2024-04-20 04:45:08, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001144071 1990 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens lactate dehydrogenase A-like 6A (LDHAL6A), transcript variant 2, mRNA. ACCESSION NM_001144071 VERSION NM_001144071.1 GI:221136808 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1990) AUTHORS Chen,X., Gu,X., Shan,Y., Tang,W., Yuan,J., Zhong,Z., Wang,Y., Huang,W., Wan,B. and Yu,L. TITLE Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA) JOURNAL Mol. Biol. Rep. 36 (4), 669-676 (2009) PUBMED 18351441 REMARK GeneRIF: expression of LDHAL6A was able to activate transcriptional activities of AP1(PMA) COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY581313.1 and AC027544.11. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The extent of this RefSeq transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AY581313.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025085 [ECO:0000348] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1713 AY581313.1 1-1713 1714-1990 AC027544.11 136287-136563 c FEATURES Location/Qualifiers source 1..1990 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="11" /map="11p15.1" gene 1..1990 /gene="LDHAL6A" /gene_synonym="LDH6A" /note="lactate dehydrogenase A-like 6A" /db_xref="GeneID:160287" /db_xref="HGNC:28335" exon 1..252 /gene="LDHAL6A" /gene_synonym="LDH6A" /inference="alignment:Splign:1.39.8" variation 23 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:114199578" variation 39 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="" /replace="ctcacacctgccaagca" /db_xref="dbSNP:78891727" variation 40..71 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="" /replace="tcacacctgccaagcatcacacctgccaagca" /db_xref="dbSNP:11274769" variation 40..55 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="" /replace="tcacacctgccaagca" /db_xref="dbSNP:140456495" variation 40..41 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="" /replace="tcacacctgccaagca" /db_xref="dbSNP:72394738" variation 98..113 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="" /replace="caagcatcacacctgc" /db_xref="dbSNP:34981749" variation 117 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="g" /replace="t" /db_xref="dbSNP:191237886" variation 161 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:114842693" misc_feature 250..252 /gene="LDHAL6A" /gene_synonym="LDH6A" /note="upstream in-frame stop codon" exon 253..387 /gene="LDHAL6A" /gene_synonym="LDH6A" /inference="alignment:Splign:1.39.8" CDS 262..1260 /gene="LDHAL6A" /gene_synonym="LDH6A" /EC_number="1.1.1.27" /codon_start=1 /product="L-lactate dehydrogenase A-like 6A" /protein_id="NP_001137543.1" /db_xref="GI:221136809" /db_xref="CCDS:CCDS7841.1" /db_xref="GeneID:160287" /db_xref="HGNC:28335" /translation="
MATIKSELIKNFAEEEAIHHNKISIVGTGSVGVACAISILLKGLSDELVLVDVDEGKLKGETMDLQHGSPFMKMPNIVSSKDYLVTANSNLVIITAGARQKKGETRLDLVQRNVSIFKLMIPNITQYSPHCKLLIVTNPVDILTYVAWKLSGFPKNRVIGSGCNLDSARFRYFIGQRLGIHSESCHGLILGEHGDSSVPVWSGVNIAGVPLKDLNPDIGTDKDPEQWENVHKKVISSGYEMVKMKGYTSWGISLSVADLTESILKNLRRVHPVSTLSKGLYGINEDIFLSVPCILGENGITDLIKVKLTLEEEACLQKSAETLWEIQKELKL
" misc_feature 316..1248 /gene="LDHAL6A" /gene_synonym="LDH6A" /note="A subgroup of L-lactate dehydrogenases; Region: LDH_1; cd05293" /db_xref="CDD:133429" misc_feature order(319..321,802..804,811..813,817..819,868..870, 883..885,1054..1062,1069..1071,1150..1155,1162..1164, 1168..1176) /gene="LDHAL6A" /gene_synonym="LDH6A" /note="tetramer (dimer of dimers) interface [polypeptide binding]; other site" /db_xref="CDD:133429" misc_feature 334..1236 /gene="LDHAL6A" /gene_synonym="LDH6A" /note="L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771" /db_xref="CDD:162525" misc_feature order(346..354,415..417,421..423,430..432,544..558, 667..669,673..675,742..744,754..756,838..840,1003..1005, 1015..1017) /gene="LDHAL6A" /gene_synonym="LDH6A" /note="NAD binding site [chemical binding]; other site" /db_xref="CDD:133429" misc_feature order(358..360,373..375,439..444,451..453,457..462, 766..768,772..777,793..795,991..996,1003..1014) /gene="LDHAL6A" /gene_synonym="LDH6A" /note="dimer interface [polypeptide binding]; other site" /db_xref="CDD:133429" misc_feature order(559..561,577..579,673..675,766..768,838..840, 973..975,1003..1005) /gene="LDHAL6A" /gene_synonym="LDH6A" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:133429" variation 355 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:146582410" variation 365 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="g" /replace="t" /db_xref="dbSNP:74544982" variation 382 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:367569227" exon 388..505 /gene="LDHAL6A" /gene_synonym="LDH6A" /inference="alignment:Splign:1.39.8" variation 409..410 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="" /replace="c" /db_xref="dbSNP:34699662" variation 433 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:7944726" variation 447 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:201032245" variation 450 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:199596094" variation 495 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:376050195" variation 498 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:142180872" exon 506..679 /gene="LDHAL6A" /gene_synonym="LDH6A" /inference="alignment:Splign:1.39.8" variation 514 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:200482205" variation 522 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="c" /db_xref="dbSNP:151221005" variation 525 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:372673468" variation 540 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:370520407" variation 544 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:201546904" variation 553 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:191515075" variation 556 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:201761125" variation 563 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="t" /db_xref="dbSNP:377608686" variation 577 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:370995438" variation 578 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:375489223" variation 595 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="c" /replace="t" /db_xref="dbSNP:200655858" variation 596 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="g" /replace="t" /db_xref="dbSNP:140413894" variation 618 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:371751789" variation 627 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="g" /db_xref="dbSNP:17851143" variation 644 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="g" /db_xref="dbSNP:373597180" variation 654 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="c" /db_xref="dbSNP:147549455" variation 679 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="g" /replace="t" /db_xref="dbSNP:183694454" exon 680..853 /gene="LDHAL6A" /gene_synonym="LDH6A" /inference="alignment:Splign:1.39.8" variation 681 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:376670096" variation 683 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:369291120" variation 690 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:369992228" variation 691 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:201969214" variation 696 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:116849705" variation 730 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:183567890" variation 732 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:141979925" variation 745 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="g" /replace="t" /db_xref="dbSNP:200811138" variation 766 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:368803699" variation 773 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:201642140" variation 839 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:377599611" exon 854..971 /gene="LDHAL6A" /gene_synonym="LDH6A" /inference="alignment:Splign:1.39.8" variation 871 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:375445135" variation 886 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:138755561" variation 900 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:200442279" variation 906 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:368556136" variation 914 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:202093514" variation 927 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:17851142" variation 929 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:138196216" variation 933 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:372150746" variation 934 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:377251361" variation 959 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:200453586" exon 972..1095 /gene="LDHAL6A" /gene_synonym="LDH6A" /inference="alignment:Splign:1.39.8" variation 979 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="g" /replace="t" /db_xref="dbSNP:79046871" variation 1002 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:149614577" variation 1036 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="g" /replace="t" /db_xref="dbSNP:371236559" variation 1052 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:371937075" variation 1060 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="g" /db_xref="dbSNP:138767324" variation 1083 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:375209572" exon 1096..1990 /gene="LDHAL6A" /gene_synonym="LDH6A" /inference="alignment:Splign:1.39.8" variation 1100 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="t" /db_xref="dbSNP:377560889" variation 1111 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="c" /db_xref="dbSNP:200783360" variation 1125 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:139641299" variation 1133 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="g" /replace="t" /db_xref="dbSNP:368993414" variation 1149 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:200836175" variation 1170 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:148353833" variation 1189 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:141551192" variation 1219 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="g" /db_xref="dbSNP:376455589" variation 1263 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:370546421" variation 1267 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="g" /replace="t" /db_xref="dbSNP:375280540" variation 1274 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:368910048" variation 1284 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="g" /db_xref="dbSNP:370149686" variation 1339 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:190066498" variation 1426 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:369461772" variation 1474 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="t" /db_xref="dbSNP:12421784" variation 1492 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:182336176" variation 1691 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:144268003" variation 1723 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="t" /db_xref="dbSNP:113924399" variation 1730 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:377688986" variation 1738 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:16935458" variation 1766 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:376119316" variation 1800 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:146552421" variation 1803 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="g" /db_xref="dbSNP:60836865" variation 1834..1838 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="" /replace="ttctt" /db_xref="dbSNP:112124648" variation 1837..1841 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="" /replace="ttttc" /db_xref="dbSNP:377563071" variation 1923..1924 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="" /replace="ta" /db_xref="dbSNP:144308288" variation 1932..1933 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="" /replace="ac" /db_xref="dbSNP:149139443" variation 1932 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="t" /db_xref="dbSNP:201745693" variation 1933..1934 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="" /replace="ac" /replace="ca" /db_xref="dbSNP:199499866" variation 1946 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="c" /replace="g" /db_xref="dbSNP:12419360" variation 1955 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="a" /replace="c" /db_xref="dbSNP:149128370" variation 1966..1967 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="" /replace="aaca" /db_xref="dbSNP:371575274" variation 1982 /gene="LDHAL6A" /gene_synonym="LDH6A" /replace="g" /replace="t" /db_xref="dbSNP:2658557" ORIGIN
agaggcgcaggcgcggtgcttcgcagcccgcttccggcctcacacctgccaagcatcacacctgccaagcatcacacctgccaagcatcacacctgccaagcatcacacctgcgatgcctgcacgagctgggtgcggtccgcgcagctgcagtaagggggcgacccggcgtctgttagtcggcggttcatctccttcgtgcctcgatgagctttaacgccattttcctccattctctttcttcacctcttgagtttccaagatggcaactatcaagagtgaacttattaagaatttcgcggaagaggaggccattcatcacaataagatctccattgtaggaactggatcggttggtgtggcttgtgctatcagcatcttattaaaaggtttgagtgatgaacttgtccttgtggatgttgatgaaggcaaactgaagggtgagacaatggatcttcaacatggcagcccttttatgaaaatgccaaatattgtctccagcaaagattacctggtcactgcaaactccaatctagtgattatcacagcaggtgcacgccagaaaaaaggagaaacacgccttgatttagtccagcgaaatgtatccatctttaaattaatgattcccaatattacccagtacagtcctcactgcaaactgcttattgttactaatccagtggatatcttaacttatgtagcctggaagttgagtggatttcccaaaaaccgtgttattggaagtggttgtaatctggactctgctcgttttcgttactttattgggcaaaggcttggcatccactctgaaagctgtcatgggctgatccttggagagcatggcgactcaagtgttcctgtgtggagtggtgtgaacattgctggcgtccctctgaaggatctgaacccagatataggaactgataaagatcctgagcagtgggaaaatgtccacaaaaaagtgatttccagtggctatgagatggtcaaaatgaaaggttatacttcttggggcattagcctatctgtagctgatttaacagaaagtattttgaagaatcttaggagagtgcatccagtttctaccctaagtaagggcctctatggaataaatgaagacatattccttagtgtcccatgtatcctgggagagaatggtatcacagacctcataaaagtaaaactgactcttgaagaggaggcctgcttgcaaaagagtgcagaaacactttgggaaattcagaaggagctcaagctttaaagttgcttaaagctaattctgtagattgaagatgaaatagtagttatggaattgtatatgtcaaacttttgaataaatttgaatttctaaaagttggaaaaatagaggaaagagtgacctatttagtatagccttccagcttttttttttttcttttttgggagggtctcattctgtcacccaggctggagtgcagtggcacaatcatggctcactgcaaccttgacctcccgagctcaggtgagcctcccacttcagcctccagagtaggtgggaccacatgcgtgtgcctccatgcctgcctaatttttgtatctttttgtagagatggggttttgccatgtcatccaagctggttttgaactcccaaagtgctgagattacaggggtgagccactgtgcctggccttagctttgatttagtatccagatgatagatgacacttttttttttttttttttaaagtgacggcatcaaagatgtttttggtacttctcagtacttgccttgtatgtatacgtaattgccatctggtccacaagaatgtgtttactgtgttacacaaatcctgattcttttcatcaggtgcatagtaattcttctctatggcttaatacctatgttcatttacatgctatctctacaatgtaaaaataaaagtgtatatatatacacacacacacagagagtaatctaaatgttcctaacactagataaaacattgatttg
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:160287 -> Molecular function: GO:0004459 [L-lactate dehydrogenase activity] evidence: IEA GeneID:160287 -> Biological process: GO:0006096 [glycolysis] evidence: IEA GeneID:160287 -> Biological process: GO:0044262 [cellular carbohydrate metabolic process] evidence: IEA GeneID:160287 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001137543 -> EC 1.1.1.27
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.