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2024-04-24 12:43:42, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001144913 2781 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens fibroblast growth factor receptor 2 (FGFR2),
transcript variant 3, mRNA.
ACCESSION NM_001144913
VERSION NM_001144913.1 GI:222144230
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2781)
AUTHORS Rinella,E.S., Shao,Y., Yackowski,L., Pramanik,S., Oratz,R.,
Schnabel,F., Guha,S., LeDuc,C., Campbell,C.L., Klugman,S.D.,
Terry,M.B., Senie,R.T., Andrulis,I.L., Daly,M., John,E.M.,
Roses,D., Chung,W.K. and Ostrer,H.
TITLE Genetic variants associated with breast cancer risk for Ashkenazi
Jewish women with strong family histories but no identifiable
BRCA1/2 mutation
JOURNAL Hum. Genet. 132 (5), 523-536 (2013)
PUBMED 23354978
REFERENCE 2 (bases 1 to 2781)
AUTHORS Zhang,K., Chu,K., Wu,X., Gao,H., Wang,J., Yuan,Y.C., Loera,S.,
Ho,K., Wang,Y., Chow,W., Un,F., Chu,P. and Yen,Y.
TITLE Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway
in high-grade liposarcoma
JOURNAL Cancer Res. 73 (4), 1298-1307 (2013)
PUBMED 23393200
REMARK GeneRIF: Data indicate that the FGFR/FRS2 signaling axis was
generally activated in about 75% of FRS2-positive high-grade
liposarcomas.
REFERENCE 3 (bases 1 to 2781)
AUTHORS Bourdeaut,F., Miquel,C., Di Rocco,F., Grison,C., Richer,W.,
Brugieres,L., Pierron,G., James,S., Baujat,G., Delattre,O. and
Collet,C.
TITLE Germline mutations in FGF receptors and medulloblastomas
JOURNAL Am. J. Med. Genet. A 161A (2), 382-385 (2013)
PUBMED 23325524
REMARK GeneRIF: FGFR2 and FGFR3 gain of function mutants might be
facilitators for oncogenic transformation in medulloblastoma.
REFERENCE 4 (bases 1 to 2781)
AUTHORS Hazan,F., Aykut,A., Unalp,A., Mese,T., Unal,N., Onay,H. and
Ozkinay,F.
TITLE Ventricular septal defect in Crouzon Syndrome: case report
JOURNAL Genet. Couns. 23 (4), 519-522 (2012)
PUBMED 23431754
REMARK GeneRIF: Crouzon Syndrome is caused by mutations in FGFR2 gene.
REFERENCE 5 (bases 1 to 2781)
AUTHORS Krakstad,C., Birkeland,E., Seidel,D., Kusonmano,K., Petersen,K.,
Mjos,S., Hoivik,E.A., Wik,E., Halle,M.K., Oyan,A.M., Kalland,K.H.,
Werner,H.M., Trovik,J. and Salvesen,H.
TITLE High-throughput mutation profiling of primary and metastatic
endometrial cancers identifies KRAS, FGFR2 and PIK3CA to be
frequently mutated
JOURNAL PLoS ONE 7 (12), E52795 (2012)
PUBMED 23300780
REMARK GeneRIF: FGFR2, KRAS and PIK3CA are frequently mutated in primary
and metastatic endometrial lesions.
REFERENCE 6 (bases 1 to 2781)
AUTHORS Dell,K.R. and Williams,L.T.
TITLE A novel form of fibroblast growth factor receptor 2. Alternative
splicing of the third immunoglobulin-like domain confers ligand
binding specificity
JOURNAL J. Biol. Chem. 267 (29), 21225-21229 (1992)
PUBMED 1400433
REFERENCE 7 (bases 1 to 2781)
AUTHORS Luqmani,Y.A., Graham,M. and Coombes,R.C.
TITLE Expression of basic fibroblast growth factor, FGFR1 and FGFR2 in
normal and malignant human breast, and comparison with other normal
tissues
JOURNAL Br. J. Cancer 66 (2), 273-280 (1992)
PUBMED 1380281
REFERENCE 8 (bases 1 to 2781)
AUTHORS Katoh,M., Hattori,Y., Sasaki,H., Tanaka,M., Sugano,K., Yazaki,Y.,
Sugimura,T. and Terada,M.
TITLE K-sam gene encodes secreted as well as transmembrane receptor
tyrosine kinase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (7), 2960-2964 (1992)
PUBMED 1313574
REFERENCE 9 (bases 1 to 2781)
AUTHORS Miki,T., Bottaro,D.P., Fleming,T.P., Smith,C.L., Burgess,W.H.,
Chan,A.M. and Aaronson,S.A.
TITLE Determination of ligand-binding specificity by alternative
splicing: two distinct growth factor receptors encoded by a single
gene
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (1), 246-250 (1992)
PUBMED 1309608
REFERENCE 10 (bases 1 to 2781)
AUTHORS Dionne,C.A., Modi,W.S., Crumley,G., O'Brien,S.J., Schlessinger,J.
and Jaye,M.
TITLE BEK, a receptor for multiple members of the fibroblast growth
factor (FGF) family, maps to human chromosome 10q25.3----q26
JOURNAL Cytogenet. Cell Genet. 60 (1), 34-36 (1992)
PUBMED 1582255
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from M97193.1, U11814.1, X56191.1,
AC009988.12 and AK026508.1.
Summary: The protein encoded by this gene is a member of the
fibroblast growth factor receptor family, where amino acid sequence
is highly conserved between members and throughout evolution. FGFR
family members differ from one another in their ligand affinities
and tissue distribution. A full-length representative protein
consists of an extracellular region, composed of three
immunoglobulin-like domains, a single hydrophobic membrane-spanning
segment and a cytoplasmic tyrosine kinase domain. The extracellular
portion of the protein interacts with fibroblast growth factors,
setting in motion a cascade of downstream signals, ultimately
influencing mitogenesis and differentiation. This particular family
member is a high-affinity receptor for acidic, basic and/or
keratinocyte growth factor, depending on the isoform. Mutations in
this gene are associated with Crouzon syndrome, Pfeiffer syndrome,
Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome,
Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome,
and syndromic craniosynostosis. Multiple alternatively spliced
transcript variants encoding different isoforms have been noted for
this gene. [provided by RefSeq, Jan 2009].
Transcript Variant: This variant (3) uses an alternate internal
in-frame coding exon (as in variant 2), and an alternate 3'
terminal exon, compared to transcript variant 1. This results in an
isoform (3) with a different, 1 aa longer protein segment in the
mid-region, and a novel shorter C-terminus, compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no quality transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments. A downstream AUG translation
start codon is selected for this RefSeq based on the presence of a
strong Kozak consensus signal, a strong community standard for the
use of the downstream start codon, and on a higher probability of
an N-terminal signal peptide being present in the resulting
protein. The use of an alternative in-frame upstream AUG start
codon would result in a protein that is 19 aa longer at the
N-terminus. Translation from the annotated downstream start codon
is likely to occur via leaky scanning and/or reinitiation.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: X56191.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
##RefSeq-Attributes-START##
CDS uses downstream in-frame AUG :: community standard (PMID:
15863034)
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-845 M97193.1 462-1306
846-1237 U11814.1 954-1345
1238-2649 X56191.1 1112-2523
2650-2651 AC009988.12 17395-17396 c
2652-2772 AK026508.1 2856-2976
2773-2781 AC009988.12 17265-17273 c
FEATURES Location/Qualifiers
source 1..2781
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q26"
gene 1..2781
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/note="fibroblast growth factor receptor 2"
/db_xref="GeneID:2263"
/db_xref="HGNC:3689"
/db_xref="MIM:176943"
exon 1..259
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/inference="alignment:Splign:1.39.8"
misc_feature 34..36
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/note="upstream in-frame stop codon"
variation 77
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="g"
/db_xref="dbSNP:4647922"
variation 90
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="g"
/replace="t"
/db_xref="dbSNP:3135721"
misc_feature 94..97
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/note="alternative translation initiation codon"
CDS 151..2460
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/EC_number="2.7.10.1"
/note="isoform 3 precursor is encoded by transcript
variant 3; hydroxyaryl-protein kinase; protein tyrosine
kinase, receptor like 14; FGF receptor; bacteria-expressed
kinase; keratinocyte growth factor receptor; soluble FGFR4
variant 4; BEK fibroblast growth factor receptor; FGFR-2"
/codon_start=1
/product="fibroblast growth factor receptor 2 isoform 3
precursor"
/protein_id="NP_001138385.1"
/db_xref="GI:222144231"
/db_xref="CCDS:CCDS44489.1"
/db_xref="GeneID:2263"
/db_xref="HGNC:3689"
/db_xref="MIM:176943"
/translation="
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI
"
sig_peptide 151..213
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 214..2457
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/product="fibroblast growth factor receptor 2 isoform 3"
misc_feature 289..522
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/note="First immunoglobulin (Ig)-like domain of fibroblast
growth factor receptor (FGFR); Region: Ig1_FGFR; cd04973"
/db_xref="CDD:143174"
misc_feature 640..894
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/note="Second immunoglobulin (Ig)-like domain of
fibroblast growth factor (FGF) receptor; Region: Ig2_FGFR;
cd05857"
/db_xref="CDD:143265"
misc_feature order(646..648,652..654,658..660)
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/note="FGF binding site [polypeptide binding]; other site"
/db_xref="CDD:143265"
misc_feature order(649..651,670..678,682..684)
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/note="ligand binding site [chemical binding]; other site"
/db_xref="CDD:143265"
misc_feature 937..1221
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 961..1224
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/note="Immunoglobulin domain; Region: Ig; cl11960"
/db_xref="CDD:213125"
misc_feature 1546..2454
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/note="Catalytic domain of the Protein Tyrosine Kinase,
Fibroblast Growth Factor Receptor 2; Region: PTKc_FGFR2;
cd05101"
/db_xref="CDD:133232"
misc_feature 1594..2424
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/note="Protein tyrosine kinase; Region: Pkinase_Tyr;
pfam07714"
/db_xref="CDD:203736"
misc_feature order(1606..1608,1612..1614,1618..1626,1636..1638,
1696..1698,1702..1704,1843..1857,1861..1863,2029..2031,
2041..2046,2050..2052,2083..2085,2137..2151,2176..2178,
2278..2280)
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/note="active site"
/db_xref="CDD:133232"
misc_feature order(1606..1608,1612..1614,1618..1623,1636..1638,
1696..1698,1843..1857,1861..1863,2050..2052,2083..2085)
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:133232"
misc_feature order(2029..2031,2041..2043,2137..2151,2176..2178,
2278..2280)
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:133232"
misc_feature 2080..2157
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/note="activation loop (A-loop); other site"
/db_xref="CDD:133232"
STS 169..801
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/standard_name="Fgfr2"
/db_xref="UniSTS:547904"
exon 260..526
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/inference="alignment:Splign:1.39.8"
variation 309
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="g"
/db_xref="dbSNP:1047102"
STS 352..470
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/standard_name="Fgfr2"
/db_xref="UniSTS:464672"
variation 444
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="g"
/db_xref="dbSNP:1047101"
exon 527..604
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/inference="alignment:Splign:1.39.8"
exon 605..774
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/inference="alignment:Splign:1.39.8"
STS 638..1006
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/standard_name="GDB:554771"
/db_xref="UniSTS:157658"
variation 707
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="c"
/replace="t"
/db_xref="dbSNP:755793"
exon 775..898
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/inference="alignment:Splign:1.39.8"
variation 846
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="g"
/db_xref="dbSNP:1047100"
exon 899..1089
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/inference="alignment:Splign:1.39.8"
variation 909
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="g"
/replace="t"
/db_xref="dbSNP:3135755"
STS 916..1131
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/standard_name="Fgfr2"
/db_xref="UniSTS:547827"
variation 1075
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="c"
/replace="t"
/db_xref="dbSNP:4647921"
exon 1090..1237
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/inference="alignment:Splign:1.39.8"
variation 1091
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="g"
/db_xref="dbSNP:3206759"
variation 1097
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="g"
/replace="t"
/db_xref="dbSNP:1129324"
variation 1099
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:1143401"
variation 1112
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="c"
/db_xref="dbSNP:1129323"
variation 1113
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="g"
/replace="t"
/db_xref="dbSNP:1129322"
variation 1121
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="t"
/db_xref="dbSNP:1129321"
variation 1123
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="c"
/db_xref="dbSNP:1129320"
variation 1131
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="g"
/db_xref="dbSNP:1143402"
variation 1140
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="g"
/db_xref="dbSNP:1129318"
variation 1148
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="c"
/db_xref="dbSNP:1047095"
variation 1152
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="c"
/replace="t"
/db_xref="dbSNP:1047090"
variation 1166
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="c"
/replace="t"
/db_xref="dbSNP:1047088"
variation 1167
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="g"
/db_xref="dbSNP:1047087"
variation 1175
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="g"
/replace="t"
/db_xref="dbSNP:1065581"
variation 1184
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="c"
/db_xref="dbSNP:1047083"
variation 1188
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="t"
/db_xref="dbSNP:1047082"
variation 1192
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="c"
/db_xref="dbSNP:1065582"
variation 1194
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="g"
/replace="t"
/db_xref="dbSNP:1047078"
variation 1199
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="t"
/db_xref="dbSNP:1047077"
variation 1203
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="c"
/replace="g"
/db_xref="dbSNP:1047076"
variation 1209
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="c"
/db_xref="dbSNP:1047074"
variation 1213
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="c"
/replace="t"
/db_xref="dbSNP:1129316"
variation 1215
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="c"
/replace="g"
/db_xref="dbSNP:1129314"
variation 1218
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="t"
/db_xref="dbSNP:1129313"
variation 1221
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="c"
/replace="t"
/db_xref="dbSNP:1129312"
exon 1238..1440
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/inference="alignment:Splign:1.39.8"
exon 1441..1592
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/inference="alignment:Splign:1.39.8"
exon 1593..1714
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/inference="alignment:Splign:1.39.8"
exon 1715..1825
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/inference="alignment:Splign:1.39.8"
exon 1826..2016
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/inference="alignment:Splign:1.39.8"
exon 2017..2139
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/inference="alignment:Splign:1.39.8"
variation 2094
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="c"
/replace="t"
/db_xref="dbSNP:35337478"
exon 2140..2210
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/inference="alignment:Splign:1.39.8"
exon 2211..2348
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/inference="alignment:Splign:1.39.8"
exon 2349..2454
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/inference="alignment:Splign:1.39.8"
variation 2442
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="c"
/replace="t"
/db_xref="dbSNP:41294229"
exon 2455..2781
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/inference="alignment:Splign:1.39.8"
STS 2522..2689
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/standard_name="GDB:335751"
/db_xref="UniSTS:156601"
variation 2530
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="c"
/replace="t"
/db_xref="dbSNP:3135816"
STS 2558..2731
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/standard_name="D1S1425"
/db_xref="UniSTS:149621"
STS 2567..2720
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/standard_name="L29953"
/db_xref="UniSTS:52164"
variation 2773
/gene="FGFR2"
/gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
JWS; K-SAM; KGFR; TK14; TK25"
/replace="a"
/replace="g"
/db_xref="dbSNP:3135817"
ORIGIN
tgactgcagcagcagcggcagcgcctcggttcctgagcccaccgcaggctgaaggcattgcgcgtagtccatgcccgtagaggaagtgtgcagatgggattaacgtccacatggagatatggaagaggaccggggattggtaccgtaaccatggtcagctggggtcgtttcatctgcctggtcgtggtcaccatggcaaccttgtccctggcccggccctccttcagtttagttgaggataccacattagagccagaagagccaccaaccaaataccaaatctctcaaccagaagtgtacgtggctgcgccaggggagtcgctagaggtgcgctgcctgttgaaagatgccgccgtgatcagttggactaaggatggggtgcacttggggcccaacaataggacagtgcttattggggagtacttgcagataaagggcgccacgcctagagactccggcctctatgcttgtactgccagtaggactgtagacagtgaaacttggtacttcatggtgaatgtcacagatgccatctcatccggagatgatgaggatgacaccgatggtgcggaagattttgtcagtgagaacagtaacaacaagagagcaccatactggaccaacacagaaaagatggaaaagcggctccatgctgtgcctgcggccaacactgtcaagtttcgctgcccagccggggggaacccaatgccaaccatgcggtggctgaaaaacgggaaggagtttaagcaggagcatcgcattggaggctacaaggtacgaaaccagcactggagcctcattatggaaagtgtggtcccatctgacaagggaaattatacctgtgtagtggagaatgaatacgggtccatcaatcacacgtaccacctggatgttgtggagcgatcgcctcaccggcccatcctccaagccggactgccggcaaatgcctccacagtggtcggaggagacgtagagtttgtctgcaaggtttacagtgatgcccagccccacatccagtggatcaagcacgtggaaaagaacggcagtaaatacgggcccgacgggctgccctacctcaaggttctcaagcactcggggataaatagttccaatgcagaagtgctggctctgttcaatgtgaccgaggcggatgctggggaatatatatgtaaggtctccaattatatagggcaggccaaccagtctgcctggctcactgtcctgccaaaacagcaagcgcctggaagagaaaaggagattacagcttccccagactacctggagatagccatttactgcataggggtcttcttaatcgcctgtatggtggtaacagtcatcctgtgccgaatgaagaacacgaccaagaagccagacttcagcagccagccggctgtgcacaagctgaccaaacgtatccccctgcggagacaggtaacagtttcggctgagtccagctcctccatgaactccaacaccccgctggtgaggataacaacacgcctctcttcaacggcagacacccccatgctggcaggggtctccgagtatgaacttccagaggacccaaaatgggagtttccaagagataagctgacactgggcaagcccctgggagaaggttgctttgggcaagtggtcatggcggaagcagtgggaattgacaaagacaagcccaaggaggcggtcaccgtggccgtgaagatgttgaaagatgatgccacagagaaagacctttctgatctggtgtcagagatggagatgatgaagatgattgggaaacacaagaatatcataaatcttcttggagcctgcacacaggatgggcctctctatgtcatagttgagtatgcctctaaaggcaacctccgagaatacctccgagcccggaggccacccgggatggagtactcctatgacattaaccgtgttcctgaggagcagatgaccttcaaggacttggtgtcatgcacctaccagctggccagaggcatggagtacttggcttcccaaaaatgtattcatcgagatttagcagccagaaatgttttggtaacagaaaacaatgtgatgaaaatagcagactttggactcgccagagatatcaacaatatagactattacaaaaagaccaccaatgggcggcttccagtcaagtggatggctccagaagccctgtttgatagagtatacactcatcagagtgatgtctggtccttcggggtgttaatgtgggagatcttcactttagggggctcgccctacccagggattcccgtggaggaactttttaagctgctgaaggaaggacacagaatggataagccagccaactgcaccaacgaactgtacatgatgatgagggactgttggcatgcagtgccctcccagagaccaacgttcaagcagttggtagaagacttggatcgaattctcactctcacaaccaatgagatctgaaagtttatggcttcattgagaaactgggaaaagttggtcaggcgcagtggctcatgcctgtaatcccagcactttgggaggccgaggcaggcggatcatgaggtcaggagttccagaccagcctggccaacatggtgaaaccctgtctctactaaagatacaaaaaattagccgggcgtgttggtgtgcacctgtaatcccagctactccgggaggctgaggcaggagagtcacttgaaccggggaggcggaggttgcagtgagccgagatcatgccattgcattccagccttggcgacagagcgagactccgtctcaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2263 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: NAS
GeneID:2263 -> Molecular function: GO:0005007 [fibroblast growth factor-activated receptor activity] evidence: IDA
GeneID:2263 -> Molecular function: GO:0005007 [fibroblast growth factor-activated receptor activity] evidence: IGI
GeneID:2263 -> Molecular function: GO:0005007 [fibroblast growth factor-activated receptor activity] evidence: NAS
GeneID:2263 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:2263 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:2263 -> Molecular function: GO:0008201 [heparin binding] evidence: IEA
GeneID:2263 -> Molecular function: GO:0017134 [fibroblast growth factor binding] evidence: IDA
GeneID:2263 -> Molecular function: GO:0017134 [fibroblast growth factor binding] evidence: IPI
GeneID:2263 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
GeneID:2263 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IPI
GeneID:2263 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: ISS
GeneID:2263 -> Biological process: GO:0001525 [angiogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0001657 [ureteric bud development] evidence: ISS
GeneID:2263 -> Biological process: GO:0001701 [in utero embryonic development] evidence: ISS
GeneID:2263 -> Biological process: GO:0002053 [positive regulation of mesenchymal cell proliferation] evidence: ISS
GeneID:2263 -> Biological process: GO:0003148 [outflow tract septum morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0003149 [membranous septum morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:2263 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
GeneID:2263 -> Biological process: GO:0007267 [cell-cell signaling] evidence: ISS
GeneID:2263 -> Biological process: GO:0007409 [axonogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0007528 [neuromuscular junction development] evidence: IEA
GeneID:2263 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IDA
GeneID:2263 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IGI
GeneID:2263 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IMP
GeneID:2263 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IEA
GeneID:2263 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: TAS
GeneID:2263 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: IDA
GeneID:2263 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: IGI
GeneID:2263 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: IPI
GeneID:2263 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
GeneID:2263 -> Biological process: GO:0008589 [regulation of smoothened signaling pathway] evidence: ISS
GeneID:2263 -> Biological process: GO:0009791 [post-embryonic development] evidence: ISS
GeneID:2263 -> Biological process: GO:0009880 [embryonic pattern specification] evidence: ISS
GeneID:2263 -> Biological process: GO:0009887 [organ morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0010453 [regulation of cell fate commitment] evidence: ISS
GeneID:2263 -> Biological process: GO:0010518 [positive regulation of phospholipase activity] evidence: IMP
GeneID:2263 -> Biological process: GO:0016331 [morphogenesis of embryonic epithelium] evidence: ISS
GeneID:2263 -> Biological process: GO:0018108 [peptidyl-tyrosine phosphorylation] evidence: IDA
GeneID:2263 -> Biological process: GO:0021769 [orbitofrontal cortex development] evidence: ISS
GeneID:2263 -> Biological process: GO:0021847 [ventricular zone neuroblast division] evidence: ISS
GeneID:2263 -> Biological process: GO:0021860 [pyramidal neuron development] evidence: ISS
GeneID:2263 -> Biological process: GO:0022612 [gland morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0030177 [positive regulation of Wnt receptor signaling pathway] evidence: ISS
GeneID:2263 -> Biological process: GO:0030282 [bone mineralization] evidence: ISS
GeneID:2263 -> Biological process: GO:0030324 [lung development] evidence: ISS
GeneID:2263 -> Biological process: GO:0030855 [epithelial cell differentiation] evidence: ISS
GeneID:2263 -> Biological process: GO:0030901 [midbrain development] evidence: ISS
GeneID:2263 -> Biological process: GO:0030916 [otic vesicle formation] evidence: ISS
GeneID:2263 -> Biological process: GO:0031069 [hair follicle morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0032808 [lacrimal gland development] evidence: ISS
GeneID:2263 -> Biological process: GO:0033688 [regulation of osteoblast proliferation] evidence: TAS
GeneID:2263 -> Biological process: GO:0035264 [multicellular organism growth] evidence: ISS
GeneID:2263 -> Biological process: GO:0035265 [organ growth] evidence: ISS
GeneID:2263 -> Biological process: GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow] evidence: ISS
GeneID:2263 -> Biological process: GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow] evidence: ISS
GeneID:2263 -> Biological process: GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development] evidence: ISS
GeneID:2263 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
GeneID:2263 -> Biological process: GO:0040014 [regulation of multicellular organism growth] evidence: ISS
GeneID:2263 -> Biological process: GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway] evidence: ISS
GeneID:2263 -> Biological process: GO:0042472 [inner ear morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0042476 [odontogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0043410 [positive regulation of MAPK cascade] evidence: IMP
GeneID:2263 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:2263 -> Biological process: GO:0045165 [cell fate commitment] evidence: ISS
GeneID:2263 -> Biological process: GO:0045667 [regulation of osteoblast differentiation] evidence: TAS
GeneID:2263 -> Biological process: GO:0045787 [positive regulation of cell cycle] evidence: ISS
GeneID:2263 -> Biological process: GO:0045839 [negative regulation of mitosis] evidence: IEA
GeneID:2263 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: ISS
GeneID:2263 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
GeneID:2263 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:2263 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: TAS
GeneID:2263 -> Biological process: GO:0048286 [lung alveolus development] evidence: ISS
GeneID:2263 -> Biological process: GO:0048489 [synaptic vesicle transport] evidence: IEA
GeneID:2263 -> Biological process: GO:0048557 [embryonic digestive tract morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0048562 [embryonic organ morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0048565 [digestive tract development] evidence: ISS
GeneID:2263 -> Biological process: GO:0048568 [embryonic organ development] evidence: ISS
GeneID:2263 -> Biological process: GO:0048608 [reproductive structure development] evidence: ISS
GeneID:2263 -> Biological process: GO:0048701 [embryonic cranial skeleton morphogenesis] evidence: IMP
GeneID:2263 -> Biological process: GO:0048705 [skeletal system morphogenesis] evidence: TAS
GeneID:2263 -> Biological process: GO:0048730 [epidermis morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0048755 [branching morphogenesis of a nerve] evidence: ISS
GeneID:2263 -> Biological process: GO:0048762 [mesenchymal cell differentiation] evidence: ISS
GeneID:2263 -> Biological process: GO:0050679 [positive regulation of epithelial cell proliferation] evidence: ISS
GeneID:2263 -> Biological process: GO:0051150 [regulation of smooth muscle cell differentiation] evidence: ISS
GeneID:2263 -> Biological process: GO:0051781 [positive regulation of cell division] evidence: ISS
GeneID:2263 -> Biological process: GO:0055010 [ventricular cardiac muscle tissue morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0060045 [positive regulation of cardiac muscle cell proliferation] evidence: ISS
GeneID:2263 -> Biological process: GO:0060174 [limb bud formation] evidence: ISS
GeneID:2263 -> Biological process: GO:0060348 [bone development] evidence: ISS
GeneID:2263 -> Biological process: GO:0060349 [bone morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0060365 [coronal suture morphogenesis] evidence: IEA
GeneID:2263 -> Biological process: GO:0060442 [branching involved in prostate gland morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0060445 [branching involved in salivary gland morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0060449 [bud elongation involved in lung branching] evidence: ISS
GeneID:2263 -> Biological process: GO:0060463 [lung lobe morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0060484 [lung-associated mesenchyme development] evidence: ISS
GeneID:2263 -> Biological process: GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0060512 [prostate gland morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0060523 [prostate epithelial cord elongation] evidence: ISS
GeneID:2263 -> Biological process: GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development] evidence: ISS
GeneID:2263 -> Biological process: GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification] evidence: ISS
GeneID:2263 -> Biological process: GO:0060601 [lateral sprouting from an epithelium] evidence: ISS
GeneID:2263 -> Biological process: GO:0060615 [mammary gland bud formation] evidence: ISS
GeneID:2263 -> Biological process: GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0060667 [branch elongation involved in salivary gland morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0060670 [branching involved in labyrinthine layer morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0060687 [regulation of branching involved in prostate gland morphogenesis] evidence: ISS
GeneID:2263 -> Biological process: GO:0060688 [regulation of morphogenesis of a branching structure] evidence: ISS
GeneID:2263 -> Biological process: GO:0060915 [mesenchymal cell differentiation involved in lung development] evidence: ISS
GeneID:2263 -> Biological process: GO:0060916 [mesenchymal cell proliferation involved in lung development] evidence: ISS
GeneID:2263 -> Biological process: GO:0061031 [endodermal digestive tract morphogenesis] evidence: IEA
GeneID:2263 -> Biological process: GO:0070307 [lens fiber cell development] evidence: IEA
GeneID:2263 -> Biological process: GO:0070372 [regulation of ERK1 and ERK2 cascade] evidence: ISS
GeneID:2263 -> Biological process: GO:0070374 [positive regulation of ERK1 and ERK2 cascade] evidence: ISS
GeneID:2263 -> Biological process: GO:0090263 [positive regulation of canonical Wnt receptor signaling pathway] evidence: ISS
GeneID:2263 -> Cellular component: GO:0005576 [extracellular region] evidence: IEA
GeneID:2263 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:2263 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:2263 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IEA
GeneID:2263 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:2263 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:2263 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: IDA
GeneID:2263 -> Cellular component: GO:0005938 [cell cortex] evidence: IDA
GeneID:2263 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
GeneID:2263 -> Cellular component: GO:0016020 [membrane] evidence: NAS
GeneID:2263 -> Cellular component: GO:0016021 [integral to membrane] evidence: NAS
GeneID:2263 -> Cellular component: GO:0016023 [cytoplasmic membrane-bounded vesicle] evidence: IEA
GeneID:2263 -> Cellular component: GO:0031012 [extracellular matrix] evidence: IDA
GeneID:2263 -> Cellular component: GO:0060076 [excitatory synapse] evidence: ISS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001138385 -> EC 2.7.10.1
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.