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2020-10-26 19:23:56, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001144               3631 bp    mRNA    linear   PRI 19-MAY-2013
DEFINITION  Homo sapiens autocrine motility factor receptor, E3 ubiquitin
            protein ligase (AMFR), mRNA.
ACCESSION   NM_001144
VERSION     NM_001144.5  GI:378744169
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3631)
  AUTHORS   Liu,S., Chen,Y., Li,J., Huang,T., Tarasov,S., King,A.,
            Weissman,A.M., Byrd,R.A. and Das,R.
  TITLE     Promiscuous interactions of gp78 E3 ligase CUE domain with
            polyubiquitin chains
  JOURNAL   Structure 20 (12), 2138-2150 (2012)
   PUBMED   23123110
  REMARK    GeneRIF: The GP78 CUE domain functions to both facilitate substrate
            binding and enable switching between adjacent ubiquitin molecules
            of a growing chain to enable processivity in ubiquitination.
REFERENCE   2  (bases 1 to 3631)
  AUTHORS   Chen,Z., Du,S. and Fang,S.
  TITLE     gp78: a multifaceted ubiquitin ligase that integrates a unique
            protein degradation pathway from the endoplasmic reticulum
  JOURNAL   Curr. Protein Pept. Sci. 13 (5), 414-424 (2012)
   PUBMED   22812524
  REMARK    GeneRIF: This review summarizes the structure and function of GP78,
            and its importance in both physiological and pathological
            processes.[review]
            Review article
REFERENCE   3  (bases 1 to 3631)
  AUTHORS   St-Pierre,P., Dang,T., Joshi,B. and Nabi,I.R.
  TITLE     Peripheral endoplasmic reticulum localization of the Gp78 ubiquitin
            ligase activity
  JOURNAL   J. Cell. Sci. 125 (PT 7), 1727-1737 (2012)
   PUBMED   22328510
  REMARK    GeneRIF: Delivery of ubiquitylated substrate to the central ER was
            regulated by ubiquitin chain elongation and opposing actions of
            gp78 CUE domain interactions and p97 recruitment.
REFERENCE   4  (bases 1 to 3631)
  AUTHORS   Grund,S., Olsson,B., Jernas,M., Jacobsson,S., Swolin,B., Nabi,I.R.,
            Carlsson,L. and Wadenvik,H.
  TITLE     The autocrine motility factor receptor is overexpressed on the
            surface of B cells in Binet C chronic lymphocytic leukemia
  JOURNAL   Med. Oncol. 28 (4), 1542-1548 (2011)
   PUBMED   20574759
  REMARK    GeneRIF: cell surface expression of AMFR is associated with
            progression in Chronic lymphocytic leukemia
REFERENCE   5  (bases 1 to 3631)
  AUTHORS   Jo,Y., Sguigna,P.V. and DeBose-Boyd,R.A.
  TITLE     Membrane-associated ubiquitin ligase complex containing gp78
            mediates sterol-accelerated degradation of
            3-hydroxy-3-methylglutaryl-coenzyme A reductase
  JOURNAL   J. Biol. Chem. 286 (17), 15022-15031 (2011)
   PUBMED   21343306
  REMARK    GeneRIF: identify two ER membrane proteins, SPFH2 and TMUB1, as
            associated proteins of gp78, a membrane-bound ubiquitin ligase that
            mediates sterol-accelerated ERAD of the cholesterol biosynthetic
            enzyme HMG-CoA reductase.
REFERENCE   6  (bases 1 to 3631)
  AUTHORS   Luo,Y., Long,J.M., Lu,C., Chan,S.L., Spangler,E.L., Mascarucci,P.,
            Raz,A., Longo,D.L., Mattson,M.P., Ingram,D.K. and Weng,N.P.
  TITLE     A link between maze learning and hippocampal expression of
            neuroleukin and its receptor gp78
  JOURNAL   J. Neurochem. 80 (2), 354-361 (2002)
   PUBMED   11902125
  REMARK    GeneRIF: hippocampal expression of NLK and its receptor gp78 is
            associated with maze learning in rats.
REFERENCE   7  (bases 1 to 3631)
  AUTHORS   Fang,S., Ferrone,M., Yang,C., Jensen,J.P., Tiwari,S. and
            Weissman,A.M.
  TITLE     The tumor autocrine motility factor receptor, gp78, is a ubiquitin
            protein ligase implicated in degradation from the endoplasmic
            reticulum
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 98 (25), 14422-14427 (2001)
   PUBMED   11724934
REFERENCE   8  (bases 1 to 3631)
  AUTHORS   Shimizu,K., Tani,M., Watanabe,H., Nagamachi,Y., Niinaka,Y.,
            Shiroishi,T., Ohwada,S., Raz,A. and Yokota,J.
  TITLE     The autocrine motility factor receptor gene encodes a novel type of
            seven transmembrane protein
  JOURNAL   FEBS Lett. 456 (2), 295-300 (1999)
   PUBMED   10456327
REFERENCE   9  (bases 1 to 3631)
  AUTHORS   Huang,B., Xie,Y. and Raz,A.
  TITLE     Identification of an upstream region that controls the
            transcription of the human autocrine motility factor receptor
  JOURNAL   Biochem. Biophys. Res. Commun. 212 (3), 727-742 (1995)
   PUBMED   7626106
REFERENCE   10 (bases 1 to 3631)
  AUTHORS   Watanabe,H., Carmi,P., Hogan,V., Raz,T., Silletti,S., Nabi,I.R. and
            Raz,A.
  TITLE     Purification of human tumor cell autocrine motility factor and
            molecular cloning of its receptor
  JOURNAL   J. Biol. Chem. 266 (20), 13442-13448 (1991)
   PUBMED   1649192
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC069197.1, BX345849.2,
            CA748782.1, AC009102.10, BX409690.2 and AA767223.1.
            On Feb 28, 2012 this sequence version replaced gi:85815824.
            
            Summary: This locus encodes a glycosylated transmembrane receptor.
            Its ligand, autocrine motility factor, is a tumor
            motility-stimulating protein secreted by tumor cells. The encoded
            receptor is also a member of the E3 ubiquitin ligase family of
            proteins. It catalyzes ubiquitination and endoplasmic
            reticulum-associated degradation of specific proteins. [provided by
            RefSeq, Feb 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069197.1, AF124145.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2477              BC069197.1         1-2477
            2478-2478           BX345849.2         166-166
            2479-3072           BC069197.1         2479-3072
            3073-3288           CA748782.1         320-535             c
            3289-3298           AC009102.10        35727-35736
            3299-3353           CA748782.1         265-319             c
            3354-3354           BX409690.2         220-220
            3355-3631           AA767223.1         1-277               c
FEATURES             Location/Qualifiers
     source          1..3631
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..3631
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /note="autocrine motility factor receptor, E3 ubiquitin
                     protein ligase"
                     /db_xref="GeneID:267"
                     /db_xref="HGNC:463"
                     /db_xref="HPRD:09130"
                     /db_xref="MIM:603243"
     exon            1..466
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="alignment:Splign:1.39.8"
     CDS             212..2143
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /EC_number="6.3.2.19"
                     /note="RING finger protein 45"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase AMFR"
                     /protein_id="NP_001135.3"
                     /db_xref="GI:21071001"
                     /db_xref="CCDS:CCDS10758.1"
                     /db_xref="GeneID:267"
                     /db_xref="HGNC:463"
                     /db_xref="HPRD:09130"
                     /db_xref="MIM:603243"
                     /translation="
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRLEETLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNKSSEDDAASESFLPSEGASSDPVTLRRRMLAAAAERRLQKQQTS
"
     misc_feature    455..517
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UKV5.2);
                     transmembrane region"
     misc_feature    467..>1357
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /note="HRD ubiquitin ligase complex, ER membrane component
                     [Posttranslational modification, protein turnover,
                     chaperones]; Region: HRD1; COG5243"
                     /db_xref="CDD:34840"
     misc_feature    575..637
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UKV5.2);
                     transmembrane region"
     misc_feature    644..706
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UKV5.2);
                     transmembrane region"
     misc_feature    767..829
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UKV5.2);
                     transmembrane region"
     misc_feature    854..916
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UKV5.2);
                     transmembrane region"
     misc_feature    1037..1099
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UKV5.2);
                     transmembrane region"
     misc_feature    1229..1357
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /note="RING-finger (Really Interesting New Gene) domain, a
                     specialized type of Zn-finger of 40 to 60 residues that
                     binds two atoms of zinc; defined by the 'cross-brace'
                     motif C-X2-C-X(9-39)-C-X(1-3)-
                     H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved
                     in...; Region: RING; cd00162"
                     /db_xref="CDD:29102"
     misc_feature    order(1232..1234,1241..1243,1277..1279,1283..1285,
                     1292..1294,1301..1303,1334..1336,1343..1345)
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /note="cross-brace motif; other site"
                     /db_xref="CDD:29102"
     misc_feature    1496..1558
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UKV5.2);
                     transmembrane region"
     misc_feature    1577..1702
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /note="Domain that may be involved in binding
                     ubiquitin-conjugating enzymes (UBCs); Region: CUE;
                     smart00546"
                     /db_xref="CDD:197783"
     misc_feature    1757..1759
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9UKV5.2); phosphorylation site"
     misc_feature    2051..2140
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UKV5.2);
                     Region: VCP/p97-interacting motif (VIM)"
     exon            467..559
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="alignment:Splign:1.39.8"
     exon            560..724
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="alignment:Splign:1.39.8"
     STS             648..736
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /standard_name="D7S2301E"
                     /db_xref="UniSTS:147336"
     exon            725..877
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="alignment:Splign:1.39.8"
     exon            878..918
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="alignment:Splign:1.39.8"
     exon            919..1051
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="alignment:Splign:1.39.8"
     exon            1052..1185
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="alignment:Splign:1.39.8"
     exon            1186..1296
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="alignment:Splign:1.39.8"
     exon            1297..1487
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="alignment:Splign:1.39.8"
     exon            1488..1591
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="alignment:Splign:1.39.8"
     exon            1592..1726
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="alignment:Splign:1.39.8"
     exon            1727..1810
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="alignment:Splign:1.39.8"
     exon            1811..1995
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="alignment:Splign:1.39.8"
     exon            1996..3600
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /inference="alignment:Splign:1.39.8"
     variation       2041
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1804880"
     variation       2478
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4924"
     variation       2838
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1050876"
     variation       2860
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13468"
     variation       2889
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1804879"
     STS             2924..3050
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /standard_name="SHGC-60751"
                     /db_xref="UniSTS:21603"
     variation       2996
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1050889"
     STS             3080..3415
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /standard_name="SHGC-60972"
                     /db_xref="UniSTS:51932"
     STS             3105..3229
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /standard_name="SHGC-61049"
                     /db_xref="UniSTS:77394"
     STS             3349..3493
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
                     /standard_name="RH70754"
                     /db_xref="UniSTS:64201"
     polyA_signal    3583..3588
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
     polyA_site      3600
                     /gene="AMFR"
                     /gene_synonym="GP78; RNF45"
ORIGIN      
ctcttccgcgccggcaggggcagcagcgggagcagcgcggggcggagcggcgccagcagccaggagcggcccggcccggcccggcgcggcggcggcggcggcagcggcagcggcagcgacgccagagcccgtgggcgccgttcgcgaggccgccgcagaggcccggccgcagcgcagggaagcctgggggccagaggtcgccgctgccgccatgccgctgctcttcctcgagcgcttcccctggcccagcctccgcacctacacgggcctcagcggcctggccctgctgggcaccatcatcagcgcctaccgcgcgctcagccagcccgaggccggccccggcgagccggaccagctaacggcctcgctgcagcctgagccgccggcgcccgcccggccgagcgccgggggaccccgggcccgcgatgtggcccagtacctgctctcagacagcctcttcgtgtgggttctagtaaataccgcttgctgtgttttgatgttggtggctaagctcatccagtgtattgtgtttggccctcttcgagtgagtgagagacagcatctcaaagacaaattttggaattttattttctacaagttcattttcatctttggtgtgctgaatgtccagacagtggaagaggtggtcatgtggtgcctctggtttgccggacttgtctttctgcacctgatggttcagctctgcaaggatcgatttgaatatctttccttctcgcccaccacgccgatgagcagccacggtcgagtcctgtccctgttggttgccatgctgctttcctgctgtggactggcggccgtctgctccatcaccggctacacccacggaatgcacaccttggctttcatggctgcagagtctcttcttgtgacagtgaggactgctcatgtgattttacgatacgtaattcacctctgggacctcaaccacgaagggacgtgggaaggaaaggggacgtatgtctattacacagactttgtcatggagctcactctcctgtccctggacctcatgcaccatattcacatgttgttatttggcaacatctggttatccatggccagcctggtcatctttatgcagctgcgttacctgtttcatgaggtgcaacgtcgaattcgtcggcacaagaactatctacgtgtggttggaaacatggaggccaggtttgcagttgcaactccagaggagctggctgtcaacaatgacgactgtgccatctgttgggactccatgcaggctgcgcggaaactgccctgtggacatcttttccacaactcctgtcttcgttcctggctagaacaagacacctcctgtccaacatgcagaatgtctcttaatattgccgacaataatcgtgtcagggaagaacatcaaggagagaacttggatgagaatttggttcctgtagcagcagccgaagggagacctcgcttaaaccaacacaatcacttcttccatttcgatgggtctcggattgcgagctggctgccgagtttttcggttgaagtgatgcacaccaccaacattcttggcattacgcaggccagcaactcccagctcaatgcaatggctcatcagattcaagagatgtttccccaggttccataccatctggtactgcaggacctccagctgacacgctcagttgaaataacaacagacaatattttagaaggacggattcaagtaccttttcctacacagcggtcagatagcatcagacctgcattgaacagtcctgtggaaaggccaagcagtgaccaggaagagggagaaacttctgctcagaccgagcgtgtgccactggacctcagtcctcgcctggaggagacgctggacttcggcgaggtggaagtggagcccagtgaggtggaagacttcgaggctcgtgggagccgcttctccaagtctgctgatgagagacagcgcatgctggtgcagcgtaaggacgaactcctccagcaagctcgcaaacgtttcttgaacaaaagttctgaagatgatgcggcctcagagagcttcctcccctcggaaggtgcgtcctctgaccccgtgaccctgcgtcgaaggatgctggctgccgccgcggaacggaggcttcagaagcagcagacctcctagcgctcccttgccttcctcagctgcctcctgcgccctgtgcccgactgactggaggaggcctgtcccaattctgcccgctccatggaaaagcgggcttgactgcattgccgctgtataaagcatgtggtcttatagtgtttggacagctgataaatttaatccttctttgtaatactttctatgtgacatttctcttccccttagaaacactgcaaattttaactgtaggtatgatctcttctggtgttgactggactgcttggggtgggggacgatcaggaggaagtgagcagtcgcctgcctgcagcaggcagcttctactcctgcctcatgcgtacgtcccacaaatgcaggtgtcctgagcaccacacccagtgggaagagtgtgggggaggcgcacagtgtgagcccgcccccacgtcgtggggtaacatctgttatcaaactgctgtcgttgttgtggaagcatgtagactgtgccagaggccagacccacgggctcatgcacccctgagccagcagggcatcttggaaaaggaactcttggttcgatacctggagcagaggaggggaaagtccagggctatagggtgtgatgaagtcacccctttctgtcccactacatctgggactgactttccgagcctccagtccaaagccggcttgatttccgtgaactctggtgctcctgcatctcatgagtgtgccccatgggtcccctcccctctcagcatttccttgtcccgtctggacctggggagtggttaggcagcaagctttggtttatggttttcattcattggtgaagtaaattaggcagtgctaaagcctgtgggtttggtccttgaacaagatgtgggccttgcaagatgggagagtaaaccttgaagggctttattaaagaaataaaaaagaacttttgtatcttttatcctgggagcactgcgttttcctagctgtgttattcctggtttaattcagcagagaaggtaaggtgtgaacctacctgccttggagagggcccaggtcccaaatctcttcaaattcttcacatgtttaactttaaggatttgaaccatgaagtcataggttacagacctcagttttatgccccattggattactttttttttttttttttttttttttttttttactctttgaaagctttgttttgtggtagtccttttgggaagaatccagtattatccacaattattggcaaagtttaaatgtattttacataacggaaagtttttagaatgttgaaaagtaattgaaaaaggtgataggtaaatttttaggcaaagataatttatttcaataaatctttcaaaagccttaccttgaaatgctgttagtaaatttctgtgatttttttttttaatttgttttgctgagagcatagctatttgtttttattgtaaaacaataataataataaaaagcaaactctaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:267 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IDA
            GeneID:267 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IMP
            GeneID:267 -> Molecular function: GO:0004872 [receptor activity] evidence: IPI
            GeneID:267 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:267 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
            GeneID:267 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: IDA
            GeneID:267 -> Biological process: GO:0006511 [ubiquitin-dependent protein catabolic process] evidence: IMP
            GeneID:267 -> Biological process: GO:0006928 [cellular component movement] evidence: TAS
            GeneID:267 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:267 -> Biological process: GO:0030433 [ER-associated protein catabolic process] evidence: IDA
            GeneID:267 -> Biological process: GO:0030433 [ER-associated protein catabolic process] evidence: IMP
            GeneID:267 -> Biological process: GO:0030968 [endoplasmic reticulum unfolded protein response] evidence: IMP
            GeneID:267 -> Biological process: GO:0051259 [protein oligomerization] evidence: IDA
            GeneID:267 -> Cellular component: GO:0016021 [integral to membrane] evidence: NAS
            GeneID:267 -> Cellular component: GO:0030176 [integral to endoplasmic reticulum membrane] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001135 -> EC 6.3.2.19

by @meso_cacase at DBCLS
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