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2024-04-24 07:23:56, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001142416 2598 bp mRNA linear PRI 29-APR-2013
DEFINITION Homo sapiens aminoacyl tRNA synthetase complex-interacting
multifunctional protein 1 (AIMP1), transcript variant 3, mRNA.
ACCESSION NM_001142416
VERSION NM_001142416.1 GI:215490010
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2598)
AUTHORS Kwon,H.S., Park,M.C., Kim,D.G., Cho,K., Park,Y.W., Han,J.M. and
Kim,S.
TITLE Identification of CD23 as a functional receptor for the
proinflammatory cytokine AIMP1/p43
JOURNAL J. Cell. Sci. 125 (PT 19), 4620-4629 (2012)
PUBMED 22767513
REMARK GeneRIF: Downregulation of CD23 attenuated AIMP1-induced TNF-alpha
secretion and AIMP1 binding.
REFERENCE 2 (bases 1 to 2598)
AUTHORS Schwarz,M.A., Thornton,J., Xu,H., Awasthi,N. and Schwarz,R.E.
TITLE Cell proliferation and migration are modulated by
Cdk-1-phosphorylated endothelial-monocyte activating polypeptide II
JOURNAL PLoS ONE 7 (3), E33101 (2012)
PUBMED 22412987
REMARK GeneRIF: EMAP II has specific intracellular effects, and that this
intracellular function appears to antagonize its extracellular
anti-angiogenic effects during fetal development and pulmonary
disease progression.
REFERENCE 3 (bases 1 to 2598)
AUTHORS Clauss,M., Voswinckel,R., Rajashekhar,G., Sigua,N.L.,
Fehrenbach,H., Rush,N.I., Schweitzer,K.S., Yildirim,A.O.,
Kamocki,K., Fisher,A.J., Gu,Y., Safadi,B., Nikam,S., Hubbard,W.C.,
Tuder,R.M., Twigg,H.L. III, Presson,R.G., Sethi,S. and Petrache,I.
TITLE Lung endothelial monocyte-activating protein 2 is a mediator of
cigarette smoke-induced emphysema in mice
JOURNAL J. Clin. Invest. 121 (6), 2470-2479 (2011)
PUBMED 21576822
REMARK GeneRIF: EMAPII is elevated in the BALF of active smokers and
patients with COPD. Expression was increased in COPD lungs and
emphysema.
Erratum:[J Clin Invest. 2012 Jul 2;122(7):2703]
REFERENCE 4 (bases 1 to 2598)
AUTHORS Kim,S.S., Hur,S.Y., Kim,Y.R., Yoo,N.J. and Lee,S.H.
TITLE Expression of AIMP1, 2 and 3, the scaffolds for the multi-tRNA
synthetase complex, is downregulated in gastric and colorectal
cancer
JOURNAL Tumori 97 (3), 380-385 (2011)
PUBMED 21789020
REMARK GeneRIF: Decreased expression of AIMP1 in gastric and colorectal
cancer tissues suggests that down-regulation of this protein may be
related to inactivation of the tumor suppressor functions of AIMP
proteins and might play a role in the development of GC and CRC.
REFERENCE 5 (bases 1 to 2598)
AUTHORS Youssef,M.M., Heng,Y.M., Powe,D.G., Edgson,J., Ellis,I.O. and
Murray,C.
TITLE Hypoxia-induced EMAP-II transcription in colorectal cancer
JOURNAL Egypt J Immunol 17 (2), 121-129 (2010)
PUBMED 23082492
REMARK GeneRIF: EMAP-II transcripts are upregulated in tumour cells in
hypoxic conditions.
REFERENCE 6 (bases 1 to 2598)
AUTHORS Kao,J., Houck,K., Fan,Y., Haehnel,I., Libutti,S.K., Kayton,M.L.,
Grikscheit,T., Chabot,J., Nowygrod,R., Greenberg,S. et al.
TITLE Characterization of a novel tumor-derived cytokine.
Endothelial-monocyte activating polypeptide II
JOURNAL J. Biol. Chem. 269 (40), 25106-25119 (1994)
PUBMED 7929199
REFERENCE 7 (bases 1 to 2598)
AUTHORS Lamour,V., Quevillon,S., Diriong,S., N'Guyen,V.C., Lipinski,M. and
Mirande,M.
TITLE Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme
as a case of horizontal gene transfer
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (18), 8670-8674 (1994)
PUBMED 8078941
REFERENCE 8 (bases 1 to 2598)
AUTHORS Shiba,K., Suzuki,N., Shigesada,K., Namba,Y., Schimmel,P. and
Noda,T.
TITLE Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence
of the anticodon-binding domain and acquisition of a new structural
unit
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (16), 7435-7439 (1994)
PUBMED 8052601
REFERENCE 9 (bases 1 to 2598)
AUTHORS Kao,J., Fan,Y.G., Haehnel,I., Brett,J., Greenberg,S., Clauss,M.,
Kayton,M., Houck,K., Kisiel,W., Seljelid,R. et al.
TITLE A peptide derived from the amino terminus of
endothelial-monocyte-activating polypeptide II modulates
mononuclear and polymorphonuclear leukocyte functions, defines an
apparently novel cellular interaction site, and induces an acute
inflammatory response
JOURNAL J. Biol. Chem. 269 (13), 9774-9782 (1994)
PUBMED 7545917
REFERENCE 10 (bases 1 to 2598)
AUTHORS Kao,J., Ryan,J., Brett,G., Chen,J., Shen,H., Fan,Y.G., Godman,G.,
Familletti,P.C., Wang,F., Pan,Y.C. et al.
TITLE Endothelial monocyte-activating polypeptide II. A novel
tumor-derived polypeptide that activates host-response mechanisms
JOURNAL J. Biol. Chem. 267 (28), 20239-20247 (1992)
PUBMED 1400342
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK303965.1, BC014051.2,
BM314663.1 and BQ447202.1.
Summary: The protein encoded by this gene is a cytokine that is
specifically induced by apoptosis, and it is involved in the
control of angiogenesis, inflammation, and wound healing. The
release of this cytokine renders the tumor-associated vasculature
sensitive to tumor necrosis factor. The precursor protein is
identical to the p43 subunit, which is associated with the
multi-tRNA synthetase complex, and it modulates aminoacylation
activity of tRNA synthetase in normal cells. This protein is also
involved in the stimulation of inflammatory responses after
proteolytic cleavage in tumor cells. Multiple transcript variants
encoding different isoforms have been found for this gene. A
pseudogene has been identified on chromosome 20. [provided by
RefSeq, Dec 2008].
Transcript Variant: This variant (3) differs in the 5' UTR and
includes an additional segment in the 5' coding region, compared to
variant 1. The resulting isoform (b) is longer at the N-terminus,
compared to isoform a.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK303965.1, BC014051.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-525 AK303965.1 1-525
526-1775 BC014051.2 492-1741
1776-2097 BM314663.1 252-573
2098-2598 BQ447202.1 1-501 c
FEATURES Location/Qualifiers
source 1..2598
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q24"
gene 1..2598
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/note="aminoacyl tRNA synthetase complex-interacting
multifunctional protein 1"
/db_xref="GeneID:9255"
/db_xref="HGNC:10648"
/db_xref="MIM:603605"
exon 1..88
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/inference="alignment:Splign:1.39.8"
variation 12
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="g"
/db_xref="dbSNP:375142405"
misc_feature 18..20
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/note="upstream in-frame stop codon"
variation 18
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:114327761"
variation 26
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="g"
/db_xref="dbSNP:115186370"
CDS 42..1052
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/note="isoform b precursor is encoded by transcript
variant 3; small inducible cytokine subfamily E, member 1
(endothelial monocyte-activating); endothelial
monocyte-activating polypeptide 2; endothelial-monocyte
activating polypeptide II; multisynthetase complex
auxiliary component p43; ARS-interacting multifunctional
protein 1; aminoacyl tRNA synthase complex-interacting
multifunctional protein 1; multisynthase complex auxiliary
component p43"
/codon_start=1
/product="aminoacyl tRNA synthase complex-interacting
multifunctional protein 1 isoform b precursor"
/protein_id="NP_001135888.1"
/db_xref="GI:215490011"
/db_xref="CCDS:CCDS47121.1"
/db_xref="GeneID:9255"
/db_xref="HGNC:10648"
/db_xref="MIM:603605"
/translation="
MLPAVAVSEPVVLRFMIFCRLLAKMANNDAVLKRLEQKGAEADQIIEYLKQQVSLLKEKAILQATLREEKKLRVENAKLKKEIEELKQELIQAEIQNGVKQIPFPSGTPLHANSMVSENVIQSTAVTTVSSGTKEQIKGGTGDEKKAKEKIEKKGEKKEKKQQSIAGSADSKPIDVSRLDLRIGCIITARKHPDADSLYVEEVDVGEIAPRTVVSGLVNHVPLEQMQNRMVILLCNLKPAKMRGVLSQAMVMCASSPEKIEILAPPNGSVPGDRITFDAFPGEPDKELNPKKKIWEQIQPDLHTNDECVATYKGVPFEVKGKGVCRAQTMSNSGIK
"
misc_feature 72..>260
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/note="ATP synthase B/B' CF(0); Region: ATP-synt_B;
cl07975"
/db_xref="CDD:212286"
mat_peptide 552..1049
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/product="aminoacyl tRNA synthase complex-interacting
multifunctional protein 1 isoform b"
misc_feature 561..869
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/note="tRNA-binding-domain-containing EMAP2-like proteins.
This family contains a diverse fraction of tRNA binding
proteins, including Caenorhabditis elegans methionyl-tRNA
synthetase (CeMetRS), human tyrosyl- tRNA synthetase
(hTyrRS), Saccharomyces cerevisiae...; Region:
tRNA_bind_EMAP-II_like; cd02799"
/db_xref="CDD:48401"
misc_feature 585..605
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/note="cytokine-active heptapeptide; other site"
/db_xref="CDD:48401"
misc_feature order(630..632,669..671,747..749,759..761,780..782,
789..791)
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/note="putative tRNA-binding site [nucleotide binding];
other site"
/db_xref="CDD:48401"
variation 65
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="g"
/replace="t"
/db_xref="dbSNP:77888521"
exon 89..222
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/inference="alignment:Splign:1.39.8"
variation 108
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:376462029"
variation 137
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11544777"
variation 182
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:369984537"
variation 184
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="t"
/db_xref="dbSNP:369840696"
exon 223..336
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/inference="alignment:Splign:1.39.8"
variation 225
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377086510"
variation 258
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373122636"
exon 337..504
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/inference="alignment:Splign:1.39.8"
variation 348
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="g"
/db_xref="dbSNP:1134648"
variation 356
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142036705"
variation 366
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:377235344"
variation 374
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:181917989"
variation 377
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369233911"
variation 379
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:202131629"
variation 382
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:36110860"
variation 388
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:202168884"
variation 396
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377566711"
variation 405..406
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace=""
/replace="ca"
/db_xref="dbSNP:387906865"
variation 422
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:151123024"
variation 423
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:113844295"
variation 425
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201162461"
variation 436
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="g"
/db_xref="dbSNP:184999759"
variation 454
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375592576"
variation 462
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2230255"
variation 470
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146841053"
variation 472
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367813302"
variation 476
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="g"
/db_xref="dbSNP:143898497"
variation 496
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:371028279"
exon 505..716
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/inference="alignment:Splign:1.39.8"
variation 505
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372933784"
variation 514
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:144311249"
variation 533
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374629021"
variation 540
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:185378147"
variation 574
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:202139899"
variation 582
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:145221722"
variation 591
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="g"
/replace="t"
/db_xref="dbSNP:367982035"
variation 597
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200374617"
variation 604
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149144042"
variation 629
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199812889"
variation 631
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:143219988"
variation 657
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148281523"
variation 664
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141415581"
variation 679
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:113532028"
variation 695
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146996325"
variation 705
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138106524"
exon 717..885
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/inference="alignment:Splign:1.39.8"
variation 727
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371607548"
variation 749
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143586104"
variation 755
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201441520"
variation 792
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="g"
/db_xref="dbSNP:374893263"
variation 806
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200239982"
variation 820
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201023640"
variation 878
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="g"
/replace="t"
/db_xref="dbSNP:371633224"
exon 886..2585
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/inference="alignment:Splign:1.39.8"
STS 968..1048
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/standard_name="SHGC-67688"
/db_xref="UniSTS:53199"
variation 976
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="t"
/db_xref="dbSNP:371587424"
variation 995
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369128827"
variation 996
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147167431"
variation 1022
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="g"
/replace="t"
/db_xref="dbSNP:201514824"
variation 1023
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="g"
/db_xref="dbSNP:373047626"
variation 1047
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:138429424"
variation 1068
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace=""
/replace="a"
/db_xref="dbSNP:368302512"
variation 1069
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:185429433"
variation 1079
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:113120506"
variation 1080
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371096541"
variation 1081
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369486213"
variation 1152
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3805410"
STS 1191..1925
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/standard_name="SCYE1_2292"
/db_xref="UniSTS:280985"
variation 1233
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:189803309"
variation 1234
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147386651"
variation 1236
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace=""
/replace="t"
/db_xref="dbSNP:34498392"
variation 1240
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="g"
/replace="t"
/db_xref="dbSNP:139649385"
variation 1256
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3805411"
variation 1310
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="t"
/db_xref="dbSNP:142599031"
variation 1480
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376349817"
variation 1490
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:116122330"
STS 1552..1745
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/standard_name="SHGC-132391"
/db_xref="UniSTS:170814"
variation 1564
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:182065529"
STS 1598..1763
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/standard_name="SHGC-59700"
/db_xref="UniSTS:23723"
variation 1644
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11544778"
variation 1647
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:111236636"
variation 1693
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:60786555"
STS 1720..1824
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/standard_name="SHGC-24759"
/db_xref="UniSTS:31095"
variation 1737
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:186440569"
polyA_signal 1755..1760
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
variation 1758
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372503930"
polyA_site 1775
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
variation 1782..1783
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace=""
/replace="t"
/db_xref="dbSNP:11383965"
polyA_signal 1830..1835
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
polyA_site 1852
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
variation 1863
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:190859723"
variation 1866
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139596725"
variation 1919
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:34894323"
variation 1997
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:6828660"
variation 2121
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="t"
/db_xref="dbSNP:3109951"
STS 2175..2423
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/standard_name="G35299"
/db_xref="UniSTS:30122"
variation 2230
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:13534"
variation 2354
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="g"
/replace="t"
/db_xref="dbSNP:11544779"
variation 2371
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371865014"
variation 2475
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:114810277"
variation 2542
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:76283285"
polyA_signal 2564..2569
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
polyA_site 2585
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
ORIGIN
gtcctttctcactgctatagtacgcgggtggctggacctacatgcttcctgctgtggctgtctcggaacccgtggtcctccgcttcatgattttctgccgtctcttggcaaaaatggcaaataatgatgctgttctgaagagactggagcagaagggtgcagaggcagatcaaatcattgaatatcttaagcagcaagtttctctacttaaggagaaagcaattttgcaggcaactttgagggaagagaagaaacttcgagttgaaaatgctaaactgaagaaagaaattgaagaactgaaacaagagctaattcaggcagaaattcaaaatggagtgaagcaaataccatttccatctggtactccactgcacgctaattctatggtttctgaaaatgtgatacagtctacagcagtaacaaccgtatcttctggtaccaaagaacagataaaaggaggaacaggagacgaaaagaaagcgaaagagaaaattgaaaagaaaggagagaagaaggagaaaaaacagcaatcaatagctggaagtgccgactctaagccaatagatgtttcccgtctggatcttcgaattggttgcatcataactgctagaaaacaccctgatgcagattctttgtatgtggaagaagtagatgtcggagaaatagccccaaggacagttgtcagtggcctggtgaatcatgttcctcttgaacagatgcaaaatcggatggtgattttactttgtaacctgaaacctgcaaagatgaggggagtattatctcaagcaatggtcatgtgtgctagttcaccagagaaaattgaaatcttggctcctccaaatgggtctgttcctggagacagaattacttttgatgctttcccaggagagcctgacaaggagctgaatcctaagaagaagatttgggagcagatccagcctgatcttcacactaatgatgagtgtgtggctacatacaaaggagttccctttgaggtgaaagggaagggagtatgtagggctcaaaccatgagcaacagtggaatcaaataaaatgcttccactaccaaaagacattagagaaaaccttaaaagtaataaagagaaatatatttgtcacttatacctaaaatatgagtggctcatttttgcattactctcttctagacttgactagtcatttacttggtatatattgttttcattgattggggaaacactagatttttacctcggtttttgatcatttataatggagagaggaagttgcctatgttttgtaataatttattttttagcaggaatattgattagcagcttttttttctttatacacatagataactaactagattaatgtttagtttcttatttgtaggcacaggatgcatgaaatttcaagctctgggattttttgtatattgtgtatctgtatcaaaaatatcctctccttttcaaaaatgacaggttggaaaatgtttgtcagacttattaactggtcatattataataatactgataatgaccaactgctcattctgaaagccaaacataaaagctaggagaagtggcatctgaacatttttgctttgctgccagagtaaccctgactaataatacaataacagcaatttttttaaaaaactgagatttcctactggcttgaagtttttctatttagcaaaataattagtaataagttttgactaggtctaaagaatgaacacattgtaaacagttgccacagtagtttctaataaattgatcataaaagcagctatcctttttttttttaattctagcttctttttaaagattatttgggtacctaataaaggataatttatatcttattacagactgatattttgctttttcatgtgtcatcatactgtcagtatattaaaagaaattacagcctaaaacttaacatataccatacatatatattaaggtgtcaaatagctattctcactcatcttacaaatattgtaagagcaataaaaattaattgaggaattataagcctacaggtcatcagccttgaggtgattactgatgatttgggcttacacacatgtcagcaagatagggagtgtggataggggagggctggtagctaacaaggggcctcacagagaaatattagtgactttaaccaggtttcagaatctgggccttacctttacaggttcaacaaaagaatggcatcaatagaggcagaagtatagacattgttttaaaaatacacacatgcacacacacacaaaacattttagcattatagctgtctgaatccttcaataagaaggagaggcacacacaaatacacacactcacacaaaactcaacaaccataaaacaaccctgcatgttataaaaggcagaattaaattttatttatttaaatccatggaactctggtaggccaggatatattatagtaccattatcaatgtgatattctgaaaatatgaactgagcgtcattaacaattgttggtacctaaacacaaaatgaatttcaaaagttactttgttctcaagatatgtcattcttttgggaataaatacttctggtgacaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9255 -> Molecular function: GO:0000049 [tRNA binding] evidence: IDA
GeneID:9255 -> Molecular function: GO:0005125 [cytokine activity] evidence: ISS
GeneID:9255 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:9255 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IDA
GeneID:9255 -> Biological process: GO:0001525 [angiogenesis] evidence: IEA
GeneID:9255 -> Biological process: GO:0001937 [negative regulation of endothelial cell proliferation] evidence: IDA
GeneID:9255 -> Biological process: GO:0006006 [glucose metabolic process] evidence: IEA
GeneID:9255 -> Biological process: GO:0006418 [tRNA aminoacylation for protein translation] evidence: TAS
GeneID:9255 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:9255 -> Biological process: GO:0006935 [chemotaxis] evidence: TAS
GeneID:9255 -> Biological process: GO:0006954 [inflammatory response] evidence: IEA
GeneID:9255 -> Biological process: GO:0007155 [cell adhesion] evidence: IEA
GeneID:9255 -> Biological process: GO:0007165 [signal transduction] evidence: NAS
GeneID:9255 -> Biological process: GO:0007267 [cell-cell signaling] evidence: IDA
GeneID:9255 -> Biological process: GO:0009611 [response to wounding] evidence: TAS
GeneID:9255 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:9255 -> Biological process: GO:0050900 [leukocyte migration] evidence: IDA
GeneID:9255 -> Cellular component: GO:0005615 [extracellular space] evidence: IEA
GeneID:9255 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:9255 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IEA
GeneID:9255 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IEA
GeneID:9255 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:9255 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
GeneID:9255 -> Cellular component: GO:0017101 [aminoacyl-tRNA synthetase multienzyme complex] evidence: IDA
GeneID:9255 -> Cellular component: GO:0030133 [transport vesicle] evidence: IEA
by
@meso_cacase at
DBCLS
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