2024-04-27 04:43:19, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001142931 3615 bp mRNA linear PRI 18-APR-2013 DEFINITION Homo sapiens apoptosis inhibitor 5 (API5), transcript variant 3, mRNA. ACCESSION NM_001142931 VERSION NM_001142931.1 GI:219283154 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3615) AUTHORS Han,B.G., Kim,K.H., Lee,S.J., Jeong,K.C., Cho,J.W., Noh,K.H., Kim,T.W., Kim,S.J., Yoon,H.J., Suh,S.W., Lee,S. and Lee,B.I. TITLE Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules JOURNAL J. Biol. Chem. 287 (14), 10727-10737 (2012) PUBMED 22334682 REMARK GeneRIF: structure and function of API5 REFERENCE 2 (bases 1 to 3615) AUTHORS Wang,Z., Liu,H., Liu,B., Ma,W., Xue,X., Chen,J. and Zhou,Q. TITLE Gene expression levels of CSNK1A1 and AAC-11, but not NME1, in tumor tissues as prognostic factors in NSCLC patients JOURNAL Med. Sci. Monit. 16 (8), CR357-CR364 (2010) PUBMED 20671611 REMARK GeneRIF: The prognostic significance of the genes casein kinase 2 alpha subunit (CSNK2A1), anti-apoptosis clone-11 (AAC-11), and tumor metastasis suppressor NME1 in completely resected non-small cell lung cancer (NSCLC) patients, was analysed. REFERENCE 3 (bases 1 to 3615) AUTHORS Ren,K., Zhang,W., Shi,Y. and Gong,J. TITLE Pim-2 activates API-5 to inhibit the apoptosis of hepatocellular carcinoma cells through NF-kappaB pathway JOURNAL Pathol. Oncol. Res. 16 (2), 229-237 (2010) PUBMED 19821157 REMARK GeneRIF: we infer that Pim-2 could activate API-5 to inhibit the apoptosis of liver cells, and NF-kappaB is the key regulator REFERENCE 4 (bases 1 to 3615) AUTHORS Need,A.C., Attix,D.K., McEvoy,J.M., Cirulli,E.T., Linney,K.L., Hunt,P., Ge,D., Heinzen,E.L., Maia,J.M., Shianna,K.V., Weale,M.E., Cherkas,L.F., Clement,G., Spector,T.D., Gibson,G. and Goldstein,D.B. TITLE A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB JOURNAL Hum. Mol. Genet. 18 (23), 4650-4661 (2009) PUBMED 19734545 REFERENCE 5 (bases 1 to 3615) AUTHORS Rigou,P., Piddubnyak,V., Faye,A., Rain,J.C., Michel,L., Calvo,F. and Poyet,J.L. TITLE The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation JOURNAL EMBO J. 28 (11), 1576-1588 (2009) PUBMED 19387494 REMARK GeneRIF: The authors report here that AAC-11, a survival protein whose expression prevents apoptosis that occurs on deprivation of growth factors, physiologically binds to Acinus and prevents Acinus-mediated DNA fragmentation. REFERENCE 6 (bases 1 to 3615) AUTHORS Li,Z., Hu,C.Y., Mo,B.Q., Xu,J.D. and Zhao,Y. TITLE [Effect of beta-carotene on gene expression of breast cancer cells] JOURNAL Ai Zheng 22 (4), 380-384 (2003) PUBMED 12703993 REFERENCE 7 (bases 1 to 3615) AUTHORS Van den Berghe,L., Laurell,H., Huez,I., Zanibellato,C., Prats,H. and Bugler,B. TITLE FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2 JOURNAL Mol. Endocrinol. 14 (11), 1709-1724 (2000) PUBMED 11075807 REFERENCE 8 (bases 1 to 3615) AUTHORS Kim,J.W., Cho,H.S., Kim,J.H., Hur,S.Y., Kim,T.E., Lee,J.M., Kim,I.K. and Namkoong,S.E. TITLE AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis JOURNAL Lab. Invest. 80 (4), 587-594 (2000) PUBMED 10780674 REFERENCE 9 (bases 1 to 3615) AUTHORS Gianfrancesco,F., Esposito,T., Ciccodicola,A., D'Esposito,M., Mazzarella,R., D'Urso,M. and Forabosco,A. TITLE Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene JOURNAL Cytogenet. Cell Genet. 84 (3-4), 164-166 (1999) PUBMED 10393420 REFERENCE 10 (bases 1 to 3615) AUTHORS Tewari,M., Yu,M., Ross,B., Dean,C., Giordano,A. and Rubin,R. TITLE AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal JOURNAL Cancer Res. 57 (18), 4063-4069 (1997) PUBMED 9307294 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA104687.1, AK294724.1, BC017709.1 and BF115210.1. Summary: This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]. Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region and a small segment in the 3' coding region that results in a frameshift, compared to variant 1. The resulting protein (isoform c) lacks an internal segment in the N-terminal region and has a shorter and distinct C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK294724.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-43 DA104687.1 1-43 44-2052 AK294724.1 1-2009 2053-3596 BC017709.1 2135-3678 3597-3615 BF115210.1 1-19 c FEATURES Location/Qualifiers source 1..3615 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="11" /map="11p11.2" gene 1..3615 /gene="API5" /gene_synonym="AAC-11; AAC11" /note="apoptosis inhibitor 5" /db_xref="GeneID:8539" /db_xref="HGNC:594" /db_xref="MIM:609774" exon 1..242 /gene="API5" /gene_synonym="AAC-11; AAC11" /inference="alignment:Splign:1.39.8" variation 22 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="g" /replace="t" /db_xref="dbSNP:113811140" variation 58 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="g" /db_xref="dbSNP:368093818" variation 77 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:5743211" variation 83 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="t" /db_xref="dbSNP:5743212" variation 87 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="g" /replace="t" /db_xref="dbSNP:184841117" variation 126 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="g" /db_xref="dbSNP:377415422" misc_feature 141..143 /gene="API5" /gene_synonym="AAC-11; AAC11" /note="upstream in-frame stop codon" variation 150 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:374625952" CDS 174..1526 /gene="API5" /gene_synonym="AAC-11; AAC11" /note="isoform c is encoded by transcript variant 3; fibroblast growth factor 2-interacting factor 2; migration-inducing protein MIG8; FIF; antiapoptosis clone 11 protein; cell migration-inducing gene 8 protein" /codon_start=1 /product="apoptosis inhibitor 5 isoform c" /protein_id="NP_001136403.1" /db_xref="GI:219283155" /db_xref="CCDS:CCDS44573.1" /db_xref="GeneID:8539" /db_xref="HGNC:594" /db_xref="MIM:609774" /translation="
MPTVEELYRNYGILADATEQVGQIRRQAIKELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLGTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKVEIGQKRASEDTTSGSPPKKSSAGPKRDARQIYNPPSGKYSSNLGNFNYERSLQGK
" misc_feature 240..1490 /gene="API5" /gene_synonym="AAC-11; AAC11" /note="Apoptosis inhibitory protein 5 (API5); Region: API5; pfam05918" /db_xref="CDD:114630" exon 243..336 /gene="API5" /gene_synonym="AAC-11; AAC11" /inference="alignment:Splign:1.39.8" variation 250 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:199828377" variation 257 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:202237645" variation 296 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:1143463" exon 337..402 /gene="API5" /gene_synonym="AAC-11; AAC11" /inference="alignment:Splign:1.39.8" variation 367 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:145077695" exon 403..554 /gene="API5" /gene_synonym="AAC-11; AAC11" /inference="alignment:Splign:1.39.8" variation 404 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:201125045" STS 407..563 /gene="API5" /gene_synonym="AAC-11; AAC11" /standard_name="RH65627" /db_xref="UniSTS:81284" variation 489 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="c" /db_xref="dbSNP:76787103" variation 489 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="c" /db_xref="dbSNP:111361790" variation 494 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:200627115" variation 524 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:140654326" variation 550 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:375559166" exon 555..761 /gene="API5" /gene_synonym="AAC-11; AAC11" /inference="alignment:Splign:1.39.8" variation 576 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="g" /db_xref="dbSNP:1804963" variation 608 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="t" /db_xref="dbSNP:377763153" STS 624..705 /gene="API5" /gene_synonym="AAC-11; AAC11" /standard_name="GDB:451846" /db_xref="UniSTS:99411" variation 665 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:112521686" variation 694 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:369837996" variation 746 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="c" /db_xref="dbSNP:201696733" exon 762..866 /gene="API5" /gene_synonym="AAC-11; AAC11" /inference="alignment:Splign:1.39.8" variation 782..783 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="" /replace="g" /db_xref="dbSNP:36082968" variation 814 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="g" /db_xref="dbSNP:370568717" variation 838..839 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="" /replace="c" /db_xref="dbSNP:35214208" exon 867..956 /gene="API5" /gene_synonym="AAC-11; AAC11" /inference="alignment:Splign:1.39.8" variation 906 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:144200699" variation 909 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:5743240" variation 913 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:147759395" variation 933 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="c" /db_xref="dbSNP:75380901" exon 957..1138 /gene="API5" /gene_synonym="AAC-11; AAC11" /inference="alignment:Splign:1.39.8" variation 957 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="g" /db_xref="dbSNP:371353181" variation 975 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="c" /db_xref="dbSNP:200528483" variation 990 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:141137610" variation 1019 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:146948287" variation 1028 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:150964963" variation 1075 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:372123869" variation 1099 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:201035525" variation 1119 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="g" /db_xref="dbSNP:140542517" exon 1139..1232 /gene="API5" /gene_synonym="AAC-11; AAC11" /inference="alignment:Splign:1.39.8" variation 1225 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:192394283" exon 1233..1289 /gene="API5" /gene_synonym="AAC-11; AAC11" /inference="alignment:Splign:1.39.8" exon 1290..1366 /gene="API5" /gene_synonym="AAC-11; AAC11" /inference="alignment:Splign:1.39.8" variation 1306 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:377039218" variation 1334 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:150466686" exon 1367..1503 /gene="API5" /gene_synonym="AAC-11; AAC11" /inference="alignment:Splign:1.39.8" variation 1395 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="t" /db_xref="dbSNP:183344229" variation 1425 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="g" /db_xref="dbSNP:376582287" variation 1426 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="g" /db_xref="dbSNP:369005910" variation 1445 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:139347770" variation 1475 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:377223822" variation 1488 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:2862934" exon 1504..3601 /gene="API5" /gene_synonym="AAC-11; AAC11" /inference="alignment:Splign:1.39.8" variation 1528 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:374457536" variation 1566 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="g" /db_xref="dbSNP:368631098" variation 1626 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:372172690" variation 1630 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="c" /db_xref="dbSNP:191181328" variation 1871 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="g" /replace="t" /db_xref="dbSNP:183520498" variation 1980 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="c" /db_xref="dbSNP:151199895" variation 2132 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:189225401" variation 2146 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:11544603" variation 2158 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="g" /replace="t" /db_xref="dbSNP:193209177" variation 2282..2283 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="" /replace="ta" /db_xref="dbSNP:374650735" variation 2323 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="c" /db_xref="dbSNP:376343843" variation 2364 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:72898985" variation 2526 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:11544606" variation 2542 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:376531554" variation 2587 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:140359514" variation 2633 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="g" /replace="t" /db_xref="dbSNP:369508239" variation 2674 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="c" /db_xref="dbSNP:190214487" variation 2756 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="" /replace="t" /db_xref="dbSNP:35080936" variation 2796 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:5743257" variation 2817 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="g" /db_xref="dbSNP:5743258" variation 3107 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:140790279" variation 3120 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="a" /replace="g" /db_xref="dbSNP:144608994" variation 3393 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="g" /replace="t" /db_xref="dbSNP:181717898" STS 3396..3472 /gene="API5" /gene_synonym="AAC-11; AAC11" /standard_name="RH36898" /db_xref="UniSTS:83787" STS 3429..3579 /gene="API5" /gene_synonym="AAC-11; AAC11" /standard_name="RH11873" /db_xref="UniSTS:92803" variation 3429 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:14754" variation 3504 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:143322264" variation 3518 /gene="API5" /gene_synonym="AAC-11; AAC11" /replace="c" /replace="t" /db_xref="dbSNP:1056535" polyA_signal 3578..3583 /gene="API5" /gene_synonym="AAC-11; AAC11" polyA_site 3601 /gene="API5" /gene_synonym="AAC-11; AAC11" ORIGIN
gtctttacgtagacgtcgggggcgcagccgcgctgtgcgcggtgactggcggctgcactggcggcagctggaggtgtaatagtgcgggtagtgggtttggagaagttccgaggcggcggtggcgccggtcaggacaaggatagcggaaccgggccctgggcttgtcgctcaccatgccgacagtagaggagctttaccgcaattatggcatcctggccgatgccacggagcaagtgggccagattcgacgtcaagcaattaaagaactgcctcaatttgccactggagaaaatcttcctcgagtggcagatatactaacgcaacttttgcagacagatgactctgcagaatttaacctagtgaacaatgccctattaagtatatttaaaatggatgcaaaagggactttaggtgggttgttcagccaaatacttcaaggagaggacattgttagagaacgagcaattaaattcctttctacaaaacttaagactttaccagatgaagtcttaacaaaggaagtggaagagcttatactaactgaatccaaaaaggtcctagaagatgtgactggtgaagaatttgttctatttatgaagatactgtctgggttaaaaagcttacagacagtgagtggaagacagcaacttgtagagttggtggctgaacaggccgacctagaacagaccttcaatccctcggatcctgactgtgtggacaggctcttacagtgcactcggcaggcagtacccctcttctctaaaaatgtccattccacaaggtttgtgacatatttctgtgagcaggttctccctaacctcggtaccttgactaccccagtggaaggtcttgatatacagttggaggtattgaaattgttggcggagatgagttcattttgtggtgacatggaaaaactagaaacaaatttaaggaaactatttgataagttattggaatacatgcccctccctccagaagaggcagaaaatggagagaatgctggtaatgaagaacccaagctacagttcagttatgtggaatgtttgttgtacagttttcaccagttgggccgaaaacttccagatttcttaacagccaaactgaatgcagaaaagctcaaagatttcaaaatcaggctgcagtactttgcacggggcctgcaagtttatatcagacaacttcgcttagctctccagggtaaaacgggtgaggccttaaaaacagaagagaacaagattaaagtcgttgcattgaaaataacaaacaatatcaatgttttaatcaaggatctcttccacattcctccttcttataagagcacagtaacactatcctggaaacctgtacaaaaggttgagattgggcaaaagagagccagtgaagatacaacttcaggttcaccacccaagaaatcttcagcaggaccaaaaagagatgccaggcagatttataaccctcccagtgggaaatatagcagcaatttgggcaactttaattatgagaggagccttcaggggaagtagaggtggccgaggttggggcacacgaggaaatcgtagtcggggaagactctactgaataagacatcagcattcttcagcattgtcatgagcttaatatacttaaattctactactcattggattgccggggatgtccctttaaacagactgctgccttcagctaaaaacttaatgttctttatacctttgtatgtatgacctacttttgtaacagaccatggttgtgtccaaggtaaaaccacagtgatatttttggatgctttgtctgcaatcttgacttgtttttgcagtatcattattcagacttcaaattgtgaatcttttaaacatcttgataatttgttgttgagagctgttcattctaaaatgtaatgaaattcagtctagttctgctgataaagatcatcagttttgaaaggttactgattttcctcttccctcttagttttttacccaatatatggagaagagtaatggtcaatcttaacattttgttttaattgtttaataaagctgctgggcagtggtgcagcattcctacctagtgtcataaaagcaaaatacttacatagctttcttaaaatataggaatgacattacatttttaggagaaagtaagttgctttgcaccgcctacttaattcttttccatatattgtgatacaaacttttgaatatggaatcttactatttgaatagaaatgtgtatgtataatatacatacatacataagcatatatgtgtgtgtgtgtgtgtatatatatatatatgcatgctgtgaaacttgactacacaacataaatcactttttaaattccaggaacgggtagtctgacacggtgattatccttttgaggctgaatccgttattaacttgttatttaggtttttactcccagtagcaagggattctaagttagttgcacttacatgattattgttatttaaaactaagaataaaggctgcattttcaaagataaattggaattgctgttggtgaaataacaaccaaaatactgaatctgatgtacatacaggtttctacaggaagagatggtataatttacaatttggagatttaataaccagggctacccagaaaaagtgacttgataacatggtaccaataagtaagggatgctctctcggtttgcttttgccactttcaagattttaacttctcaggttattaatcaaaattattgtataagttagccaatagaatttttaggttaaaacaacagatggggggtttgtggagtgtttaatgtcatgggcatttttagtagcatagaccctttgttctgcatttgaatgtttcgtatatttttgtttcacagttaatcttccctccccaagtttgctattcaaatcaactgcctgaatgacatttctagtagtctgatgtatttttctgaggaatagtttgtgattccaatgcaggtgtcttcattaccattacctctacactgcagaagaagcaaaactcctttattagaattactgcacatgtgtatggggaaaatagttctgaaaggctagaatgatacaagtgagcaaaagttggtcagcttggctatggagtggtggcaataatctctaaacattccaaaagaccatgagctgaacctaaactcccttggaatctgaacaaaggaatataaaattgccatttgaaaactgaccagctaatctggacctcagagatagatcagccagtggcccaaagccatttcaagtacagaaattatagagactacagctaaataaatttgaacattaaatataattttaccactttttgtctttataagcatatttgtaaactcagaactgagcagaagtgactttactttctcaagtttgatactgagttgactgttcccttatccctcacccttccccttccctttcctaaggcaatagtgcacaacttaggttatttttgcttccgaatttgaatgaaaaacttaatgccatggatttttttcttttgcaagacacctgtttatcatcttgtttaaatgtaaatgtccccttatgcttttgaaataaatttccttttgtaattttgaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:8539 -> Molecular function: GO:0017134 [fibroblast growth factor binding] evidence: IPI GeneID:8539 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:8539 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IMP GeneID:8539 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: ISS GeneID:8539 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: NAS GeneID:8539 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:8539 -> Cellular component: GO:0005681 [spliceosomal complex] evidence: ISS GeneID:8539 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA GeneID:8539 -> Cellular component: GO:0005737 [cytoplasm] evidence: NAS
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