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2024-04-25 03:19:05, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001143677 2459 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens serum/glucocorticoid regulated kinase 1 (SGK1),
transcript variant 3, mRNA.
ACCESSION NM_001143677
VERSION NM_001143677.1 GI:219521877
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2459)
AUTHORS Alamares-Sapuay,J.G., Martinez-Gil,L., Stertz,S., Miller,M.S.,
Shaw,M.L. and Palese,P.
TITLE Serum- and glucocorticoid-regulated kinase 1 is required for
nuclear export of the ribonucleoprotein of influenza A virus
JOURNAL J. Virol. 87 (10), 6020-6026 (2013)
PUBMED 23487453
REMARK GeneRIF: Authors also demonstrate that SGK1 is required for
influenza A virus ribonucleoprotein nuclear export.
REFERENCE 2 (bases 1 to 2459)
AUTHORS Velez Edwards,D.R., Naj,A.C., Monda,K., North,K.E., Neuhouser,M.,
Magvanjav,O., Kusimo,I., Vitolins,M.Z., Manson,J.E.,
O'Sullivan,M.J., Rampersaud,E. and Edwards,T.L.
TITLE Gene-environment interactions and obesity traits among
postmenopausal African-American and Hispanic women in the Women's
Health Initiative SHARe Study
JOURNAL Hum. Genet. 132 (3), 323-336 (2013)
PUBMED 23192594
REFERENCE 3 (bases 1 to 2459)
AUTHORS Miranda,P., Cadaveira-Mosquera,A., Gonzalez-Montelongo,R.,
Villarroel,A., Gonzalez-Hernandez,T., Lamas,J.A., Alvarez de la
Rosa,D. and Giraldez,T.
TITLE The neuronal serum- and glucocorticoid-regulated kinase 1.1 reduces
neuronal excitability and protects against seizures through
upregulation of the M-current
JOURNAL J. Neurosci. 33 (6), 2684-2696 (2013)
PUBMED 23392695
REMARK GeneRIF: Transgenic mice with increased SGK1.1 activity shows
diminished sensitivity to induced seizures.
REFERENCE 4 (bases 1 to 2459)
AUTHORS Raikwar,N.S., Liu,K.Z. and Thomas,C.P.
TITLE A regulated NH2-terminal Sgk1 variant with enhanced function is
expressed in the collecting duct
JOURNAL Am. J. Physiol. Renal Physiol. 303 (11), F1527-F1533 (2012)
PUBMED 23034940
REMARK GeneRIF: Renally expressed Sgk1 isoform, Sgk1_i3, stimulates ENaC
activity when heterologously expressed in collecting duct cells.
REFERENCE 5 (bases 1 to 2459)
AUTHORS Ronchi,C.L., Sbiera,S., Leich,E., Tissier,F., Steinhauer,S.,
Deutschbein,T., Fassnacht,M. and Allolio,B.
TITLE Low SGK1 expression in human adrenocortical tumors is associated
with ACTH-independent glucocorticoid secretion and poor prognosis
JOURNAL J. Clin. Endocrinol. Metab. 97 (12), E2251-E2260 (2012)
PUBMED 23055545
REMARK GeneRIF: Low SGK1 expression is related to ACTH-independent
cortisol secretion in adrenocortical tumors and is a new prognostic
factor in adrenocortical carcinoma.
REFERENCE 6 (bases 1 to 2459)
AUTHORS Kobayashi,T., Deak,M., Morrice,N. and Cohen,P.
TITLE Characterization of the structure and regulation of two novel
isoforms of serum- and glucocorticoid-induced protein kinase
JOURNAL Biochem. J. 344 (PT 1), 189-197 (1999)
PUBMED 10548550
REFERENCE 7 (bases 1 to 2459)
AUTHORS Park,J., Leong,M.L., Buse,P., Maiyar,A.C., Firestone,G.L. and
Hemmings,B.A.
TITLE Serum and glucocorticoid-inducible kinase (SGK) is a target of the
PI 3-kinase-stimulated signaling pathway
JOURNAL EMBO J. 18 (11), 3024-3033 (1999)
PUBMED 10357815
REFERENCE 8 (bases 1 to 2459)
AUTHORS Kobayashi,T. and Cohen,P.
TITLE Activation of serum- and glucocorticoid-regulated protein kinase by
agonists that activate phosphatidylinositide 3-kinase is mediated
by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2
JOURNAL Biochem. J. 339 (PT 2), 319-328 (1999)
PUBMED 10191262
REFERENCE 9 (bases 1 to 2459)
AUTHORS Waldegger,S., Erdel,M., Nagl,U.O., Barth,P., Raber,G., Steuer,S.,
Utermann,G., Paulmichl,M. and Lang,F.
TITLE Genomic organization and chromosomal localization of the human SGK
protein kinase gene
JOURNAL Genomics 51 (2), 299-302 (1998)
PUBMED 9722955
REFERENCE 10 (bases 1 to 2459)
AUTHORS Waldegger,S., Barth,P., Raber,G. and Lang,F.
TITLE Cloning and characterization of a putative human serine/threonine
protein kinase transcriptionally modified during anisotonic and
isotonic alterations of cell volume
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 94 (9), 4440-4445 (1997)
PUBMED 9114008
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA309338.1, AK098509.1 and
BP384292.1.
Summary: This gene encodes a serine/threonine protein kinase that
plays an important role in cellular stress response. This kinase
activates certain potassium, sodium, and chloride channels,
suggesting an involvement in the regulation of processes such as
cell survival, neuronal excitability, and renal sodium excretion.
High levels of expression of this gene may contribute to conditions
such as hypertension and diabetic nephropathy. Several
alternatively spliced transcript variants encoding different
isoforms have been noted for this gene. [provided by RefSeq, Jan
2009].
Transcript Variant: This variant (3) contains an alternative
in-frame, 5' terminal exon compared to transcript variant 1,
resulting in an isoform (3) with a longer and an unique N-terminus
compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: FM205708.1, AK293383.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-469 DA309338.1 34-502
470-2441 AK098509.1 393-2364
2442-2459 BP384292.1 485-502
FEATURES Location/Qualifiers
source 1..2459
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6q23"
gene 1..2459
/gene="SGK1"
/gene_synonym="SGK"
/note="serum/glucocorticoid regulated kinase 1"
/db_xref="GeneID:6446"
/db_xref="HGNC:10810"
/db_xref="MIM:602958"
exon 1..210
/gene="SGK1"
/gene_synonym="SGK"
/inference="alignment:Splign:1.39.8"
misc_feature 27..29
/gene="SGK1"
/gene_synonym="SGK"
/note="upstream in-frame stop codon"
CDS 51..1430
/gene="SGK1"
/gene_synonym="SGK"
/EC_number="2.7.11.1"
/note="isoform 3 is encoded by transcript variant 3;
serine/threonine protein kinase SGK;
serine/threonine-protein kinase Sgk1;
serum/glucocorticoid-regulated kinase 1; Sgk1 variant i3"
/codon_start=1
/product="serine/threonine-protein kinase Sgk1 isoform 3"
/protein_id="NP_001137149.1"
/db_xref="GI:219521878"
/db_xref="CCDS:CCDS47477.1"
/db_xref="GeneID:6446"
/db_xref="HGNC:10810"
/db_xref="MIM:602958"
/translation="
MSSQSSSLSEACSREAYSSHNWALPPASRSNPQPAYPWATRRMKEEAIKPPLKAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
"
misc_feature <213..308
/gene="SGK1"
/gene_synonym="SGK"
/note="The Phox Homology domain, a phosphoinositide
binding module; Region: PX_domain; cl02563"
/db_xref="CDD:207644"
misc_feature 426..1199
/gene="SGK1"
/gene_synonym="SGK"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature 438..1406
/gene="SGK1"
/gene_synonym="SGK"
/note="Catalytic domain of the Protein Serine/Threonine
Kinase, Serum- and Glucocorticoid-induced Kinase; Region:
STKc_SGK; cd05575"
/db_xref="CDD:173666"
misc_feature order(444..449,453..464,468..470,507..509,513..515,
612..614,663..665,669..671,681..683,687..689,798..800,
804..806,810..815,819..821,849..854,861..863,903..920,
999..1001,1017..1019,1026..1028)
/gene="SGK1"
/gene_synonym="SGK"
/note="active site"
/db_xref="CDD:173666"
misc_feature order(444..449,453..464,468..470,507..509,513..515,
612..614,663..665,669..671,804..806,810..815,819..821,
849..851)
/gene="SGK1"
/gene_synonym="SGK"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173666"
misc_feature order(456..458,681..683,687..689,798..800,804..806,
810..812,861..863,903..920,999..1001,1017..1019,
1026..1028)
/gene="SGK1"
/gene_synonym="SGK"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173666"
misc_feature 849..920
/gene="SGK1"
/gene_synonym="SGK"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173666"
misc_feature 1323..1325
/gene="SGK1"
/gene_synonym="SGK"
/note="turn motif phosphorylation site [posttranslational
modification]; other site"
/db_xref="CDD:173666"
misc_feature 1386..1403
/gene="SGK1"
/gene_synonym="SGK"
/note="hydrophobic motif (HM); other site"
/db_xref="CDD:173666"
exon 211..286
/gene="SGK1"
/gene_synonym="SGK"
/inference="alignment:Splign:1.39.8"
exon 287..362
/gene="SGK1"
/gene_synonym="SGK"
/inference="alignment:Splign:1.39.8"
variation 324
/gene="SGK1"
/gene_synonym="SGK"
/replace="a"
/replace="c"
/db_xref="dbSNP:11554163"
exon 363..467
/gene="SGK1"
/gene_synonym="SGK"
/inference="alignment:Splign:1.39.8"
exon 468..551
/gene="SGK1"
/gene_synonym="SGK"
/inference="alignment:Splign:1.39.8"
exon 552..683
/gene="SGK1"
/gene_synonym="SGK"
/inference="alignment:Splign:1.39.8"
exon 684..796
/gene="SGK1"
/gene_synonym="SGK"
/inference="alignment:Splign:1.39.8"
exon 797..920
/gene="SGK1"
/gene_synonym="SGK"
/inference="alignment:Splign:1.39.8"
variation 854
/gene="SGK1"
/gene_synonym="SGK"
/replace="c"
/replace="t"
/db_xref="dbSNP:1057293"
STS 857..1074
/gene="SGK1"
/gene_synonym="SGK"
/standard_name="MARC_12229-12230:1007996328:1"
/db_xref="UniSTS:267375"
exon 921..1016
/gene="SGK1"
/gene_synonym="SGK"
/inference="alignment:Splign:1.39.8"
exon 1017..1172
/gene="SGK1"
/gene_synonym="SGK"
/inference="alignment:Splign:1.39.8"
variation 1021..1022
/gene="SGK1"
/gene_synonym="SGK"
/replace="c"
/replace="t"
/db_xref="dbSNP:1057934"
variation 1067
/gene="SGK1"
/gene_synonym="SGK"
/replace="a"
/replace="c"
/db_xref="dbSNP:78176488"
exon 1173..1262
/gene="SGK1"
/gene_synonym="SGK"
/inference="alignment:Splign:1.39.8"
exon 1263..2452
/gene="SGK1"
/gene_synonym="SGK"
/inference="alignment:Splign:1.39.8"
STS 1276..1398
/gene="SGK1"
/gene_synonym="SGK"
/standard_name="RH16308"
/db_xref="UniSTS:9291"
variation 1277
/gene="SGK1"
/gene_synonym="SGK"
/replace="c"
/replace="g"
/db_xref="dbSNP:1135343"
variation 1584..1585
/gene="SGK1"
/gene_synonym="SGK"
/replace="g"
/replace="t"
/db_xref="dbSNP:1057300"
variation 1826
/gene="SGK1"
/gene_synonym="SGK"
/replace="a"
/replace="g"
/db_xref="dbSNP:11554162"
STS 1853..2142
/gene="SGK1"
/gene_synonym="SGK"
/standard_name="PMC86685P1"
/db_xref="UniSTS:273543"
STS 2044..2173
/gene="SGK1"
/gene_synonym="SGK"
/standard_name="RH102"
/db_xref="UniSTS:2151"
STS 2149..2323
/gene="SGK1"
/gene_synonym="SGK"
/standard_name="STS-T33566"
/db_xref="UniSTS:55519"
STS 2300..2424
/gene="SGK1"
/gene_synonym="SGK"
/standard_name="WI-13202"
/db_xref="UniSTS:71093"
polyA_signal 2424..2429
/gene="SGK1"
/gene_synonym="SGK"
polyA_site 2452
/gene="SGK1"
/gene_synonym="SGK"
ORIGIN
aagtggggttcataacagaacagggatagccgtctctggctcgtgctctcatgtcatctcagagttccagcttatcagaggcatgtagcagggaggcttattccagccataactgggctctacctccagcctccagaagtaatccccaacctgcatatccttgggcaacccgaagaatgaaagaagaagctataaaaccccctttgaaagctttcatgaagcagaggaggatgggtctgaacgactttattcagaagattgccaataactcctatgcatgcaaacaccctgaagttcagtccatcttgaagatctcccaacctcaggagcctgagcttatgaatgccaacccttctcctccaccaagtccttctcagcaaatcaaccttggcccgtcgtccaatcctcatgctaaaccatctgactttcacttcttgaaagtgatcggaaagggcagttttggaaaggttcttctagcaagacacaaggcagaagaagtgttctatgcagtcaaagttttacagaagaaagcaatcctgaaaaagaaagaggagaagcatattatgtcggagcggaatgttctgttgaagaatgtgaagcaccctttcctggtgggccttcacttctctttccagactgctgacaaattgtactttgtcctagactacattaatggtggagagttgttctaccatctccagagggaacgctgcttcctggaaccacgggctcgtttctatgctgctgaaatagccagtgccttgggctacctgcattcactgaacatcgtttatagagacttaaaaccagagaatattttgctagattcacagggacacattgtccttactgacttcggactctgcaaggagaacattgaacacaacagcacaacatccaccttctgtggcacgccggagtatctcgcacctgaggtgcttcataagcagccttatgacaggactgtggactggtggtgcctgggagctgtcttgtatgagatgctgtatggcctgccgcctttttatagccgaaacacagctgaaatgtacgacaacattctgaacaagcctctccagctgaaaccaaatattacaaattccgcaagacacctcctggagggcctcctgcagaaggacaggacaaagcggctcggggccaaggatgacttcatggagattaagagtcatgtcttcttctccttaattaactgggatgatctcattaataagaagattactcccccttttaacccaaatgtgagtgggcccaacgacctacggcactttgaccccgagtttaccgaagagcctgtccccaactccattggcaagtcccctgacagcgtcctcgtcacagccagcgtcaaggaagctgccgaggctttcctaggcttttcctatgcgcctcccacggactctttcctctgaaccctgttagggcttggttttaaaggattttatgtgtgtttccgaatgttttagttagccttttggtggagccgccagctgacaggacatcttacaagagaatttgcacatctctggaagcttagcaatcttattgcacactgttcgctggaagctttttgaagagcacattctcctcagtgagctcatgaggttttcatttttattcttccttccaacgtggtgctatctctgaaacgagcgttagagtgccgccttagacggaggcaggagtttcgttagaaagcggacgctgttctaaaaaaggtctcctgcagatctgtctgggctgtgatgacgaatattatgaaatgtgccttttctgaagagattgtgttagctccaaagcttttcctatcgcagtgtttcagttctttattttcccttgtggatatgctgtgtgaaccgtcgtgtgagtgtggtatgcctgatcacagatggattttgttataagcatcaatgtgacacttgcaggacactacaacgtgggacattgtttgtttcttccatatttggaagataaatttatgtgtagacttttttgtaagatacggttaataactaaaatttattgaaatggtcttgcaatgactcgtattcagatgcttaaagaaagcattgctgctacaaatatttctatttttagaaagggtttttatggaccaatgccccagttgtcagtcagagccgttggtgtttttcattgtttaaaatgtcacctgtaaaatgggcattatttatgtttttttttttgcattcctgataattgtatgtattgtataaagaacgtctgtacattgggttataacactagtatatttaaacttacaggcttatttgtaatgtaaaccaccattttaatgtactgtaattaacatggttataatacgtacaatccttccctcatcccatcacacaactttttttgtgtgtgataaactgattttggtttgcaataaaaccttgaaaaatatttacatataaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6446 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA
GeneID:6446 -> Molecular function: GO:0005246 [calcium channel regulator activity] evidence: TAS
GeneID:6446 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:6446 -> Molecular function: GO:0015459 [potassium channel regulator activity] evidence: TAS
GeneID:6446 -> Molecular function: GO:0017080 [sodium channel regulator activity] evidence: TAS
GeneID:6446 -> Molecular function: GO:0017081 [chloride channel regulator activity] evidence: TAS
GeneID:6446 -> Biological process: GO:0001558 [regulation of cell growth] evidence: TAS
GeneID:6446 -> Biological process: GO:0006468 [protein phosphorylation] evidence: TAS
GeneID:6446 -> Biological process: GO:0006814 [sodium ion transport] evidence: TAS
GeneID:6446 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:6446 -> Biological process: GO:0006950 [response to stress] evidence: TAS
GeneID:6446 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IEA
GeneID:6446 -> Biological process: GO:0007616 [long-term memory] evidence: TAS
GeneID:6446 -> Biological process: GO:0008217 [regulation of blood pressure] evidence: TAS
GeneID:6446 -> Biological process: GO:0030334 [regulation of cell migration] evidence: TAS
GeneID:6446 -> Biological process: GO:0032411 [positive regulation of transporter activity] evidence: TAS
GeneID:6446 -> Biological process: GO:0034220 [ion transmembrane transport] evidence: TAS
GeneID:6446 -> Biological process: GO:0042127 [regulation of cell proliferation] evidence: TAS
GeneID:6446 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:6446 -> Biological process: GO:0050790 [regulation of catalytic activity] evidence: TAS
GeneID:6446 -> Biological process: GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] evidence: TAS
GeneID:6446 -> Biological process: GO:0055085 [transmembrane transport] evidence: TAS
GeneID:6446 -> Biological process: GO:0060453 [regulation of gastric acid secretion] evidence: TAS
GeneID:6446 -> Biological process: GO:0070294 [renal sodium ion absorption] evidence: TAS
GeneID:6446 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:6446 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
GeneID:6446 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: IEA
GeneID:6446 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:6446 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001137149 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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