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2024-03-29 10:47:30, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001145001            2810 bp    mRNA    linear   PRI 18-APR-2013
DEFINITION  Homo sapiens NIMA-related kinase 6 (NEK6), transcript variant 1,
            mRNA.
ACCESSION   NM_001145001
VERSION     NM_001145001.2  GI:261244918
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2810)
  AUTHORS   Cao,X., Xia,Y., Yang,J., Jiang,J., Chen,L., Ni,R., Li,L. and Gu,Z.
  TITLE     Clinical and biological significance of never in mitosis gene
            A-related kinase 6 (NEK6) expression in hepatic cell cancer
  JOURNAL   Pathol. Oncol. Res. 18 (2), 201-207 (2012)
   PUBMED   21725899
  REMARK    GeneRIF: High Nek6 is associated with hepatic cell cancer.
REFERENCE   2  (bases 1 to 2810)
  AUTHORS   Bertran,M.T., Sdelci,S., Regue,L., Avruch,J., Caelles,C. and
            Roig,J.
  TITLE     Nek9 is a Plk1-activated kinase that controls early centrosome
            separation through Nek6/7 and Eg5
  JOURNAL   EMBO J. 30 (13), 2634-2647 (2011)
   PUBMED   21642957
  REMARK    GeneRIF: Nek9 is a Plk1-activated kinase that controls early
            centrosome separation through Nek6/7 and Eg5.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2810)
  AUTHORS   Jee,H.J., Kim,H.J., Kim,A.J., Song,N., Kim,M. and Yun,J.
  TITLE     Nek6 suppresses the premature senescence of human cancer cells
            induced by camptothecin and doxorubicin treatment
  JOURNAL   Biochem. Biophys. Res. Commun. 408 (4), 669-673 (2011)
   PUBMED   21539811
  REMARK    GeneRIF: These results suggest that the increased expression of
            Nek6 renders cancer cells resistant to premature senescence, and
            targeting Nek6 could be an efficient strategy for cancer treatment.
REFERENCE   4  (bases 1 to 2810)
  AUTHORS   Regue,L., Sdelci,S., Bertran,M.T., Caelles,C., Reverter,D. and
            Roig,J.
  TITLE     DYNLL/LC8 protein controls signal transduction through the
            Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9
  JOURNAL   J. Biol. Chem. 286 (20), 18118-18129 (2011)
   PUBMED   21454704
  REMARK    GeneRIF: DYNLL/LC8 protein controls signal transduction through the
            Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9.
REFERENCE   5  (bases 1 to 2810)
  AUTHORS   Meirelles,G.V., Silva,J.C., Mendonca Yde,A., Ramos,C.H.,
            Torriani,I.L. and Kobarg,J.
  TITLE     Human Nek6 is a monomeric mostly globular kinase with an unfolded
            short N-terminal domain
  JOURNAL   BMC Struct. Biol. 11, 12 (2011)
   PUBMED   21320329
  REMARK    GeneRIF: the first low resolution 3D structure of hNek6 protein in
            solution
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2810)
  AUTHORS   Belham,C., Comb,M.J. and Avruch,J.
  TITLE     Identification of the NIMA family kinases NEK6/7 as regulators of
            the p70 ribosomal S6 kinase
  JOURNAL   Curr. Biol. 11 (15), 1155-1167 (2001)
   PUBMED   11516946
REFERENCE   7  (bases 1 to 2810)
  AUTHORS   Kimura,M. and Okano,Y.
  TITLE     Identification and assignment of the human NIMA-related protein
            kinase 7 gene (NEK7) to human chromosome 1q31.3
  JOURNAL   Cytogenet. Cell Genet. 94 (1-2), 33-38 (2001)
   PUBMED   11701951
  REMARK    GeneRIF: Also includes phylogenetic analysis and tissue-specific
            RT-PCR of human NEK6 and NEK7.
REFERENCE   8  (bases 1 to 2810)
  AUTHORS   Kandli,M., Feige,E., Chen,A., Kilfin,G. and Motro,B.
  TITLE     Isolation and characterization of two evolutionarily conserved
            murine kinases (Nek6 and nek7) related to the fungal mitotic
            regulator, NIMA
  JOURNAL   Genomics 68 (2), 187-196 (2000)
   PUBMED   10964517
REFERENCE   9  (bases 1 to 2810)
  AUTHORS   Kobayashi,T. and Cohen,P.
  TITLE     Activation of serum- and glucocorticoid-regulated protein kinase by
            agonists that activate phosphatidylinositide 3-kinase is mediated
            by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2
  JOURNAL   Biochem. J. 339 (PT 2), 319-328 (1999)
   PUBMED   10191262
REFERENCE   10 (bases 1 to 2810)
  AUTHORS   Li,M.Z., Yu,L., Liu,Q., Chu,J.Y. and Zhao,S.Y.
  TITLE     Assignment of NEK6, a NIMA-related gene, to human chromosome 9q33.
            3-->q34.11 by radiation hybrid mapping
  JOURNAL   Cytogenet. Cell Genet. 87 (3-4), 271-272 (1999)
   PUBMED   10702691
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CF994196.1, BC004174.2,
            AL137846.24, AF087909.1 and BC012761.2.
            On Oct 10, 2009 this sequence version replaced gi:222418621.
            
            Summary: The protein encoded by this gene is a kinase required for
            progression through the metaphase portion of mitosis. Inhibition of
            the encoded protein can lead to apoptosis. This protein also can
            enhance tumorigenesis by suppressing tumor cell senescence. Several
            transcript variants encoding a few different isoforms have been
            found for this gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1 and 7
            encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004174.2 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               CF994196.1         28-127
            101-1059            BC004174.2         54-1012
            1060-1060           AL137846.24        13825-13825
            1061-1738           BC004174.2         1014-1691
            1739-1739           AF087909.1         1510-1510
            1740-2810           BC012761.2         1522-2592
FEATURES             Location/Qualifiers
     source          1..2810
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3-q34.11"
     gene            1..2810
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /note="NIMA-related kinase 6"
                     /db_xref="GeneID:10783"
                     /db_xref="HGNC:7749"
                     /db_xref="MIM:604884"
     exon            1..169
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /inference="alignment:Splign:1.39.8"
     variation       100
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11556891"
     variation       169
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112601072"
     exon            170..334
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /inference="alignment:Splign:1.39.8"
     variation       223
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200229612"
     misc_feature    235..237
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /note="upstream in-frame stop codon"
     variation       256
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199720840"
     CDS             262..1305
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative serine-threonine protein kinase;
                     serine/threonine-protein kinase Nek6; protein kinase
                     SID6-1512; nimA-related protein kinase 6; never in mitosis
                     A-related kinase 6; NIMA (never in mitosis gene a)-related
                     kinase 6"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Nek6 isoform 1"
                     /protein_id="NP_001138473.1"
                     /db_xref="GI:222418622"
                     /db_xref="CCDS:CCDS48015.1"
                     /db_xref="GeneID:10783"
                     /db_xref="HGNC:7749"
                     /db_xref="MIM:604884"
                     /translation="
MPRREVCWEAAHFRQEEQSLPRPRVRALVRLACRMAGQPGHMPHGGSSNNLCHTLGPVHPPDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRPDIGYVHQVAKQMHIWMSST
"
     misc_feature    487..1284
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinases, Never In Mitosis gene A-related kinase 6 and 7;
                     Region: STKc_Nek6_Nek7; cd08224"
                     /db_xref="CDD:173764"
     misc_feature    496..1293
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    order(514..528,538..540,577..579,583..585,679..681,
                     727..738,748..750,754..756,877..879,883..885,889..894,
                     898..900,931..933,940..942,946..948,988..999)
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /note="active site"
                     /db_xref="CDD:173764"
     misc_feature    order(514..519,523..528,538..540,577..579,583..585,
                     679..681,730..738,748..750,892..894,898..900,946..948)
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173764"
     misc_feature    order(526..528,748..750,754..756,877..879,883..885,
                     889..891,940..942,988..999)
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173764"
     misc_feature    928..999
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173764"
     exon            335..453
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /inference="alignment:Splign:1.39.8"
     variation       345
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373043424"
     variation       350
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79304695"
     variation       392
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377403028"
     variation       411
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:145488745"
     variation       420
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35882196"
     variation       439
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140978005"
     exon            454..594
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /inference="alignment:Splign:1.39.8"
     variation       468
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116276253"
     variation       491
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183673274"
     variation       505
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148262318"
     exon            595..657
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /inference="alignment:Splign:1.39.8"
     variation       612
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141841414"
     variation       624
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200803888"
     variation       633
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150614386"
     variation       638
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183711992"
     exon            658..768
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /inference="alignment:Splign:1.39.8"
     variation       660
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138847171"
     variation       672
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199829118"
     variation       696
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186179243"
     variation       704
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370008827"
     variation       712
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143094065"
     variation       714
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:115563387"
     exon            769..877
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /inference="alignment:Splign:1.39.8"
     variation       796
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11556892"
     variation       797
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368466543"
     variation       798
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372516510"
     variation       810
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375715210"
     variation       836
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200565078"
     variation       846
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201692889"
     variation       859
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369950028"
     exon            878..985
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /inference="alignment:Splign:1.39.8"
     variation       915
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147517890"
     variation       940
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140109985"
     variation       948
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144636007"
     variation       950
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200086787"
     variation       954
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201207004"
     variation       969
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145520134"
     exon            986..1080
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /inference="alignment:Splign:1.39.8"
     variation       1047
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144397688"
     variation       1053
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201833354"
     variation       1060
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:10760354"
     variation       1077
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200895433"
     exon            1081..1194
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /inference="alignment:Splign:1.39.8"
     variation       1104
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142081750"
     variation       1119
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:151138282"
     variation       1143
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191153129"
     variation       1173
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201681080"
     variation       1188
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140302963"
     variation       1189
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144052872"
     exon            1195..2800
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /inference="alignment:Splign:1.39.8"
     variation       1199
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200398623"
     variation       1214
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201113183"
     variation       1234
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146443565"
     variation       1257
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375270617"
     variation       1258
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200235098"
     variation       1264
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376476122"
     variation       1269
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141017419"
     variation       1278
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200021823"
     variation       1307
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370917966"
     variation       1318
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375568776"
     STS             1319..1469
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /standard_name="RH11482"
                     /db_xref="UniSTS:58088"
     variation       1319
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201649447"
     variation       1422..1423
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:36107117"
     variation       1508
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:138529813"
     STS             1530..1790
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /standard_name="RH12239"
                     /db_xref="UniSTS:63110"
     variation       1644
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187874166"
     STS             1649..1798
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /standard_name="SGC33089"
                     /db_xref="UniSTS:78220"
     variation       1680
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190024004"
     variation       1681
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142713923"
     variation       1693
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:58099088"
     variation       1739
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2416"
     variation       1748..1749
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace=""
                     /replace="tcaa"
                     /db_xref="dbSNP:374990567"
     variation       1807
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146937021"
     variation       1809
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77933598"
     variation       1811
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:12555646"
     variation       1868
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182662225"
     variation       1880
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147972018"
     variation       1902
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186630550"
     variation       1989
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191474528"
     variation       2009
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185386620"
     variation       2049
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141687734"
     variation       2119
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:28687204"
     variation       2170
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11556890"
     variation       2206
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:189086459"
     STS             2278..2411
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /standard_name="RH77983"
                     /db_xref="UniSTS:226"
     variation       2347
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:192831011"
     variation       2388
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:150524435"
     variation       2397
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:139595461"
     variation       2402
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:76125733"
     STS             2496..2733
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /standard_name="RH11599"
                     /db_xref="UniSTS:61308"
     STS             2519..2792
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /standard_name="A006A17"
                     /db_xref="UniSTS:68860"
     STS             2519..2792
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /standard_name="G20648"
                     /db_xref="UniSTS:68859"
     variation       2548
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371394348"
     variation       2562
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146280734"
     variation       2568
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13467"
     variation       2570
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185361860"
     variation       2650
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:377058344"
     variation       2701
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189170661"
     polyA_signal    2751..2756
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
     polyA_site      2800
                     /gene="NEK6"
                     /gene_synonym="SID6-1512"
ORIGIN      
gggcgggcgcgcgggcgcgcgggcccgcgcaggcggtggcggcggcggcggaaccgagctgacgggcgtgcggccgctgcgccgcaaactcgtgtgggacgcaccgctccagccgcccgcgggccagcgcaccggtcccccagcggcagccgagcccgcccgcgcgccggagaagaagacacatgaattagagacagcacgggggagcaggctgtggagctgggagtgacggggtgagtccaggaaggctgcctggaggagatgcccaggagagaagtttgctgggaggcagctcatttccggcaggaggagcagagcctgccaaggcctcgagttcgtgccctcgtgaggctggcatgcaggatggcaggacagcccggccacatgccccatggagggagttccaacaacctctgccacaccctggggcctgtgcatcctcctgacccacagaggcatcccaacacgctgtcttttcgctgctcgctggcggacttccagatcgaaaagaagataggccgaggacagttcagcgaggtgtacaaggccacctgcctgctggacaggaagacagtggctctgaagaaggtgcagatctttgagatgatggacgccaaggcgaggcaggactgtgtcaaggagatcggcctcttgaagcaactgaaccacccaaatatcatcaagtatttggactcgtttatcgaagacaacgagctgaacattgtgctggagttggctgacgcaggggacctctcgcagatgatcaagtactttaagaagcagaagcggctcatcccggagaggacagtatggaagtactttgtgcagctgtgcagcgccgtggagcacatgcattcacgccgggtgatgcaccgagacatcaagcctgccaacgtgttcatcacagccacgggcgtcgtgaagctcggtgaccttggtctgggccgcttcttcagctctgagaccaccgcagcccactccctagtggggacgccctactacatgtcaccggagaggatccatgagaacggctacaacttcaagtccgacatctggtccctgggctgtctgctgtacgagatggcagccctccagagccccttctatggagataagatgaatctcttctccctgtgccagaagatcgagcagtgtgactaccccccactccccggggagcactactccgagaagttacgagaactggtcagcatgtgcatctgccctgacccccaccagagacctgacatcggatacgtgcaccaggtggccaagcagatgcacatctggatgtccagcacctgagcgtggatgcaccgtgccttatcaaagccagcaccactttgccttacttgagtcgtcttctcttcgagtggccacctggtagcctagaacagctaagaccacagggttcagcaggttccccaaaaggctgcccagccttacagcagatgctgaaggcagagcagctgagggaggggcgctggccacatgtcactgatggtcagattccaaagtcctttctttatactgttgtggacaatctcagctgggtcaataagggcaggtggttcagcgagccacggcagccccctgtatctggattgtaatgtgaatctttagggtaattcctccagtgacctgtcaaggcttatgctaacaggagacttgcaggagaccgtgtgatttgtgtagtgagcctttgaaaatggttagtaccgggttcagtttagttcttagtatcttttcaatcaagctgtgtgcttaatttactctgttgtaaagggataaagtggaaatcatttttttccgtggagtggtgattctgctaacatttttatctacgttttataacttggtgagtgacgatgagagccctgcacctggccagagtgtcacaggcaaaaggcatcgggaagcaggagcatcttcttggcagccaggctgggccatcttctcctggacacctgctgtgtaccaggaacttcgtcacctccttgaatgctggcggttcatttcatgatcagtgttaagcattttcctccatgggaaggaagcatgggatatagaaaagcgaagggctgtcctttacaaattctggttctgcaacttcctagcgtgactttgggcttgggcaagtttcttagccgttctgagccttcatttcctcatctgtacaatgagattaatagtacctatcatctaccttcaggattgctgacagacagaatttgaaataaaatatgcaagttagctaatacaaaaagtagatgatccaaaaatggtagccactcacccttcacaaactgaagtccatggaccacggaagtcgagaattaatgtacacctgtatcatgtgtaggaaaccagaaatgtgttccttatttcttgttcccaaacaggattaactgtgaagactaatttataaatgtgaacctaagaaaactccacctctgaaggaaatcatttgaattttgtttttgtacgtaaagttaaccttccaattgtctgagctgtcgtcactgacttcatgacagtctggccctccagacaagagcagcgctggcatcgggcaggtgattcctgacacctgctgcctgcaggcattcactgaccaggcctttcctggaggaaacacccagggccgggcggctgctgtttccacacgtggactcggatctgctgtgacaccgtcagcccgacagtctctccatatgcagcctttcctctgtacttttctccatggttgaaataaaacagggtgactgggagttacttagaattcatgaagattttaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:10783 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: IDA
            GeneID:10783 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
            GeneID:10783 -> Molecular function: GO:0004871 [signal transducer activity] evidence: IMP
            GeneID:10783 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:10783 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
            GeneID:10783 -> Molecular function: GO:0019894 [kinesin binding] evidence: IPI
            GeneID:10783 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI
            GeneID:10783 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
            GeneID:10783 -> Biological process: GO:0000910 [cytokinesis] evidence: TAS
            GeneID:10783 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
            GeneID:10783 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:10783 -> Biological process: GO:0007059 [chromosome segregation] evidence: IDA
            GeneID:10783 -> Biological process: GO:0007067 [mitosis] evidence: IEA
            GeneID:10783 -> Biological process: GO:0007077 [mitotic nuclear envelope disassembly] evidence: TAS
            GeneID:10783 -> Biological process: GO:0007165 [signal transduction] evidence: IMP
            GeneID:10783 -> Biological process: GO:0007346 [regulation of mitotic cell cycle] evidence: TAS
            GeneID:10783 -> Biological process: GO:0018105 [peptidyl-serine phosphorylation] evidence: IDA
            GeneID:10783 -> Biological process: GO:0030071 [regulation of mitotic metaphase/anaphase transition] evidence: IDA
            GeneID:10783 -> Biological process: GO:0031572 [G2 DNA damage checkpoint] evidence: IMP
            GeneID:10783 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IMP
            GeneID:10783 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
            GeneID:10783 -> Biological process: GO:0051225 [spindle assembly] evidence: TAS
            GeneID:10783 -> Biological process: GO:2000772 [regulation of cellular senescence] evidence: TAS
            GeneID:10783 -> Cellular component: GO:0000922 [spindle pole] evidence: IEA
            GeneID:10783 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:10783 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:10783 -> Cellular component: GO:0005815 [microtubule organizing center] evidence: IEA
            GeneID:10783 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:10783 -> Cellular component: GO:0005874 [microtubule] evidence: IEA
            GeneID:10783 -> Cellular component: GO:0016607 [nuclear speck] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001138473 -> EC 2.7.11.1

by @meso_cacase at DBCLS
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