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2024-04-20 07:12:55, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001143837 4615 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens NADPH oxidase 4 (NOX4), transcript variant 3, mRNA.
ACCESSION NM_001143837
VERSION NM_001143837.1 GI:219842347
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4615)
AUTHORS Koziel,R., Pircher,H., Kratochwil,M., Lener,B., Hermann,M.,
Dencher,N.A. and Jansen-Durr,P.
TITLE Mitochondrial respiratory chain complex I is inactivated by NADPH
oxidase Nox4
JOURNAL Biochem. J. 452 (2), 231-239 (2013)
PUBMED 23514110
REMARK GeneRIF: Nox4 specifically inhibits the activity of mitochondrial
electron transport chain complex I, decreasing the concentration of
complex I subunits and mitochondrial function by a new pathway.
REFERENCE 2 (bases 1 to 4615)
AUTHORS Matsushima,S., Kuroda,J., Ago,T., Zhai,P., Ikeda,Y., Oka,S.,
Fong,G.H., Tian,R. and Sadoshima,J.
TITLE Broad suppression of NADPH oxidase activity exacerbates
ischemia/reperfusion injury through inadvertent downregulation of
hypoxia-inducible factor-1alpha and upregulation of peroxisome
proliferator-activated receptor-alpha
JOURNAL Circ. Res. 112 (8), 1135-1149 (2013)
PUBMED 23476056
REMARK GeneRIF: Nox4 protects the heart from ischemia/reperfusion injury
by regulating hypoxia-inducible factor-1alpha and peroxisome
proliferator-activated receptor-alpha.
REFERENCE 3 (bases 1 to 4615)
AUTHORS Anilkumar,N., Jose,G.S., Sawyer,I., Santos,C.X., Sand,C.,
Brewer,A.C., Warren,D. and Shah,A.M.
TITLE A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and
involved in redox signaling in vascular cells
JOURNAL Arterioscler. Thromb. Vasc. Biol. 33 (4), E104-E112 (2013)
PUBMED 23393389
REMARK GeneRIF: Nox4D is a nuclear-localized and functionally active
splice variant of Nox4 that may have important pathophysiologic
effects through modulation of nuclear signaling and DNA damage in
vascular cells.
REFERENCE 4 (bases 1 to 4615)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS ONE 7 (12), E51954 (2012)
PUBMED 23251661
REFERENCE 5 (bases 1 to 4615)
AUTHORS Chang,G., Chen,L., Lin,H.M., Lin,Y. and Maranchie,J.K.
TITLE Nox4 inhibition enhances the cytotoxicity of cisplatin in human
renal cancer cells
JOURNAL J. Exp. Ther. Oncol. 10 (1), 9-18 (2012)
PUBMED 22946340
REMARK GeneRIF: Nox4 contributes to renal cancer cells chemo-resistance
through modulation of pro-apoptotic and anti-apoptotic signaling,
suggesting that Nox4 inhibition might enhance the efficacy of
conventional cytotoxic drugs against RCC.
REFERENCE 6 (bases 1 to 4615)
AUTHORS Bedard,K. and Krause,K.H.
TITLE The NOX family of ROS-generating NADPH oxidases: physiology and
pathophysiology
JOURNAL Physiol. Rev. 87 (1), 245-313 (2007)
PUBMED 17237347
REMARK Review article
REFERENCE 7 (bases 1 to 4615)
AUTHORS Brar,S.S., Kennedy,T.P., Sturrock,A.B., Huecksteadt,T.P.,
Quinn,M.T., Whorton,A.R. and Hoidal,J.R.
TITLE An NAD(P)H oxidase regulates growth and transcription in melanoma
cells
JOURNAL Am. J. Physiol., Cell Physiol. 282 (6), C1212-C1224 (2002)
PUBMED 11997235
REFERENCE 8 (bases 1 to 4615)
AUTHORS Cheng,G., Cao,Z., Xu,X., van Meir,E.G. and Lambeth,J.D.
TITLE Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4,
and Nox5
JOURNAL Gene 269 (1-2), 131-140 (2001)
PUBMED 11376945
REFERENCE 9 (bases 1 to 4615)
AUTHORS Shiose,A., Kuroda,J., Tsuruya,K., Hirai,M., Hirakata,H., Naito,S.,
Hattori,M., Sakaki,Y. and Sumimoto,H.
TITLE A novel superoxide-producing NAD(P)H oxidase in kidney
JOURNAL J. Biol. Chem. 276 (2), 1417-1423 (2001)
PUBMED 11032835
REFERENCE 10 (bases 1 to 4615)
AUTHORS Geiszt,M., Kopp,J.B., Varnai,P. and Leto,T.L.
TITLE Identification of renox, an NAD(P)H oxidase in kidney
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (14), 8010-8014 (2000)
PUBMED 10869423
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA970477.1, AP002404.2,
AK057189.1, AK298323.1, AP001815.4 and AW207163.1.
Summary: This gene encodes a member of the NOX-family of enzymes
that functions as the catalytic subunit the NADPH oxidase complex.
The encoded protein is localized to non-phagocytic cells where it
acts as an oxygen sensor and catalyzes the reduction of molecular
oxygen to various reactive oxygen species (ROS). The ROS generated
by this protein have been implicated in numerous biological
functions including signal transduction, cell differentiation and
tumor cell growth. A pseudogene has been identified on the other
arm of chromosome 11. Alternative splicing results in multiple
transcript variants.[provided by RefSeq, Jan 2009].
Transcript Variant: This variant (3) differs in the 5' UTR and
coding region compared to variant 1. These differences cause
translation initiation at a downstream AUG and result in a protein
(isoform c) with a shorter N-terminus compared to isoform a.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: AK057189.1 [ECO:0000331]
RNAseq introns :: mixed/partial sample support ERS025081,
ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-302 DA970477.1 1-302
303-303 AP002404.2 33049-33049 c
304-794 AK057189.1 304-794
795-813 AK298323.1 344-362
814-2122 AK057189.1 814-2122
2123-4172 AP001815.4 17607-19656 c
4173-4615 AW207163.1 1-443 c
FEATURES Location/Qualifiers
source 1..4615
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q14.2-q21"
gene 1..4615
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/note="NADPH oxidase 4"
/db_xref="GeneID:50507"
/db_xref="HGNC:7891"
/db_xref="MIM:605261"
exon 1..172
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 173..231
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 232..422
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 423..521
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
misc_feature 519..521
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/note="upstream in-frame stop codon"
exon 522..617
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
CDS 537..2201
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/EC_number="1.6.3.-"
/note="isoform c is encoded by transcript variant 3;
kidney superoxide-producing NADPH oxidase; renal
NAD(P)H-oxidase; kidney oxidase-1"
/codon_start=1
/product="NADPH oxidase 4 isoform c"
/protein_id="NP_001137309.1"
/db_xref="GI:219842348"
/db_xref="CCDS:CCDS44696.1"
/db_xref="GeneID:50507"
/db_xref="HGNC:7891"
/db_xref="MIM:605261"
/translation="
MNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHVAAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTYAIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLPEYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVISHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGKTVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
"
misc_feature 669..1079
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/note="Ferric reductase like transmembrane component;
Region: Ferric_reduct; pfam01794"
/db_xref="CDD:201977"
misc_feature 1395..2195
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/note="NADPH oxidase (NOX) catalyzes the generation of
reactive oxygen species (ROS) such as superoxide and
hydrogen peroxide. ROS were originally identified as
bactericidal agents in phagocytes, but are now also
implicated in cell signaling and metabolism. NOX...;
Region: NOX_Duox_like_FAD_NADP; cd06186"
/db_xref="CDD:99783"
misc_feature order(1476..1478,1518..1529,1572..1580,1587..1598,
1761..1763)
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/note="FAD binding pocket [chemical binding]; other site"
/db_xref="CDD:99783"
misc_feature order(1518..1520,1524..1529)
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/note="FAD binding motif [chemical binding]; other site"
/db_xref="CDD:99783"
misc_feature 1746..1778
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/note="NAD pyrophosphate binding region [chemical
binding]; other site"
/db_xref="CDD:99783"
misc_feature order(1746..1748,1758..1769,1773..1775)
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/note="beta-alpha-beta stucture motif; other site"
/db_xref="CDD:99783"
misc_feature order(1761..1766,1848..1856,2106..2111)
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/note="NAD binding pocket [chemical binding]; other site"
/db_xref="CDD:99783"
misc_feature order(1842..1847,1854..1856)
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/note="NADP ribose binding motif [chemical binding]; other
site"
/db_xref="CDD:99783"
exon 618..728
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 729..813
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
variation 775..776
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/replace=""
/replace="c"
/db_xref="dbSNP:34078833"
exon 814..911
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 912..939
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 940..1012
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1013..1093
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1094..1310
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1311..1475
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1476..1538
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1539..1599
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1600..1681
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1682..1801
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1802..1910
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1911..1979
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1980..2080
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 2081..4604
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
STS 2129..2717
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/standard_name="NOX4_8033"
/db_xref="UniSTS:467805"
STS 2382..2546
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/standard_name="RH92457"
/db_xref="UniSTS:89303"
polyA_signal 2441..2446
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
polyA_site 2464
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
polyA_signal 2590..2595
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
polyA_site 2613
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
variation 3033..3034
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/replace=""
/replace="ac"
/db_xref="dbSNP:67347334"
variation 3465..3466
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/replace=""
/replace="c"
/db_xref="dbSNP:34486773"
variation 3565..3566
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/replace=""
/replace="g"
/db_xref="dbSNP:35013442"
STS 3600..3765
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/standard_name="G35510"
/db_xref="UniSTS:44150"
polyA_signal 4585..4590
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
polyA_site 4604
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
ORIGIN
acacttcactcaaatggctggctgcagctggtgctagttatggtctgggatctcagatgaggctgctaagccgaatgtgttgttactcctttacatcgtctctccacatggcttgaacttctcacagcatgcctgctggattcgaagagatggcattcaagtgcttaaaaatcaagaagaccctcaccaggtgccagcgtctagacattggattttccagcctccagaacttacttctagtctagttggagaaacaacctagaaaatgcaccaacaaatggggcacaataactactctgagagagagtggcacacagtggacgcaaagaagaggttcctgatgcagctgggaagagtctacatgggcctctagcaggagaagatactggtcttgagtttggagactaagtaagcatctccagtgtcgaataggtacctgggtcaactccacacacttctcactcttcactggacctctggtacaagattgagaggattcctattacttacaaacagactagttcatctggctctccatgaatgtcctgcttttctggaaaaccttcttgctgtataaccaagggccagagtatcactacctccaccagatgttggggctaggattgtgtctaagcagagcctcagcatctgttcttaacctcaactgcagccttatccttttacccatgtgccgaacactcttggcttacctccgaggatcacagaaggttccaagcaggagaaccaggagattgttggataaaagcagaacattccatattacctgtggtgttactatctgtattttctcaggcgtgcatgtggctgcccatctggtgaatgccctcaacttctcagtgaattacagtgaagactttgttgaactgaatgcagcaagataccgagatgaggatcctagaaaacttctcttcacaactgttcctggcctgacaggggtctgcatggtggtggtgctattcctcatgatcacagcctctacatatgcaataagagtttctaactatgatatcttctggtatactcataacctcttctttgtcttctacatgctgctgacgttgcatgtttcaggagggctgctgaagtatcaaactaatttagatacccaccctcccggctgcatcagtcttaaccgaaccagctctcagaatatttccttaccagagtatttctcagaacattttcatgaacctttccctgaaggattttcaaaaccggcagagtttacccagcacaaatttgtgaagatttgtatggaagagcccagattccaagctaattttccacagacttggctttggatttctggacctttgtgcctgtactgtgccgaaagactttacaggtatatccggagcaataagccagtcaccatcatttcggtcataagtcatccctcagatgtcatggaaatccgaatggtcaaagaaaattttaaagcaagacctggtcagtatattactctacattgtcccagtgtatctgcattagaaaatcatccatttaccctcacaatgtgtccaactgaaaccaaagcaacatttggggttcatcttaaaatagtaggagactggacagaacgatttcgagatttactactgcctccatctagtcaagactccgaaattctgcccttcattcaatctagaaattatcccaagctgtatattgatggtccttttggaagtccatttgaggaatcactgaactatgaggtcagcctctgcgtggctggaggcattggagtaactccatttgcatcaatactcaacaccctgttggatgactggaaaccatacaagcttagaagactatactttatttgggtatgcagagatatccagtccttccgttggtttgcagatttactctgtatgttgcataacaagttttggcaagagaacagacctgactatgtcaacatccagctgtacctcagtcaaacagatgggatacagaagataattggagaaaaatatcatgcactgaattcaagactgtttataggacgtcctcggtggaaacttttgtttgatgaaatagcaaaatataacagaggaaaaacagttggtgttttctgttgtggacccaattcactatccaagactcttcataaactgagtaaccagaacaactcatatgggacaagatttgaatacaataaagagtctttcagctgaaaacttttgccatgaagcaggactctaaagaaggaatgagtgcaatttctaagactttgaaactcagcggaatcaatcagctgtgttatgccaaagaatagtaaggttttcttatttatgattatttaaaatggaaatgtgagaatgtggcaagatgaccgtcacattacatgtttaatctggaaaccaaagagaccctgaagaatatttgatgtgatgattcacttttcagttctcaaattaaaagaaaactgttagatgcacactgttgattttcatggtggattcaagaactccctagtgaggagctgaacttgctcaatctaaggctgattgtcgtgttcctctttaaattgtttttggttgaacaaatgcaagattgaacaaaattaaaaattcattgaagctgaaattccattttctgtgttgtgtataaacagagtagctttaatttgcaagcactccaggcaaatatattagatgtttgaaaacacagcacaagactctgtattgatacgggtactttgtgtcaatatctaatcgtctccactacttatgctaatacctctatttgatatctgaagactatatgctaactgaaccttcctcaaatgttgttatagtatctatttttatatatttttttctttttattcctctctctagggaaatatgccttcccttagcatgcattagacataatgatttaataggtccctttcatcttcatttaaatctatcactattgcatggtaatgaaaatattcctactataaattataaagggatatatatatatggatatatatatgtatatacacatatatatatacacacacacacacatatatatatatatatatatatatacacatatactaataacttttcccttttttcagcatttttgtctctattattattattgtttttttcccaggtagggtttgtcttaggctgtagcctctaaggatagttagttaatttgcactttgagaccaaaggacatcatgtgtgtcagtagggactgaatataagatttatctcctttgccacacattggtttatgatggagacattgaaagtctagtcatattcctgaacagtaaaacctgtattttaccttttaagtaagaggaaatatgatattcttattcaaacttaagtttagaatccagaatattactgtcgcactttttggtatcctgagtttccatagggaactattgggtttaaagtcaccgttggaactacactgtgtgatcttataaacttatgttccctggctatcatattcttggctcagaacaatatttcccattactatcttaagaattaaggcattcatggctcacgcctgtaatcccggcactttgggaggccaaggcaggtggatcacgaggtcagagttcaagaccagcctgaccaagttggtgaaaccccatcgctactaaaaatacaaatattaggcgggtgtggtggcgggtgcctataatcccaactactcgggagactgaggcaaagaatcgcttgaacccggtgggcggaggttgcagtgagccaagattgcaccactgcactccagcctgggtgacagagcaagattccatctcaaaaaaaaaaaaaaaaaaaaaaaaaaagaattaaagcattcatacagtttagtgattttgtttagtagtcggctatcaattgctatcaaatataacactgctgaaatcagcagtgtgacttaccttgccattgttaaaatgttacataaaacataacatgatagatgctaaggcctttttttgctataattcaccaatagcaatcaagcatgctaacccatactgaatgatatttacttgtagatatttcttcctttccttgaaattctcctttctatggaaagaagatgaacccaaaaaagtgataggaaatgtggaatgctcatgcagatttagctctgaaggcatatttaataactagtatgtcttgacaacagtctttagattaaaaagaattttcatggaaacatttaacagaaagaactagtaaaaagacactttgagttagtccaggcttaatgtgcaatactgactctatactgatcataatttatttatgcgatcatattaatagacctaatttcattaaaacaggtagaagatttttcaaaagaaagatgatgtttcaaagctggtctgccattctagatgagcctccttgcttatttaagttccagtaggtgttcaaatgttaaatgttaaacataggtcatctttgcttctgcagggcttcatcttgcatgtttaagagaactttgttttattttgagggattatttctctggggatcattcttataatacaagccttaaatcactaattttagtagcaataaatgttaaaattgaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:50507 -> Molecular function: GO:0000166 [nucleotide binding] evidence: TAS
GeneID:50507 -> Molecular function: GO:0009055 [electron carrier activity] evidence: TAS
GeneID:50507 -> Molecular function: GO:0016174 [NAD(P)H oxidase activity] evidence: TAS
GeneID:50507 -> Molecular function: GO:0016175 [superoxide-generating NADPH oxidase activity] evidence: IEA
GeneID:50507 -> Molecular function: GO:0019826 [oxygen sensor activity] evidence: TAS
GeneID:50507 -> Molecular function: GO:0020037 [heme binding] evidence: TAS
GeneID:50507 -> Molecular function: GO:0050660 [flavin adenine dinucleotide binding] evidence: TAS
GeneID:50507 -> Molecular function: GO:0072341 [modified amino acid binding] evidence: IDA
GeneID:50507 -> Biological process: GO:0000902 [cell morphogenesis] evidence: ISS
GeneID:50507 -> Biological process: GO:0001666 [response to hypoxia] evidence: IEA
GeneID:50507 -> Biological process: GO:0006954 [inflammatory response] evidence: TAS
GeneID:50507 -> Biological process: GO:0007569 [cell aging] evidence: ISS
GeneID:50507 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: ISS
GeneID:50507 -> Biological process: GO:0014911 [positive regulation of smooth muscle cell migration] evidence: IEA
GeneID:50507 -> Biological process: GO:0035051 [cardiocyte differentiation] evidence: IEA
GeneID:50507 -> Biological process: GO:0042554 [superoxide anion generation] evidence: ISS
GeneID:50507 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
GeneID:50507 -> Biological process: GO:0043406 [positive regulation of MAP kinase activity] evidence: IEA
GeneID:50507 -> Biological process: GO:0045453 [bone resorption] evidence: IEA
GeneID:50507 -> Biological process: GO:0050667 [homocysteine metabolic process] evidence: IDA
GeneID:50507 -> Biological process: GO:0051496 [positive regulation of stress fiber assembly] evidence: IEA
GeneID:50507 -> Biological process: GO:0051897 [positive regulation of protein kinase B signaling cascade] evidence: IEA
GeneID:50507 -> Biological process: GO:0055114 [oxidation-reduction process] evidence: IDA
GeneID:50507 -> Biological process: GO:0070374 [positive regulation of ERK1 and ERK2 cascade] evidence: IEA
GeneID:50507 -> Biological process: GO:0071320 [cellular response to cAMP] evidence: IEA
GeneID:50507 -> Biological process: GO:0071333 [cellular response to glucose stimulus] evidence: IEA
GeneID:50507 -> Biological process: GO:0071480 [cellular response to gamma radiation] evidence: IEA
GeneID:50507 -> Biological process: GO:0071560 [cellular response to transforming growth factor beta stimulus] evidence: IEA
GeneID:50507 -> Biological process: GO:0072593 [reactive oxygen species metabolic process] evidence: IDA
GeneID:50507 -> Biological process: GO:2000379 [positive regulation of reactive oxygen species metabolic process] evidence: IEA
GeneID:50507 -> Biological process: GO:2000573 [positive regulation of DNA biosynthetic process] evidence: IEA
GeneID:50507 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:50507 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
GeneID:50507 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: IEA
GeneID:50507 -> Cellular component: GO:0005925 [focal adhesion] evidence: IEA
GeneID:50507 -> Cellular component: GO:0016021 [integral to membrane] evidence: TAS
GeneID:50507 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IEA
GeneID:50507 -> Cellular component: GO:0043020 [NADPH oxidase complex] evidence: IEA
GeneID:50507 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001137309 -> EC 1.6.3.-
by
@meso_cacase at
DBCLS
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