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2024-04-18 12:24:30, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001141969            2632 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens death-domain associated protein (DAXX), transcript
            variant 1, mRNA.
ACCESSION   NM_001141969
VERSION     NM_001141969.1  GI:215422387
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2632)
  AUTHORS   Pan,W.W., Zhou,J.J., Liu,X.M., Xu,Y., Guo,L.J., Yu,C., Shi,Q.H. and
            Fan,H.Y.
  TITLE     Death domain-associated protein DAXX promotes ovarian cancer
            development and chemoresistance
  JOURNAL   J. Biol. Chem. 288 (19), 13620-13630 (2013)
   PUBMED   23539629
  REMARK    GeneRIF: DAXX is a novel ovarian cancer oncogene that promotes
            ovarian cancer cell proliferation and chemoresistance in ovarian
            cancer cells.
REFERENCE   2  (bases 1 to 2632)
  AUTHORS   Winkler,L.L., Hwang,J. and Kalejta,R.F.
  TITLE     Ubiquitin-independent proteasomal degradation of tumor suppressors
            by human cytomegalovirus pp71 requires the 19S regulatory particle
  JOURNAL   J. Virol. 87 (8), 4665-4671 (2013)
   PUBMED   23408605
  REMARK    GeneRIF: Authors show that only the proteasome 19S regulatory
            particle that normally participates in ubiquitin-dependent protein
            degradation, is required for human herpesvirus 5 pp71-mediated
            degradation of Rb and Daxx.
REFERENCE   3  (bases 1 to 2632)
  AUTHORS   Kwan,P.S., Lau,C.C., Chiu,Y.T., Man,C., Liu,J., Tang,K.D.,
            Wong,Y.C. and Ling,M.T.
  TITLE     Daxx regulates mitotic progression and prostate cancer
            predisposition
  JOURNAL   Carcinogenesis 34 (4), 750-759 (2013)
   PUBMED   23239745
  REMARK    GeneRIF: Daxx may function as a novel APC/C inhibitor, which
            promotes chromosome instability during prostate cancer development.
REFERENCE   4  (bases 1 to 2632)
  AUTHORS   Li,J., Gu,L., Zhang,H., Liu,T., Tian,D., Zhou,M. and Zhou,S.
  TITLE     Berberine represses DAXX gene transcription and induces cancer cell
            apoptosis
  JOURNAL   Lab. Invest. 93 (3), 354-364 (2013)
   PUBMED   23295648
  REMARK    GeneRIF: Downregulation of DAXX by berberine resulted in inhibition
            of MDM2 and subsequently, activation of p53, leading to cancer cell
            death.
REFERENCE   5  (bases 1 to 2632)
  AUTHORS   Oberg,K.
  TITLE     The genetics of neuroendocrine tumors
  JOURNAL   Semin. Oncol. 40 (1), 37-44 (2013)
   PUBMED   23391111
  REMARK    GeneRIF: Studies indicate that mutations of the MEN-1 and ATRX/DAXX
            genes in sporadic pancreatic NETs (PNETs) provided insights into
            tumor development tumor development and therapy.
REFERENCE   6  (bases 1 to 2632)
  AUTHORS   Chang,H.Y., Nishitoh,H., Yang,X., Ichijo,H. and Baltimore,D.
  TITLE     Activation of apoptosis signal-regulating kinase 1 (ASK1) by the
            adapter protein Daxx
  JOURNAL   Science 281 (5384), 1860-1863 (1998)
   PUBMED   9743501
REFERENCE   7  (bases 1 to 2632)
  AUTHORS   Pluta,A.F., Earnshaw,W.C. and Goldberg,I.G.
  TITLE     Interphase-specific association of intrinsic centromere protein
            CENP-C with HDaxx, a death domain-binding protein implicated in
            Fas-mediated cell death
  JOURNAL   J. Cell. Sci. 111 (PT 14), 2029-2041 (1998)
   PUBMED   9645950
REFERENCE   8  (bases 1 to 2632)
  AUTHORS   Herberg,J.A., Beck,S. and Trowsdale,J.
  TITLE     TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form
            a dense cluster at the centromeric end of the MHC
  JOURNAL   J. Mol. Biol. 277 (4), 839-857 (1998)
   PUBMED   9545376
REFERENCE   9  (bases 1 to 2632)
  AUTHORS   Kiriakidou,M., Driscoll,D.A., Lopez-Guisa,J.M. and Strauss,J.F.
            III.
  TITLE     Cloning and expression of primate Daxx cDNAs and mapping of the
            human gene to chromosome 6p21.3 in the MHC region
  JOURNAL   DNA Cell Biol. 16 (11), 1289-1298 (1997)
   PUBMED   9407001
REFERENCE   10 (bases 1 to 2632)
  AUTHORS   Yang,X., Khosravi-Far,R., Chang,H.Y. and Baltimore,D.
  TITLE     Daxx, a novel Fas-binding protein that activates JNK and apoptosis
  JOURNAL   Cell 89 (7), 1067-1076 (1997)
   PUBMED   9215629
  REMARK    GeneRIF: A partial human cDNA clone was identified by its
            interaction with murine Fas in a yeast two-hybrid screening. The
            human clone was then used to clone the murine Daxx, which was
            further characterized.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC359186.1, BC073776.1,
            AK223404.1 and BM997178.1.
            
            Summary: This gene encodes a multifunctional protein that resides
            in multiple locations in the nucleus and in the cytoplasm. It
            interacts with a wide variety of proteins, such as apoptosis
            antigen Fas, centromere protein C, and transcription factor
            erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the
            encoded protein functions as a potent transcription repressor that
            binds to sumoylated transcription factors. Its repression can be
            relieved by the sequestration of this protein into promyelocytic
            leukemia nuclear bodies or nucleoli. This protein also associates
            with centromeres in G2 phase. In the cytoplasm, the encoded protein
            may function to regulate apoptosis. The subcellular localization
            and function of this protein are modulated by post-translational
            modifications, including sumoylation, phosphorylation and
            polyubiquitination. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Nov 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript but encodes the shorter isoform (a). Variants 1 and 2
            encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223404.1, AK292187.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                DC359186.1         1-71
            72-1394             BC073776.1         1-1323
            1395-2560           AK223404.1         1393-2558
            2561-2632           BM997178.1         1-72                c
FEATURES             Location/Qualifiers
     source          1..2632
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.3"
     gene            1..2632
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /note="death-domain associated protein"
                     /db_xref="GeneID:1616"
                     /db_xref="HGNC:2681"
                     /db_xref="MIM:603186"
     exon            1..155
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /inference="alignment:Splign:1.39.8"
     exon            156..414
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    199..201
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /note="upstream in-frame stop codon"
     CDS             208..2430
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /note="isoform a is encoded by transcript variant 1;
                     death-associated protein 6; Fas-binding protein; CENP-C
                     binding protein; ETS1-associated protein 1; death
                     domain-associated protein 6; fas death domain-associated
                     protein"
                     /codon_start=1
                     /product="death domain-associated protein 6 isoform a"
                     /protein_id="NP_001135441.1"
                     /db_xref="GI:215422388"
                     /db_xref="CCDS:CCDS4776.1"
                     /db_xref="GeneID:1616"
                     /db_xref="HGNC:2681"
                     /db_xref="MIM:603186"
                     /translation="
MATANSIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGARGSSSSGGKKCYKLENEKLFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNILSRVLSRARSRPAKLYVYINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDPTNAENTASQSPRTRGSRRQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKKICTLPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQTPHSQPPRPGTCKTSVATQCDPEEIIVLSDSD
"
     misc_feature    208..2427
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /note="Daxx Family; Region: Daxx; pfam03344"
                     /db_xref="CDD:146136"
     misc_feature    208..687
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UER7.2);
                     Region: Necessary for interaction with USP7"
     misc_feature    739..741
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9UER7.2); phosphorylation site"
     misc_feature    844..846
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9UER7.2); phosphorylation site"
     misc_feature    1246..1917
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UER7.2);
                     Region: Necessary for interaction with USP7"
     misc_feature    1378..1392
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UER7.2);
                     Region: Nuclear localization signal (Potential)"
     misc_feature    1690..1692
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9UER7.2); phosphorylation site"
     misc_feature    1708..2082
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UER7.2);
                     Region: Interaction with MAP3K5"
     misc_feature    1741..1743
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (Q9UER7.2); acetylation site"
     misc_feature    2083..2427
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UER7.2);
                     Region: Interaction with SPOP"
     misc_feature    2089..2109
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UER7.2);
                     Region: Nuclear localization signal (Potential)"
     misc_feature    2209..2211
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9UER7.2); phosphorylation site"
     misc_feature    2218..2220
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9UER7.2); phosphorylation site"
     misc_feature    2269..2271
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9UER7.2); phosphorylation site"
     misc_feature    2311..2313
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9UER7.2); phosphorylation site"
     misc_feature    2404..2427
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UER7.2);
                     Region: Sumo interaction motif (SIM)"
     misc_feature    2416..2418
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9UER7.2); phosphorylation site"
     misc_feature    2422..2424
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9UER7.2); phosphorylation site"
     exon            415..1246
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /inference="alignment:Splign:1.39.8"
     variation       513
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12720095"
     STS             698..1049
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /standard_name="PMC230316P1"
                     /db_xref="UniSTS:272179"
     exon            1247..1458
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /inference="alignment:Splign:1.39.8"
     variation       1344
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1059231"
     exon            1459..1672
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /inference="alignment:Splign:1.39.8"
     exon            1673..2147
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /inference="alignment:Splign:1.39.8"
     variation       2121
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2051625"
     exon            2148..2370
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /inference="alignment:Splign:1.39.8"
     variation       2189
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1801850"
     variation       2319
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11873"
     variation       2346
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1801849"
     exon            2371..2615
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /inference="alignment:Splign:1.39.8"
     variation       2460
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1802272"
     polyA_signal    2586..2591
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
     polyA_signal    2593..2598
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
     polyA_site      2615
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1"
ORIGIN      
acgacaatatggcggcgcttagttgcatgaaggcggaaactctgtgacttccggtccgtagtggggcctgcggtgggagtgggaaggaaggcggagggaaccatgcgaggttctgagaattgcggcgagggtcgcctcgagagacggtttctgagcaggaattctgaaatccccaccacttcctccctccgggggatttgatcccctatggccaccgctaacagcatcatcgtgctggatgatgatgacgaagatgaagcagctgctcagccagggccctcccacccactccccaatgcggcctcacctggggcagaagcccctagctcctctgagcctcatggggccagaggaagcagtagttcgggcggcaagaaatgctacaagctggagaatgagaagctgttcgaagagttccttgaactttgtaagatgcagacagcagaccaccctgaggtggtcccattcctctataaccggcagcaacgtgcccactctctgtttttggcctcggcggagttctgcaacatcctctctagggtcctgtctcgggcccggagccggccagccaagctctatgtctacatcaatgagctctgcactgttctcaaggcccactcagccaaaaagaagctgaacttggcccctgccgccaccacctccaatgagccctctgggaataaccctcccacacacctctccttggaccccacaaatgctgaaaacactgcctctcagtctccaaggacccgtggttcccggcggcagatccagcgtttggagcagctgctggcgctctatgtggcagagatccggcggctgcaggaaaaggagttggatctctcagaattggatgacccagactccgcatacctgcaggaggcacggttgaagcgtaagctgatccgcctctttgggcgactatgtgagctgaaagactgctcttcactgaccggccgtgtcatagagcagcgcatcccctaccgtggcacccgctacccagaggttaacaggcgcattgagcggctcatcaacaagccagggcctgataccttccctgactatggggatgtgcttcgggctgtagagaaggcagctgcccgacacagccttggcctcccccgacagcagctccagctcatggctcaggatgccttccgagatgtgggcatcaggttacaggagcgacgtcacctcgatctcatctacaactttggctgccacctcacagatgactataggccaggcgttgaccctgcactatcagatcctgtgttggcccggcgccttcgggaaaaccggagtttggccatgagtcggctggatgaggtcatctccaaatatgcaatgttgcaagacaaaagtgaggagggcgagagaaaaaagagaagagctcggctccaaggcacctcttcccactctgcagacacccccgaagcctccttggattctggtgagggccctagtggaatggcatcccaggggtgcccttctgcctccagagctgagacagatgacgaagacgatgaggagagtgatgaggaagaggaggaggaggaggaagaagaagaggaggaggccacagattctgaagaggaggaggatctggaacagatgcaggagggtcaggaggatgatgaagaggaggacgaagaggaagaagcagcagcaggtaaagatggagacaagagccccatgtcctcactacagatctccaatgaaaagaacctggaacctggcaaacagatcagcagatcttcaggggagcagcaaaacaaaggacgcatagtgtcaccatcgttactgtcagaagaacccctggccccctccagcatagatgctgaaagcaatggagaacagcctgaggagctgaccctggaggaagaaagccctgtgtctcagctctttgagctagagattgaagctttgcccctggataccccttcctctgtggagacggacatttcctcttccaggaagcaatcagaggagcccttcaccactgtcttagagaatggagcaggcatggtctcttctacttccttcaatggaggcgtctctcctcacaactggggagattctggtcccccctgcaaaaaatctcggaaggagaagaagcaaacaggatcagggccattaggaaacagctatgtggaaaggcaaaggtcagtgcatgagaagaatgggaaaaagatatgtaccctgcccagcccaccttcccccttggcttccttggccccagttgctgattcctccacgagggtggactctcccagccatggcctggtgaccagctccctctgcatcccttctccagcccggctgtcccaaaccccccattcacagcctcctcggcctggtacttgcaagacaagtgtggccacacaatgcgatccagaagagatcatcgtgctctcagactctgattagctgcctccccttctccctgcctccagaatgttctgggataacatttggaggaaggtgggaagcagatgactgaggaagggatggactaagctaatccccttttggtggtgtttctttaaaaaaaaaaaaaagcttaagttttacacagaaacattaataaacaataaagttcttttcttactgtaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:1616 -> Molecular function: GO:0002039 [p53 binding] evidence: IPI
            GeneID:1616 -> Molecular function: GO:0005057 [receptor signaling protein activity] evidence: TAS
            GeneID:1616 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:1616 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IDA
            GeneID:1616 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
            GeneID:1616 -> Molecular function: GO:0031072 [heat shock protein binding] evidence: TAS
            GeneID:1616 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI
            GeneID:1616 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IDA
            GeneID:1616 -> Molecular function: GO:0047485 [protein N-terminus binding] evidence: IPI
            GeneID:1616 -> Molecular function: GO:0050681 [androgen receptor binding] evidence: IPI
            GeneID:1616 -> Biological process: GO:0000281 [mitotic cytokinesis] evidence: IEA
            GeneID:1616 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:1616 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:1616 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:1616 -> Biological process: GO:0006917 [induction of apoptosis] evidence: ISS
            GeneID:1616 -> Biological process: GO:0007257 [activation of JUN kinase activity] evidence: TAS
            GeneID:1616 -> Biological process: GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] evidence: TAS
            GeneID:1616 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
            GeneID:1616 -> Biological process: GO:0030521 [androgen receptor signaling pathway] evidence: IDA
            GeneID:1616 -> Biological process: GO:0031396 [regulation of protein ubiquitination] evidence: IDA
            GeneID:1616 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:1616 -> Cellular component: GO:0000775 [chromosome, centromeric region] evidence: IEA
            GeneID:1616 -> Cellular component: GO:0000792 [heterochromatin] evidence: IEA
            GeneID:1616 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:1616 -> Cellular component: GO:0005634 [nucleus] evidence: IMP
            GeneID:1616 -> Cellular component: GO:0005730 [nucleolus] evidence: IEA
            GeneID:1616 -> Cellular component: GO:0005737 [cytoplasm] evidence: TAS
            GeneID:1616 -> Cellular component: GO:0005829 [cytosol] evidence: ISS
            GeneID:1616 -> Cellular component: GO:0016605 [PML body] evidence: IDA
            GeneID:1616 -> Cellular component: GO:0016605 [PML body] evidence: TAS

by @meso_cacase at DBCLS
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