2024-04-25 15:37:41, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001143676 3208 bp mRNA linear PRI 15-JUL-2013 DEFINITION Homo sapiens serum/glucocorticoid regulated kinase 1 (SGK1), transcript variant 2, mRNA. ACCESSION NM_001143676 VERSION NM_001143676.1 GI:219521875 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3208) AUTHORS Alamares-Sapuay,J.G., Martinez-Gil,L., Stertz,S., Miller,M.S., Shaw,M.L. and Palese,P. TITLE Serum- and glucocorticoid-regulated kinase 1 is required for nuclear export of the ribonucleoprotein of influenza A virus JOURNAL J. Virol. 87 (10), 6020-6026 (2013) PUBMED 23487453 REMARK GeneRIF: Authors also demonstrate that SGK1 is required for influenza A virus ribonucleoprotein nuclear export. REFERENCE 2 (bases 1 to 3208) AUTHORS Velez Edwards,D.R., Naj,A.C., Monda,K., North,K.E., Neuhouser,M., Magvanjav,O., Kusimo,I., Vitolins,M.Z., Manson,J.E., O'Sullivan,M.J., Rampersaud,E. and Edwards,T.L. TITLE Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study JOURNAL Hum. Genet. 132 (3), 323-336 (2013) PUBMED 23192594 REFERENCE 3 (bases 1 to 3208) AUTHORS Miranda,P., Cadaveira-Mosquera,A., Gonzalez-Montelongo,R., Villarroel,A., Gonzalez-Hernandez,T., Lamas,J.A., Alvarez de la Rosa,D. and Giraldez,T. TITLE The neuronal serum- and glucocorticoid-regulated kinase 1.1 reduces neuronal excitability and protects against seizures through upregulation of the M-current JOURNAL J. Neurosci. 33 (6), 2684-2696 (2013) PUBMED 23392695 REMARK GeneRIF: Transgenic mice with increased SGK1.1 activity shows diminished sensitivity to induced seizures. REFERENCE 4 (bases 1 to 3208) AUTHORS Raikwar,N.S., Liu,K.Z. and Thomas,C.P. TITLE A regulated NH2-terminal Sgk1 variant with enhanced function is expressed in the collecting duct JOURNAL Am. J. Physiol. Renal Physiol. 303 (11), F1527-F1533 (2012) PUBMED 23034940 REMARK GeneRIF: Renally expressed Sgk1 isoform, Sgk1_i3, stimulates ENaC activity when heterologously expressed in collecting duct cells. REFERENCE 5 (bases 1 to 3208) AUTHORS Ronchi,C.L., Sbiera,S., Leich,E., Tissier,F., Steinhauer,S., Deutschbein,T., Fassnacht,M. and Allolio,B. TITLE Low SGK1 expression in human adrenocortical tumors is associated with ACTH-independent glucocorticoid secretion and poor prognosis JOURNAL J. Clin. Endocrinol. Metab. 97 (12), E2251-E2260 (2012) PUBMED 23055545 REMARK GeneRIF: Low SGK1 expression is related to ACTH-independent cortisol secretion in adrenocortical tumors and is a new prognostic factor in adrenocortical carcinoma. REFERENCE 6 (bases 1 to 3208) AUTHORS Kobayashi,T., Deak,M., Morrice,N. and Cohen,P. TITLE Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase JOURNAL Biochem. J. 344 (PT 1), 189-197 (1999) PUBMED 10548550 REFERENCE 7 (bases 1 to 3208) AUTHORS Park,J., Leong,M.L., Buse,P., Maiyar,A.C., Firestone,G.L. and Hemmings,B.A. TITLE Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway JOURNAL EMBO J. 18 (11), 3024-3033 (1999) PUBMED 10357815 REFERENCE 8 (bases 1 to 3208) AUTHORS Kobayashi,T. and Cohen,P. TITLE Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2 JOURNAL Biochem. J. 339 (PT 2), 319-328 (1999) PUBMED 10191262 REFERENCE 9 (bases 1 to 3208) AUTHORS Waldegger,S., Erdel,M., Nagl,U.O., Barth,P., Raber,G., Steuer,S., Utermann,G., Paulmichl,M. and Lang,F. TITLE Genomic organization and chromosomal localization of the human SGK protein kinase gene JOURNAL Genomics 51 (2), 299-302 (1998) PUBMED 9722955 REFERENCE 10 (bases 1 to 3208) AUTHORS Waldegger,S., Barth,P., Raber,G. and Lang,F. TITLE Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume JOURNAL Proc. Natl. Acad. Sci. U.S.A. 94 (9), 4440-4445 (1997) PUBMED 9114008 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK055077.1, EU518415.1 and BP384292.1. Summary: This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]. Transcript Variant: This variant (2) contains additional in-frame exons at the 5' end compared to transcript variant 1, resulting in an isoform (2) with a longer and an unique N-terminus compared to isoform 1. Isoform 2 is reported to have an increased protein half-life, and is preferentially targeted to the plasma membrane. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK055077.1, FM205709.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1506 AK055077.1 1-1506 1507-2179 EU518415.1 909-1581 2180-3196 AK055077.1 2180-3196 3197-3208 BP384292.1 491-502 FEATURES Location/Qualifiers source 1..3208 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="6" /map="6q23" gene 1..3208 /gene="SGK1" /gene_synonym="SGK" /note="serum/glucocorticoid regulated kinase 1" /db_xref="GeneID:6446" /db_xref="HGNC:10810" /db_xref="MIM:602958" exon 1..667 /gene="SGK1" /gene_synonym="SGK" /inference="alignment:Splign:1.39.8" variation 231 /gene="SGK1" /gene_synonym="SGK" /replace="c" /replace="g" /db_xref="dbSNP:3813344" variation 352 /gene="SGK1" /gene_synonym="SGK" /replace="g" /replace="t" /db_xref="dbSNP:4145423" misc_feature 545..547 /gene="SGK1" /gene_synonym="SGK" /note="upstream in-frame stop codon" CDS 599..2179 /gene="SGK1" /gene_synonym="SGK" /EC_number="2.7.11.1" /note="isoform 2 is encoded by transcript variant 2; serine/threonine protein kinase SGK; serine/threonine-protein kinase Sgk1; serum/glucocorticoid-regulated kinase 1; Sgk1 variant i3" /codon_start=1 /product="serine/threonine-protein kinase Sgk1 isoform 2" /protein_id="NP_001137148.1" /db_xref="GI:219521876" /db_xref="CCDS:CCDS47476.1" /db_xref="GeneID:6446" /db_xref="HGNC:10810" /db_xref="MIM:602958" /translation="
MVNKDMNGFPVKKCSAFQFFKKRVRRWIKSPMVSVDKHQSPSLKYTGSSMVHIPPGEPDFESSLCQTCLGEHAFQRGVLPQENESCSWETQSGCEVREPCNHANILTKPDPRTFWTNDDPAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
" misc_feature <923..1057 /gene="SGK1" /gene_synonym="SGK" /note="The Phox Homology domain, a phosphoinositide binding module; Region: PX_domain; cl02563" /db_xref="CDD:207644" misc_feature order(929..934,974..976) /gene="SGK1" /gene_synonym="SGK" /note="phosphoinositide binding site [chemical binding]; other site" /db_xref="CDD:132768" misc_feature 1175..1948 /gene="SGK1" /gene_synonym="SGK" /note="Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220" /db_xref="CDD:197582" misc_feature 1187..2161 /gene="SGK1" /gene_synonym="SGK" /note="Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1; Region: STKc_SGK1; cd05602" /db_xref="CDD:173693" misc_feature order(1193..1198,1202..1213,1217..1219,1256..1258, 1262..1264,1361..1363,1412..1414,1418..1420,1430..1432, 1436..1438,1547..1549,1553..1555,1559..1564,1568..1570, 1598..1603,1610..1612,1652..1669,1748..1750,1766..1768, 1775..1777) /gene="SGK1" /gene_synonym="SGK" /note="active site" /db_xref="CDD:173693" misc_feature order(1193..1198,1202..1213,1217..1219,1256..1258, 1262..1264,1361..1363,1412..1414,1418..1420,1553..1555, 1559..1564,1568..1570,1598..1600) /gene="SGK1" /gene_synonym="SGK" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:173693" misc_feature order(1205..1207,1430..1432,1436..1438,1547..1549, 1553..1555,1559..1561,1610..1612,1652..1669,1748..1750, 1766..1768,1775..1777) /gene="SGK1" /gene_synonym="SGK" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:173693" misc_feature 1598..1669 /gene="SGK1" /gene_synonym="SGK" /note="activation loop (A-loop); other site" /db_xref="CDD:173693" misc_feature 2072..2074 /gene="SGK1" /gene_synonym="SGK" /note="turn motif phosphorylation site [posttranslational modification]; other site" /db_xref="CDD:173693" misc_feature 2135..2152 /gene="SGK1" /gene_synonym="SGK" /note="hydrophobic motif (HM); other site" /db_xref="CDD:173693" exon 668..883 /gene="SGK1" /gene_synonym="SGK" /inference="alignment:Splign:1.39.8" exon 884..959 /gene="SGK1" /gene_synonym="SGK" /inference="alignment:Splign:1.39.8" exon 960..1035 /gene="SGK1" /gene_synonym="SGK" /inference="alignment:Splign:1.39.8" exon 1036..1111 /gene="SGK1" /gene_synonym="SGK" /inference="alignment:Splign:1.39.8" variation 1073 /gene="SGK1" /gene_synonym="SGK" /replace="a" /replace="c" /db_xref="dbSNP:11554163" exon 1112..1216 /gene="SGK1" /gene_synonym="SGK" /inference="alignment:Splign:1.39.8" exon 1217..1300 /gene="SGK1" /gene_synonym="SGK" /inference="alignment:Splign:1.39.8" exon 1301..1432 /gene="SGK1" /gene_synonym="SGK" /inference="alignment:Splign:1.39.8" exon 1433..1545 /gene="SGK1" /gene_synonym="SGK" /inference="alignment:Splign:1.39.8" exon 1546..1669 /gene="SGK1" /gene_synonym="SGK" /inference="alignment:Splign:1.39.8" variation 1603 /gene="SGK1" /gene_synonym="SGK" /replace="c" /replace="t" /db_xref="dbSNP:1057293" STS 1606..1823 /gene="SGK1" /gene_synonym="SGK" /standard_name="MARC_12229-12230:1007996328:1" /db_xref="UniSTS:267375" exon 1670..1765 /gene="SGK1" /gene_synonym="SGK" /inference="alignment:Splign:1.39.8" exon 1766..1921 /gene="SGK1" /gene_synonym="SGK" /inference="alignment:Splign:1.39.8" variation 1770..1771 /gene="SGK1" /gene_synonym="SGK" /replace="c" /replace="t" /db_xref="dbSNP:1057934" variation 1816 /gene="SGK1" /gene_synonym="SGK" /replace="a" /replace="c" /db_xref="dbSNP:78176488" exon 1922..2011 /gene="SGK1" /gene_synonym="SGK" /inference="alignment:Splign:1.39.8" exon 2012..3201 /gene="SGK1" /gene_synonym="SGK" /inference="alignment:Splign:1.39.8" STS 2025..2147 /gene="SGK1" /gene_synonym="SGK" /standard_name="RH16308" /db_xref="UniSTS:9291" variation 2026 /gene="SGK1" /gene_synonym="SGK" /replace="c" /replace="g" /db_xref="dbSNP:1135343" variation 2333..2334 /gene="SGK1" /gene_synonym="SGK" /replace="g" /replace="t" /db_xref="dbSNP:1057300" variation 2575 /gene="SGK1" /gene_synonym="SGK" /replace="a" /replace="g" /db_xref="dbSNP:11554162" STS 2602..2891 /gene="SGK1" /gene_synonym="SGK" /standard_name="PMC86685P1" /db_xref="UniSTS:273543" STS 2793..2922 /gene="SGK1" /gene_synonym="SGK" /standard_name="RH102" /db_xref="UniSTS:2151" STS 2898..3072 /gene="SGK1" /gene_synonym="SGK" /standard_name="STS-T33566" /db_xref="UniSTS:55519" STS 3049..3173 /gene="SGK1" /gene_synonym="SGK" /standard_name="WI-13202" /db_xref="UniSTS:71093" polyA_signal 3173..3178 /gene="SGK1" /gene_synonym="SGK" polyA_site 3201 /gene="SGK1" /gene_synonym="SGK" ORIGIN
agatattcatgaaccgttgcttcttccagcctcgccttctcgctccctctgcctttctggcgctgttctccctccctccctctggcttctgctctttcttactccttctctcagctgcttaactacagctcccactggaacttgcacaatcaaaaacaactctcctctctcaagccgcctccaggagcgcatcacctggagaagagcgactcgctccccgcgccggccgcggaagagcagccaggtagctgggggcggggaggcgtacccttctcccgctcggtaagagccacagcatctccccggagattggccgtatcccaccgtccggcccccagggtcctgcagcggtgatgcatatgtttcggagcaatgatggaaggagaaaagccgctgtcggtggcaactgaaagtggggagaggttgctgcagtagctggtgctgcagaatgcgcgagtgaagaactgagccccgctagattctccatcccgctcagtcttcattaactgtctgcaggaggtaaaccggggaaacagatatgcactaaccaggcgggtgccaacctggatctataactgtgaattccccacggtggaaaatggtaaacaaagacatgaatggattcccagtcaagaaatgctcagccttccaattttttaagaagcgggtacgaaggtggatcaagagcccaatggtcagtgtggacaagcatcagagtcccagcctgaagtacaccggctcctccatggtgcacatccctccaggggagccagacttcgagtcttccttgtgtcaaacatgcctgggtgaacatgctttccaaagaggggttctccctcaggagaacgagtcatgttcatgggaaactcaatctgggtgtgaagtgagagagccatgtaatcatgccaacatcctgaccaagcccgatccaagaaccttctggactaatgatgatccagctttcatgaagcagaggaggatgggtctgaacgactttattcagaagattgccaataactcctatgcatgcaaacaccctgaagttcagtccatcttgaagatctcccaacctcaggagcctgagcttatgaatgccaacccttctcctccaccaagtccttctcagcaaatcaaccttggcccgtcgtccaatcctcatgctaaaccatctgactttcacttcttgaaagtgatcggaaagggcagttttggaaaggttcttctagcaagacacaaggcagaagaagtgttctatgcagtcaaagttttacagaagaaagcaatcctgaaaaagaaagaggagaagcatattatgtcggagcggaatgttctgttgaagaatgtgaagcaccctttcctggtgggccttcacttctctttccagactgctgacaaattgtactttgtcctagactacattaatggtggagagttgttctaccatctccagagggaacgctgcttcctggaaccacgggctcgtttctatgctgctgaaatagccagtgccttgggctacctgcattcactgaacatcgtttatagagacttaaaaccagagaatattttgctagattcacagggacacattgtccttactgacttcggactctgcaaggagaacattgaacacaacagcacaacatccaccttctgtggcacgccggagtatctcgcacctgaggtgcttcataagcagccttatgacaggactgtggactggtggtgcctgggagctgtcttgtatgagatgctgtatggcctgccgcctttttatagccgaaacacagctgaaatgtacgacaacattctgaacaagcctctccagctgaaaccaaatattacaaattccgcaagacacctcctggagggcctcctgcagaaggacaggacaaagcggctcggggccaaggatgacttcatggagattaagagtcatgtcttcttctccttaattaactgggatgatctcattaataagaagattactcccccttttaacccaaatgtgagtgggcccaacgacctacggcactttgaccccgagtttaccgaagagcctgtccccaactccattggcaagtcccctgacagcgtcctcgtcacagccagcgtcaaggaagctgccgaggctttcctaggcttttcctatgcgcctcccacggactctttcctctgaaccctgttagggcttggttttaaaggattttatgtgtgtttccgaatgttttagttagccttttggtggagccgccagctgacaggacatcttacaagagaatttgcacatctctggaagcttagcaatcttattgcacactgttcgctggaagctttttgaagagcacattctcctcagtgagctcatgaggttttcatttttattcttccttccaacgtggtgctatctctgaaacgagcgttagagtgccgccttagacggaggcaggagtttcgttagaaagcggacgctgttctaaaaaaggtctcctgcagatctgtctgggctgtgatgacgaatattatgaaatgtgccttttctgaagagattgtgttagctccaaagcttttcctatcgcagtgtttcagttctttattttcccttgtggatatgctgtgtgaaccgtcgtgtgagtgtggtatgcctgatcacagatggattttgttataagcatcaatgtgacacttgcaggacactacaacgtgggacattgtttgtttcttccatatttggaagataaatttatgtgtagacttttttgtaagatacggttaataactaaaatttattgaaatggtcttgcaatgactcgtattcagatgcttaaagaaagcattgctgctacaaatatttctatttttagaaagggtttttatggaccaatgccccagttgtcagtcagagccgttggtgtttttcattgtttaaaatgtcacctgtaaaatgggcattatttatgtttttttttttgcattcctgataattgtatgtattgtataaagaacgtctgtacattgggttataacactagtatatttaaacttacaggcttatttgtaatgtaaaccaccattttaatgtactgtaattaacatggttataatacgtacaatccttccctcatcccatcacacaactttttttgtgtgtgataaactgattttggtttgcaataaaaccttgaaaaatatttacatataaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:6446 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA GeneID:6446 -> Molecular function: GO:0005246 [calcium channel regulator activity] evidence: TAS GeneID:6446 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA GeneID:6446 -> Molecular function: GO:0015459 [potassium channel regulator activity] evidence: TAS GeneID:6446 -> Molecular function: GO:0017080 [sodium channel regulator activity] evidence: TAS GeneID:6446 -> Molecular function: GO:0017081 [chloride channel regulator activity] evidence: TAS GeneID:6446 -> Biological process: GO:0001558 [regulation of cell growth] evidence: TAS GeneID:6446 -> Biological process: GO:0006468 [protein phosphorylation] evidence: TAS GeneID:6446 -> Biological process: GO:0006814 [sodium ion transport] evidence: TAS GeneID:6446 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:6446 -> Biological process: GO:0006950 [response to stress] evidence: TAS GeneID:6446 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IEA GeneID:6446 -> Biological process: GO:0007616 [long-term memory] evidence: TAS GeneID:6446 -> Biological process: GO:0008217 [regulation of blood pressure] evidence: TAS GeneID:6446 -> Biological process: GO:0030334 [regulation of cell migration] evidence: TAS GeneID:6446 -> Biological process: GO:0032411 [positive regulation of transporter activity] evidence: TAS GeneID:6446 -> Biological process: GO:0034220 [ion transmembrane transport] evidence: TAS GeneID:6446 -> Biological process: GO:0042127 [regulation of cell proliferation] evidence: TAS GeneID:6446 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS GeneID:6446 -> Biological process: GO:0050790 [regulation of catalytic activity] evidence: TAS GeneID:6446 -> Biological process: GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] evidence: TAS GeneID:6446 -> Biological process: GO:0055085 [transmembrane transport] evidence: TAS GeneID:6446 -> Biological process: GO:0060453 [regulation of gastric acid secretion] evidence: TAS GeneID:6446 -> Biological process: GO:0070294 [renal sodium ion absorption] evidence: TAS GeneID:6446 -> Cellular component: GO:0005634 [nucleus] evidence: IEA GeneID:6446 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA GeneID:6446 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: IEA GeneID:6446 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:6446 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001137148 -> EC 2.7.11.1
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