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2019-03-20 11:56:27, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001144033            2020 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens stomatin (EPB72)-like 3 (STOML3), transcript variant
            2, mRNA.
ACCESSION   NM_001144033
VERSION     NM_001144033.1  GI:221316743
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2020)
  AUTHORS   Nagaishi,M., Kim,Y.H., Mittelbronn,M., Giangaspero,F., Paulus,W.,
            Brokinkel,B., Vital,A., Tanaka,Y., Nakazato,Y., Legras-Lachuer,C.,
            Lachuer,J. and Ohgaki,H.
  TITLE     Amplification of the STOML3, FREM2, and LHFP genes is associated
            with mesenchymal differentiation in gliosarcoma
  JOURNAL   Am. J. Pathol. 180 (5), 1816-1823 (2012)
   PUBMED   22538188
  REMARK    GeneRIF: Amplification of the STOML3 gene is associated with
            mesenchymal differentiation in gliosarcoma.
REFERENCE   2  (bases 1 to 2020)
  AUTHORS   Zabaneh,D. and Balding,D.J.
  TITLE     A genome-wide association study of the metabolic syndrome in Indian
            Asian men
  JOURNAL   PLoS ONE 5 (8), E11961 (2010)
   PUBMED   20694148
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2020)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   4  (bases 1 to 2020)
  AUTHORS   Kobayakawa,K., Hayashi,R., Morita,K., Miyamichi,K., Oka,Y.,
            Tsuboi,A. and Sakano,H.
  TITLE     Stomatin-related olfactory protein, SRO, specifically expressed in
            the murine olfactory sensory neurons
  JOURNAL   J. Neurosci. 22 (14), 5931-5937 (2002)
   PUBMED   12122055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK304159.1, DB200356.1, BC025760.1 and BM982114.1.
            
            Transcript Variant: This variant (2) contains an additional
            in-frame coding exon compared to transcript variant 1. This results
            in translation initiation from a downstream AUG found in this novel
            exon, and a shorter isoform (2) with a distinct N-terminus compared
            to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK304159.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AK304159.1         1-28
            29-485              DB200356.1         8-464
            486-1211            AK304159.1         486-1211
            1212-1469           BC025760.1         1115-1372
            1470-1662           BM982114.1         354-546             c
            1663-2020           BC025760.1         1565-1922
FEATURES             Location/Qualifiers
     source          1..2020
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q13.3"
     gene            1..2020
                     /gene="STOML3"
                     /gene_synonym="Epb7.2l; SRO"
                     /note="stomatin (EPB72)-like 3"
                     /db_xref="GeneID:161003"
                     /db_xref="HGNC:19420"
                     /db_xref="MIM:608327"
     exon            1..190
                     /gene="STOML3"
                     /gene_synonym="Epb7.2l; SRO"
                     /inference="alignment:Splign:1.39.8"
     exon            191..274
                     /gene="STOML3"
                     /gene_synonym="Epb7.2l; SRO"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    235..237
                     /gene="STOML3"
                     /gene_synonym="Epb7.2l; SRO"
                     /note="upstream in-frame stop codon"
     CDS             250..1098
                     /gene="STOML3"
                     /gene_synonym="Epb7.2l; SRO"
                     /note="isoform 2 is encoded by transcript variant 2;
                     stomatin-like protein 3; erythrocyte band 7 integral
                     membrane protein; protein 7.2B; SLP-3"
                     /codon_start=1
                     /product="stomatin-like protein 3 isoform 2"
                     /protein_id="NP_001137505.1"
                     /db_xref="GI:221316744"
                     /db_xref="CCDS:CCDS45040.1"
                     /db_xref="GeneID:161003"
                     /db_xref="HGNC:19420"
                     /db_xref="MIM:608327"
                     /translation="
MNSRGELVGVNNKRLGVCGWILFSLSFLLVIITFPISIWMCLKIIKEYERAVVFRLGRIQADKAKGPGLILVLPCIDVFVKVDLRTVTCNIPPQEILTRDSVTTQVDGVVYYRIYSAVSAVANVNDVHQATFLLAQTTLRNVLGTQTLSQILAGREEIAHSIQTLLDDATELWGIRVARVEIKDVRIPVQLQRSMAAEAEATREARAKVLAAEGEMNASKSLKSASMVLAESPIALQLRYLQTLSTVATEKNSTIVFPLPMNILEGIGGVSYDNHKKLPNKA
"
     misc_feature    337..>903
                     /gene="STOML3"
                     /gene_synonym="Epb7.2l; SRO"
                     /note="Membrane protease subunits, stomatin/prohibitin
                     homologs [Posttranslational modification, protein
                     turnover, chaperones]; Region: HflC; COG0330"
                     /db_xref="CDD:30678"
     misc_feature    382..1029
                     /gene="STOML3"
                     /gene_synonym="Epb7.2l; SRO"
                     /note="Band_7_stomatin_like: A subgroup of the band 7
                     domain of flotillin (reggie) like proteins similar to
                     stomatin and podicin (two lipid raft-associated integral
                     membrane proteins). Individual proteins of this band 7
                     domain family may cluster to form...; Region:
                     Band_7_stomatin_like; cd03403"
                     /db_xref="CDD:48215"
     exon            275..378
                     /gene="STOML3"
                     /gene_synonym="Epb7.2l; SRO"
                     /inference="alignment:Splign:1.39.8"
     exon            379..451
                     /gene="STOML3"
                     /gene_synonym="Epb7.2l; SRO"
                     /inference="alignment:Splign:1.39.8"
     exon            452..534
                     /gene="STOML3"
                     /gene_synonym="Epb7.2l; SRO"
                     /inference="alignment:Splign:1.39.8"
     exon            535..738
                     /gene="STOML3"
                     /gene_synonym="Epb7.2l; SRO"
                     /inference="alignment:Splign:1.39.8"
     exon            739..873
                     /gene="STOML3"
                     /gene_synonym="Epb7.2l; SRO"
                     /inference="alignment:Splign:1.39.8"
     exon            874..1998
                     /gene="STOML3"
                     /gene_synonym="Epb7.2l; SRO"
                     /inference="alignment:Splign:1.39.8"
     variation       1470
                     /gene="STOML3"
                     /gene_synonym="Epb7.2l; SRO"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:66601384"
     polyA_site      1998
                     /gene="STOML3"
                     /gene_synonym="Epb7.2l; SRO"
ORIGIN      
aaagagaaggaatgtctttcactctctcatactttctcctctcccctctcccaagcacatctgagttgctgcctgttcttcacacttagctccaaacccatgaaaaattgccaagtataaaagcttctcaagaatgagatggattctagggtgtcttcacctgagaagcaagataaagagaatttcgtggcacgtctattacctaatggagctgagcctcatgtgcacgtgtaatgatgcaagggcttgatgaactccagaggcgagcttgtaggtgtcaacaataaacggcttggtgtatgtggctggatcctgttttccctctctttcctgttggtgatcattaccttccccatctccatatggatgtgcttgaagatcattaaggagtatgaacgtgctgttgtattccgtctgggacgcatccaagctgacaaagccaaggggccaggtttgatcctggtcctgccatgcatagatgtgtttgtcaaagttgacctccgaacagttacttgcaacattcctccacaagagatcctcaccagagactccgtaactactcaggtagatggagttgtctattacagaatctatagtgctgtctcagcagtggctaatgtcaacgatgtccatcaagcaacatttctgctggctcaaaccactctgagaaatgtcttagggacacagaccttgtcccagatcttagctggacgagaagagatcgcccatagcatccagactttacttgatgatgccaccgaactgtgggggatccgggtggcccgagtggaaatcaaagatgttcggattcccgtgcagttgcagagatccatggcagccgaggctgaggccacccgggaagcgagagccaaggtccttgcagctgaaggagaaatgaatgcttccaaatccctgaagtcagcctccatggtgctggctgagtctcccatagctctccagctgcgctacctgcagaccttgagcacggtagccaccgagaagaattctacgattgtgtttcctctgcccatgaatatactagagggcattggtggcgtcagctatgataaccacaagaagcttccaaataaagcctgaggtcctcttgcggtagtcagctattgcatagagagtggtgtctattcctatggagaagccagtagttagaaacggtgagaattccaacactgttcatgtaacagtaactccatagatggaagagcattggcaggaaaaagctctagaggctatacagagaagaaaaaaagagcaaaaatgagacctgtatattacttttatttttaggaccataatcaactttgtaatattcttatataattaattagtggtggtctccgactttatagcaggaactttctggtagtatgagaagaaatcattgggtgactatgactaatgtttcagaattactttttaattgttttaaaaagcactccagataatttatagagtaacataggcctcatatttacactatatgttcgctttataattccgaagttgttatttgctaaatctccaatggttgcaatcaaaccccacaatgctgaaaacagagattgattttgatgttaagaacaaaagaagtatggaaacttccaggctcaaacatgtcccccgtgccacaaggcaaactgcgatgagctcacagtccaggtctcttgctgtgtgtcctgcagggagtggccaactctccaccttccagcaccattatcagagggtgggaaaaggcacatgaaagtggccagctcctgtcaatttatttgcttacaagggagaatgcttggaaaggttgcattggttgaaaccactgaggagcatcaccctggggatttcatgttttcactctgttcttagtcccaggagccacaggtaatcgagaatgtttgtgaactctatccacatcccctcccccacctgccaaataacctgttcaaaacaaagaaggcatagaatataaatgaatttcaaaagttaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:161003 -> Biological process: GO:0007165 [signal transduction] evidence: IEA
            GeneID:161003 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
            GeneID:161003 -> Cellular component: GO:0005929 [cilium] evidence: IEA
            GeneID:161003 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
            GeneID:161003 -> Cellular component: GO:0045121 [membrane raft] evidence: IEA

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