagtccatggaccacggaagtcgagaattaatgtacacctgtatcatgtgtaggaaaccagaaatgtgttccttatttcttgttcccaaacaggattaactgtgaagactaatttataaatgtgaacctaagaaaactccacctctgaaggaaatcatttgaattttgtttttgtacgtaaagttaaccttccaattgtctgagctgtcgtcactgacttcatgacagtctggccctccagacaagagcagcgctggcatcgggcaggtgattcctgacacctgctgcctgcaggcattcactgaccaggcctttcctggaggaaacacccagggccgggcggctgctgtttccacacgtggactcggatctgctgtgacaccgtcagcccgacagtctctccatatgcagcctttcctctgtacttttctccatggttgaaataaaacagggtgactgggagttacttagaattcatgaagattttaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:10783 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: IDA GeneID:10783 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA GeneID:10783 -> Molecular function: GO:0004871 [signal transducer activity] evidence: IMP GeneID:10783 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:10783 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA GeneID:10783 -> Molecular function: GO:0019894 [kinesin binding] evidence: IPI GeneID:10783 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI GeneID:10783 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS GeneID:10783 -> Biological process: GO:0000910 [cytokinesis] evidence: TAS GeneID:10783 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA GeneID:10783 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:10783 -> Biological process: GO:0007059 [chromosome segregation] evidence: IDA GeneID:10783 -> Biological process: GO:0007067 [mitosis] evidence: IEA GeneID:10783 -> Biological process: GO:0007077 [mitotic nuclear envelope disassembly] evidence: TAS GeneID:10783 -> Biological process: GO:0007165 [signal transduction] evidence: IMP GeneID:10783 -> Biological process: GO:0007346 [regulation of mitotic cell cycle] evidence: TAS GeneID:10783 -> Biological process: GO:0018105 [peptidyl-serine phosphorylation] evidence: IDA GeneID:10783 -> Biological process: GO:0030071 [regulation of mitotic metaphase/anaphase transition] evidence: IDA GeneID:10783 -> Biological process: GO:0031572 [G2 DNA damage checkpoint] evidence: IMP GeneID:10783 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IMP GeneID:10783 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA GeneID:10783 -> Biological process: GO:0051225 [spindle assembly] evidence: TAS GeneID:10783 -> Biological process: GO:2000772 [regulation of cellular senescence] evidence: TAS GeneID:10783 -> Cellular component: GO:0000922 [spindle pole] evidence: IEA GeneID:10783 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:10783 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:10783 -> Cellular component: GO:0005815 [microtubule organizing center] evidence: IEA GeneID:10783 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:10783 -> Cellular component: GO:0005874 [microtubule] evidence: IEA GeneID:10783 -> Cellular component: GO:0016607 [nuclear speck] evidence: IEA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001138473 -> EC 2.7.11.1
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